BGC0002125: FR900359 biosynthetic gene cluster from Chromobacterium vaccinii MWU205
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Location: 1 - 40,174 nt. (total: 40,174 nt).
This entry is originally from NCBI GenBank MT876545.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002125
Short description FR900359 biosynthetic gene cluster from Chromobacterium vaccinii MWU205
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT876545.1
via Knock-out studies, Enzymatic assays
Compounds
  • FR900359
Species Chromobacterium vaccinii MWU205 [taxonomy]
References
Chemical products information
FR900359 Evidence: NMR, Mass spectrometry, Total synthesis
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QPI18723.1
  • frsA
 1140 - 4958 (+) nonribosomal peptide synthetase
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    • QPI18724.1
    • frsB
    		 4977 - 5195 (+) MbtH-like short protein
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      • QPI18725.1
      • frsC
      		 5192 - 6178 (+) MDH/LDH-like protein
      • Reduction
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      • QPI18726.1
      • frsD
      		 6300 - 9380 (+) nonribosomal peptide synthetase
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        • QPI18727.1
        • frsE
        		 9383 - 18433 (+) nonribosomal peptide synthetase
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          • QPI18728.1
          • frsF
          		 18423 - 25979 (+) nonribosomal peptide synthetase
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            • QPI18729.1
            • frsG
            		 25969 - 35376 (+) nonribosomal peptide synthetase
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              • QPI18730.1
              • frsH
              		 35395 - 36990 (+) non-heme diiron monooxygenase
              • Hydroxylation
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              Biosynthesis information

              Biosynthetic modules

              Name
              1
              Type
              nrps-type1
              Genes
              frsG
              Substrates
              leucine (evidence: Structure-based inference, Homology)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              2
              Type
              nrps-type1
              Genes
              frsG
              Substrates
              O-methylthreonine (evidence: Structure-based inference [4])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              3
              Type
              nrps-type1
              Genes
              frsF
              Substrates
              alanine (evidence: Structure-based inference [4])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              4
              Type
              nrps-type1
              Genes
              frsF
              Substrates
              alanine (evidence: Structure-based inference [4])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              5
              Type
              nrps-type1
              Genes
              frsE
              Substrates
              phenylalanine (evidence: Structure-based inference [4])
              Integrated Monomers
              Domains
              condensation (LCL), adenylation
              Name
              6
              Type
              nrps-type1
              Genes
              frsE
              Substrates
              serine (evidence: Structure-based inference [4])
              Integrated Monomers
              Domains
              condensation (DCL), adenylation
              Name
              7
              Type
              nrps-type1
              Genes
              frsD
              Substrates
              leucine (evidence: Structure-based inference, ATP-PPi exchange assay)
              Integrated Monomers
              Domains
              condensation (Starter), adenylation
              Name
              8
              Type
              nrps-type1
              Genes
              frsA
              Substrates
              leucine (evidence: Structure-based inference, Knock-out studies, ATP-PPi exchange assay)
              Integrated Monomers
              Domains
              condensation (Starter), adenylation
              Annotation changelog

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-10-07
              Changed chemical structures for compounds: FR900359.
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-10-07
              Added NPAtlas links to compounds: FR900359.
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Fixed subcluster gene ID
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Added organism name
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Fix thioesterase gene ID
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Add information lost in migration from 1.4 to 2.0
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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