BGC0002088: everninomicin A biosynthetic gene cluster from Micromonospora carbonacea africana
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Location: 835,716 - 887,304 nt. (total: 51,589 nt).
This entry is originally from NCBI GenBank CP058905.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002088
Short description everninomicin A biosynthetic gene cluster from Micromonospora carbonacea africana
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • saccharide (oligosaccharide)
Loci
CP058905.1
835716 - 887304
via Knock-out studies, Enzymatic assays, Gene expression correlated with compound production
Compounds
  • everninomicin A
Species Micromonospora carbonacea africana [taxonomy]
References
Chemical products information
everninomicin A Evidence: NMR, Mass spectrometry, X-ray crystallography, Total synthesis
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Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • HZU44_03975
  • QLJ99321.1
  • eveU1
835716 - 836462 (+) HAD-IA family hydrolase
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    • HZU44_03980
    • QLJ99322.1
    • eveS1
    836610 - 837677 (+) glucose-1-phosphate thymidylyltransferase
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      • HZU44_03985
      • QLJ99323.1
      • eveS2
      837677 - 838666 (+) dTDP-glucose 4
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        • HZU44_03990
        • QLJ99324.1
        • eveS3
        838769 - 839797 (+) NAD-dependent epimerase/dehydratase family protein
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          • HZU44_03995
          • QLJ99325.1
          • eveM1
          839852 - 840589 (+) class I SAM-dependent methyltransferase
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            • HZU44_04000
            • QLJ99326.1
            • eveO1
            840586 - 841260 (+) phytanoyl-CoA dioxygenase family protein
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              • HZU44_04005
              • QLK01199.2
              • eveGT1
              841313 - 842584 (+) DUF1205 domain-containing protein
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                • HZU44_04010
                • QLJ99327.1
                • eveM2
                842661 - 843404 (+) class I SAM-dependent methyltransferase
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                  • HZU44_04015
                  • QLJ99328.1
                  • eveU2
                  843450 - 844478 (+) aldo/keto reductase
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                    • HZU44_04020
                    • QLK01200.2
                    • eveM3
                    844468 - 845241 (+) FkbM family methyltransferase
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                      • HZU44_04025
                      • QLJ99329.1
                      • eveO2
                      845238 - 846182 (+) phytanoyl-CoA dioxygenase family protein
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                        • HZU44_04030
                        • QLJ99330.2
                        • eveM4
                        846179 - 847027 (+) methyltransferase domain-containing protein
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                          • HZU44_04035
                          • QLK01201.2
                          • eveM5
                          847029 - 848309 (+) class I SAM-dependent methyltransferase
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                            • HZU44_04040
                            • QLK01202.2
                            • eveS4
                            848342 - 849535 (+) radical SAM protein
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                              • HZU44_04045
                              • QLK01203.2
                              • eveU3
                              849582 - 850919 (+) cation:proton antiporter
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                                • HZU44_04050
                                • QLJ99331.2
                                • eveD1
                                850997 - 854761 (-) acyltransferase domain-containing protein
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                                  • HZU44_04055
                                  • QLJ99332.1
                                  • eveD2
                                  854850 - 855884 (-) ketoacyl-ACP synthase III family protein
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                                    • HZU44_04060
                                    • QLJ99333.2
                                    • eveX1
                                    856238 - 857299 (+) methyltransferase domain-containing protein
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                                      • HZU44_04065
                                      • QLJ99334.1
                                      • eveU4
                                      857304 - 858806 (-) multicopper oxidase family protein
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                                        • HZU44_04070
                                        • QLJ99335.1
                                        • eveD3
                                        858934 - 860412 (-) tryptophan 7-halogenase
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                                          • HZU44_04075
                                          • QLJ99336.2
                                          • eveU5
                                          860570 - 862102 (-) MFS transporter
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                                            • HZU44_04080
                                            • QLK01204.1
                                            • eveS5
                                            862566 - 863606 (+) GDP-mannose 4
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                                              • HZU44_04085
                                              • QLJ99337.1
                                              • eveS6
                                              863600 - 865057 (+) NDP-hexose 2
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                                                • HZU44_04090
                                                • QLJ99338.1
                                                • eveS7
                                                865062 - 866096 (+) Gfo/Idh/MocA family oxidoreductase
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                                                  • HZU44_04095
                                                  • QLJ99339.2
                                                  • eveS8
                                                  866131 - 867066 (+) NAD(P)-dependent oxidoreductase
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                                                    • HZU44_04100
                                                    • QLK01205.2
                                                    • eveR1
                                                    868055 - 868303 (+) response regulator
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                                                      • HZU44_04105
                                                      • QLK01206.2
                                                      • eveGT2
                                                      868454 - 869368 (+) glycosyltransferase
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                                                        • HZU44_04110
                                                        • QMV28500.1
                                                        • eveS9
                                                        869021 - 870292 (-) NAD-dependent epimerase/dehydratase family protein
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                                                          • HZU44_04115
                                                          • QLK01207.2
                                                          • eveU6
                                                          870300 - 871052 (-) HAD family hydrolase
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                                                            • HZU44_04120
                                                            • QLJ99340.1
                                                            • eveO3
                                                            871252 - 872013 (+) phytanoyl-CoA dioxygenase family protein
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                                                              • HZU44_04125
                                                              • QLK01208.2
                                                              • eveGT3
                                                              872112 - 873134 (-) glycosyltransferase
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                                                                • HZU44_04130
                                                                • QLJ99341.1
                                                                • eveU7
                                                                873149 - 874204 (-) hypothetical protein
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                                                                  • HZU44_04135
                                                                  • QLJ99342.1
                                                                  • eveGT4
                                                                  874201 - 875244 (-) glycosyltransferase family 2 protein
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                                                                    • HZU44_04140
                                                                    • QLJ99343.1
                                                                    • eveS10
                                                                    875241 - 876179 (-) NAD-dependent epimerase/dehydratase family protein
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                                                                      • HZU44_04145
                                                                      • QLJ99344.2
                                                                      • eveGT5
                                                                      876164 - 877333 (-) glycosyltransferase family 1 protein
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                                                                        • HZU44_04150
                                                                        • QLJ99345.1
                                                                        • eveN1
                                                                        877589 - 878854 (+) acyl-CoA/acyl-ACP dehydrogenase
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                                                                          • HZU44_04155
                                                                          • QLJ99346.1
                                                                          • eveS11
                                                                          878865 - 879986 (+) DegT/DnrJ/EryC1/StrS family aminotransferase
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                                                                            • HZU44_04160
                                                                            • QLJ99347.1
                                                                            • eveM6
                                                                            880095 - 881345 (+) class I SAM-dependent methyltransferase
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                                                                              • HZU44_04165
                                                                              • QLJ99348.1
                                                                              • eveS12
                                                                              881353 - 881955 (+) dTDP-4-dehydrorhamnose 3
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                                                                                • HZU44_04170
                                                                                • QLJ99349.1
                                                                                • eveS13
                                                                                881913 - 882992 (-) NAD-dependent epimerase/dehydratase family protein
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                                                                                  • HZU44_04175
                                                                                  • QLJ99350.1
                                                                                  • eveM7
                                                                                  882994 - 883923 (-) putative sugar O-methyltransferase
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                                                                                    • HZU44_04180
                                                                                    • QLJ99351.1
                                                                                    • eveU8
                                                                                    884180 - 885244 (+) aldo/keto reductase
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                                                                                      • HZU44_04185
                                                                                      • QLJ99352.1
                                                                                      • eveU9
                                                                                      885365 - 886219 (+) phytanoyl-CoA dioxygenase
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                                                                                        • HZU44_04190
                                                                                        • QLJ99353.1
                                                                                        • eveM8
                                                                                        886216 - 887304 (+) methyltransferase
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                                                                                          Biosynthesis information
                                                                                          Annotation changelog

                                                                                          Entry version: 2

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          Update chemical activity to schema version 2.11
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                          Entry version: 1

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          Entry added
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                          Detailed domain annotation
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