BGC0002108 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002108 (Streptomyces viridosporus ATCC 14672)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,arylpolyene	1	60,261	cinnapeptin	NRPS:Type I	100%

BGC0002108 - Region 1 - NRPS,arylpolyene

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Location: 1 - 60,261 nt. (total: 60,261 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 60,262
Label		BGC0002108

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002108	1.39	NRP	cinnapeptin	Streptomyces viridosporus ATCC 14672
BGC0000016	0.56	Other	amphotericin B	Streptomyces nodosus
BGC0001975	0.55	NRP	atratumycin	Streptomyces atratus
BGC0001343	0.53	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001075	0.51	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0002711	0.50	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001897	0.50	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000265	0.50	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0000243	0.48	Polyketide	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0002069	0.48	Other (Aminocoumarin)	styrolide A, styrolide B	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002108	0.99	NRP	cinnapeptin	Streptomyces viridosporus ATCC 14672
BGC0001133	0.75	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.74	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001185	0.70	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000309	0.69	NRP	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401	0.69	NRP	paenibactin	Paenibacillus elgii B69
BGC0002017	0.69	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0000359	0.69	NRP	fuscachelin A, fuscachelin B, fuscachelin C	Thermobifida fusca YX
BGC0001833	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417	0.68	NRP	rhodochelin	Rhodococcus jostii RHA1

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 60261:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr - D-Phe - X - D-Tyr - D-Lys) + (X - Ser - Tyr - D-Thr) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 28245:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr - D-Phe - X - D-Tyr - D-Lys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cip4

PKS_AT (16..271): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.6
Methoxymalonyl-CoA: 47.3
Methylmalonyl-CoA: 42.2
inactive: 33.8
Propionyl-CoA: 19.0
2-Methylbutyryl-CoA: 10.3
Isobutyryl-CoA: 5.6
Acetyl-CoA: 5.2
fatty_acid: 4.3
Ethylmalonyl-CoA: 4.3
CHC-CoA: 2.7
Benzoyl-CoA: 2.3
trans-1,2-CPDA: 0.9
3-Methylbutyryl-CoA: 0.4

cip22

Search NORINE for peptide: strict or relaxed

AMP-binding (464..880): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2000..2386): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVAAVCK
Nearest Stachelhaus code(s):: Phe DAWTVAAVCK (100% 8Å match); Ph-Ser DAWTVAAVCK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3515..3911): X

nrpys: Leu, 3OH-Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DALLIGAVVK
Nearest Stachelhaus code(s):: Leu or 3OH-Leu DALLIGAVVK (100% 8Å match); Leu DALLIGAVVK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4574..4971): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6105..6519): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTDDMGFIDK
Nearest Stachelhaus code(s):: Lys DTDDMGFIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

cip23

Search NORINE for peptide: strict or relaxed

AMP-binding (463..858): X

nrpys: Leu, 3OH-Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DALLIGAVVK
Nearest Stachelhaus code(s):: Leu or 3OH-Leu DALLIGAVVK (100% 8Å match); Leu DALLIGAVVK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1520..1922): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLVDK
Nearest Stachelhaus code(s):: Ser DVWHISLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2583..2980): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3644..4060): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

cip24

AMP-binding (471..871): X

nrpys: 3OH-Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALLVGAVAK
Nearest Stachelhaus code(s):: 3OH-Leu DALLVGAVAK (100% 8Å match); Leu DALLVGAVAK (79% 8Å match)
Stachelhaus code match:: 100% (strong)