BGC0002086: rosamicin biosynthetic gene cluster from Micromonospora carbonacea
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Location: 1,361,829 - 1,422,030 nt. (total: 60,202 nt).
This entry is originally from NCBI GenBank CP058322.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002086
Short description rosamicin biosynthetic gene cluster from Micromonospora carbonacea
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: CP058322.1
Compounds
  • rosamicin
Species Micromonospora carbonacea [taxonomy]
References
Chemical products information
rosamicin [synonyms: rosaramicin]
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • HXZ27_06100
  • QLD23832.2
  • rosA
 1361829 - 1363511 (+) ABC-F type ribosomal protection protein
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  • HXZ27_06105
  • QLD28379.2
  • rosB
 1363556 - 1364350 (-) thioesterase
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  • HXZ27_06110
  • QLD23833.1
  • rosC
 1364457 - 1365689 (-) cytochrome P450
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  • HXZ27_06115
  • QLD23834.1
  • rosD
 1366193 - 1367401 (+) cytochrome P450
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  • HXZ27_06120
  • QLD23835.2
  • rosE
 1367530 - 1380945 (+) SDR family NAD(P)-dependent oxidoreductase
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  • HXZ27_06125
  • QLD23836.1
  • rosF
 1380972 - 1386749 (+) SDR family NAD(P)-dependent oxidoreductase
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  • HXZ27_06130
  • QLD28380.2
  • rosG
 1386821 - 1398064 (+) SDR family NAD(P)-dependent oxidoreductase
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  • HXZ27_06135
  • QLD23837.1
  • rosH
 1398126 - 1402850 (+) SDR family NAD(P)-dependent oxidoreductase
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  • HXZ27_06140
  • QLD23838.1
  • rosI
 1402883 - 1408237 (+) SDR family NAD(P)-dependent oxidoreductase
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  • HXZ27_06145
  • QLD23839.2
  • rosJ
 1408234 - 1409628 (+) P450-derived glycosyltransferase activator
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  • HXZ27_06150
  • QLD23840.2
  • rosK
 1409628 - 1410917 (+) activator-dependent family glycosyltransferase
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  • HXZ27_06155
  • QLD23841.2
  • rosL
 1410926 - 1411648 (+) class I SAM-dependent methyltransferase
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  • HXZ27_06160
  • QLD28381.2
  • rosM
 1411702 - 1413060 (+) crotonyl-CoA carboxylase/reductase
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  • HXZ27_06165
  • QLD23842.1
  • rosN
 1413247 - 1415250 (+) helix-turn-helix domain-containing protein
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  • HXZ27_06170
  • QLD23843.1
  • rosO
 1415192 - 1416403 (-) transposase
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  • HXZ27_06175
  • QLD23844.1
  • rosP
 1416731 - 1418176 (+) GTPase HflX
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  • HXZ27_06180
  • QLD23845.1
  • rosQ
 1418242 - 1419468 (+) dTDP-4-dehydro-6-deoxyglucose aminotransferase
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  • HXZ27_06185
  • QLD23846.2
  • rosR
 1419491 - 1420957 (+) dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
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  • HXZ27_06190
  • QLD23847.1
  • rosS
 1421197 - 1422030 (+) 23S ribosomal RNA methyltransferase Erm
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Polyketide-specific information
Subclass Macrolide
Starter unit Methylmalonyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: VXQQS2VBYGA6KXCJ4IF2SC56, no GDPR consent given).
  • Hidden contributor (ID: AYT6WP6PINVPWSBOCVXGSMXM, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Added version to NCBI accession
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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