BGC0002114: sandarazol A biosynthetic gene cluster from Sandaracinus sp. MSr10575
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Location: 43,000 - 89,000 nt. (total: 46,001 nt).
This entry is originally from NCBI GenBank MW053453.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002114
Short description sandarazol A biosynthetic gene cluster from Sandaracinus sp. MSr10575
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
MW053453.1
43000 - 89000
via Heterologous expression
Compounds
  • sandarazol A
  • sandarazol C
  • sandarazol E
  • sandarazol G
  • sandarazol B
  • sandarazol D
  • sandarazol F
  • Sandarazol A
  • Sandarazol B
  • Sandarazol E
  • Sandarazol F
  • Sandarazol G
  • Sandarazol C
  • Sandarazol D
Species Sandaracinus sp. MSr10575 [taxonomy]
References
Chemical products information
sandarazol A Evidence: NMR [1]
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C30H46N4O7
Chemical database entries
NPAtlas
sandarazol C Evidence: NMR [1]
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Chemical database entries
NPAtlas
sandarazol E Evidence: NMR [1]
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Chemical database entries
NPAtlas
sandarazol G Evidence: NMR [1]
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Chemical database entries
NPAtlas
sandarazol B Evidence: NMR [1]
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Chemical database entries
NPAtlas
sandarazol D Evidence: NMR [1]
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Chemical database entries
NPAtlas
sandarazol F Evidence: NMR [1]
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Chemical database entries
NPAtlas
Sandarazol A Evidence: NMR [1]
(no structure information available)
Sandarazol B Evidence: NMR [1]
(no structure information available)
Sandarazol E Evidence: NMR [1]
(no structure information available)
Sandarazol F Evidence: NMR [1]
(no structure information available)
Sandarazol G Evidence: NMR [1]
(no structure information available)
Sandarazol C Evidence: NMR [1]
(no structure information available)
Sandarazol D Evidence: NMR [1]
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MSR10575_88360
  • QRN75749.1
 44462 - 45190 (+) Oxidoreductase FAD/NAD(P)-binding domain protein
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    • MSR10575_88370
    • QRN75750.1
    		 45218 - 46258 (+) 3-Aminoalanin synthase
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      • MSR10575_88380
      • QRN75751.1
      		 46255 - 47103 (+) Acyltransferase/malonyl CoA-acyl carrier protein transacylase
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        • MSR10575_88390
        • QRN75752.1
        		 47100 - 47843 (+) Enoyl-CoA hydratase/isomerase
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          • MSR10575_88400
          • QRN75753.1
          		 47836 - 58599 (+) Polyketide synthase
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            • MSR10575_88410
            • QRN75754.1
            		 58596 - 69254 (+) Polyketide synthase
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              • MSR10575_88420
              • QRN75755.1
              		 69290 - 75655 (+) Amino acid adenylation domain protein
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                • MSR10575_88430
                • QRN75756.1
                		 75652 - 80040 (+) Short-chain dehydrogenase/reductase SDR
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                  • MSR10575_88440
                  • QRN75757.1
                  		 80103 - 81854 (+) halogenase
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                    • MSR10575_88450
                    • QRN75758.1
                    		 81863 - 82915 (+) Pyridoxal-phosphate dependent enzyme family
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                      • MSR10575_88460
                      • QRN75759.1
                      • acpP
                      		 82912 - 83196 (+) Acyl carrier protein
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                        • MSR10575_88470
                        • QRN75760.1
                        		 83193 - 84515 (+) Beta-ketoacyl-ACP synthase
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                          • MSR10575_88480
                          • QRN75761.1
                          		 84512 - 85747 (+) hydroxymethylglutaryl-CoA synthase
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                            • MSR10575_88490
                            • QRN75762.1
                            		 85744 - 86487 (+) Enoyl-CoA hydratase/isomerase
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                              • MSR10575_88500
                              • QRN75763.1
                              		 86591 - 87379 (+) Thioesterase
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                                • MSR10575_88510
                                • QRN75764.1
                                		 87428 - 88675 (+) FAD binding monooxygenase
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  MSR10575_88410
                                  Substrates
                                  2,3-diaminopropionic acid (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  MSR10575_88420
                                  Substrates
                                  valine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  MSR10575_88420
                                  Substrates
                                  leucine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: next

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2024-05-14
                                  MIBiG v4 annotathon
                                  • (ID: FRQQORKO3VK7P3VSIR32QDKU)
                                  • (ID: 4ZBJCWV5NZUBDJXCSIV4TKIA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-10-07
                                  Changed chemical structures for compounds: sandarazol A.
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-10-07
                                  Added compounds: sandarazol C, sandarazol E, sandarazol G, sandarazol B, sandarazol D, sandarazol F.
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-10-07
                                  Added NPAtlas links to compounds: sandarazol C, sandarazol E, sandarazol G, sandarazol B, sandarazol D, sandarazol A, sandarazol F.
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Fixed biosynthetic classes
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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