BGC0002100: colibrimycin biosynthetic gene cluster from Streptomyces sp. CS147
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Location: 4,724,124 - 4,793,015 nt. (total: 68,892 nt).
This entry is originally from NCBI GenBank KZ819182.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002100
Short description colibrimycin biosynthetic gene cluster from Streptomyces sp. CS147
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • other (other)
Loci
KZ819182.1
4724124 - 4793015
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • colibrimycin
Species Streptomyces sp. CS147 [taxonomy]
References
Chemical products information
colibrimycin Evidence: NMR, Mass spectrometry
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C27H28Cl1N5O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DBP21_21545
  • PVC99845.1
 4724124 - 4725680 (+) Adenylation-domain-containg protein
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    • DBP21_21550
    • PVD00181.1
    		 4725819 - 4726037 (+) MbtH family protein
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      • DBP21_21555
      • PVC99846.1
      		 4726079 - 4727011 (+) ABC transporter ATP binding
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        • DBP21_21560
        • PVC99847.1
        		 4727060 - 4728187 (+) ArsR Transcriptional regulator
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          • DBP21_21565
          • PVC99848.1
          		 4728313 - 4730844 (-) ABC transporter ATP binding
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            • DBP21_21570
            • PVC99849.1
            		 4730841 - 4731647 (-) ABC transporter ATP binding
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              • DBP21_21575
              • PVC99850.1
              		 4731644 - 4732429 (-) Hypothetical protein
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                • DBP21_21580
                • PVC99851.1
                		 4732426 - 4732659 (-) Hypothetical protein
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                  • DBP21_21585
                  • PVC99852.1
                  		 4732656 - 4732982 (-) ArsR transcriptional regulator
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                    • DBP21_21590
                    • PVC99853.1
                    		 4733187 - 4733702 (-) Flavin reductase
                    • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771ae6290>
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                    • DBP21_21595
                    • PVC99854.1
                    		 4733699 - 4735000 (-) Na/H antiporter
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                      • DBP21_21600
                      • PVC99855.1
                      		 4735025 - 4736668 (-) Tryptophan-7-halogenase
                      • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771ae6b10>
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                      • DBP21_21605
                      • PVC99856.1
                      		 4736903 - 4737964 (+) 2,3-diaminopropionate biosynthesis protein SbnB
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                        • DBP21_21610
                        • PVD00182.1
                        		 4737980 - 4738957 (+) 2,3-diaminopropionate biosynthesis protein SbnA
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                          • DBP21_21615
                          • PVC99857.1
                          		 4739281 - 4741458 (+) MMPL family transporter
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                            • DBP21_21620
                            • PVC99858.1
                            		 4741630 - 4742427 (+) AfsR/SARP family transcriptional regulator
                            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771ae7690>
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                            • DBP21_21625
                            • PVC99859.1
                            		 4742644 - 4743618 (+) LysR family transcriptional regulator
                            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771ae7450>
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                            • DBP21_21630
                            • PVC99860.1
                            		 4743727 - 4744005 (+) acyl carrier protein
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                              • DBP21_21635
                              • PVC99861.1
                              		 4744035 - 4745267 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                                • DBP21_21640
                                • PVC99862.1
                                		 4745267 - 4746355 (+) 3-oxoacyl-ACP synthase
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                                  • DBP21_21645
                                  • PVC99863.1
                                  		 4746470 - 4747216 (+) 3-oxoacyl-ACP reductase FabG
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                                    • DBP21_21650
                                    • PVC99864.1
                                    		 4747335 - 4748039 (+) DsbA family protein
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                                      • DBP21_21655
                                      • PVC99865.1
                                      		 4748172 - 4759388 (+) non-ribosomal peptide synthetase
                                      • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771ae8510>
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                                      • DBP21_21660
                                      • PVD00183.1
                                      		 4759499 - 4760278 (+) ABC transporter permease
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                                        • DBP21_21665
                                        • PVC99866.1
                                        		 4760305 - 4761552 (+) cytochrome P450
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                                          • DBP21_21670
                                          • PVC99867.1
                                          		 4761536 - 4762513 (+) TauD/TfdA family dioxygenase
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                                            • DBP21_21675
                                            • PVC99868.1
                                            		 4762572 - 4763459 (-) FkbM family methyltransferase
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                                              • DBP21_21680
                                              • PVC99869.1
                                              		 4763625 - 4764437 (+) indole-3-glycerol phosphate synthase TrpC
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                                                • DBP21_21685
                                                • PVD00184.1
                                                • trpD
                                                		 4764409 - 4765473 (-) anthranilate phosphoribosyltransferase
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                                                  • DBP21_21690
                                                  • PVC99870.1
                                                  		 4765588 - 4766976 (+) PLP-dependent aminotransferase family protein
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                                                    • DBP21_21695
                                                    • PVC99871.1
                                                    		 4766963 - 4767595 (-) aminodeoxychorismate/anthranilate synthase component II
                                                    • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771ae9e90>
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                                                    • DBP21_21700
                                                    • PVC99872.1
                                                    		 4767643 - 4769163 (-) anthranilate synthase component I family protein
                                                    • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7fd771aea2d0>
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                                                    • DBP21_21705
                                                    • PVC99873.1
                                                    		 4769470 - 4770861 (+) 3-deoxy-7-phosphoheptulonate synthase class II
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                                                      • DBP21_21710
                                                      • PVC99874.1
                                                      		 4770836 - 4771561 (-) thioesterase
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                                                        • DBP21_21715
                                                        • PVC99875.1
                                                        		 4772096 - 4775056 (-) tetratricopeptide repeat protein
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                                                          • DBP21_21720
                                                          • PVC99876.1
                                                          		 4775370 - 4776590 (+) amidohydrolase
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                                                            • DBP21_21725
                                                            • PVC99877.1
                                                            		 4776704 - 4777531 (-) MerR family transcriptional regulator
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                                                              • DBP21_21730
                                                              • PVC99878.1
                                                              		 4777686 - 4777889 (-) cold-shock protein
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                                                                • DBP21_21735
                                                                • PVC99879.1
                                                                		 4778176 - 4779057 (+) menaquinone biosynthesis protein
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                                                                  • DBP21_21740
                                                                  • PVC99880.1
                                                                  		 4779351 - 4781387 (+) serine/threonine protein kinase
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                                                                    • DBP21_21745
                                                                    • PVC99881.1
                                                                    • mqnC
                                                                    		 4781459 - 4782658 (+) dehypoxanthine futalosine cyclase
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                                                                      • DBP21_21750
                                                                      • PVC99882.1
                                                                      		 4782666 - 4783325 (+) hypothetical protein
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                                                                        • DBP21_21755
                                                                        • PVC99883.1
                                                                        		 4783347 - 4784390 (-) DUF3152 domain-containing protein
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                                                                          • DBP21_21760
                                                                          		 4784408 - 4784896 (-) hypothetical protein
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                                                                            • DBP21_21765
                                                                            • PVC99884.1
                                                                            		 4784907 - 4785416 (-) SigE family RNA polymerase sigma factor
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                                                                              • DBP21_21770
                                                                              • PVC99885.1
                                                                              		 4785672 - 4786364 (+) demethylmenaquinone methyltransferase
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                                                                                • DBP21_21775
                                                                                • PVC99886.1
                                                                                		 4786380 - 4786907 (-) GNAT family N-acetyltransferase
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                                                                                  • DBP21_21780
                                                                                  • PVC99887.1
                                                                                  		 4787005 - 4788288 (+) geranylgeranyl reductase family protein
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                                                                                    • DBP21_21785
                                                                                    • PVC99888.1
                                                                                    		 4788361 - 4788984 (-) CGNR zinc finger domain-containing protein
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                                                                                      • DBP21_21790
                                                                                      • PVD00185.1
                                                                                      		 4789094 - 4789831 (+) metallophosphoesterase
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                                                                                        • DBP21_21795
                                                                                        • PVC99889.1
                                                                                        		 4790575 - 4791819 (+) MFS transporter
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                                                                                          • DBP21_21800
                                                                                          • PVC99890.1
                                                                                          		 4791821 - 4792666 (-) C40 family peptidase
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                                                                                            Biosynthesis information
                                                                                            Annotation changelog

                                                                                            Entry version: 1

                                                                                            Date
                                                                                            Changes
                                                                                            Submitters
                                                                                            Reviewers
                                                                                            2022-09-15
                                                                                            Submitted
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            2022-09-15
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                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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