BGC0002126: hypeptin biosynthetic gene cluster from Lysobacter sp. K5869
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Location: 3,884,795 - 3,951,610 nt. (total: 66,816 nt).
This entry is originally from NCBI GenBank CP072597.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0002126
Short description hypeptin biosynthetic gene cluster from Lysobacter sp. K5869
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP072597.1
3896012 - 3931610
via Enzymatic assays
Compounds
  • hypeptin
Species Lysobacter sp. K5869 [taxonomy]
References
Chemical products information
hypeptin Evidence: NMR, Mass spectrometry
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • J5226_16915
  • QWP75299.1
 3896012 - 3899098 (-) efflux RND transporter permease subunit
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    • J5226_16920
    • QWP75300.1
    		 3899100 - 3900215 (-) efflux RND transporter periplasmic adaptor subunit
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      • J5226_16925
      • QWP75301.1
      		 3900302 - 3901264 (-) Fe(II)/alpha-ketoglutarate dependent hydroxylase
      • Hydroxylation
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      • J5226_16930
      • QWP75302.1
      		 3901368 - 3903137 (-) ABC transporter ATP-binding protein
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        • J5226_16935
        • QWP75303.1
        		 3903191 - 3904786 (-) non-heme diiron monooxygenase
        • Hydroxylation
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        • J5226_16940
        • QWP75304.1
        		 3904795 - 3912138 (-) non-ribosomal peptide synthase
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          • J5226_16945
          • QWP75305.1
          		 3912135 - 3931610 (-) non-ribosomal peptide synthase
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            Biosynthesis information

            Biosynthetic modules

            Name
            1
            Type
            nrps-type1
            Genes
            J5226_16945
            Substrates
            alanine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            adenylation
            Name
            2
            Type
            nrps-type1
            Genes
            J5226_16945
            Substrates
            leucine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (LCL), adenylation
            Name
            3
            Type
            nrps-type1
            Genes
            J5226_16945
            Substrates
            arginine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (Dual), adenylation
            Name
            4
            Type
            nrps-type1
            Genes
            J5226_16945
            Substrates
            asparagine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (Dual), adenylation
            Name
            5
            Type
            nrps-type1
            Genes
            J5226_16945
            Substrates
            asparagine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (LCL), adenylation
            Name
            6
            Type
            nrps-type1
            Genes
            J5226_16945
            Substrates
            tyrosine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (Dual), adenylation
            Name
            7
            Type
            nrps-type1
            Genes
            J5226_16940
            Substrates
            leucine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (LCL), adenylation
            Name
            8
            Type
            nrps-type1
            Genes
            J5226_16940
            Substrates
            isoleucine (evidence: Structure-based inference [2])
            Integrated Monomers
            Domains
            condensation (LCL), adenylation
            Annotation changelog

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-10-07
            Changed chemical structures for compounds: hypeptin.
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-10-07
            Added NPAtlas links to compounds: hypeptin.
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Fixed thioesterase gene ID
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Removed NRPS module 0
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Add information lost in migration from 1.4 to 2.0
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated NRP substrate specificities
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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            Modifications to original record
            • J5226_00005 crossed the origin and was split into two features