BGC0002089: thaxtomin D biosynthetic gene cluster from Streptomyces scabiei 87.22
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Location: 3,598,008 - 3,616,472 nt. (total: 18,465 nt).
This entry is originally from NCBI GenBank FN554889.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002089
Short description thaxtomin D biosynthetic gene cluster from Streptomyces scabiei 87.22
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FN554889.1
3598008 - 3616472
via Knock-out studies
Compounds
  • thaxtomin D
  • thaxtomin A
  • thaxtomin C
  • thaxtomin B
Species Streptomyces scabiei 87.22 [taxonomy]
References
Chemical products information
thaxtomin D Evidence:
(no structure information available)
thaxtomin A Evidence:
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Chemical database entries
NPAtlas
thaxtomin C Evidence:
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Chemical database entries
NPAtlas
thaxtomin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCAB_31761
  • CBG70274.1
  • txtC
3598108 - 3599295 (-) putative monooxygenase
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    • SCAB_31762
    3599358 - 3599507 (-) putative pseudogene (fragment)
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      • SCAB_31763
      3599729 - 3599965 (-) hypothetical protein
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        • SCAB_31771
        • CBG70277.1
        • txtH
        3600056 - 3600253 (-) putative MbtH-like antibiotic biosynthesis related protein
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          • SCAB_31781
          • CBG70278.1
          • txtB
          3600343 - 3604809 (-) thaxtomin synthetase B
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            • SCAB_31791
            • CBG70279.1
            • txtA
            3604857 - 3609233 (-) thaxtomin synthetase A
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              • SCAB_31801
              • CBG70280.1
              • txtR
              3610905 - 3611753 (+) cellobiose-dependent regulator TxtR
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                • SCAB_31811
                3612331 - 3612576 (-) conserved hypothetical protein (fragment)
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                  • SCAB_31812
                  3612951 - 3613352 (+) conserved hypothetical protein (fragment)
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                    • SCAB_31821
                    • CBG70283.1
                    3613501 - 3613722 (-) hypothetical protein
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                      • SCAB_31831
                      • CBG70284.1
                      3613916 - 3615136 (+) putative P450-like protein
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                        • SCAB_31841
                        • CBG70285.1
                        • txtD
                        3615200 - 3616372 (+) putative oxygenase
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          Unk01
                          Type
                          nrps-type1
                          Genes
                          txtA
                          Substrates
                          phenylalanine (evidence: Structure-based inference [1])
                          Integrated Monomers
                          Domains
                          adenylation
                          Name
                          Unk02
                          Type
                          nrps-type1
                          Genes
                          txtB
                          Substrates
                          4-nitrotryptophan (evidence: Structure-based inference [1])
                          Integrated Monomers
                          Domains
                          adenylation
                          Annotation changelog

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          Entry added
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Added NRP substrate specificities
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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