BGC0002126: hypeptin biosynthetic gene cluster from Lysobacter sp. K5869
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Location: 3,896,012 - 3,931,610 nt. (total: 35,599 nt).
This entry is originally from NCBI GenBank CP072597.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0002126
Short description hypeptin biosynthetic gene cluster from Lysobacter sp. K5869
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP072597.1
3896012 - 3931610
via Enzymatic assays
Compounds
  • hypeptin
Species Lysobacter sp. K5869 [taxonomy]
References
Chemical products information
hypeptin Evidence: NMR, Mass spectrometry
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • J5226_16915
  • QWP75299.1
 3896012 - 3899098 (-) efflux RND transporter permease subunit
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    • J5226_16920
    • QWP75300.1
    		 3899100 - 3900215 (-) efflux RND transporter periplasmic adaptor subunit
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      • J5226_16925
      • QWP75301.1
      		 3900302 - 3901264 (-) Fe(II)/alpha-ketoglutarate dependent hydroxylase
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        • J5226_16930
        • QWP75302.1
        		 3901368 - 3903137 (-) ABC transporter ATP-binding protein
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          • J5226_16935
          • QWP75303.1
          		 3903191 - 3904786 (-) non-heme diiron monooxygenase
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            • J5226_16940
            • QWP75304.1
            		 3904795 - 3912138 (-) non-ribosomal peptide synthase
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              • J5226_16945
              • QWP75305.1
              		 3912135 - 3931610 (-) non-ribosomal peptide synthase
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                Biosynthesis information

                Biosynthetic modules

                Name
                1
                Type
                nrps-type1
                Genes
                J5226_16945
                Substrates
                alanine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                adenylation
                Name
                2
                Type
                nrps-type1
                Genes
                J5226_16945
                Substrates
                leucine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                3
                Type
                nrps-type1
                Genes
                J5226_16945
                Substrates
                arginine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (Dual), adenylation
                Name
                4
                Type
                nrps-type1
                Genes
                J5226_16945
                Substrates
                asparagine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (Dual), adenylation
                Name
                5
                Type
                nrps-type1
                Genes
                J5226_16945
                Substrates
                asparagine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                6
                Type
                nrps-type1
                Genes
                J5226_16945
                Substrates
                tyrosine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (Dual), adenylation
                Name
                7
                Type
                nrps-type1
                Genes
                J5226_16940
                Substrates
                leucine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                8
                Type
                nrps-type1
                Genes
                J5226_16940
                Substrates
                isoleucine (evidence: Structure-based inference [1])
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Annotation changelog

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-10-07
                Changed chemical structures for compounds: hypeptin.
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-10-07
                Added NPAtlas links to compounds: hypeptin.
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Fixed thioesterase gene ID
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed NRPS module 0
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Add information lost in migration from 1.4 to 2.0
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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                Modifications to original record
                • J5226_00005 crossed the origin and was split into two features