BGC0002096 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002096 (Streptomyces sp. AJS327)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	35,401	tetrachlorizine	PKS	100%

BGC0002096 - Region 1 - T1PKS

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Location: 1 - 35,401 nt. (total: 35,401 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,402
Label		BGC0002096

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002096	1.00	Polyketide	tetrachlorizine	Streptomyces sp. AJS327
BGC0001172	0.32	NRP, Polyketide	chlorizidine A	Streptomyces sp. CNH-287
BGC0002341	0.32	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002443	0.32	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0000131	0.29	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001925	0.29	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000068	0.28	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001068	0.28	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001273	0.27	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.27	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002096	1.00	Polyketide	tetrachlorizine	Streptomyces sp. AJS327
BGC0001172	0.66	NRP, Polyketide	chlorizidine A	Streptomyces sp. CNH-287
BGC0002341	0.65	Other	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002443	0.65	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0000131	0.63	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001925	0.63	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000068	0.61	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001068	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001273	0.61	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.61	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78

Similar known gene clusters from MIBiG 4.0

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 35401:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - pk) + (mal)
Non-colinear ordering:: E0L36_23605 + E0L36_23600

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

E0L36_23555

Search NORINE for peptide: strict or relaxed

AMP-binding (9..390): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLFYLAWVCK
Nearest Stachelhaus code(s):: Pro DLFYLAWVCK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

E0L36_23600

PKS_AT (580..879): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 194.1
inactive: 110.9
Methoxymalonyl-CoA: 72.1
Methylmalonyl-CoA: 67.5
Isobutyryl-CoA: 51.6
Ethylmalonyl-CoA: 42.9
Propionyl-CoA: 39.6
CHC-CoA: 31.4
Benzoyl-CoA: 27.6
2-Methylbutyryl-CoA: 26.6
trans-1,2-CPDA: 21.8
Acetyl-CoA: 20.5
3-Methylbutyryl-CoA: 13.2
fatty_acid: 9.4

E0L36_23605

PKS_AT (576..881): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 75.0%; CE-Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 153.9
Methoxymalonyl-CoA: 129.9
Malonyl-CoA: 124.7
Ethylmalonyl-CoA: 113.7
Isobutyryl-CoA: 102.0
2-Methylbutyryl-CoA: 101.6
Propionyl-CoA: 83.2
trans-1,2-CPDA: 68.7
3-Methylbutyryl-CoA: 67.8
Benzoyl-CoA: 63.5
CHC-CoA: 61.5
inactive: 48.4
fatty_acid: 35.4
Acetyl-CoA: 30.6

PKS_AT (1678..1972): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 112.4
Ethylmalonyl-CoA: 96.3
Methoxymalonyl-CoA: 93.4
Propionyl-CoA: 74.7
Malonyl-CoA: 74.1
Isobutyryl-CoA: 62.7
Acetyl-CoA: 55.6
2-Methylbutyryl-CoA: 55.0
Benzoyl-CoA: 51.5
trans-1,2-CPDA: 50.8
CHC-CoA: 43.4
fatty_acid: 32.5
3-Methylbutyryl-CoA: 15.1
inactive: 14.7