BGC0002087: gladiostatin A biosynthetic gene cluster from Burkholderia gladioli 238
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Location: 3,449,913 - 3,530,217 nt. (total: 80,305 nt).
This entry is originally from NCBI GenBank NZ_UZVS01000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002087
Short description gladiostatin A biosynthetic gene cluster from Burkholderia gladioli 238
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
NZ_UZVS01000001.1
3449913 - 3530217
via Knock-out studies, Enzymatic assays
Compounds
  • gladiostatin A
Species Burkholderia gladioli 238 [taxonomy]
References
Chemical products information
gladiostatin A [synonyms: gladiofungin a] Evidence:
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C27H39N1O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ELY54_RS14315
  • WP_036055464.1
 3450463 - 3451386 (+) LysR family transcriptional regulator
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    • ELY54_RS14320
    • WP_080741976.1
    		 3451469 - 3452125 (-) aldehyde dehydrogenase family protein
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      • ELY54_RS14325
      • WP_126241641.1
      		 3452303 - 3453082 (+) MBL fold metallo-hydrolase
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        • ELY54_RS14330
        • WP_046580519.1
        		 3453131 - 3453871 (+) SDR family oxidoreductase
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          • ELY54_RS14335
          • WP_230686150.1
          • argE
          		 3453980 - 3455176 (-) acetylornithine deacetylase
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            • ELY54_RS14340
            • WP_036040227.1
            		 3455169 - 3455846 (-) DUF1028 domain-containing protein
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              • ELY54_RS14345
              • WP_013691298.1
              		 3455867 - 3456304 (-) RidA family protein
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                • ELY54_RS14350
                • WP_013691299.1
                		 3456393 - 3456827 (-) RidA family protein
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                  • ELY54_RS14355
                  • WP_036055459.1
                  		 3456827 - 3458167 (-) NAD(P)/FAD-dependent oxidoreductase
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                    • ELY54_RS14360
                    • WP_126241642.1
                    		 3458471 - 3460987 (+) DUF6531 domain-containing protein
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                      • ELY54_RS14365
                      • WP_046580515.1
                      		 3460984 - 3461520 (+) hypothetical protein
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                        • ELY54_RS14370
                        • WP_036055457.1
                        		 3461600 - 3462790 (-) M20 aminoacylase family protein
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                          • ELY54_RS14375
                          • WP_105848787.1
                          		 3462891 - 3464225 (-) DUF3100 domain-containing protein
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                            • ELY54_RS14380
                            • WP_105851111.1
                            		 3464273 - 3465790 (-) aldehyde dehydrogenase family protein
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                              • ELY54_RS14385
                              • WP_036040212.1
                              		 3465860 - 3466732 (-) NAD(P)-dependent oxidoreductase
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                                • ELY54_RS14390
                                • WP_025099964.1
                                		 3466876 - 3467784 (+) LysR family transcriptional regulator
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                                  • ELY54_RS14395
                                  • WP_042287319.1
                                  		 3468082 - 3469104 (-) NADP-dependent oxidoreductase
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                                    • ELY54_RS14400
                                    • WP_105848784.1
                                    		 3469139 - 3469852 (-) hypothetical protein
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                                      • ELY54_RS14405
                                      • WP_164720583.1
                                      		 3469913 - 3500437 (-) SDR family NAD(P)-dependent oxidoreductase
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                                        • ELY54_RS14410
                                        • WP_126241644.1
                                        		 3500471 - 3510217 (-) SDR family oxidoreductase
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                                          • ELY54_RS14415
                                          • WP_036055452.1
                                          • asnB
                                          		 3510210 - 3512207 (-) asparagine synthase (glutamine-hydrolyzing)
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                                            • ELY54_RS14420
                                            • WP_036055451.1
                                            		 3512302 - 3512544 (-) phosphopantetheine-binding protein
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                                              • ELY54_RS14425
                                              • WP_126241645.1
                                              • fabD
                                              		 3512586 - 3515927 (-) ACP S-malonyltransferase
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                                                • ELY54_RS14430
                                                • WP_036055450.1
                                                		 3516003 - 3516704 (-) histidine phosphatase family protein
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                                                  • ELY54_RS14435
                                                  		 3517684 - 3518291 (-) IS5 family transposase
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                                                    • ELY54_RS14440
                                                    • WP_046583239.1
                                                    		 3518456 - 3519175 (+) YceH family protein
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                                                      • ELY54_RS14445
                                                      • WP_126241646.1
                                                      		 3519338 - 3520600 (-) MFS transporter
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                                                        • ELY54_RS37970
                                                        • WP_164720584.1
                                                        		 3521333 - 3521470 (+) hypothetical protein
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                                                          • ELY54_RS14450
                                                          • WP_105828638.1
                                                          		 3521820 - 3524000 (+) TonB-dependent siderophore receptor
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                                                            • ELY54_RS14455
                                                            • WP_126241647.1
                                                            		 3524481 - 3527105 (+) GH92 family glycosyl hydrolase
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                                                              • ELY54_RS14460
                                                              • WP_105828640.1
                                                              		 3527220 - 3528413 (-) hypothetical protein
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                                                                • ELY54_RS14465
                                                                • WP_105857611.1
                                                                		 3528528 - 3529865 (-) ATP-grasp domain-containing protein
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                                                                  Biosynthesis information

                                                                  Biosynthetic modules

                                                                  Name
                                                                  1
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14410
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  2
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14410
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, carrier (ACP)
                                                                  Name
                                                                  3
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14410
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase
                                                                  Name
                                                                  4
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, carrier (ACP)
                                                                  Name
                                                                  5
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP), carrier (ACP)
                                                                  Name
                                                                  6
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, dehydratase, carrier (ACP)
                                                                  Name
                                                                  7
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, ketoreductase, carrier (ACP), carrier (ACP), carrier (ACP)
                                                                  Name
                                                                  8
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  9
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                                  Name
                                                                  10
                                                                  Type
                                                                  pks-trans-at
                                                                  Genes
                                                                  ELY54_RS14405
                                                                  Substrates
                                                                  Integrated Monomers
                                                                  Domains
                                                                  ketosynthase
                                                                  Annotation changelog

                                                                  Entry version: next

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2024-03-19
                                                                  MIBiG v4 annotathon
                                                                  • (ID: JYES6HFUFY5A364LX52FGPY5)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-10-07
                                                                  Changed chemical structures for compounds: gladiostatin A.
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-10-07
                                                                  Added NPAtlas links to compounds: gladiostatin A.
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Fixed biosynthetic classes
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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