BGC0002095 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002095 (Streptomyces roseus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	22,455	leupeptin Pr/leupeptin Ac	NRPS:Type I	100%

BGC0002095 - Region 1 - NRPS

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Location: 1 - 22,455 nt. (total: 22,455 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,456
Label		BGC0002095

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002095	1.00	NRP	leupeptin Pr, leupeptin Ac	Streptomyces roseus
BGC0001050	0.39	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0002017	0.36	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001185	0.34	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401	0.33	NRP	paenibactin	Paenibacillus elgii B69
BGC0001833	0.32	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132	0.32	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825	0.31	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000417	0.30	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000457	0.30	NRP	vicibactin	Rhizobium etli CFN 42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002095	1.00	NRP	leupeptin Pr, leupeptin Ac	Streptomyces roseus
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0002017	0.69	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001185	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401	0.66	NRP	paenibactin	Paenibacillus elgii B69
BGC0001833	0.65	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132	0.65	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825	0.64	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000417	0.63	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000457	0.63	NRP	vicibactin	Rhizobium etli CFN 42

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 22455:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Thr - Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

extra_gene

Search NORINE for peptide: strict or relaxed

AMP-binding (471..891): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1566..1961): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ACS04_34650

AMP-binding (471..868): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFMGATFK
Nearest Stachelhaus code(s):: Leu or Ile DALFMGATFK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

ACS04_34660

Search NORINE for peptide: strict or relaxed

AMP-binding (13..418): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVENVGCITK
Nearest Stachelhaus code(s):: Arg DVENVGGITK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)