BGC0002098 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002098 (Amycolatopsis keratiniphila)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	101,044	ECO-0501	PKS	100%

BGC0002098 - Region 1 - T1PKS

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Location: 1 - 101,044 nt. (total: 101,044 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 101,045
Label		BGC0002098

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002098	0.99	Polyketide	ECO-0501	Amycolatopsis keratiniphila
BGC0000016	0.40	Other	amphotericin B	Streptomyces nodosus
BGC0001137	0.37	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000041	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.34	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001647	0.34	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000018	0.33	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001925	0.32	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001749	0.31	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0000122	0.31	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002098	1.00	Polyketide	ECO-0501	Amycolatopsis keratiniphila
BGC0000016	0.72	Other	amphotericin B	Streptomyces nodosus
BGC0001137	0.70	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000041	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.67	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001647	0.67	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000018	0.66	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001925	0.66	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001749	0.65	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0000122	0.65	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 100780:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - Me-redmal) + (ccmal - redmal - Me-redmal) + (pk) + (Me-ohmal - ccmal) + (ccmal - ccmal - ccmal) + (pk)
Non-colinear ordering:: AORI_2945 + AORI_2946 + AORI_2947 + AORI_2948 + AORI_2949 + AORI_2950

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AORI_2941

AMP-binding (14..410): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SVTYYGIVIK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

AORI_2943

Search NORINE for peptide: strict or relaxed

AMP-binding (10..410): Hpr

nrpys: Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: pip (Hpr)

Stachelhaus prediction details:

Stachelhaus sequence:: TFCMFGGPVK
Nearest Stachelhaus code(s):: nLev GFCMYGGCSK (79% 8Å match)
Stachelhaus code match:: 60% (weak)

AORI_2945

PKS_AT (651..941): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 103.5
Methoxymalonyl-CoA: 72.1
Methylmalonyl-CoA: 66.5
Isobutyryl-CoA: 31.7
Propionyl-CoA: 30.0
Acetyl-CoA: 25.4
2-Methylbutyryl-CoA: 21.5
Ethylmalonyl-CoA: 19.9
CHC-CoA: 17.6
Benzoyl-CoA: 14.8
fatty_acid: 10.0
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2298..2589): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.1
Ethylmalonyl-CoA: 200.3
Methoxymalonyl-CoA: 159.6
2-Methylbutyryl-CoA: 142.3
trans-1,2-CPDA: 121.0
CHC-CoA: 110.9
Propionyl-CoA: 108.0
Malonyl-CoA: 84.8
Isobutyryl-CoA: 61.8
Benzoyl-CoA: 59.4
Acetyl-CoA: 53.1
3-Methylbutyryl-CoA: 41.3
inactive: 28.5
fatty_acid: 22.8

AORI_2946

PKS_AT (544..817): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.2
inactive: 100.7
Methoxymalonyl-CoA: 54.6
Methylmalonyl-CoA: 51.2
Ethylmalonyl-CoA: 29.4
Isobutyryl-CoA: 24.8
Benzoyl-CoA: 24.7
Propionyl-CoA: 23.3
2-Methylbutyryl-CoA: 16.2
Acetyl-CoA: 16.1
fatty_acid: 13.3
CHC-CoA: 11.0
trans-1,2-CPDA: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2167..2441): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.3
inactive: 109.7
Methoxymalonyl-CoA: 54.0
Methylmalonyl-CoA: 48.6
Benzoyl-CoA: 30.8
Ethylmalonyl-CoA: 28.9
Isobutyryl-CoA: 26.9
Propionyl-CoA: 24.6
Acetyl-CoA: 18.1
trans-1,2-CPDA: 16.8
fatty_acid: 15.2
2-Methylbutyryl-CoA: 12.8
CHC-CoA: 12.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (4144..4434): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 219.9
Ethylmalonyl-CoA: 208.0
Methoxymalonyl-CoA: 173.7
2-Methylbutyryl-CoA: 161.4
trans-1,2-CPDA: 125.6
Propionyl-CoA: 121.3
CHC-CoA: 118.4
Malonyl-CoA: 97.3
Isobutyryl-CoA: 78.0
Benzoyl-CoA: 66.8
Acetyl-CoA: 48.1
3-Methylbutyryl-CoA: 43.0
fatty_acid: 39.8
inactive: 29.9

AORI_2947

PKS_AT (562..833): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.5
Methylmalonyl-CoA: 210.8
Methoxymalonyl-CoA: 164.9
2-Methylbutyryl-CoA: 136.7
trans-1,2-CPDA: 123.8
CHC-CoA: 115.6
Propionyl-CoA: 111.6
Malonyl-CoA: 82.9
Benzoyl-CoA: 63.3
Isobutyryl-CoA: 62.1
Acetyl-CoA: 47.0
3-Methylbutyryl-CoA: 33.1
inactive: 29.8
fatty_acid: 19.5

AORI_2948

PKS_AT (562..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.4
Ethylmalonyl-CoA: 204.2
Methoxymalonyl-CoA: 173.8
2-Methylbutyryl-CoA: 154.3
trans-1,2-CPDA: 132.8
Propionyl-CoA: 130.3
CHC-CoA: 107.8
Malonyl-CoA: 102.7
Isobutyryl-CoA: 76.0
Benzoyl-CoA: 57.5
fatty_acid: 44.4
Acetyl-CoA: 41.4
3-Methylbutyryl-CoA: 37.4
inactive: 25.3

PKS_AT (2049..2332): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 99.5
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 68.0
Propionyl-CoA: 38.0
trans-1,2-CPDA: 31.2
Ethylmalonyl-CoA: 31.2
Isobutyryl-CoA: 27.6
Benzoyl-CoA: 26.6
Acetyl-CoA: 24.7
fatty_acid: 20.2
CHC-CoA: 19.9
2-Methylbutyryl-CoA: 15.8
3-Methylbutyryl-CoA: 7.4

AORI_2949

PKS_AT (562..835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.1
inactive: 102.4
Methoxymalonyl-CoA: 55.2
Methylmalonyl-CoA: 49.2
Propionyl-CoA: 28.2
Ethylmalonyl-CoA: 26.5
Benzoyl-CoA: 23.2
Isobutyryl-CoA: 21.4
Acetyl-CoA: 18.6
2-Methylbutyryl-CoA: 12.0
fatty_acid: 10.6
CHC-CoA: 10.2
trans-1,2-CPDA: 9.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2205..2476): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.5
inactive: 105.6
Methoxymalonyl-CoA: 56.9
Methylmalonyl-CoA: 49.7
Benzoyl-CoA: 27.8
Ethylmalonyl-CoA: 25.3
Propionyl-CoA: 22.9
Isobutyryl-CoA: 22.5
Acetyl-CoA: 18.4
trans-1,2-CPDA: 15.2
fatty_acid: 13.6
CHC-CoA: 13.5
2-Methylbutyryl-CoA: 13.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (3841..4133): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.8
inactive: 93.6
Methoxymalonyl-CoA: 62.6
Methylmalonyl-CoA: 60.4
Isobutyryl-CoA: 39.7
Propionyl-CoA: 33.7
Acetyl-CoA: 18.4
Benzoyl-CoA: 17.1
Ethylmalonyl-CoA: 15.9
fatty_acid: 10.2
CHC-CoA: 9.6
2-Methylbutyryl-CoA: 5.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

AORI_2950

PKS_AT (553..824): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.5
Methylmalonyl-CoA: 210.8
Methoxymalonyl-CoA: 164.9
2-Methylbutyryl-CoA: 136.7
trans-1,2-CPDA: 123.8
CHC-CoA: 115.6
Propionyl-CoA: 111.6
Malonyl-CoA: 82.9
Benzoyl-CoA: 63.3
Isobutyryl-CoA: 62.1
Acetyl-CoA: 47.0
3-Methylbutyryl-CoA: 33.1
inactive: 29.8
fatty_acid: 19.5

AORI_2951

PKS_AT (57..280): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

AORI_2952

AMP-binding (11..370): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: QYSDCGSAFK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)