BGC0002123: pseudovibriamide A1 biosynthetic gene cluster from Pseudovibrio brasiliensis Ab134
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Location: 141,580 - 213,419 nt. (total: 71,840 nt).
This entry is originally from NCBI GenBank CP074128.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0002123
Short description pseudovibriamide A1 biosynthetic gene cluster from Pseudovibrio brasiliensis Ab134
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
CP074128.1
160098 - 203291
via Knock-out studies
Compounds
  • pseudovibriamide A1
  • pseudovibriamide B1
  • pseudovibriamide A2
  • pseudovibriamide A3
  • pseudovibriamide A4
  • pseudovibriamide B2
  • pseudovibriamide A5
  • pseudovibriamide A6
  • pseudovibriamide B3
  • pseudovibriamide B4
  • pseudovibriamide B6
  • pseudovibriamide B5
Species Pseudovibrio brasiliensis Ab134 [taxonomy]
References
Chemical products information
pseudovibriamide A1 Evidence: NMR, Mass spectrometry
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C36H49N11O11S1
Chemical database entries
NPAtlas
pseudovibriamide B1 Evidence: NMR, Mass spectrometry
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C51H73N13O16S1
Chemical database entries
NPAtlas
pseudovibriamide A2 Evidence: NMR, Mass spectrometry
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C36H47N11O10S1
Chemical database entries
NPAtlas
pseudovibriamide A3 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide A4 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide B2 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide A5 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide A6 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide B3 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide B4 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide B6 Evidence:
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Chemical database entries
NPAtlas
pseudovibriamide B5 Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • KGB56_24745
  • QUS58934.1
 160086 - 160871 (+) thioesterase
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    • KGB56_24750
    • QUS58935.1
    		 160878 - 161645 (+) 4'-phosphopantetheinyl transferase superfamily protein
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      • KGB56_24755
      • QUS58936.1
      		 161580 - 170558 (-) non-ribosomal peptide synthetase
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        • KGB56_24760
        • QUS58937.1
        		 170567 - 174685 (-) non-ribosomal peptide synthetase
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          • KGB56_24765
          • QUS58938.1
          		 174682 - 185085 (-) amino acid adenylation domain-containing protein
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            • KGB56_24770
            • QUS58939.1
            		 185122 - 193419 (-) amino acid adenylation domain-containing protein
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              • KGB56_24775
              • QUS58940.1
              		 193637 - 194878 (+) MFS transporter
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                • KGB56_24780
                • QUS58941.1
                		 194913 - 195959 (+) GSCFA domain-containing protein
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                  • KGB56_24785
                  • QUS58942.1
                  		 195928 - 196641 (+) hypothetical protein
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                    • KGB56_24790
                    • QUS58943.1
                    		 196628 - 197260 (+) hypothetical protein
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                      • KGB56_24795
                      • QUS58944.1
                      		 197290 - 198201 (+) TauD/TfdA family dioxygenase
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                        • KGB56_24800
                        • QUS58945.1
                        		 198307 - 199539 (-) MFS transporter
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                          • KGB56_24805
                          • QUS58946.1
                          		 199683 - 200156 (-) GNAT family N-acetyltransferase
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                            • KGB56_24810
                            • QUS58947.1
                            		 200237 - 201274 (-) ABC transporter substrate-binding protein
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                              • KGB56_24815
                              • QUS58948.1
                              		 201244 - 202629 (-) HAMP domain-containing histidine kinase
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                                • KGB56_24820
                                • QUS58949.1
                                		 202626 - 203291 (-) response regulator transcription factor
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24770
                                  Substrates
                                  tyrosine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24770
                                  Substrates
                                  threonine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24770
                                  Substrates
                                  alanine, glycine (evidence: Structure-based inference, Mass spectrometry)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24765
                                  Substrates
                                  arginine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24765
                                  Substrates
                                  proline (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24765
                                  Substrates
                                  cysteine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24760
                                  Substrates
                                  glutamine (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk08
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24755
                                  Substrates
                                  valine, leucine, isoleucine (evidence: Structure-based inference, Mass spectrometry)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk09
                                  Type
                                  nrps-type1
                                  Genes
                                  KGB56_24755
                                  Substrates
                                  proline (evidence: Structure-based inference [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Changed chemical structures for compounds: pseudovibriamide A1, pseudovibriamide A2, pseudovibriamide B1.
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-10-07
                                  Added compounds: pseudovibriamide A3, pseudovibriamide A4, pseudovibriamide B2, pseudovibriamide A5, pseudovibriamide A6, pseudovibriamide B3, pseudovibriamide B4, pseudovibriamide B6, pseudovibriamide B5.
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-10-07
                                  Added NPAtlas links to compounds: pseudovibriamide A3, pseudovibriamide A4, pseudovibriamide B2, pseudovibriamide A5, pseudovibriamide A1, pseudovibriamide A2, pseudovibriamide A6, pseudovibriamide B3, pseudovibriamide B4, pseudovibriamide B6, pseudovibriamide B1, pseudovibriamide B5.
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Entry added
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRPS substrate integrated monomers from duplicate entry BGC0002371
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                  Detailed domain annotation
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                                  Modifications to original record
                                  • KGB56_24075 crossed the origin and was split into two features