BGC0002106 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002106 (Streptomyces rimosus subsp. rimosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	96,694	rimocidin	PKS:Modular type I	100%

BGC0002106 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 96,694 nt. (total: 96,694 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 96,695
Label		BGC0002106

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000138	1.25	Polyketide	rimocidin	Streptomyces diastaticus
BGC0002106	1.13	Polyketide	rimocidin	Streptomyces rimosus subsp. rimosus NRRL WC-3558
BGC0002631	0.62	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000122	0.56	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001817	0.51	Other	vancosamine	Streptomyces sp. WAC2288
BGC0001164	0.49	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002597	0.46	NRP, Polyketide	nocuolactylates	Nodularia sp. LEGE 06071
BGC0000996	0.46	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001704	0.46	Other	nocuolin A	Nodularia sp. HBU26
BGC0002171	0.45	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002106	0.95	Polyketide	rimocidin	Streptomyces rimosus subsp. rimosus NRRL WC-3558
BGC0000138	0.83	Polyketide	rimocidin	Streptomyces diastaticus
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0000122	0.70	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164	0.65	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001163	0.65	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001273	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002631	0.64	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001244	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 96694:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ohmal - Me-ohmal - ohmal - ohmal - ohmal) + (ohmal - ccmal - ccmal - ccmal) + (X - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IH19_RS0119115

PKS_AT (558..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.7
inactive: 75.0
Methoxymalonyl-CoA: 54.8
Methylmalonyl-CoA: 48.9
Propionyl-CoA: 33.1
Acetyl-CoA: 26.8
Ethylmalonyl-CoA: 17.1
trans-1,2-CPDA: 14.5
Isobutyryl-CoA: 13.4
2-Methylbutyryl-CoA: 11.8
CHC-CoA: 11.1
Benzoyl-CoA: 10.9
fatty_acid: 4.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2313..2612): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.2
inactive: 77.9
Methoxymalonyl-CoA: 76.5
Methylmalonyl-CoA: 62.6
Propionyl-CoA: 36.8
Isobutyryl-CoA: 33.0
Ethylmalonyl-CoA: 28.4
Benzoyl-CoA: 24.2
Acetyl-CoA: 22.8
2-Methylbutyryl-CoA: 18.1
CHC-CoA: 15.3
fatty_acid: 13.3
trans-1,2-CPDA: 13.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (3852..4149): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.0
Ethylmalonyl-CoA: 191.1
Methoxymalonyl-CoA: 168.9
trans-1,2-CPDA: 125.9
2-Methylbutyryl-CoA: 122.1
Propionyl-CoA: 101.7
CHC-CoA: 94.2
Malonyl-CoA: 87.6
Isobutyryl-CoA: 61.4
Benzoyl-CoA: 54.9
Acetyl-CoA: 31.3
3-Methylbutyryl-CoA: 26.2
fatty_acid: 21.1
inactive: 18.2

PKS_AT (5382..5682): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.8
inactive: 105.9
Methoxymalonyl-CoA: 72.3
Methylmalonyl-CoA: 62.3
Isobutyryl-CoA: 46.4
Propionyl-CoA: 26.9
Ethylmalonyl-CoA: 20.2
fatty_acid: 19.4
Acetyl-CoA: 18.1
Benzoyl-CoA: 17.1
2-Methylbutyryl-CoA: 16.6
3-Methylbutyryl-CoA: 16.3
CHC-CoA: 10.6
trans-1,2-CPDA: 6.5

PKS_AT (6902..7187): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.5
inactive: 106.7
Methoxymalonyl-CoA: 63.0
Methylmalonyl-CoA: 56.4
Propionyl-CoA: 34.8
Acetyl-CoA: 26.0
Benzoyl-CoA: 25.2
Isobutyryl-CoA: 20.5
2-Methylbutyryl-CoA: 17.4
trans-1,2-CPDA: 16.2
Ethylmalonyl-CoA: 15.3
CHC-CoA: 9.9
fatty_acid: 8.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (8408..8700): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 230.9
inactive: 111.9
Methoxymalonyl-CoA: 68.9
Methylmalonyl-CoA: 66.5
Isobutyryl-CoA: 40.4
Propionyl-CoA: 34.2
Ethylmalonyl-CoA: 32.6
Benzoyl-CoA: 25.1
Acetyl-CoA: 22.9
2-Methylbutyryl-CoA: 19.3
CHC-CoA: 16.7
fatty_acid: 14.2
trans-1,2-CPDA: 9.6
3-Methylbutyryl-CoA: 0.0

IH19_RS0119135

PKS_AT (565..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.2
inactive: 106.6
Methoxymalonyl-CoA: 70.7
Methylmalonyl-CoA: 63.5
Isobutyryl-CoA: 44.7
Propionyl-CoA: 38.2
Ethylmalonyl-CoA: 22.3
Acetyl-CoA: 20.9
Benzoyl-CoA: 18.2
2-Methylbutyryl-CoA: 17.3
trans-1,2-CPDA: 14.2
CHC-CoA: 11.1
fatty_acid: 9.4
3-Methylbutyryl-CoA: 7.3

PKS_AT (2095..2394): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 238.9
inactive: 115.0
Methoxymalonyl-CoA: 54.6
Methylmalonyl-CoA: 44.6
Acetyl-CoA: 22.1
Propionyl-CoA: 20.8
Ethylmalonyl-CoA: 18.1
Benzoyl-CoA: 17.7
2-Methylbutyryl-CoA: 15.2
trans-1,2-CPDA: 9.7
fatty_acid: 9.1
Isobutyryl-CoA: 7.7
CHC-CoA: 4.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (3824..4114): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 221.2
inactive: 101.1
Methoxymalonyl-CoA: 51.1
Methylmalonyl-CoA: 41.2
Propionyl-CoA: 28.0
Acetyl-CoA: 20.0
Ethylmalonyl-CoA: 16.8
2-Methylbutyryl-CoA: 16.7
fatty_acid: 15.8
Benzoyl-CoA: 15.2
Isobutyryl-CoA: 13.1
CHC-CoA: 3.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5510..5800): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.9
inactive: 122.8
Methoxymalonyl-CoA: 54.4
Methylmalonyl-CoA: 41.2
Acetyl-CoA: 23.8
Propionyl-CoA: 23.5
2-Methylbutyryl-CoA: 23.4
Ethylmalonyl-CoA: 19.2
Benzoyl-CoA: 16.8
Isobutyryl-CoA: 12.8
fatty_acid: 10.9
trans-1,2-CPDA: 6.4
CHC-CoA: 4.6
3-Methylbutyryl-CoA: 0.0

IH19_RS0119170

AMP-binding (20..428): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LFQFRAVTGK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

PKS_AT (1184..1486): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 144.3
Methoxymalonyl-CoA: 76.1
Methylmalonyl-CoA: 72.1
inactive: 54.2
Propionyl-CoA: 36.8
Isobutyryl-CoA: 32.8
Ethylmalonyl-CoA: 32.5
Acetyl-CoA: 19.4
trans-1,2-CPDA: 17.1
2-Methylbutyryl-CoA: 14.5
fatty_acid: 12.8
CHC-CoA: 10.5
Benzoyl-CoA: 8.9
3-Methylbutyryl-CoA: 0.0