BGC0002095: leupeptin Pr biosynthetic gene cluster from Streptomyces roseus
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Location: 93,602 - 116,056 nt. (total: 22,455 nt).
This entry is originally from NCBI GenBank LFML01000163.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
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TTA codons
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Gene details
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General
Compounds
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NRP
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NRPS/PKS domains
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Modifications
General information about the BGC
MIBiG accession BGC0002095
Short description leupeptin Pr biosynthetic gene cluster from Streptomyces roseus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: LFML01000163.1
Compounds
  • leupeptin Pr
  • leupeptin Ac
Species Streptomyces roseus [taxonomy]
References
Chemical products information
leupeptin Pr [synonyms: N-propionyl-L-leucyl-L-leucyl-L-argininal]
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Chemical database entries
NPAtlas
leupeptin Ac [synonyms: N-acetyl-L-leucyl-L-leucyl-L-argininal]
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Chemical database entries
PubCHEM
ChEBI
ChemSpider
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • extra_gene
 93602 - 100912 (+) NRPS/PKS
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACS04_34625
  • KMO93430.1
 101102 - 102670 (+) Argininosuccinate lyase
  • Precursor biosynthesis
Sequence-based prediction
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  • ACS04_34630
  • KMO93431.1
 102636 - 103616 (+) Threonine kinase
  • Precursor biosynthesis
Sequence-based prediction
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  • ACS04_34635
  • KMO93432.1
 103619 - 105886 (+) Cysteine synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • ACS04_34640
  • KMO93433.1
 105961 - 106185 (+) MbtH protein
  • Activation / processing
Sequence-based prediction
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  • ACS04_34645
  • KMO93434.1
 106178 - 107965 (+) NRPS/PKS
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACS04_34650
  • KMO93435.1
 107962 - 111171 (+) NRPS/PKS
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACS04_34660
  • KMO93436.1
 114518 - 116056 (+) NRPS/PKS
  • Scaffold biosynthesis
Sequence-based prediction
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NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: 4CEPXXFDQQ46VQJXBT4B4AUO, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Added version to NCBI accession
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • extra_gene was added