BGC0002125: FR900359 biosynthetic gene cluster from Chromobacterium vaccinii MWU205
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Location: 1 - 40,174 nt. (total: 40,174 nt).
This entry is originally from NCBI GenBank MT876545.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002125
Short description FR900359 biosynthetic gene cluster from Chromobacterium vaccinii MWU205
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT876545.1
via Knock-out studies, Enzymatic assays
Compounds
  • FR900359
Species Chromobacterium vaccinii MWU205 [taxonomy]
References
Chemical products information
FR900359 Evidence: NMR, Mass spectrometry, Total synthesis
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QPI18723.1
  • frsA
 1140 - 4958 (+) nonribosomal peptide synthetase
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    • QPI18724.1
    • frsB
    		 4977 - 5195 (+) MbtH-like short protein
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      • QPI18725.1
      • frsC
      		 5192 - 6178 (+) MDH/LDH-like protein
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        • QPI18726.1
        • frsD
        		 6300 - 9380 (+) nonribosomal peptide synthetase
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          • QPI18727.1
          • frsE
          		 9383 - 18433 (+) nonribosomal peptide synthetase
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            • QPI18728.1
            • frsF
            		 18423 - 25979 (+) nonribosomal peptide synthetase
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              • QPI18729.1
              • frsG
              		 25969 - 35376 (+) nonribosomal peptide synthetase
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                • QPI18730.1
                • frsH
                		 35395 - 36990 (+) non-heme diiron monooxygenase
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  1
                  Type
                  nrps-type1
                  Genes
                  frsG
                  Substrates
                  leucine (evidence: Structure-based inference, Homology)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  2
                  Type
                  nrps-type1
                  Genes
                  frsG
                  Substrates
                  O-methylthreonine (evidence: Structure-based inference [1])
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  3
                  Type
                  nrps-type1
                  Genes
                  frsF
                  Substrates
                  alanine (evidence: Structure-based inference [1])
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  4
                  Type
                  nrps-type1
                  Genes
                  frsF
                  Substrates
                  alanine (evidence: Structure-based inference [1])
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  5
                  Type
                  nrps-type1
                  Genes
                  frsE
                  Substrates
                  phenylalanine (evidence: Structure-based inference [1])
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  6
                  Type
                  nrps-type1
                  Genes
                  frsE
                  Substrates
                  serine (evidence: Structure-based inference [1])
                  Integrated Monomers
                  Domains
                  condensation (DCL), adenylation
                  Name
                  7
                  Type
                  nrps-type1
                  Genes
                  frsD
                  Substrates
                  leucine (evidence: Structure-based inference, ATP-PPi exchange assay)
                  Integrated Monomers
                  Domains
                  condensation (Starter), adenylation
                  Name
                  8
                  Type
                  nrps-type1
                  Genes
                  frsA
                  Substrates
                  leucine (evidence: Structure-based inference, Knock-out studies, ATP-PPi exchange assay)
                  Integrated Monomers
                  Domains
                  condensation (Starter), adenylation
                  Annotation changelog

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-10-07
                  Changed chemical structures for compounds: FR900359.
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-10-07
                  Added NPAtlas links to compounds: FR900359.
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Fixed subcluster gene ID
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Added organism name
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Fix thioesterase gene ID
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Add information lost in migration from 1.4 to 2.0
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Updated NRP substrate specificities
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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