BGC0002092: stechlisin B2 biosynthetic gene cluster from Pseudomonas sp.
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Location: 1 - 77,514 nt. (total: 77,514 nt).
This entry is originally from NCBI GenBank MT080808.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002092
Short description stechlisin B2 biosynthetic gene cluster from Pseudomonas sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT080808.1
via
Compounds
  • stechlisin B2
  • stechlisin C3
  • stechlisin D3
  • tensin
  • stechlisin E2
  • stechlisin F
Species Pseudomonas sp. [taxonomy]
References
Chemical products information
stechlisin B2 Evidence: NMR, Mass spectrometry
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C65H112N12O12
Chemical database entries
NPAtlas
stechlisin C3 Evidence: NMR, Mass spectrometry
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C66H114N12O20
Chemical database entries
NPAtlas
stechlisin D3 Evidence: NMR, Mass spectrometry
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C67H116N12O20
Chemical database entries
NPAtlas
tensin Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C67H116N12O20
Chemical database entries
NPAtlas
stechlisin E2 Evidence: NMR, Mass spectrometry
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C68H118N12O20
Chemical database entries
NPAtlas
stechlisin F Evidence: NMR, Mass spectrometry
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C69H120N12O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QNL34621.1
  • luxR
 18718 - 19512 (-) LuxR
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    • QNL34616.1
    • steA
    		 20001 - 26411 (+) SteA
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      • QNL34617.1
      • steB
      		 26658 - 39674 (+) SteB
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        • QNL34618.1
        • steC
        		 39671 - 57514 (+) SteC
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          • QNL34619.1
          • macA
          		 57581 - 58729 (+) MacA
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            • QNL34620.1
            • macB2
            		 58732 - 60690 (+) MacB2
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              Biosynthesis information

              Biosynthetic modules

              Name
              1
              Type
              nrps-type1
              Genes
              steA
              Substrates
              leucine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Starter), adenylation
              Name
              2
              Type
              nrps-type1
              Genes
              steA
              Substrates
              aspartic acid, glutamic acid (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              3
              Type
              nrps-type1
              Genes
              steB
              Substrates
              threonine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              4
              Type
              nrps-type1
              Genes
              steB
              Substrates
              leucine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              5
              Type
              nrps-type1
              Genes
              steB
              Substrates
              leucine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              6
              Type
              nrps-type1
              Genes
              steB
              Substrates
              serine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              10
              Type
              nrps-type1
              Genes
              steC
              Substrates
              leucine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              11
              Type
              nrps-type1
              Genes
              steC
              Substrates
              glutamic acid (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              7
              Type
              nrps-type1
              Genes
              steC
              Substrates
              leucine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Name
              8
              Type
              nrps-type1
              Genes
              steC
              Substrates
              glutamine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              9
              Type
              nrps-type1
              Genes
              steC
              Substrates
              leucine (evidence: Structure-based inference [3])
              Integrated Monomers
              Domains
              condensation (Dual), adenylation
              Annotation changelog

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-10-07
              Changed chemical structures for compounds: stechlisin E2, stechlisin B2, stechlisin C3, stechlisin F, stechlisin D3, tensin.
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-10-07
              Added NPAtlas links to compounds: stechlisin E2, stechlisin B2, stechlisin C3, stechlisin D3.
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Submitted
              • (ID: 7JBBERLOMRODNNGUFOT34CPQ)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Added version to NCBI accession
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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