BGC0002100 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002100 (Streptomyces sp. CS147)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	HR-T2PKS,NRPS	1	68,892	colibrimycin	NRPS:Type I+other:other	100%

BGC0002100 - Region 1 - HR-T2PKS,NRPS

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Location: 1 - 68,892 nt. (total: 68,892 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 68,893
Label		BGC0002100

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002100	1.52	NRP, Other	colibrimycin	Streptomyces sp. CS147
BGC0001185	0.68	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000417	0.66	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000653	0.63	Terpene	pentalenolactone	Streptomyces arenae
BGC0000371	0.63	NRP	heterobactin A, heterobactin S2	Rhodococcus erythropolis PR4
BGC0002696	0.63	NRP	heterobactin B, heterobactin S2	Rhodococcus erythropolis
BGC0002359	0.59	NRP	dudomycin A	Streptomyces albus subsp. chlorinus
BGC0002058	0.58	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287	0.58	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0002437	0.57	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002100	0.99	NRP, Other	colibrimycin	Streptomyces sp. CS147
BGC0002043	0.76	RiPP	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0000016	0.68	Other	amphotericin B	Streptomyces nodosus
BGC0001185	0.68	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000343	0.66	NRP	enterobactin	Pseudomonas sp. J465
BGC0000417	0.66	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002031	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000371	0.66	NRP	heterobactin A, heterobactin S2	Rhodococcus erythropolis PR4
BGC0002696	0.65	NRP	heterobactin B, heterobactin S2	Rhodococcus erythropolis
BGC0001444	0.65	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 55265:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Phe - Phe - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 42232:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Phe - Phe - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 4048 - 55265:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Phe - Phe - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

DBP21_21545

AMP-binding (28..419): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKMGHIGK
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

DBP21_21655

Search NORINE for peptide: strict or relaxed

AMP-binding (466..871): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWEINVDDK
Nearest Stachelhaus code(s):: Dpr DVWEMNADDK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2010..2411): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWGAAGVSK
Nearest Stachelhaus code(s):: Phe DAWTIAGVCK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (3072..3335): X