BGC0002095: leupeptin Pr biosynthetic gene cluster from Streptomyces roseus
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Location: 93,602 - 116,056 nt. (total: 22,455 nt).
This entry is originally from NCBI GenBank LFML01000163.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
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Modifications
General information about the BGC
MIBiG accession BGC0002095
Short description leupeptin Pr biosynthetic gene cluster from Streptomyces roseus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
LFML01000163.1
93602 - 116056
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • leupeptin Pr
  • leupeptin Ac
Species Streptomyces roseus [taxonomy]
References
Chemical products information
leupeptin Pr Evidence:
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Chemical database entries
NPAtlas
leupeptin Ac Evidence: Mass spectrometry
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Chemical database entries
PubCHEM
ChEBI
ChemSpider
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • extra_gene
 93602 - 100912 (+) NRPS/PKS
  • Scaffold biosynthesis
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  • ACS04_34625
  • KMO93430.1
 101102 - 102670 (+) Argininosuccinate lyase
  • Precursor biosynthesis
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  • ACS04_34630
  • KMO93431.1
 102636 - 103616 (+) Threonine kinase
  • Precursor biosynthesis
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  • ACS04_34635
  • KMO93432.1
 103619 - 105886 (+) Cysteine synthase
  • Precursor biosynthesis
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  • ACS04_34640
  • KMO93433.1
 105961 - 106185 (+) MbtH protein
  • Activation / processing
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  • ACS04_34645
  • KMO93434.1
 106178 - 107965 (+) NRPS/PKS
  • Scaffold biosynthesis
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  • ACS04_34650
  • KMO93435.1
 107962 - 111171 (+) NRPS/PKS
  • Scaffold biosynthesis
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  • ACS04_34660
  • KMO93436.1
 114518 - 116056 (+) NRPS/PKS
  • Scaffold biosynthesis
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Biosynthesis information
Annotation changelog

Entry version: 2

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Submitted
  • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Added version to NCBI accession
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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Similar known gene clusters from MIBiG 4.0
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Modifications to original record
  • extra_gene was added