BGC0002086 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002086 (Micromonospora carbonacea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	80,708	High	rosamicin	PKS

BGC0002086 - Region 1 - T1PKS

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Location: 1 - 80,708 nt. (total: 80,708 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 80,709
Label		BGC0002086

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

HXZ27_06110: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HXZ27_06115: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HXZ27_06145: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HXZ27_06160: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase

HXZ27_06135: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

HXZ27_06150: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

HXZ27_06155: methyltransferase

smcogs: SMCOG1248: methyltransferase

HXZ27_06180: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: esterase

HXZ27_06105: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

HXZ27_06120: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

HXZ27_06130: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

HXZ27_06140: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002086.3	1.00	PKS	rosamicin	Micromonospora carbonacea
BGC0001812.3	0.92	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0001276.3	0.77	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000018.5	0.76	PKS	angolamycin	Streptomyces eurythermus
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0000113.5	0.73	PKS	niddamycin	Streptomyces caelestis
BGC0000166.5	0.71	PKS	tylactone	Streptomyces fradiae
BGC0001830.3	0.69	PKS	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002086.3	1.00	PKS	rosamicin	Micromonospora carbonacea
BGC0001812.3	0.92	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0001276.3	0.77	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000018.5	0.76	PKS	angolamycin	Streptomyces eurythermus
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0000113.5	0.73	PKS	niddamycin	Streptomyces caelestis
BGC0000166.5	0.71	PKS	tylactone	Streptomyces fradiae
BGC0001830.3	0.69	PKS	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 80708:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - Me-ccmal) + (ccmal) + (Me-ohmal - redemal) + (Me-ohmal) + (ohmal)
Non-colinear ordering:: HXZ27_06120 + HXZ27_06125 + HXZ27_06130 + HXZ27_06135 + HXZ27_06140

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HXZ27_06120: mmal - mmal - mmal

PKS_AT (569..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.0
Ethylmalonyl-CoA: 168.4
Methoxymalonyl-CoA: 150.4
2-Methylbutyryl-CoA: 122.7
trans-1,2-CPDA: 101.8
Propionyl-CoA: 91.9
Malonyl-CoA: 82.1
Isobutyryl-CoA: 78.1
CHC-CoA: 73.3
Benzoyl-CoA: 67.4
Acetyl-CoA: 36.9
inactive: 27.6
fatty_acid: 24.2
3-Methylbutyryl-CoA: 12.0

PKS_AT (1598..1898): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 170.6
Methoxymalonyl-CoA: 153.2
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 102.9
Propionyl-CoA: 91.6
Malonyl-CoA: 81.7
Isobutyryl-CoA: 80.3
CHC-CoA: 74.3
Benzoyl-CoA: 69.0
Acetyl-CoA: 35.0
inactive: 29.5
fatty_acid: 24.3
3-Methylbutyryl-CoA: 13.7

PKS_AT (3118..3418): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 170.6
Methoxymalonyl-CoA: 153.2
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 102.9
Propionyl-CoA: 91.6
Malonyl-CoA: 81.7
Isobutyryl-CoA: 80.3
CHC-CoA: 74.3
Benzoyl-CoA: 69.0
Acetyl-CoA: 35.0
inactive: 29.5
fatty_acid: 24.3
3-Methylbutyryl-CoA: 13.7

HXZ27_06125: mal

PKS_AT (601..901): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.3
inactive: 107.0
Methylmalonyl-CoA: 75.2
Methoxymalonyl-CoA: 74.6
Ethylmalonyl-CoA: 44.9
Isobutyryl-CoA: 43.6
Propionyl-CoA: 31.8
CHC-CoA: 22.6
Benzoyl-CoA: 17.9
trans-1,2-CPDA: 15.7
Acetyl-CoA: 14.9
2-Methylbutyryl-CoA: 13.6
fatty_acid: 11.3
3-Methylbutyryl-CoA: 0.0

HXZ27_06130: mmal - emal

PKS_AT (600..900): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.0
Ethylmalonyl-CoA: 170.6
Methoxymalonyl-CoA: 153.2
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 102.9
Propionyl-CoA: 91.6
Malonyl-CoA: 81.7
Isobutyryl-CoA: 80.3
CHC-CoA: 74.3
Benzoyl-CoA: 69.0
Acetyl-CoA: 35.0
inactive: 29.5
fatty_acid: 24.3
3-Methylbutyryl-CoA: 13.7

PKS_AT (2123..2421): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 235.2
Methylmalonyl-CoA: 202.9
Methoxymalonyl-CoA: 180.1
trans-1,2-CPDA: 166.5
2-Methylbutyryl-CoA: 159.8
Propionyl-CoA: 121.3
CHC-CoA: 98.1
Malonyl-CoA: 83.6
Isobutyryl-CoA: 72.1
Benzoyl-CoA: 61.4
Acetyl-CoA: 59.5
fatty_acid: 48.6
3-Methylbutyryl-CoA: 34.9
inactive: 16.4

HXZ27_06135: mmal

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.3
Ethylmalonyl-CoA: 190.5
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 138.5
trans-1,2-CPDA: 128.2
Propionyl-CoA: 97.8
Malonyl-CoA: 85.8
CHC-CoA: 85.1
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 56.3
3-Methylbutyryl-CoA: 38.3
fatty_acid: 38.2
Acetyl-CoA: 29.8
inactive: 17.5

HXZ27_06140: mal

PKS_AT (568..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.5
inactive: 111.7
Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 48.9
Propionyl-CoA: 25.3
Acetyl-CoA: 18.2
Isobutyryl-CoA: 17.3
Benzoyl-CoA: 16.9
fatty_acid: 13.8
CHC-CoA: 12.0
Ethylmalonyl-CoA: 11.3
2-Methylbutyryl-CoA: 9.3
3-Methylbutyryl-CoA: 5.0
trans-1,2-CPDA: 0.0

Link to PARAS substrate predictor