LOCUS       BGC0002127              3014 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0002127
VERSION     BGC0002127
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 07:10:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1277477
            Orig. end    :: 1280491
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..3014
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Polyketide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3014
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            148..1272
                     /gene="SCO1206"
                     /gene_synonym="2SCG58.06"
     CDS             148..1272
                     /codon_start=1
                     /db_xref="GOA:Q9FCA7"
                     /db_xref="InterPro:IPR001099"
                     /db_xref="InterPro:IPR011141"
                     /db_xref="InterPro:IPR012328"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="PDB:1U0M"
                     /gene="SCO1206"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:chalcone and stilbene synthase domain protein
                     (Score: 387.2; E-value: 9.4e-118)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="2SCG58.06"
                     /note="2SCG58.06, possible polyketide synthase, len: 374
                     aa; highly similar to TR:Q54240 (EMBL:AB018074)
                     Streptomyces griseus ORF-1 protein similar to chalcone
                     synthase, 372 aa; fasta scores: opt: 1769 z-score: 1998.4
                     E(): 0; 70.4% identity in 361 aa overlap and to
                     SW:CHSJ_PETHY (EMBL:X14597) Petunia hybrida chalcone
                     synthase J (EC 2.3.1.74) ChsJ, 389 aa; fasta scores: opt:
                     412 z-score: 469.3 E(): 1.1e-18; 29.5% identity in 312 aa
                     overlap. Contains Pfam match to entry PF00195
                     Chal_stil_synt, Chalcone and stilbene synthases"
                     /product="putative polyketide synthase"
                     /protein_id="CAC01488.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 6e-19, bitscore:
                     56.5, seeds: 21, tool: rule-based-clusters)"
                     /sec_met_domain="Chal_sti_synt_C (E-value: 3.8e-23,
                     bitscore: 70.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATLCRPSVSVPEHVITMEETLELARRRHTDHPQLPLALRLIENT
                     GVRTRHIVQPIEDTLEHPGFEDRNKVYEREAKSRVPAVIQRALDDAELLATDIDVIIYV
                     SCTGFMMPSLTAWLINEMGFDSTTRQIPIAQLGCAAGGAAINRAHDFCTAYPEANALIV
                     ACEFCSLCYQPTDLGVGSLLCNGLFGDGIAAAVVRGRGGTGVRLERNGSYLIPKTEDWI
                     MYDVKATGFHFLLDKRVPATMEPLAPALKELAGEHGWDASDLDFYIVHAGGPRILDDLS
                     TFLEVDPHAFRFSRATLTEYGNIASAVVLDALRRLFDEGGVEEGARGLLAGFGPGITAE
                     MSLGCWQTADVRRGIRQDVTRTAARGVSRRVRQA"
     misc_feature    265..1167
                     /gene="SCO1206"
                     /gene_synonym="2SCG58.06"
                     /note="Pfam match to entry PF00195 Chal_stil_synt, Chalcone
                     and stilbene synthases, score 117.50, E-value 1.4e-33"
     regulatory      1260..1263
                     /gene="SCO1206"
                     /gene_synonym="2SCG58.06"
                     /regulatory_class="ribosome_binding_site"
     gene            1269..2483
                     /gene="SCO1207"
                     /gene_synonym="2SCG58.07"
     CDS             1269..2483
                     /codon_start=1
                     /db_xref="GOA:Q9FCA6"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="PDB:1S1F"
                     /db_xref="PDB:1SE6"
                     /db_xref="PDB:1T93"
                     /db_xref="PDB:2D09"
                     /db_xref="PDB:2D0E"
                     /db_xref="PDB:3TNK"
                     /db_xref="PDB:3TZO"
                     /gene="SCO1207"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 379.8; E-value:
                     2.4e-115)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="2SCG58.07"
                     /note="2SCG58.07, probable cytochrome P450, len: 404 aa;
                     similar to SW:CPXF_STRGO (EMBL:M32239) Streptomyces
                     griseolus cytochrome P450-Su2 (EC 1.14.-.-) SubC, 402 aa;
                     fasta scores: opt: 791 z-score: 895.3 E(): 0; 37.1%
                     identity in 412 aa overlap and to TR:CAB88975
                     (EMBL:AL353864) Streptomyces coelicolor cytochrome P450
                     SC8F11.24c, 407 aa; fasta scores: opt: 1736 z-score: 1959.5
                     E(): 0; 61.2% identity in 407 aa overlap. Contains Pfam
                     match to entry PF00067 p450, Cytochrome P450 and match to
                     Prosite entry PS00086 Cytochrome P450 cysteine heme-iron
                     ligand signature"
                     /product="putative cytochrome P450"
                     /protein_id="CAC01489.1"
                     /sec_met_domain="p450 (E-value: 3.6e-21, bitscore: 63.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEETISQAVPPVRDWPAVDLPGSDFDPVLTELMREGPVTRISLP
                     NGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFIPARGAVGFLDPPDHTRL
                     RRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGV
                     PATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAV
                     GRDEITLSEAVGLAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSEPEIRPRAIDEL
                     LRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSP
                     NPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEA
                     LPVTW"
     misc_feature    1551..2435
                     /gene="SCO1207"
                     /gene_synonym="2SCG58.07"
                     /note="Pfam match to entry PF00067 p450, Cytochrome P450,
                     score 144.70, E-value 4e-40"
     misc_feature    2304..2333
                     /gene="SCO1207"
                     /gene_synonym="2SCG58.07"
                     /note="PS00086 Cytochrome P450 cysteine heme-iron ligand
                     signature"
     gene            2480..3013
                     /gene="SCO1208"
                     /gene_synonym="2SCG58.08"
     CDS             2480..3013
                     /codon_start=1
                     /db_xref="GOA:Q9FCA5"
                     /db_xref="InterPro:IPR006045"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q9FCA5"
                     /gene="SCO1208"
                     /gene_synonym="2SCG58.08"
                     /note="2SCG58.08, hypothetical protein, len: 177 aa;
                     similar to TR:CAB92104 (EMBL:AL356334) Streptomyces
                     coelicolor hypothetical 21.7 kD protein SCD69.03, 200 aa;
                     fasta scores: opt: 195 z-score: 238.2 E(): 8.4e-06; 31.7%
                     identity in 164 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="CAC01490.1"
                     /transl_table=11
                     /translation="MSGLVAAAEGLLVPPGQGRVVQAPAQHVTFKVTGSHSRMASTFEV
                     IVPPGFDVGAHVHSRSEELFYVLEGELDVLAFEPRIRTPDSWREWESTSGNRVVRATPG
                     TVIVVPPGCPHAFANPTGEPAKMFFQASPPPDHERYFEELLEILGEGGPPDHEAIEALR
                     AKYDIEQLTPLRHG"
ORIGIN
        1 cgcctgccgc ccagctcccc gggacggagt aacccggcgg gagatcaccg ccccggtgag
       61 tgatcgtgga tgggcacccc tgaaaaggtg caccactttc cggccggggg gcgcaagcct
      121 tccgcgaggc gaaagcaggc acggttcatg gcgactttgt gcagaccctc ggtgtccgtc
      181 ccggagcacg tgatcacgat ggaggagacg ctggagctgg cgcgtcggcg tcacacggac
      241 catcctcaac tgccgctcgc gctccggctg atagagaaca ccggggtccg cacccggcac
      301 atcgtgcagc ccatcgagga cacgctggag caccccggct tcgaggaccg caacaaggtc
      361 tacgaacggg aggcgaagtc ccgtgtcccg gccgtgatcc agcgcgctct ggacgacgcg
      421 gagctgctcg ccaccgacat cgacgtgatc atctacgtct cctgcacggg cttcatgatg
      481 ccgtcgctca cggcgtggct catcaacgag atgggtttcg acagcaccac gcgccagata
      541 cccatcgcgc agctgggctg cgcggccggc ggtgcggcga tcaaccgggc ccacgacttc
      601 tgcaccgcct acccggaggc caacgcgctc atcgtggcct gcgagttctg ctcgctgtgc
      661 taccagccca ccgacctcgg cgtgggctcc ctgctctgca acggcctctt cggcgacgga
      721 atcgccgccg cggtggtccg cggccggggc ggcaccggag tgcgcctgga gcgcaacggc
      781 tcgtacctga tccccaagac cgaggactgg atcatgtacg acgtgaaggc gaccggtttc
      841 cacttcctgc tggacaagcg ggtgccggcc accatggagc cgctcgcgcc ggcgctcaag
      901 gagctggcgg gagagcacgg ttgggacgcc tccgacctgg acttctacat cgtgcacgcg
      961 ggcggccccc ggatcctcga cgatctcagc acgttcctgg aggtcgaccc gcacgcgttc
     1021 cgcttcagcc gggccacgct caccgagtac ggcaacatcg ccagcgccgt cgtcctggac
     1081 gcgctgcgca ggctcttcga cgaaggcggc gtcgaggagg gggcacgtgg gctgctggcc
     1141 ggcttcggtc ccggcatcac cgcggagatg tcgctgggct gctggcagac ggcggacgtg
     1201 cggcggggca tacggcagga cgtgacgcgg accgcggcac ggggcgtgtc gcggagggtg
     1261 aggcaggcat gactgaagaa acgatttccc aggccgtgcc acccgtccgg gactggccgg
     1321 ccgtcgacct tcccggcagc gacttcgacc cggtgctgac cgagctgatg cgcgagggtc
     1381 ccgtcacccg gatctcgctg cccaacggcg agggctgggc ctggctcgtg acccgccacg
     1441 acgacgtccg cctggtcacc aacgaccccc ggttcgggcg cgaggccgtc atggaccgcc
     1501 aggtcacccg gctggccccg cacttcatcc cggcgcgcgg cgcggtgggc ttcctggacc
     1561 cgcccgacca cacccggctg cgccgctcgg tggccgcggc cttcaccgcg cggggcgtgg
     1621 agcgggtgcg cgagcggtcc cggggcatgc tcgacgagct ggtcgacgcc atgctgaggg
     1681 ccggtccgcc cgccgacctc accgaggcgg tgctgagccc gttccccatc gcggtgatct
     1741 gcgagctgat gggtgtgccg gccaccgacc ggcactccat gcacacctgg acccagctga
     1801 tcctgtcctc ctcgcacggc gccgaggtca gcgagcgggc caagaacgag atgaacgcct
     1861 acttctcgga tctcatcggg ctccgctccg acagcgcggg cgaggacgtc acctcgctgc
     1921 tgggtgccgc cgtggggcgg gacgagatca cgctgtcgga ggccgtcggg ctcgcggtgc
     1981 tgctccagat cggcggcgag gcggtcacca acaacagcgg gcagatgttc cacctgctgc
     2041 tgagccgccc ggagctggcc gaacgcctgc gctccgagcc ggagatccgc ccccgggcca
     2101 tcgacgagct gctgcgctgg atcccgcacc gcaacgccgt ggggctgtcc cggatcgccc
     2161 tggaggacgt ggagatcaag ggggtgcgga tccgcgcggg cgacgccgtc tacgtctcgt
     2221 acctggcggc caaccgcgac ccggaggtgt tccccgaccc ggaccgcatc gacttcgagc
     2281 gctcccccaa cccgcacgtc tccttcggct tcggcccgca ctactgtccc ggcggcatgc
     2341 tggcgcggct ggagtcggag ctgctcgtcg acgcggtcct ggaccgcgtg ccggggctga
     2401 agctcgcggt ggcgccggag gacgtgccct tcaagaaggg tgcgctgatc cgcgggcccg
     2461 aggccctgcc ggtgacgtgg tgagcggcct ggtcgcggcg gccgagggcc tgctggtgcc
     2521 gcccggtcag ggcagggtgg tgcaggcgcc ggcccagcac gtgaccttca aggtgaccgg
     2581 ttcgcactca cgcatggcgt ccaccttcga ggtgatcgtg ccgccggggt tcgacgtcgg
     2641 cgcccatgtg cactcccgca gcgaggagct gttctacgtg ctggagggcg agctggacgt
     2701 gctcgccttc gagccgcgga tccgtacgcc ggacagctgg cgggagtggg agtcgacttc
     2761 cggcaaccgg gtggtgcgcg ccacccccgg aacggtcatc gtcgtacccc ccggctgtcc
     2821 gcacgccttc gcgaacccga cgggcgagcc ggccaagatg ttcttccagg ccagcccgcc
     2881 cccggaccac gagcgctact tcgaggaact gctggagatc ctcggcgagg gcggcccgcc
     2941 ggaccacgag gcgatcgagg ccctgcgggc gaagtacgac atcgagcagc tcacgccgct
     3001 gcgacacggt tagc
//
