BGC0002091: holomycin biosynthetic gene cluster from Yersinia ruckeri ATCC 29473
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Location: 3,593 - 21,565 nt. (total: 17,973 nt).
This entry is originally from NCBI GenBank ACCC01000028.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002091
Short description holomycin biosynthetic gene cluster from Yersinia ruckeri ATCC 29473
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
ACCC01000028.1
3593 - 21565
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • holomycin
Species Yersinia ruckeri ATCC 29473 [taxonomy]
References
Chemical products information
holomycin Evidence: NMR
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Chemical database entries
NPAtlas
PubCHEM
ChEBI
ChEMBL
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • yruck0001_11670
  • EEP98509.1
 3594 - 4163 (+) hypothetical protein
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    • yruck0001_11680
    • EEP98510.1
    		 4250 - 4795 (-) Lantibiotic biosynthesis protein, flavoprotein
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      • yruck0001_11690
      • EEP98511.1
      		 4857 - 5288 (-) Globin
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        • yruck0001_11700
        • EEP98512.1
        		 5369 - 6241 (-) Acetyltransferase
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          • yruck0001_11710
          • EEP98513.1
          		 6266 - 7396 (-) Acyl-CoA dehydrogenase fadE20
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            • yruck0001_11720
            • EEP98514.1
            		 7413 - 8144 (-) hypothetical protein
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              • yruck0001_11730
              • EEP98515.1
              		 8165 - 9772 (-) Glucose-methanol-choline oxidoreductase
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                • yruck0001_11740
                • EEP98516.1
                		 9781 - 13152 (-) Peptide synthetase
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                  • yruck0001_11750
                  • EEP98517.1
                  		 13985 - 15346 (+) Transporter, major facilitator family
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                    • yruck0001_11760
                    • EEP98518.1
                    		 15403 - 15951 (-) Transcriptional regulator, ArsR family/rhodanese-like domain protein
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                      • yruck0001_11770
                      • EEP98519.1
                      		 16210 - 16716 (+) hypothetical protein
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                        • yruck0001_11780
                        • EEP98520.1
                        		 16967 - 17218 (+) hypothetical protein
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                          • yruck0001_11790
                          • EEP98521.1
                          		 17521 - 18375 (-) rRNA (Guanine-N1-)-methyltransferase
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                            • yruck0001_11800
                            • EEP98522.1
                            		 18473 - 20182 (-) Peptidoglycan synthetase ftsI
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                              • yruck0001_11810
                              • EEP98523.1
                              		 20394 - 21134 (+) hypothetical protein
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                                • yruck0001_11820
                                • EEP98524.1
                                		 21243 - 21434 (+) Cold shock-like protein cspE
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                                  • yruck0001_11830
                                  • EEP98525.1
                                  		 21449 - 21565 (-) hypothetical protein
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                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    yruck0001_11740
                                    Substrates
                                    cysteine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-10-07
                                    Changed chemical structures for compounds: holomycin.
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-09-15
                                    Added version to NCBI accession
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-09-15
                                    Convert from RefSeq to Genbank
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    Detailed domain annotation
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