LOCUS       BGC0002116             26188 bp    DNA     linear   CON 19-DEC-2022
DEFINITION  Photorhabdus khanii strain HGB 1456
            NODE_1_length_1453311_cov_38.469422, whole genome shotgun sequence.
ACCESSION   BGC0002116
VERSION     BGC0002116
KEYWORDS    WGS; RefSeq.
SOURCE      Photorhabdus khanii
  ORGANISM  Photorhabdus khanii
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Photorhabdus.
REFERENCE   1  (bases 1 to 1453311)
  AUTHORS   Imai,Y., Meyer,K.J., Iinishi,A., Favre-Godal,Q., Green,R.,
            Manuse,S., Caboni,M., Mori,M., Niles,S., Ghiglieri,M., Honrao,C.,
            Ma,X., Guo,J.J., Makriyannis,A., Linares-Otoya,L., Boehringer,N.,
            Wuisan,Z.G., Kaur,H., Wu,R., Mateus,A., Typas,A., Savitski,M.M.,
            Espinoza,J.L., O'Rourke,A., Nelson,K.E., Hiller,S., Noinaj,N.,
            Schaeberle,T.F., D'Onofrio,A. and Lewis,K.
  TITLE     A new antibiotic selectively kills Gram-negative pathogens
  JOURNAL   Nature 576 (7787), 459-464 (2019)
  REMARK    DOI: 10.1038/s41586-019-1791-1
REFERENCE   2  (bases 1 to 1453311)
  AUTHORS   Imai,Y., Meyer,K.J., Linishi,A., Favre-Godal,Q., Green,R.,
            Manuse,S., Caboni,M., Mori,M., Niles,S., Ghiglieri,M., Honrao,C.,
            Ma,X., Guo,J., Makriyannis,A., Linares-Otoya,L., Bohringer,N.,
            Wuisan,Z.G., Kaur,H., Wu,R., Mateus,A., Typas,A., Savitski,M.,
            Espinoza,J.L., O'Rourke,A., Nelson,K.E., Hiller,S., Noinaj,N.,
            Schaberle,T.F., Donofrio,A. and Lewis,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2019) Biology, Northeastern University, 360
            Huntington Ave, Boston, MA 02115, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.11
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 45.0x
            Sequencing Technology             :: Illumina MiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/19/2022 14:06:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.4
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,646
            CDSs (total)                      :: 4,569
            Genes (coding)                    :: 4,223
            CDSs (with protein)               :: 4,223
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            partial rRNAs                     :: 1, 2, 1 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 346
            CDSs (without protein)            :: 346
            Pseudo Genes (ambiguous residues) :: 0 of 346
            Pseudo Genes (frameshifted)       :: 79 of 346
            Pseudo Genes (incomplete)         :: 284 of 346
            Pseudo Genes (internal stop)      :: 64 of 346
            Pseudo Genes (multiple problems)  :: 68 of 346
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-5707d64f
            Run date                          :: 2025-08-15 21:01:06
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHZZ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26188
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="darobactin"
                     /region_number="1"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     darobactin_precursor) or darobactin_rSAM)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..26188
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002116"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..26188
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and darobactin_precursor) or darobactin_rSAM)"
                     /kind="single"
                     /product="darobactin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26188
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:16188](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and darobactin_precursor) or darobactin_rSAM)"
                     /neighbourhood="10000"
                     /product="darobactin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16188
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and darobactin_precursor) or darobactin_rSAM)"
                     /neighbourhood="10000"
                     /product="darobactin"
                     /protocluster_number="1"
     gene            1266..1397
                     /locus_tag="GEA64_RS04980"
                     /old_locus_tag="GEA64_05020"
     gene            complement(<1647..1901)
                     /locus_tag="GEA64_RS04985"
                     /old_locus_tag="GEA64_05025"
                     /pseudo=""
     gene            complement(2176..2508)
                     /gene="mdtI"
                     /locus_tag="GEA64_RS04990"
                     /old_locus_tag="GEA64_05030"
     gene            complement(2510..2926)
                     /gene="mdtJ"
                     /locus_tag="GEA64_RS04995"
                     /old_locus_tag="GEA64_05035"
     gene            complement(3433..4908)
                     /gene="zwf"
                     /locus_tag="GEA64_RS05000"
                     /old_locus_tag="GEA64_05040"
     gene            5255..6115
                     /locus_tag="GEA64_RS05005"
                     /old_locus_tag="GEA64_05045"
     gene            6521..7534
                     /locus_tag="GEA64_RS05010"
                     /old_locus_tag="GEA64_05050"
     gene            7953..9395
                     /gene="pyk"
                     /locus_tag="GEA64_RS05015"
                     /old_locus_tag="GEA64_05055"
     gene            10001..10177
                     /gene="darA-a"
                     /locus_tag="GEA64_RS05020"
     CDS             10001..10177
                     /codon_start=1
                     /gene="darA-a"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     darobactin: darobactin_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_152962143.1"
                     /locus_tag="GEA64_RS05020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide antibiotic darobactin A"
                     /protein_id="WP_152962143.1"
                     /sec_met_domain="darobactin_precursor (E-value: 1.0,
                     bitscore: 7.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNTLNETVKTQEALNSLAASFKETELSITDKALNELSNKPKIPE
                     ITAWNWSKSFQEI"
     gene            10574..12943
                     /gene="darB"
                     /locus_tag="GEA64_RS05025"
                     /old_locus_tag="GEA64_05060"
     CDS             10574..12943
                     /codon_start=1
                     /gene="darB"
                     /inference="COORDINATES: protein motif:HMM:NF038008.1"
                     /locus_tag="GEA64_RS05025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GEA64_05060"
                     /product="darobactin export ABC transporter permease
                     subunit"
                     /protein_id="WP_152962144.1"
                     /transl_table=11
                     /translation="MNAINISESMKRFNILVSILSVSIAILAIYLLSTAFYSDARVDNY
                     YQDNGNIYRVETTFNLPNGEKVRSAKSPLPLIDELEKDKRINRADYFFKLNTTIELQGK
                     KITKVPVFAVSHQFLNTLSPFKKIDNILGANEIYITKEFNNRYLGLENPKGKSIVLDNE
                     TYIIKDIVEKRHDSSLNMNAIISFKPTLIKNYNKEIFNWYDTHAYIFIKLSDEKSISNR
                     DALLNHIIATKAPNLPGAPFTASEFIHLSLKKSKDIHYQDGLPDEISIGLSKEIIYSSY
                     IAFAFILFSTLTNYYNLTSADSAEKRDIYQLKKALGASTFNIICDSLPAMLIKIILSTL
                     IFLLLIITIFNVSLYINNIFTLLEADSLIYLGIFSVVIAFIFISSIHFSFSLRFYIYQR
                     NRKMDMRYESTLASWFRKSSLAIQLLVSGISIYLVTGLTNQYIHLVDLHTPYDNAKTIS
                     IAINNDNNKKSTIDELSYEFIRKYNTSKITLSNWRPFDMSRENITINYSGQQNRNNYIS
                     SNVITADENFTDVWRMKILAGGDKRVYQSDNADVVHALVTKEFLKQNGILKYDDIFNNY
                     YWYTMEDKKIQIRFIQIIDDFNLGAVDEPFRPIVVFIKKDHGKYASLNLNNMKNLSPVL
                     NELSKQGFDNNEIDLTSHLFNSYYDNYLKVIKLSSAVAIFSVLLLVIACFTTSMTDFNA
                     MKRELSIMESIGGSIYTNLIHFLSKSVIPIIASIFVAYISGRTILVYLLDEYSVIYTDS
                     FVYSAIALSATMIFTVIIMMTTYLVNYRKLSATKFL"
     gene            12952..14205
                     /gene="darC"
                     /locus_tag="GEA64_RS05030"
                     /old_locus_tag="GEA64_05065"
     CDS             12952..14205
                     /codon_start=1
                     /gene="darC"
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF038010.1"
                     /locus_tag="GEA64_RS05030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GEA64_05065"
                     /product="darobactin export ABC transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_152962145.1"
                     /transl_table=11
                     /translation="MDIEIRKKGIHNREKLLILIFFIAFISFVVFIIYYVVSAKDAFVN
                     ENEVTQFQVSSKVDSDILKTRAVVVPDKSVSISTEIGGIVTDIMKKPSQDVLKNEEIVK
                     LSNFNFTLNNSSMLADVTDKLNNLINIRINLQSDYRDINNRFLEAAKELKEVEDKLKRY
                     HDLVHKNYISKETMSDLRIKRDYWHDVYLFYKKLKNDKDRDISKQLKEIDEFVEKQRKL
                     SDIIENGFEQLSIKSPIAGNISSLDLILGQRLKPGDKIAIVDDLSNFYFESEINEYYLN
                     KITYHSSASLIYNNGKIPLLVKLISSEVNNGTFKVRFELEDKKTINFKRGQSVDVMIKL
                     DEDRKIFSVPSSMVFSIDNKNYVFVYHPDKKIARRIQVSTGQDNGSDIEIKSGVTEGQT
                     LVSFGKNKLVNNDTVRIE"
     gene            14207..14869
                     /gene="darD"
                     /locus_tag="GEA64_RS05035"
                     /old_locus_tag="GEA64_05070"
     CDS             14207..14869
                     /codon_start=1
                     /gene="darD"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015834597.1"
                     /locus_tag="GEA64_RS05035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GEA64_05070"
                     /product="darobactin export ABC transporter ATP-binding
                     protein"
                     /protein_id="WP_152962146.1"
                     /transl_table=11
                     /translation="MISMMNICKSYKTKFIQTNVLNDINLNIDKGEFISIMGASGSGKS
                     TLLNVIGMFETIDSGQLTLNNSNILTMKYSEKISFRREFIGYIFQSFNLLPNLTVFENI
                     ELPLKYRGFPKKQRKSKVFDAINSFGLENRENHKPIQLSGGQQQRVAIARAMIANPTIL
                     LADEPTGNLDSVNGQNILSSLKELNENGTTIVMVTHSVEAAAFSDRILTMRDGHLLV"
     gene            14899..16188
                     /gene="darE"
                     /locus_tag="GEA64_RS05040"
                     /old_locus_tag="GEA64_05075"
     CDS             14899..16188
                     /codon_start=1
                     /gene="darE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     darobactin: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     darobactin: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     darobactin: darobactin_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015834598.1"
                     /locus_tag="GEA64_RS05040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GEA64_05075"
                     /product="darobactin maturation radical SAM/SPASM protein
                     DarE"
                     /protein_id="WP_152962147.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.2e-84, bitscore:
                     272.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.1e-14, bitscore: 42.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.6e-14, bitscore:
                     40.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="darobactin_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTIIPIKYLDSDESSILKKSSKINYRQLACRIIGEISAEKILDD
                     DELALYNKEISIHFSPEIINANKLVVVVKATRLCNLRCTYCHSWAEGKGNTLTFFNLMR
                     SIHRFLSLPNIKRFEFVWHGGEVTLLNVNYFKKLIWLQEQFKKPDQVITNSVQTNAVNI
                     PEDWLVFLKGIGMGVGISVDGIPEIHDSRRLDYRGRPTSHKVAASMKKLRSYGIPYGAL
                     IVVDRDVYESNIEKMLSYFYEIGLTDIEFLNIVPDNRCQPGDDPGGSYITYHNYINFLS
                     KVFRVWWNGYQGKINIRLFDGFIDSIKSSQKKMSDCYWAGNCSQEIITLEPNGTVSACD
                     KYVGAEGNNYGSIIDNDLGNLLSKSNTNKDHLKEEMESYEKMHQCKWFHLCNGGCPHDR
                     VTNRKHNPNYDGSCCGTGGLLETIKQTIAA"
     gene            complement(16438..17406)
                     /gene="lpxM"
                     /gene_synonym="msbB"
                     /locus_tag="GEA64_RS05045"
                     /old_locus_tag="GEA64_05080"
     gene            complement(17558..>18865)
                     /gene="mepM"
                     /locus_tag="GEA64_RS05050"
                     /old_locus_tag="GEA64_05085"
                     /pseudo=""
     gene            complement(18886..19833)
                     /gene="znuA"
                     /locus_tag="GEA64_RS05055"
                     /old_locus_tag="GEA64_05090"
     gene            19910..20665
                     /gene="znuC"
                     /locus_tag="GEA64_RS05060"
                     /old_locus_tag="GEA64_05095"
     gene            20665..21450
                     /gene="znuB"
                     /locus_tag="GEA64_RS05065"
                     /old_locus_tag="GEA64_05100"
     gene            complement(21553..22554)
                     /gene="ruvB"
                     /locus_tag="GEA64_RS05070"
                     /old_locus_tag="GEA64_05105"
     gene            complement(22570..>23187)
                     /gene="ruvA"
                     /locus_tag="GEA64_RS05075"
                     /old_locus_tag="GEA64_05110"
                     /pseudo=""
     gene            complement(23266..23787)
                     /gene="ruvC"
                     /locus_tag="GEA64_RS05080"
                     /old_locus_tag="GEA64_05115"
     gene            complement(23898..24641)
                     /locus_tag="GEA64_RS05085"
                     /old_locus_tag="GEA64_05120"
     gene            complement(24671..25108)
                     /gene="nudB"
                     /locus_tag="GEA64_RS05090"
                     /old_locus_tag="GEA64_05125"
ORIGIN
        1 tattatggcg taccgcacgg aagtgcggga tcaagctcag ttacagaaga gcgcggatcg
       61 tctgagtcaa agtactcagg atttccggct ggcattgggg gagaatggct atcgggggaa
      121 tttgcgggaa ttgttgcaaa atccgcaggt gcaacgggcg ctggtatttc ttgatgacgc
      181 acttgagctt tgttatgacg tggtgaaatt gtcgctgggg cgttcagtta tgctggatgc
      241 ggcctttgaa cgggcgacaa tttaccgtaa ccgtcttaaa cgcctgaaag atgtgactat
      301 ccccggttac agttattggt ttgaaagtta tggtcgccat tttcttttgg cgttaacacc
      361 tctgtctgtc tccgacaaat tcagcgaaat tattaatgag caatcaggtt gttgggtttt
      421 cacgtcagct acattatccg tcaacgaaca gctttcacat ttcaccgaac ggcttgggct
      481 aaaagaagcg aaaactttac tgttgccaag tccatttgat tatcaacgtc aaacgctgct
      541 ttgtgttcct cgtcatttac cgtcaccgaa tcagcccggt ggtgcaaaat ggctggcgag
      601 aatgcttaag ccgctgattg aaactaataa aggccgttgt ttctttttat gcacgtcaca
      661 ccagatgatg cgcagtttgg ccgaagagtt ccgggccagc atgacgttac cggttttggt
      721 tcagggtgaa accagtaaag gtcaattact ttctcagttt atttctgccg ggaacgcgtt
      781 attggtggca accagcagtt tttgggaggg tgtggatgtg cggggtgatg cgctttcctg
      841 tgtcattatc gataaactgc cttttacagc gccggatgat ccgctgttaa aagcccgcat
      901 tgaagattgc cagcttaaag gcggtgatgc atttaatgaa gttcagttgc cagatgcggt
      961 tattagcctg aaacagggtg tcgggcggct tattcgtgat gttgatgatt atggtgtggt
     1021 tgtgatttgt gataaccgac tggtgatgcg tccttatggc gaagtatttc ttaacagttt
     1081 gccgccttca ccacgcaccc gcgatttagc aaaagctgtt gcctttctgc aagcccggca
     1141 atctctgaaa agctccggta ggaaagatta attatatctg ctgattgagc gaacaattat
     1201 gaaactgtga ttctagggtt gtctgatgaa aaattagcca acccaaattc tcccaagaag
     1261 cagccatgct actcggagaa caaatcaagc taggcagaaa acaacgtcgg tggtcagaaa
     1321 agaatttggc agaacgtgcg ggtatatcca gaactacact gcaaaaaatt gaaaaaggag
     1381 atatgggctg tttatgagcc agaattacca ttaaaatcag gtattattgt cccactgagt
     1441 gacctcacaa tacctggctg tatccgcaat gcatcatttt ttatctgttg attacgctcg
     1501 gttaagcaga atattcaaca tacggcgcaa cggttcggct gcaccccaca gcagttgatc
     1561 accgacggtg aggacagaat agattggttc atcattaagt gacattttct tataacggcc
     1621 gacacccacg cacaaagagc cactgataac gctggataaa tggccttggt gtaatcgccg
     1681 ccttgacagg taatgattat gtccatttct gccaacgcat tgaccgaatt ggcgtcttta
     1741 agttgataag taatgccatc aatgacagga ccagcggaac cggcacttga tgtactataa
     1801 aagtgcgggg caatacctcg aaaatcactt tcttccagca tacgctgcaa caaaacagag
     1861 cccaccattc cccgccaacc gattaaaccg acctttttca tctatatata ttttacctgt
     1921 attaagttat aaaattgtta agcattttgt tatacatcag tgatagatta atgtcattaa
     1981 ggattacaac tgtttgataa gtcatagata aatctcctca ccgacataaa agatgattaa
     2041 caacgctaac ctcatcagca aatcatacag gtggcatccg ctcgatgggt gatatgttcg
     2101 caaatgacat cgcttaaaca aagctcagat tattataagt taatcaatca attagaatcc
     2161 aagtcactct tacggctacg ccatcttaat catcaccatc ccgagcaaca acaaaacaat
     2221 accgccccaa cctttacaat tcagacgttg attaaacata acccagccgg cagcaatcgt
     2281 ggcaataatg ccgaaagcgc cccacaaagc ataagcgatg gaaagttcga ttccctccac
     2341 tgcctgggca agcgcactaa acgccccaag aacagcaacc agtgagaaaa cccccatcca
     2401 atggcgtctg aaaccatcag acaatttcaa taaaatattc gctaaaatct ccaacacgac
     2461 agcaagaaac aggaacgcag catgccacca ttcaaattgt tgcaacatgt tatgcctcct
     2521 taattttact gtttttagtt acggcggcat tgacagcttt atctgccatc tttttcaccg
     2581 cctcagccga tttcttaact gccacttttt tagtcccgga tttaatcaac ataatccctg
     2641 tcaccagcag agccagaccg cccactttca tcaacgacaa tgattcatca aaccacatca
     2701 cactaaaaac agtaataaac aggataccaa tcccttccca caacgcatac gcaacaccca
     2761 gcgcaacttt tttcaccgcc attgccagca aaatatagga tgtagcgatc ataatgtaca
     2821 tcactgccat gccccccatc ccacctgaaa cgctggcatg tttcatcgac aaagtaccga
     2881 taacttcggt gacgattgcc attgcaagga ataaccagta aatcattttc tttctcctga
     2941 acacgcaaat acgcacgtca agacgcaagc cagtaaaaac actgaactca tcagcaaatg
     3001 agatgagaaa taaataacct gacgttttga cgaaatagaa atgccggttg aaaaccggtt
     3061 aacaggagta agacgctata acgcaccgca ccagtagtgc tcactggata aaatggcaga
     3121 aaggaaaagc atgtgggtag atctttgaaa ccggacgctt ttggcgctgt tcatgatatc
     3181 tcattctttc atcgcactga tattccgcac gatatactaa gaatcctcat agttatagtg
     3241 ttagttagcc tattacttct accatataga ataatagaaa gcaactgctc aattttattc
     3301 ttttcttgac tgaaggcaca aataagcgaa aaaattgggg tattctatat cttgatgaca
     3361 ccaacccaag ccgctcacaa cgcagcttgg gcctcaatat aaggactctt acaatcccac
     3421 gctcattacc cgttattcaa actcattcca cgagcggcca tcacgggtga tcatggcaac
     3481 agaagcaacc ggcccccatg tccccgcctg ataaggctta ggcgcatcat tatccgcagc
     3541 ccatgcattc ataatggaat caacccactt ccaggcttct tctacctcat cacgacgaac
     3601 aaacagcgcc tgaatacctc gcattgcttc cagcaacaat ctctcataag catccgccag
     3661 cagaatatgg ttgaacgttt cagagaaact cagatccagt ttggttgttt gcaaacgatg
     3721 tttatgctca agccccggcg ctttgttcaa cacttcaata tcaatacctt catccggttg
     3781 cagacgaatc gtcaacttgt tctgcggcag ttgctgatag gattcagaga acaggttcaa
     3841 cgctggtttt ttaaaataaa ccaccacttc agaacattta gttggcaaac gtttgccggt
     3901 tctcagatag aaaggaaccc cagcccaacg ccaatcatca atatcgaccc ggatagagac
     3961 aaaagtttct gtcctactgg attggttcgc cccctcttcc tccagataac ctggcacctt
     4021 attcccctga acaaaaccgg cagtatattg accacgtact gttttctccc gcacgttggt
     4081 gtgatcaata cggcgcaagg aacgcaatac tttcactttt tcatcacgga tatggtccgt
     4141 agtcagatct gccggaggag acatggcaat catcgtcagg atttgcaaca gatgattctg
     4201 aatcatatcg cgcatctgcc cggcttgatc aaaataaccc caacggccct caataccgac
     4261 ttcttccgct accgtaattt gaacatgatc aatggtccgg ttatcccagt tattcacaaa
     4321 caatgaattg gcaaaacgca gtgccagcaa attcaatacg gtttctttac ccagataatg
     4381 gtcaatacga tagacctgac actcattaaa atatttggca acttcatcat taatggccct
     4441 ggatgattca agatcggtac ctaaaggctt ttccatgaca acccggtttg gctctttatt
     4501 cagccccgcc agccccaatc cgtggcagac agaaccaaaa gtactcggtg gcatggcaaa
     4561 atagtggatt gcaggccggt tatcttgctt aagaattttt ttcagtctgg tgaaatcttc
     4621 cttttgatta acatccagat tgcagaaatt cagacgcgcg ctcaatgcct tccataattc
     4681 tggatcgagt ttttccggca aaaatgtatt cagagcttct tcaacaacct gggtataagc
     4741 ttttttatcc caatcagccc ggccaacacc aataatccgg gtttctgggt ggatataacc
     4801 cgctttctca agctgataaa gggagggtaa taatttccgg cgagccaaat cccctttagc
     4861 gccaaaaata actaaatcac aagcctgagc cgtagaagta accgccatat gtatctcctc
     4921 attgcgggat attgtaattt tgttacagcc ttaaccgata atgtaccctt ttggctatat
     4981 cgcgtaaaca gctatagcaa ataaccctcg ccttcatgtt agcgacctgt accaccgcag
     5041 ctaaactagt gatagtttta tgtaattttc caacttacat gaaatatagt taccaatatg
     5101 aaaattagac acttgtcata cttttatgaa aaatattgga ttattgtgac ttcccgctgc
     5161 cagcttcaat ttattgctag taatatattt tcataaaact tacatagatt tctcctctga
     5221 atgaaatcgc taaaatcaca ggtcactgcg ttttatgaat acactggaac gagtccaaaa
     5281 cagtattgaa tacttgagca agtcagaaaa aaaagtggcg caaataatcc tggcttcacc
     5341 acaaactgcc attcattcca gtatcgcaac actggcaaaa atggcggaag tcagtgaacc
     5401 caccgttaac cgtttttgcc gccgtctgga taccaaaggt tttcctgact tcaaactcca
     5461 cctggcccaa agccttgcca atggcacgcc ttatgtaaac cgtaatgttg aagagagcga
     5521 tacagtcagt gcctatacca ataagatctt tgaatcggcc atggcgacgc tggacacggt
     5581 aaaaaacaat ttggacatcg cagccgttaa ccgagctgtc gatttattga ctcaggcgcg
     5641 gaaaatttca ttttttggtt taggggcttc tgccgccgtt gctcatgacg cgatgaataa
     5701 attcttccga ttcaacattc cggttatcta ttttgacgat atcgtgatgc agcgaatgag
     5761 ctgtattaac agtgccgaag gtgatgtggt cgtgctgata tcccatactg gcagaaccaa
     5821 aagcctggtt gaagcggcgc agcttgcgcg ggaaaatgac gcggcagtca tcgccattac
     5881 ctctcacaat tcccctctcg cccgcgaagc aaccctggcg atacttctgg atgcaccgga
     5941 agatacggac atttacatgc caatggtatc aagaattgcc caattaaccg tcatagatgt
     6001 tctggctacc ggttttaccc tgcgccgtgg cgcaaagttt agagataact taaaaagagt
     6061 taaagaagcg ctgcgagatt cacgttttga taaaattgac tttcccccaa tctgaaagcc
     6121 ctatagctat tgaataaatc gcaaaaattg gactgagctc acctcaagtg agctactatt
     6181 tttgaaacgt tgtttaatac gatcacctaa aagagaaatt ataaagtcat gggaggaaaa
     6241 atgtatatca ccgggttaat ctaataaaat aataatcacc ctgaaaaaag caccaaaatg
     6301 aatagtgtga gaaataattt tcaaatattt atccggccac ccagcctcag gatcttcatt
     6361 accaacaatt atataaaaaa agttatcctt ctaagtgata aggatatttt atcctatttt
     6421 ccctagacta aactatcatt gacataagtc gcaaaaatca tcttaaaaat aatttaacca
     6481 attgattata aatcaatatt atttaattcc aggagagcat atgagtccga aaaatgattt
     6541 taaagctttt tccattagtg ataacgctaa tgtaattaac caagaaaaat atgaagaaaa
     6601 tcaaaatata aagacaggat ttccaacaga aaatattact actcaattgc taaataaggt
     6661 attacgtcaa tcatcaacaa tatcatctgt catagctgat tttatcgcga cacaatctgg
     6721 caatgatgtg ctggatgatg gtgatatagc taaactcacg acccaattag atgaagcatt
     6781 aaaacaaaaa atcacaacag aagttccgaa tgcctcatta acacaaaaag gcgttattca
     6841 actcacagaa aaaacaggcg atagtaatac actggcagcc actcagaaac ttgtttctga
     6901 tgtaaacgat aatgctaata accgactaga aaaaaaccaa aacggcgcag acattcctga
     6961 taaaaatgca tttttgaaaa atctcggctt aatagaaacc attattaaca cacaatatcc
     7021 tgtaggaatt gtggtttggt ttgcccaaaa taaaaaccca aatgagctat ttccgggcac
     7081 taaatgggaa tatatcggtg aaaataaaac cgttcgatta gccaaagcca atggtgccga
     7141 tattttatca accggtggta atgattcggt aaatctgacg acggcacaaa taccagcgca
     7201 caatcataca ttttttggga caacgagcac atttgattat ggcaccaaaa ccaccagtat
     7261 cgccggagat cactatcatg atagcggttg gggtgaagct ttcggtgggc gttatggcta
     7321 ttatgacaac actagaaaca atacagggtc aagctctata gattcagaca attacaaatt
     7381 caacaccagc actaatggcg cccattctca tattgtatca ataggatcac ataaccatac
     7441 aatttcaggt aatacgggag acacgggcgc caatgctgcg atttcaatta caaattcata
     7501 tgtcaaattg atgggatggt atcgaaaagc ataaggccac tgcatcctcc tgaacgttga
     7561 caaacctcac gtaaatagct gtctcttgat cacaaatcta acttaagaga cagctcacat
     7621 agtggaattt atccttcatc attgaaaata ccgcttaccg cttttcaata ccaaaaccct
     7681 tcaagaccat tagattgttg ataaaccggg aacaaatcat gataggatag aaacgcggca
     7741 ataaatatcc ccgccataga agggctagct gattcgccag ggcatagtga ttgtgtaaag
     7801 cgttccccct gtagttcccc tacagagaca actagtcagc acaagcacta cagcgaaaag
     7861 tatcggtata agctgatacg ggtcacaaaa agccctacga tagtcgcttg cgactttgcg
     7921 gtgggcatac taacaggtca acggagtaat gcatgtctag acggctcaga agaactaaga
     7981 ttgttactac acttggtccg gctaccgacc gcgataataa ccttgaaaag attattactg
     8041 cgggtgcaaa cgtagtccgc ctcaactttt cccacggcac cgcagaagat cacatccagc
     8101 gtgccaataa agtccgcgag atcgccgccc gcctggggcg tcatgtcgct attcttggcg
     8161 atcttcaggg acctaaaatc cgcgtatcaa cgtttaaaga gggcaaaatt ttcctgaata
     8221 tcggagataa atttctgctt gatgccaacc ttagtaaagg cgaaggcgat aaggagaaag
     8281 tcggtattga ttacaaagga ttacccgctg atgttgtccc gggcgatatt ctcctactgg
     8341 atgatggccg tgttcaactg aaagtattag cagttcaggg aatgaaagta tttacggaag
     8401 tgaccgtggg tggcccgcta tccaacaata agggtatcaa caaactgggc gggggtttat
     8461 ccgctgaagc cctgaccgaa aaagataaag aagacattat cactgccgct agaatcggtg
     8521 ttgattacct cgctgtttct tttccccgca ccggtgaaga tctcaattat gcccgccgtc
     8581 tggcgcggga tgccggttgc gaaacacaga tcgtggcaaa agttgaacgt gcagaagccg
     8641 ttagcagtga tgaaatcatt gatgaaatca ttctggcttc cgatgtcgtg atggttgccc
     8701 gtggtgacct cggcgtagaa atcggtgatc cggaactggt tggtgtgcag aaaaaattga
     8761 tccgccgcgc ccgccaactg aatcgtgtag tgattaccgc aacacagatg atggaatcca
     8821 tgatcaccaa cccaatgccg acccgtgcag aagttatgga cgtggcaaac gcggttcttg
     8881 acggtactga cgcggtgatg ctctccgctg aaaccgcagc gggccaatac cctgccgaaa
     8941 ccgttgccgc gatggcgcgg gtctgtctgg gagcggaaaa gatgccaggg ctcagtgtat
     9001 ccaaacatcg gctagacacg actttcgaca gtaccgaaga ggcgattgcc atgtccacca
     9061 tgtacgcggc aaaccatcta aacggtgtta aagcaattat cgcaatgacc gaatcaggcc
     9121 gcactacacg aataatgtcc cgcatcagtt ctggcctgcc tattttctct atgtcccgcc
     9181 atgagaaaac cctgaaccag acagcacttt accggggagt tacaccggtt tattgcagca
     9241 gtcatactga cggcatcaca gcagcgaatg aagccgttaa ccgcctgcga gataaaggtt
     9301 atctaatatc cggcgacctt gttctggtga ctcagggcga ccaaatggga accattggca
     9361 gtactaacac ctgccgtatt cttgaagtgg aataaaaact cactacattt tagcgtcggg
     9421 ctttcgggga ggacacagat taaatcggga agactggcgc acttcgctta tccaatacaa
     9481 ccgacggtaa aaaagttttt accgtctcag attgttgaca aaatgctgtt ttttatccgt
     9541 cattctgttt tcaatacaat attaaactta gagtaaatat cttcacctta aataatataa
     9601 ataataataa tttaagtaga ttctcattag ctaaaaatta atctccatca aagcgctacc
     9661 tgtctgatat atctaaaaat ccagtttata tcttctgagt tacatcataa aaggcagaaa
     9721 attatattga caatcattca acataacatt agtaattagg cgttgatatc agcattttcc
     9781 atgtggaaat accaaatttc ccgatgatat acttttatta gaaggaaata atgagctaac
     9841 taattaatca tctatacctt atagatttca agatgcatcg cgacggcaag ggagcgaatc
     9901 cccgtgagca tagcgaacta tgtgaccggg gtgagcgagc gcagccaaca aagaggtaac
     9961 ttgaaagata accggtataa gaaataaagt ggagattatc atgcataata ccttaaatga
    10021 aaccgttaaa actcaagaag cactcaattc tcttgctgca tcattcaaag agactgaact
    10081 ctcaattact gataaagcac taaacgaatt aagcaataaa cctaagatcc ctgagatcac
    10141 ggcctggaac tggtcaaaaa gcttccagga aatttaaagc ttatcccatc aggttatttt
    10201 attttcctga aaaaacaatg tccattggga taaacaatca agttgttcag ttaaaataaa
    10261 taattttttg aaccttaatc atagggtaat cctatgtatt atccgggatt accctaaata
    10321 ctttcataaa gtaaatataa aaatttgaat aatacagata agttttttta acctgaatgg
    10381 aaggtttgta ttttatcatt aaacacaacc accttttacc actaatatta ttggattttt
    10441 tcatttcaag atgaaaatat aatagatttc agtaactaaa aagggtaata gcctgtccca
    10501 gcaggtgtta ctgatgcagg caaataaaat agccctaata ggatgggctt taagtaagga
    10561 acggtagcca taaatgaatg ctattaacat ctcagaatcc atgaaacgtt tcaatatatt
    10621 ggtatcgata ctctcagtat caatagcaat attagcaatt tatttacttt ctactgcctt
    10681 ctattcagat gctcgagttg ataactatta tcaagataat ggcaacattt accgggtgga
    10741 aaccaccttt aatttgccca atggagaaaa agtgagatcg gcaaaatcgc cattgccgct
    10801 catagacgag ctagaaaaag ataaaaggat aaatcgtgca gactactttt tcaaacttaa
    10861 cacgacgatt gagttacaag gaaaaaagat caccaaagtt cccgtgtttg cagtcagtca
    10921 tcaattcctg aataccctgt ctccctttaa gaaaatcgat aatatcctgg gagcaaatga
    10981 gatttacatc acaaaagagt tcaataatcg ctatctcggc ctggaaaatc ccaaaggaaa
    11041 atctattgtt ctggataatg aaacctatat catcaaggat atcgtagaaa aacgtcatga
    11101 ttcgagtctt aatatgaatg ctattatttc atttaagcca acacttatca aaaactacaa
    11161 taaagaaata ttcaattggt atgatacaca tgcttatatt tttataaaac tctctgatga
    11221 aaaatcaata tccaatcgcg atgcgcttct taatcatatt attgcaacca aagcccccaa
    11281 tcttccaggc gctccattta ctgccagtga atttattcac ctatcattaa aaaaatcaaa
    11341 agatattcat taccaagatg gattgcctga tgaaatttct attggtttat caaaggagat
    11401 aatttatagc tcatatatcg cgttcgcatt tatcttattt tccacattaa ccaactatta
    11461 taatttaact tctgctgatt cagcagaaaa aagggatatt tatcagttaa agaaagcgct
    11521 aggcgcttca actttcaata ttatttgcga ttcactgccg gccatgttga tcaaaataat
    11581 cctttccacc cttatctttt tgttacttat cataactata tttaatgtct ctctctatat
    11641 aaataatata tttaccctat tagaagcaga cagtttaata tatctaggga tattttcagt
    11701 tgttattgcc tttatcttta tttcatcaat acatttttca ttctcattac gtttttatat
    11761 ttatcaaaga aacagaaaaa tggatatgag atatgaatca acccttgcct cttggtttag
    11821 gaaatcatca ttggctattc aattacttgt ttccggaata tctatttatt tagtcaccgg
    11881 attaaccaat caatatattc accttgttga tttacatact ccatatgata atgccaagac
    11941 aatatcaata gcaattaata acgataataa taaaaaatca actattgatg aattaagcta
    12001 tgagtttatc agaaaataca atacttcaaa aataaccctc agtaattggc gaccatttga
    12061 tatgtcaaga gaaaatatca ctattaatta ttccggccaa caaaacagga ataactatat
    12121 ctcttcaaat gttattactg cggatgaaaa tttcactgat gtgtggagaa tgaagatatt
    12181 agccggtggt gataaacgag tatatcagag tgataatgct gatgtagtcc atgcattagt
    12241 gacaaaagaa tttttaaaac agaatggaat tctcaaatat gatgatattt ttaacaacta
    12301 ctattggtac acaatggagg ataaaaagat ccaaatcaga tttattcaga ttatagatga
    12361 tttcaattta ggtgctgtag atgaaccatt caggccaata gttgttttca tcaaaaaaga
    12421 tcatggaaaa tatgcttcgc tgaatttaaa caatatgaaa aacctttctc cggtacttaa
    12481 cgaactatca aaacagggtt ttgataataa tgaaattgat ttaaccagtc acttatttaa
    12541 ctcttattat gataattatt taaaagtaat aaaattatca tctgccgtcg ctattttctc
    12601 ggttctatta ttagtcatcg cctgctttac taccagcatg actgacttta acgcgatgaa
    12661 aagggagtta agtataatgg aatctattgg tggttctatt tacaccaatc tcattcactt
    12721 tttatcgaaa agtgtcatcc cgataatcgc atcaattttc gtggcatata tatcaggaag
    12781 aactatttta gtttatctgc ttgatgaata tagtgtgatt tacaccgatt cttttgtata
    12841 cagtgctatc gccctatctg ctacaatgat attcaccgtt attataatga tgactaccta
    12901 tttggtgaat tatagaaaat tatccgccac taaatttttg tgagattaat tatggatata
    12961 gaaatcagaa aaaaaggcat acataacaga gagaaattac tcattctcat tttctttatc
    13021 gcttttattt catttgttgt atttattatc tattatgtcg tttcggctaa agacgctttc
    13081 gtgaatgaaa atgaagttac ccagtttcag gtcagcagca aagtagatag tgatattctg
    13141 aaaaccaggg cagttgtggt tcctgataaa agtgtctcta tctcaaccga gataggggga
    13201 atcgttaccg atataatgaa aaaaccatca caagatgttt taaagaatga agaaatcgtg
    13261 aaattatcta attttaattt cacattgaat aattcttcga tgttagcgga cgtgacagat
    13321 aaactcaata atttaataaa cataagaata aacttgcaat ctgactatcg ggatatcaat
    13381 aaccgattct tagaagccgc caaagaacta aaagaagtag aagataaatt aaagcgatat
    13441 cacgatcttg tacataaaaa ttatatttct aaagaaacta tgtccgattt aaggattaaa
    13501 agagattatt ggcacgatgt ttatctattc tacaaaaaat taaaaaatga taaagatcgt
    13561 gatatatcaa aacagttaaa ggaaatcgac gagtttgtcg aaaaacagag aaaactctct
    13621 gacatcatcg aaaatggttt cgagcagctt tcaataaaat cccctatcgc cggtaatatc
    13681 agttcattag atttaatttt aggacaacgg ttaaaacctg gcgataaaat agctattgtt
    13741 gatgatttat caaactttta ttttgaatca gaaatcaacg aatactattt aaacaaaata
    13801 acataccatt catctgccag tttaatctat aacaatggaa aaataccttt actggtgaaa
    13861 ttaatttcat ctgaagtgaa taatggaaca ttcaaagtca gatttgaatt ggaagataaa
    13921 aaaacaatta acttcaaacg ggggcaatcc gttgatgtca tgattaaact tgatgaagat
    13981 cggaaaatat tctccgtacc ttcatctatg gtgttttcta ttgacaataa aaactatgtg
    14041 tttgtttacc atccagataa aaaaattgcc cgacgtattc aagtttccac cggccaagat
    14101 aatggttctg atattgagat caaaagtggt gttactgaag gacaaacgct cgttagcttt
    14161 ggtaagaata aattagttaa taatgataca gtaaggattg aataaaatga ttagcatgat
    14221 gaatatctgt aaatcatata aaacgaaatt cattcaaaca aatgttttga atgacataaa
    14281 tctcaatata gataaaggcg aatttatttc tataatggga gcgtcagggt cagggaaatc
    14341 aacattactg aatgtcattg gcatgtttga aacaatcgat agcggtcaat taacactgaa
    14401 caatagcaat attttaacaa tgaaatattc tgaaaaaata tcattcagac gagaatttat
    14461 tggttatatt tttcaatcat tcaatctgtt acccaatttg acggtatttg aaaacataga
    14521 gttaccgtta aaatacagag gttttcctaa aaaacagcgg aaaagcaaag tatttgatgc
    14581 aataaatagt tttggattag aaaatcggga aaatcataaa ccgatacaat tatctggtgg
    14641 acaacagcaa cgtgttgcta tcgccagagc aatgatagca aaccccacca ttttattagc
    14701 tgatgaacca acggggaacc tggatagcgt aaatggtcag aatattttat cttcacttaa
    14761 ggagctgaat gaaaacggta cgacgattgt tatggtaacc cattccgtag aagcggcagc
    14821 gttttctgac agaatattaa cgatgaggga tggccacttg cttgtttgag cataaataac
    14881 ataataaagg agttctttat ggacacaata atccccataa aatatttaga ttcagacgaa
    14941 tcatcgattc ttaagaaatc atctaaaatt aactacaggc aattagcttg cagaattatc
    15001 ggtgaaatct ccgccgaaaa aatattagat gatgatgaac tggctttata taataaagaa
    15061 atcagtatac atttcagccc tgaaattatt aatgctaata aattagttgt ggttgtgaaa
    15121 gccaccaggc tttgcaattt aagatgcact tattgtcact cctgggcaga aggaaaagga
    15181 aataccttaa cattcttcaa tttaatgcgt tccattcacc gtttcttatc cctaccgaat
    15241 atcaagcgat ttgaattcgt ctggcatggc ggcgaagtaa cgttgttgaa tgttaattac
    15301 tttaagaaac tcatctggtt acaggaacaa tttaaaaaac cggatcaagt tatcaccaat
    15361 tcggtacaga caaatgccgt caatattcct gaagattggt tagtgttcct caaaggtatt
    15421 ggaatggggg taggaataag cgttgatggt attccggaaa tacacgatag caggagatta
    15481 gattacagag gaaggccaac atcccataaa gtcgcggcaa gtatgaaaaa gttaagaagt
    15541 tatggcatac cttacggtgc gcttatcgtc gtcgaccgcg atgtttatga atcaaatata
    15601 gaaaaaatgc tctcttattt ttacgaaatc ggtttaacgg atattgaatt tctgaatatt
    15661 gtcccagata accgatgcca gccgggtgat gatcctggag gaagttatat aacttaccat
    15721 aactatatta atttcctttc taaggttttc cgtgtctggt ggaatggtta tcaaggcaaa
    15781 atcaatattc gcttgtttga cggatttatt gacagtatca aatcgtccca aaagaaaatg
    15841 tcagattgtt attgggcggg taactgttct caggaaataa tcacattaga acctaatggt
    15901 acggtatcag catgtgataa atatgttggt gctgaaggga ataattatgg ttcgattatt
    15961 gataatgatc ttgggaattt actatctaaa tcaaatacaa ataaggatca tcttaaagag
    16021 gaaatggaat catatgaaaa aatgcatcaa tgtaaatggt ttcatttgtg taatggtgga
    16081 tgcccacacg atcgagtgac caacaggaag cacaatccaa attatgatgg ttcatgttgt
    16141 ggaaccggcg gtttgttgga gacaataaaa caaaccatcg cggcgtaaat gctatcctga
    16201 tatttcaaat gcaagtaaaa tgtttcatca taataacccc taatcattgg atatgatgtc
    16261 caatattagg ggttaagttc aaactgtgat aatgacttca tatatatacc gaatagattt
    16321 cgagttgcag cgcggcggca agtgaacgaa cccccaggag catagataac tatgtgactg
    16381 gggtgagtga aagcagccaa caaagcagca acttgaaaga tgaagggtat attagaatta
    16441 aagatcttct ctattatacg gctcaatatc cccttctttg cgggtcttaa gcaatttaag
    16501 gatccaagtg tattgctcag gatttggccg cactaattgt tccaactctt cattcatccg
    16561 gcgggcaata aaagcatcat ctttgccttc aatatcatcc attggagggc gaatataaat
    16621 atcaagctga tgagtacggt aattataaac cggaaacaat ggcacaatcg ccgcacgaca
    16681 aatcttcatc agcctcccaa tggccggtaa tgttgcctta tacgttgcga agaaatcgac
    16741 aaattcactg tgctcctcgc catgatcttg atcaggaaga taatatcccc agtaaccctg
    16801 gcgaacggta gcaataaaag gtttaatgcc agcatcacgg gaatgtaagc gaccaccaaa
    16861 gcgaccccgg actttattcc acagataatc tgctacaggg ttcttctgat gatgaaacat
    16921 cgccgctgct ttctgtccat tggctgtcaa taatatcgcc ggaagatcca ccgcccagcc
    16981 atgaggaacc ataaaaataa tgttttttcc ctgcgctttc agttggcgag taatctcttc
    17041 accatgccaa tgcgtccggc ttaaagctga ttttgtgcca cgtaaacaaa tctcagccag
    17101 cataacaaaa ggttgaggcg cagtagaaaa catctcatca atcaacgcct cgcgctgctg
    17161 ctctgtcagt tccggcatac agtagcacag attgatcctc gctctgcggc gcgccccttt
    17221 tgccagcctg ccagccagcc agcctatttt agccaacaaa ggatcacgca ttttaaccgg
    17281 gaagtaagtc agcccagcca atacacctac tcccaaccat aatccccaat agcgaggatg
    17341 caggtaggat ttatgaaatg tcggcacata acccacttta ctgtctgtat ctgtctcttt
    17401 atgcatgagc taactcttta gaacaaaacg atgtctgcca ttttagtaca gagatttata
    17461 tcagtggata tcaacccatc tttttctggc atagacaaaa caacggcgga tgatatcaat
    17521 catccacctt aaagtctgtc attaatgttc aattaagcta atccagcaaa agctgaggtg
    17581 ttacctcttt taccgttgcc aggaattctg tgcgatcttt accactcaga ccaccagaac
    17641 gcggcaattt cgcagttaat ggatttaccg cctgctgatt gatccagaat tcatagtgca
    17701 aatgaggccc cgtggaacga ccggtactac cggacaacgc gatacgatca ccacgtttca
    17761 ccttctgccc tggtttcacc aacagttttc tcaggtgcat ataacgggtg gtatattggc
    17821 ggccatgacg aatagcgatg aagttccctg ccgccccatt atatttggag acaataacct
    17881 caccgtcacc taccgccaaa accgggcttc ccaccggcat agcaaaatcc acccctttgt
    17941 gtggtgcgac acgccctgtt accggattca cacgccgggg attaaagtga gaagatacac
    18001 ggaattgttt cgttgttgga aaacgtaaaa agccgcgttc aagaccggaa ccttcacgat
    18061 cataaaaacg cccatcttcc gcacggatag cataataatc tttaccgcta ctgttcaggc
    18121 gaacacccag taattggctc tgttcactgt gaccatccag catttcacgg gaaagtaata
    18181 cagagaagcg atcaccttta tgtaatttgc gcaaatcaat ttgccattgc agtgccttgg
    18241 tgacttcacg tgcttcactg ctggttaatc ccgcgtttaa agcactgctg gtaaagttac
    18301 tatcaaccac acctataatc gcgctgtttt tccactcacc tttctgaaat gatttcgttt
    18361 ctttaaagac atcaccttca cgggtataaa tacggctttc acgacgggaa acaccccaag
    18421 tcagactttg cagatcaccc gcttcattta ccgtccatga taatggctga ccaatgttca
    18481 gcccccgtaa cactttatgc tgacttgcca gtaacgccac gtcagaagca tcaataccaa
    18541 attgcgtcaa aatgctactg agggtatcac cgtcagagac aatatattca tgcggagttt
    18601 gagccgtcgc ttccgaattc gtctcttcat cgggaatgcc ctcatccggt aattgctcac
    18661 tactatccgc aataatctca tcagtatttg ccggggcact gattgcaata ctgtcggtgc
    18721 ttatttcttc ctgttcatga tgataaacaa ttggctgcca catcgtgaca accaatgtcg
    18781 ccaaagtcag cgaacccagc ataatcttat gcggtcgcgg taactcccta tacaccagaa
    18841 cgatagtttt aactatctgc tgcactaatc gaattcctta ttactttaat tcaggcaact
    18901 cgcgtattgt tccgacaact gagttataaa tttcatatag ctgtccttat ccaatacgat
    18961 gcggcctcct aacgggtcta aagtgcccat acgcaccccc gtattcttcg ctaccgcatt
    19021 aataacggtc ggcctgaatt gcggttcagc aaaaatgcag gttgccttct gctcaaccaa
    19081 ttgtgttcgt atatgatgta atttttgcgc gccgggctgt atttcagggt taatcgtaaa
    19141 atgccctaac ggggtcaagc cataatgctg ttcgaaatag ccataggcgt cgtgaaaaac
    19201 aaaatacccc ctaccgcgcg ccagcttaag aatattagca atatttttgt cagtttgcgc
    19261 aagatgaacg ttgaatttac gtaggtttac gtccagtgcc acttttttct gcggataacg
    19321 cgctaataat tggtcatgga tcccctgagc agcctgtttc gctatttctg gcgacaacca
    19381 aatgtgcata ttatattcac catgagaatg atgttcatgg ttctcttcat ggttatgatg
    19441 attcgattcc tgtaaatctt catcattctt tagcaatagt ggtttaatcg ccggcaattg
    19501 cgctaatacc agctgtttat cttgtggcac tttggttaac ggtttagaca aaaagatttc
    19561 catatcagga ccaacccaca caaataaatc tgcctgatta atcttcttaa gatcagacgg
    19621 tttcaatgca taatcatgtg gtgaagcgcc atcaggcaac aatacctgcg tattagtaac
    19681 accctcagtt attgccgcag caataaaacc caacggacga attgatgtca ccacatcagc
    19741 attagccgat ggtattgttc ctgacataaa aacagtggca attgcagctt tgcagaaaaa
    19801 tttctgcgcc aatttatatg atttgtgcaa cataatgtaa atatctcgtg gacagaagca
    19861 agaattgtta tattataaca tctcaatgtt cacgcaagat atatttagca tgtcgacact
    19921 catcacttta aaaaatgttg cagttacctt cggcaaccgt caggtattaa acaatatttc
    19981 tcttagcttg caacaaggga atatcctgac gttgctgggt cccaatggtg ccggtaagtc
    20041 aacattagtc cgtgttgttt tggggcttat tgcgccgtca tccggcacga ttgagcatac
    20101 cgatggactg agaatcggct atgttccaca gaagttgcat cttgatccta ccctgccact
    20161 gacagtcaaa cgctttatga tgctaaaacc cggcgtaaaa tccgccgata tattgccgac
    20221 gcttgaacgg gttaacgcgg ctcatctctt gcagcaaccg atgcaaaaat tatccggcgg
    20281 agaaaaccaa cgggttttat tagccagagc gctattaaat caaccccaat tgctggtgct
    20341 tgatgaaccg acacaaggcg ttgatgttaa tggtcagtta gcactgtatg atttaattaa
    20401 tcaaatcaga actgaattac attgtgctgt actgatggta tcccatgatt tgcatttggt
    20461 gatggcgaaa acagacgaag ttttatgcct taatcaacat atttgctgtt ccggtacacc
    20521 ggaagttgtt tcaactcacc ctgaatttat cgctatgttt ggtcatcatg gcaccgggca
    20581 attagcaata tatcggcatc aacataatca ccatcatgat ctgaaaggaa aaattatctt
    20641 gaaaaataac agggaatgcc agtgatgatt gaattattac tccccggttg gttggccggc
    20701 atattattgg cgattgctgc cggaccatta ggatcatttg ttgtctggcg cagaatgtcc
    20761 tattttggcg atactctggc tcatgcgtca ttattgggcg tcgctttcgg attattactc
    20821 aatatcagcc cgttttacgc ggttatcgcg gtcacgttga tattggcaat catgctggtc
    20881 tggctggaga aacgcccaca actggccatt gatactttat tggggattat ggctcacagc
    20941 gccttatcat taggcttggt ggttgtcagt ttaatgtcca atgtgcgggt tgatttaatg
    21001 gcttatctgt ttggtgactt actgtcagtc acttatgaag atatctggct gattgtaatc
    21061 ggtgtcgcta ttgttactac actgctgttc cggcaatgga acgccctgct ttctatgaca
    21121 gtcagccaag aaatggcgtt tgtggatggc attaaaatcc agcggttgag agtgctgtta
    21181 atgctggtaa cagccttgac aattggcctg gcaatgaagt ttgtcggcgc tctgattatc
    21241 acttctctgc tgattattcc cgctgccacc gcgcgccgtt ttgcccgtac accggaacaa
    21301 atggccggta ttgccattat cgttggtatg ctcgctgtca ccggcggatt agctttttcc
    21361 gccttttacg acacgccagc cgggccttct gttgttctgt gcgctgcggt gctatttatt
    21421 atcagcctac tcagtaaggc aagaagttga ttcactgagt tgctacgctc aattaccaat
    21481 gaagaaaacc cgggataggg ttcccttgac ggagccccat cccaattagc tcacactgca
    21541 aactgattgt gcctaatctc tgaccatacc aaaatggcga taagcatgat cggtggcgat
    21601 tcgtccacgg gaagtccgtt gaataaaacc ttgctggatc aggaatggct ccagcacatc
    21661 ctcaatcgtt tcccgctcct caccgatggc ggcggcaagg ttatccaccc ccacaggccc
    21721 gcccataaat ttatcaatga tggcaatcaa taacttacga tccagataat caaaaccggc
    21781 agaatccaca ctcagcatat ccagcgcctt ggtagcaatt tcactatcaa tcccaccatt
    21841 ccctttcacc tgagcaaaat cacgcacccg acgcagtaaa cggttggtaa tacgcggcgt
    21901 tccacgggaa cgcatggcaa tctgccgcgc accatcatta gtaatatcca cccccatata
    21961 acgggcactg cgggagacaa tactttgcaa atcatccaca ttataaaatt caaggcgctg
    22021 cacaataccg aaacgatcac gcagtggaga agtcagggag cctgcacgcg tggtagcgcc
    22081 aatcagggta aaaggcggca aatcaatttt gatcgaacgg gctgccggcc cctcgccaat
    22141 cataatatcc agctgatagt cttccattgc cggatagaga atttcttcca ctaccggcga
    22201 taaacggtga atttcgtcga taaacaaaac atcgtgcggt tcaagatttg tcagcattgc
    22261 cgccaaatcc cccgcctttt ccaagaccgg gccagacgtt gtgcgaagat ttacccccat
    22321 ctcattggca acaatattcg ccagggttgt tttccccaac ccgggcgggc caaaaatcag
    22381 cagatggtca agggcatcac cacgctgtct ggccgcctga ataaaaatct ccatctgctc
    22441 acagacctgc ggctgcccga catattcaga cagtaatttg ggtctgattg cgcggtcaat
    22501 ggcttcatca tcttgtaaaa cttccgcgga aaccagacgg tcagcttcaa tcatggtata
    22561 cccctgtgat taaagagcgg cgcgaagggc ttcgcggata agtgtttcac aatcagctcc
    22621 cggtttagcg actttactga tcattcggct ggcctcttgc agcttataac ccagagagac
    22681 taacgcggcg gcggcttccg cttcgatatc agcatcagaa gttgtctgtt tggcggttgc
    22741 tggcagatta atatcactgc tctgattaaa cagatcgcca ttaagccctt taaaacgatc
    22801 tttcatttca accaccagcc gttcagccgt ttttttaccc acacccggca atttaaccag
    22861 agaagcaatc gcctctttct caatcgcaga aacaaattgc tgcgcagaca tacccgaaag
    22921 aatagccagc gctagtttag ggccgacgcc attcacttta atcagttcac ggaacagcgc
    22981 ccgctcctgt ttatcattaa aaccataaag taattgcgca tcttcacgca ccacaaagtg
    23041 agtaaacaga acagtttcct gtccggtctc aggcaattca taaaaacagg tcattggcat
    23101 ataaacttca taacccacgc cattcgtttc cagcaaaacc aacggtggtt gtttttccag
    23161 cacaattcct ctgagacgcc ctatcacttg tttaccccct gcaaataaaa ctgattattc
    23221 tgctaatgct tataacataa aaaaagctgg atgcatatcc agccgttatt ttaaacgtcc
    23281 tcgcgccagc attaatctgg gatcaccgac acgcaaaaga ttctgattaa agtggcaatg
    23341 ggttatcgca attgccaacg catctgccgc atcagattgc ggattagcag acaatttcag
    23401 catagaacgc accatatgct gaacctgact tttttcagcc gccccagtgc cgacaactgt
    23461 ctgtttaacc tgccgggcag catattcaaa aaccggtaca gattgattta ccgcagccag
    23521 aatagcaacg ccacgcgctt gccctaattt cagcgctgaa tccgggtttt tcgccataaa
    23581 tacctgctca atagcaaagg catccggttg gaattgcgta ataatttcaa ggataccggc
    23641 ataaatgcgc tgtaaccggt taggcagatc atcaactttt gtccggatac agccactgcc
    23701 aaggtagatc aaatggcgcc cctgctggcg gatcacacca taaccggtga cgcgggaacc
    23761 tgggtcgata cctaagataa tcgccatatc tgtttattcg cctttacgat catctttaat
    23821 aagggggaat aaaaacgtta gagaaagtgc cctgaacccc cagtgcactt tctctacgct
    23881 atacaacccg attgaaatta cagcagagct gcaacttcat cagagatttc accgttatgg
    23941 taaacctctt gtacgtcgtc tgaatcttcc agcatatcga taagacgcag taacttaggc
    24001 gcggtttccg catccaattc agctttagtg gaagggatca tcgaaacttc tgctgattcg
    24061 gcaacaaaac cggcagcatc caatgcatct ttcacgtcac caaacgtttc tggtgaggtg
    24121 tagacatcaa tagcgccatc atcataagtt tccacatcat cagcccctgc ttccaacgcc
    24181 gcttccataa ccgcatcttc atccaatccc ggcgcataag aaattacgcc tttcttggtg
    24241 aacagataag caacagagcc atccgtaccc agattaccgc cggttttagt gaaagcatga
    24301 cgaacatcag aaaccgtacg gttacggtta tcactcagac attcaaccat taccgcggta
    24361 ccccccggac cataaccttc ataaatgatg gtttccatgt tgtcagcatc atcgttgcca
    24421 acaccacggg caatagcccg gttcaaggta tcgcgggtca tgttgttgga cagcgcttta
    24481 tcaaccgccg cccgcagacg tgggttagct gccggatcac caccacccaa acgggcagcc
    24541 gttaccaact cccgaataat tttggtgaaa attttaccgc gtttcgcatc ctgtgccgct
    24601 ttgcggtgct tggtattggc ccatttacta tgacctgcca taaggttctc cgataaaaca
    24661 tctaattaac ttaattaatc acaaattctt caattgcctg ccgattactc catgacttag
    24721 tgagctttgc cgctttatcc gcatccagcc actggtaagc ctggtgttca gtcaacagga
    24781 gttctcgctc ttgaggcaat gccagacaga accagtactc tttattacgg gttactcccg
    24841 gagcataacg atgacgcaaa tgggtaaaaa tctcataata aagcgagcgc cggcaatcta
    24901 tcagttcaag attttcaccg atgatatcaa taccgacttc ttcttgcact tcacgcaatg
    24961 ctgtctcacg cggcgtttcg tccccgtcaa ggctacccgt cacagattgc caaaaatcag
    25021 gatcatcccg ccgctgtagc atcagcaccc gtctgctgga aaacgcataa ataacaacca
    25081 gaacagattc agggcgctta taagccatta ttcactctct ttccgggcca caaccgaaat
    25141 tgacagatct tcaagcgcgg ccagatttgc ataacttggc gcttcggtca tcagacaagc
    25201 agcagcggtt gttttaggga acgcgataac atcacggatg ttgtcagtcc ctgtcagcaa
    25261 catcaccaga cggtcaagac cgaatgccag gcctgcatgg ggtggagtcc caaacttcag
    25321 cgcatccagc aggaaaccaa atttttcctg ctgttcctgc tcattaattc ccaaaatgcg
    25381 gaacaccgtt tgttgcatgt cgttacggtg aatacgcact gaaccaccgc ctacttcata
    25441 accattaatc accatatcgt aagcattggc aatggccgaa agcggatttt gcgccaacgc
    25501 ttccgctgac atatcacgcg gtgaagtaaa cggatggtgc attgcactca ggccgccttc
    25561 atcgtcatct tcgaacattg ggaaatcgat aacccacaac ggttgccagc tatccagttg
    25621 cgtcaagttc aaatcgcggc ctaatttcag acgaagtgct cccaaggcat cagtgaccac
    25681 ttttgtactg ccggcgccga agaacagaat atcgccatcc tgcgcaccgg tacgggaaag
    25741 cagaccgtca atcacttctg cattcaggaa cttagccacc gggctttgta ccccttccag
    25801 accagcgcca cgattattga cttttatcca cgccaaccct ttggcgccat aaatcccaac
    25861 aaatttgcca tattcatcaa tttgtttacg gctcagttca gccccacccg gaacacggat
    25921 aacggccaca cggcctttac tgtcattcgc cggttcagca aaaacgctga actccacatt
    25981 tttgaccaga tcagcgacat cgaccaattc cagtgggtta cgcaaatcag gtttatcaga
    26041 accgaaacga cgcatagcct cagcaaaagt catgaccggg aaatgcccga gatcaacacc
    26101 tttaatttca agccacaatt cgcggatcat ttgttccatc atttccctga cctgctcggc
    26161 agtcataaag gaagtttcca cgtcgatc
//
