LOCUS       BGC0002128              8672 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0002128
VERSION     BGC0002128
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 07:10:33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 8279372
            Orig. end    :: 8288044
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..8672
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Other"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8672
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      253..257
                     /regulatory_class="ribosome_binding_site"
     gene            265..1392
                     /gene="SCO7467"
                     /gene_synonym="SCBAC14E8.07"
     CDS             265..1392
                     /codon_start=1
                     /db_xref="GOA:Q9ADJ2"
                     /db_xref="InterPro:IPR017795"
                     /db_xref="UniProtKB/TrEMBL:Q9ADJ2"
                     /gene="SCO7467"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SCBAC14E8.07"
                     /note="SCBAC14E8.07, unknown, len: 375 aa"
                     /product="hypothetical protein"
                     /protein_id="CAC36059.1"
                     /sec_met_domain="indole_PTase (E-value: 4.2e-149, bitscore:
                     485.5, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAASTGADPQDASTLGSFTGGQLRRLGSVAGLSRADVETYAQVL
                     TDALGPVAQRPLSLAPPTRTFLSDDHTPVEFSLSFRPGAAPAMRVLVEPGCGATSLADN
                     GRAGLEAVRTMARRWHFTTDALDELLDLFLPPAPQGPLALWCALELRPGGVPGVKVYLN
                     PAVGGEERSAATVREALRRLGHHQAFDSLPQGSGYPFLALDLGNWTEPRAKVYLRHDNL
                     TAGRAARLSRTDSGLVPTAVEGFFRTAAGPGSDAGGLDGRPAQSCHSFTDPGAERPSGF
                     TLYIPVRDYVRHDGEALARASTVLHHHGMDASVLHRALAALTERRPEDGVGLIAYLALA
                     GQRDQPPRVTAYLSSEAYTVRPPVVETVRQPLSVG"
     gene            complement(1495..2793)
                     /gene="SCO7468"
                     /gene_synonym="SCBAC14E8.08c"
                     /gene_synonym="SCBAC17A6.01c"
     CDS             complement(1495..2793)
                     /codon_start=1
                     /db_xref="GOA:Q8CJJ9"
                     /db_xref="InterPro:IPR000960"
                     /db_xref="InterPro:IPR020946"
                     /db_xref="UniProtKB/TrEMBL:Q8CJJ9"
                     /gene="SCO7468"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 328.2; E-value: 1.8e-99)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCBAC14E8.08c"
                     /gene_synonym="SCBAC17A6.01c"
                     /note="SCBAC17A6.01c, possible flavin-containing
                     monooxygenase, len: >327aa: similar to many eg. TR:Q9S204
                     (EMBL:AL109747) putative flavin-containing monooxygenase
                     SCJ21.03 from Streptomyces coelicolor (458 aa) fasta
                     scores; opt: 909, Z-score: 1021.7, 45.399% identity
                     (45.679% ungapped) in 326 aa overlap and SW:P31513
                     (FMO3_HUMAN) hepatic flavin-containing monooxygenase FMO3
                     (defects in which cause fish-odour syndrome) (531 aa) fasta
                     scores; opt: 661, Z-score: 743.2, 34.024% identity (35.826%
                     ungapped) in 338 aa overlap. Contains Pfam match to entry
                     PF00743 FMO-like, Flavin-binding monooxygenase-like.;
                     SCBAC14E8.08c, possible monooxigenase (fragment), len: >140
                     aa; similar to C-terminal region of SW:FMO5_RABIT
                     (EMBL:L08449) Oryctolagus cuniculus dimethylaniline
                     monooxygenase [N-oxide forming] 5 (EC 1.14.13.8) Fmo5, 532
                     aa; fasta scores: opt: 259 Z-score: 319.3 bits: 66.9 E():
                     3.3e-10; 32.353% identity in 136 aa overlap"
                     /product="putative flavin-binding monooxygenase"
                     /protein_id="CAD55403.1"
                     /sec_met_domain="FMO-like (E-value: 9e-84, bitscore: 270.9,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAMGHALKERGISFVCLEKAPDVGGIWRQPGAG
                     ERGPGYQSLHLNTARQLTGYADFPMPSDYPLYPRHDQVAAYLRSFAEWAGLLDHVELRT
                     EVLSVRQDSDGSWTVVSRDADGAQSARRFEQVVVASGHHTDPALPDPLPAGADSFAGTI
                     LHSLDYRDGGDFAGRRVVVVGLGASAVDIAADLSRHAERTLLSVRRGLHIVPKQVFGMS
                     LDEIAEAPWWNEMPFAERRRWVEQALLVARGRLSDYGLPEPDHPILSSATTLSDEILSR
                     IRHGAVTPKPAIASFESDRVVFTDGSSEAADTVVYCTGFHMTFPFLPPGCPVAADGAVE
                     LYRRIVPADRPGLYFVGLVRPAGALTRLVEAQAQWVARLVDGAAALPGTEEMREEISTY
                     LAGIVERYGRTRGASIQVDVSPYLAEFREPLPV"
     misc_feature    complement(1819..2790)
                     /gene="SCO7468"
                     /gene_synonym="SCBAC14E8.08c"
                     /gene_synonym="SCBAC17A6.01c"
                     /note="Pfam match to entry PF00743 FMO-like, Flavin-binding
                     monooxygenase-like, score -144.60, E-value 1.2e-14"
     gene            complement(2905..4251)
                     /gene="SCO7469"
                     /gene_synonym="paaK"
                     /gene_synonym="SCBAC17A6.02c"
     CDS             complement(2905..4251)
                     /EC_number="6.2.1.30"
                     /NRPS_PKS="Domain: AMP-binding (101-352). E-value: 4e-20.
                     Score: 63.5. Matches aSDomain:
                     nrpspksdomains_SCO7469_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:Q93JC7"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR011880"
                     /db_xref="InterPro:IPR028154"
                     /db_xref="UniProtKB/TrEMBL:Q93JC7"
                     /gene="SCO7469"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 70.8;
                     E-value: 1.3e-21)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="paaK"
                     /gene_synonym="SCBAC17A6.02c"
                     /note="SCBAC17A6.02c, phenylacetate-CoA ligase, len: 448
                     aa: strongly similar to many e.g. TR:Q9L9C1 (EMBL:AF176259)
                     aerobic phenylacetate-CoA ligase from Azoarcus evansii (440
                     aa) fasta scores; opt: 1896, Z-score: 2065.6, 63.825%
                     identity (64.871% ungapped) in 434 aa overlap. Contains 2
                     Pfam matches to entry PF00501 AMP-binding, AMP-binding
                     enzyme."
                     /product="phenylacetate-CoA ligase"
                     /protein_id="CAC44647.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-27, bitscore:
                     85.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTGTAPAPRRGEPLPHDLLDDAERLSREQLRELQLDRLRA
                     TLRHAYDNVELYRKKFDAAGVTPDDCRSLADLSRFPFTTKADLRDTYPFGMFAVPMADV
                     RRVHASSGTTGRATVVGYTENDLSMWADVVARSIRAAGGRPGHKVHISYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFERQGVDPRTS
                     SLQVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECVETKDGLHIWEDH
                     FYPEVVDPLTDAVLPGGEEGEIVFTSLTKEALPVIRYRTRDLTRLLPGTARPAFRRMRK
                     VTGRCDDMIILRGVNVFPTQVEEIVLRTPGVAPHFQMRLTERGRMDHMTVRVEARPDAA
                     PEQRDAAARAIAQGVKDGVGVTVEVEVVEPETLERSLGKIRRVWDQRGA"
     misc_feature    complement(3136..3231)
                     /gene="SCO7469"
                     /gene_synonym="paaK"
                     /gene_synonym="SCBAC17A6.02c"
                     /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
                     enzyme, score 21.30, E-value 5e-05"
     CDS_motif       complement(3166..3228)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO7469_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="SCO7469"
                     /protein_end="362"
                     /protein_start="341"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQVE"
     aSDomain        complement(3196..3948)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO7469_AMP-binding.1"
                     /evalue="4.00E-20"
                     /label="SCO7469_AMP-binding.1"
                     /locus_tag="SCO7469"
                     /protein_end="352"
                     /protein_start="101"
                     /score="63.5"
                     /tool="antismash"
                     /translation="ADVRRVHASSGTTGRATVVGYTENDLSMWADVVARSIRAAGGRPG
                     HKVHISYGYGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYM
                     LTLLDEFERQGVDPRTSSLQVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGV
                     AQECVETKDGLHIWEDHFYPEVVDPLTDAVLPGGEEGEIVFTSLTKEALPVIRYRTRDL
                     TRLLPGTARPAFRRMRKVTGRCDDMIILR"
     misc_feature    complement(3340..3780)
                     /gene="SCO7469"
                     /gene_synonym="paaK"
                     /gene_synonym="SCBAC17A6.02c"
                     /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
                     enzyme, score 42.90, E-value 4.2e-11"
     gene            complement(4248..4760)
                     /gene="SCO7470"
                     /gene_synonym="paaI"
                     /gene_synonym="SCBAC17A6.03c"
     CDS             complement(4248..4760)
                     /codon_start=1
                     /db_xref="GOA:Q93JC6"
                     /db_xref="InterPro:IPR003736"
                     /db_xref="InterPro:IPR006683"
                     /db_xref="InterPro:IPR011973"
                     /db_xref="InterPro:IPR029069"
                     /db_xref="UniProtKB/TrEMBL:Q93JC6"
                     /gene="SCO7470"
                     /gene_synonym="paaI"
                     /gene_synonym="SCBAC17A6.03c"
                     /note="SCBAC17A6.03c, possible phenylacetic acid
                     degradation protein PaaI, len: 170 aa: similar to many e.g.
                     SW:P76084 (PAAI_ECOLI) phenylacetic acid degradation
                     protein PaaI from Escherichia coli (140 aa) fasta scores;
                     opt: 342, Z-score: 414.6, 45.902% identity (46.281%
                     ungapped) in 122 aa overlap. Contains Pfam match to entry
                     PF02584 DUF157, Uncharacterized protein PaaI."
                     /product="putative phenylacetic acid degradation protein
                     PaaI"
                     /protein_id="CAC44648.1"
                     /transl_table=11
                     /translation="MVDTVSQATEQTPTEAMFSADEASRGLGIELVEHGEGTALVRMTV
                     TPAMVNGHRIAHGGFLFLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAE
                     ERVRYGRSGIYDVSVRRGDEVVAEFRGRSRSVRDDGRDRSARDDAGSRDARQDTARETP
                     GTTKESR"
     misc_feature    complement(4347..4712)
                     /gene="SCO7470"
                     /gene_synonym="paaI"
                     /gene_synonym="SCBAC17A6.03c"
                     /note="Pfam match to entry PF02584 DUF157, Uncharacterized
                     protein PaaI, COG2050, score 102.20, E-value 1e-26"
     gene            4925..5911
                     /gene="SCO7471"
                     /gene_synonym="paaA"
                     /gene_synonym="SCBAC17A6.04"
     CDS             4925..5911
                     /codon_start=1
                     /db_xref="InterPro:IPR007814"
                     /db_xref="InterPro:IPR009078"
                     /db_xref="InterPro:IPR011881"
                     /db_xref="InterPro:IPR012347"
                     /db_xref="UniProtKB/TrEMBL:Q93JC5"
                     /gene="SCO7471"
                     /gene_synonym="paaA"
                     /gene_synonym="SCBAC17A6.04"
                     /note="SCBAC17A6.04, possible phenylacetic acid degradation
                     protein PaaA, len: 328 aa: similar to many e.g. SW:P76077
                     (PAAA_ECOLI) phenylacetic acid degradation protein PaaA
                     from Escherichia coli (309 aa) fasta scores; opt: 1540,
                     Z-score: 1801.2, 69.967% identity (69.967% ungapped) in 303
                     aa overlap."
                     /product="putative phenylacetic acid degradation protein
                     PaaA"
                     /protein_id="CAC44649.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPDAPDGLQEHFDATIARDQRIEPRDWMPDGYRKT
                     LVRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTERLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTDAQREMVQDAVNRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEESGHHDFGTPDWDELMR
                     VIKGDGPCNDRRMERRRTAHEEGAWVREAATAHAAKQAARAEKGAVA"
     gene            5908..6219
                     /gene="SCO7472"
                     /gene_synonym="paaB"
                     /gene_synonym="SCBAC17A6.05"
     CDS             5908..6219
                     /codon_start=1
                     /db_xref="InterPro:IPR009359"
                     /db_xref="UniProtKB/TrEMBL:Q93JC4"
                     /gene="SCO7472"
                     /gene_synonym="paaB"
                     /gene_synonym="SCBAC17A6.05"
                     /note="SCBAC17A6.05, possible phenylacetic acid degradation
                     protein PaaB, len: 103 aa: similar to many e.g. SW:P76078
                     (PAAB_ECOLI) phenylacetic acid degradation protein PaaB
                     from Escherichia coli (95 aa) fasta scores; opt: 427,
                     Z-score: 565.4, 66.667% identity (66.667% ungapped) in 90
                     aa overlap."
                     /product="putative phenylacetic acid degradation protein
                     PaaB"
                     /protein_id="CAC44650.1"
                     /transl_table=11
                     /translation="MTPETARKPDGRGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALT
                     HARDLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            6229..7056
                     /gene="SCO7473"
                     /gene_synonym="paaC"
                     /gene_synonym="SCBAC17A6.06"
     CDS             6229..7056
                     /codon_start=1
                     /db_xref="InterPro:IPR007814"
                     /db_xref="InterPro:IPR009078"
                     /db_xref="InterPro:IPR011882"
                     /db_xref="InterPro:IPR012347"
                     /db_xref="UniProtKB/TrEMBL:Q93JC3"
                     /gene="SCO7473"
                     /gene_synonym="paaC"
                     /gene_synonym="SCBAC17A6.06"
                     /note="SCBAC17A6.06, possible phenylacetic acid degradation
                     protein PaaC, len: 275 aa: similar to many e.g. SW:P76079
                     (PAAC_ECOLI) phenylacetic acid degradation protein PaaC
                     from Escherichia coli (248 aa) fasta scores; opt: 470,
                     Z-score: 547.8, 41.057% identity (44.105% ungapped) in 246
                     aa overlap."
                     /product="putative phenylacetic acid degradation protein
                     PaaC"
                     /protein_id="CAC44651.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVDTTVPEGVDATA
                     LAAECVALADDALVSAQRLAEWVTRAPELEEEVALANIGLDLLGQARLLYSRAGQADGT
                     GRGEDAYAYFRDAGDFRNVRLTELPGGDFAFAVVRLLVLSSWRLAHFRRLETHPDPVLA
                     AVAAKGVKELTYHRQYAAEWCVRLGDGTDESHRRMRAALDEVAPYLGELHTAYDVRDEV
                     ADDLRQVTEAAGLPLPVYRPLPGSGRAGEHTEHLAPLLTELQGIARAHPEATW"
     gene            7053..7565
                     /gene="SCO7474"
                     /gene_synonym="paaD"
                     /gene_synonym="SCBAC17A6.07"
     CDS             7053..7565
                     /codon_start=1
                     /db_xref="InterPro:IPR002744"
                     /db_xref="InterPro:IPR011883"
                     /db_xref="UniProtKB/TrEMBL:Q93JC2"
                     /gene="SCO7474"
                     /gene_synonym="paaD"
                     /gene_synonym="SCBAC17A6.07"
                     /note="SCBAC17A6.07, possible phenylacetic acid degradation
                     protein PaaD, len: 170 aa: similar to many e.g. SW:P76080
                     (PAAD_ECOLI) phenylacetic acid degradation protein PaaD
                     from Escherichia coli (167 aa) fasta scores; opt: 474,
                     Z-score: 518.6, 45.395% identity (47.586% ungapped) in 152
                     aa overlap. Contains Pfam match to entry PF01883 DUF59,
                     Domain of unknown function DUF59."
                     /product="putative phenylacetic acid degradation protein
                     PaaD"
                     /protein_id="CAC44652.1"
                     /transl_table=11
                     /translation="MTRDPALADARRARHVAEQVPDPELPMLTLADLGVLRDVEVDGDG
                     TVVASLTPTYSGCPAMAEMRADVAARLRAAGYPRVEIRTVLDPPWTSDWITESGRGKLA
                     EHGIAPPGAAPRGPVSLVLSPTRPAVPCPRCGSADTEETSRFAATSCKALWRCRACREP
                     FEYVKEI"
     misc_feature    7077..7304
                     /gene="SCO7474"
                     /gene_synonym="paaD"
                     /gene_synonym="SCBAC17A6.07"
                     /note="Pfam match to entry PF01883 DUF59, Domain of unknown
                     function DUF59, score 58.60, E-value 1.3e-13"
     gene            7565..8671
                     /gene="SCO7475"
                     /gene_synonym="SCBAC17A6.08"
     CDS             7565..8671
                     /codon_start=1
                     /db_xref="GOA:Q93JC1"
                     /db_xref="InterPro:IPR001041"
                     /db_xref="InterPro:IPR001221"
                     /db_xref="InterPro:IPR001433"
                     /db_xref="InterPro:IPR001709"
                     /db_xref="InterPro:IPR006058"
                     /db_xref="InterPro:IPR008333"
                     /db_xref="InterPro:IPR011884"
                     /db_xref="InterPro:IPR012675"
                     /db_xref="InterPro:IPR017927"
                     /db_xref="InterPro:IPR017938"
                     /db_xref="UniProtKB/TrEMBL:Q93JC1"
                     /gene="SCO7475"
                     /gene_functions="other (smcogs) SMCOG1094:ferredoxin
                     (Score: 221; E-value: 3.1e-67)"
                     /gene_kind="other"
                     /gene_synonym="SCBAC17A6.08"
                     /note="SCBAC17A6.08, possible phenylacetic acid degradation
                     NADH oxidoreductase PaaE, len: 368 aa; similar to many e.g.
                     SW:P76081 (PAAE_ECOLI) probable phenylacetic acid
                     degradation NADH oxidoreductase PaaE from Escherichia coli
                     (356 aa) fasta scores; opt: 871, Z-score: 943.6, 39.943%
                     identity (40.870% ungapped) in 353 aa overlap. Contains
                     Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur
                     cluster binding domains; Pfam match to entry PF00175
                     NAD_binding, Oxidoreductase FAD/NAD-binding domain; Pfam
                     match to entry PF00970 FAD_binding_6, Oxidoreductase
                     FAD-binding domain and Prosite match to PS00197 2Fe-2S
                     ferredoxins, iron-sulfur binding region signature."
                     /product="putative phenylacetic acid degradation NADH
                     oxidoreductase PaaE"
                     /protein_id="CAC44653.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPVRTRRRPAFHRLRVAAVERLCADAAAVSFEIPDE
                     LAGEFVFAPGQSLTLRREVDGRDERRSYSICAPAGSAPRIGVRVVPGGLFSAWLVDEVR
                     PGDTVEVMAPTGLFTPDLSTPGHHVLVAAGSGITPMVSIAESVLAADDRSTVTLFYGNR
                     RTDTVMFADELADLKDLHPTRFHLAHVLSREPREAEVLSGRLDAGRLAALVGSLVDVER
                     ADHWWLCGPQGMVADAQQVLTGLGVPAGRVHRELFYADDEPVREVRHEESGPEGPVSEV
                     TITLDGRSTTSSLSRERSVLDGAQQTRPDLPFACKGGVCGTCRALVTDGSVDMRRNYAL
                     ETAEVDAGYVLTCQSYPVSEKLTVDYDS"
     misc_feature    7628..7921
                     /gene="SCO7475"
                     /gene_synonym="SCBAC17A6.08"
                     /note="Pfam match to entry PF00970 FAD_binding_6,
                     Oxidoreductase FAD-binding domain, score 74.00, E-value
                     3.1e-18"
     misc_feature    7937..8287
                     /gene="SCO7475"
                     /gene_synonym="SCBAC17A6.08"
                     /note="Pfam match to entry PF00175 NAD_binding,
                     Oxidoreductase FAD/NAD-binding domain, score 64.90, E-value
                     1.7e-15"
     misc_feature    8405..8641
                     /gene="SCO7475"
                     /gene_synonym="SCBAC17A6.08"
                     /note="Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur
                     cluster binding domains, score 48.10, E-value 2e-10"
     misc_feature    8507..8533
                     /gene="SCO7475"
                     /gene_synonym="SCBAC17A6.08"
                     /note="PS00197 2Fe-2S ferredoxins, iron-sulfur binding
                     region signature"
ORIGIN
        1 gagtgggaag cagacgtgaa cgcccacgac accgccccgg tgctccggcc gcggtgatcc
       61 gcgcaacacc tccccaaccc gccccaatcg catgaagatc gaacggcacg ggtagtgagc
      121 aacgcggtac tcaagttgct tacgagtcaa aggaggtgtc gtggaccaca tatccacgaa
      181 cgccgctctc ccggcgccga aacccccggt acccgccccc cgaggcgggt atcgctttgt
      241 gcggctccgg ccggaggcgg accgttgagg gccgcgtcga cgggcgcgga cccgcaggac
      301 gcatccacgc tcggctcttt caccggcggc cagttgcgaa gactcggctc ggtcgccggt
      361 ctgtcccgcg ccgacgtcga gacctacgca caggtcctga ccgacgcatt gggcccggtg
      421 gcccagcggc cgctgagcct ggcgccgccc acccgcacct tcctgtcgga cgaccacacc
      481 cccgtggagt tctccctctc cttccggccc ggggcggcgc ccgccatgcg ggtcctcgtg
      541 gaaccgggct gcggtgcgac cagcctggcc gacaacggcc gtgccggtct tgaggcggtc
      601 cgcacgatgg cgcggcgctg gcacttcacc accgacgccc tcgacgaact cctggacctg
      661 ttcctgccgc ccgctccgca gggccccctc gccctgtggt gcgccctgga actcaggccc
      721 gggggtgtac cgggcgtcaa ggtctatctg aaccctgcgg tgggcgggga ggaacgttcc
      781 gccgcgacgg tgcgcgaggc cctgcgccgg ctcgggcacc accaggcctt cgacagcctc
      841 ccccagggca gtggataccc gttcctcgcc ctggacctcg ggaactggac ggagccccgg
      901 gcgaaggtct acctgcgcca cgacaacctc acggccggtc gggccgcacg gctgtcccgg
      961 acggactcgg gcctcgtgcc gaccgcggtc gagggtttct tccgcaccgc cgcgggtccc
     1021 ggctccgacg cgggtgggct cgacgggcgg cctgctcagt cctgccactc cttcaccgac
     1081 cccggcgcgg agcggccgag cggcttcacc ctgtacatcc cggttcgtga ctacgtccgg
     1141 catgacgggg aggccctggc gcgggcgtcc accgtgctgc accaccacgg catggacgcc
     1201 tccgtgctcc accgcgccct ggccgccctc accgagcggc ggcccgagga cggggtgggc
     1261 ctgatcgcct acctggccct cgccggccaa cgggaccagc cgccgcgggt gacggcctac
     1321 ctctcctcgg aggcctacac ggtccggccg ccggtcgtgg agaccgtccg ccaaccgctg
     1381 tcggtcggct gaacggaacg tccgcccgcg aaacagggcc cccggcgcga tccgccggga
     1441 gccctgggcg cggtcacggc cgggcgtgac cgccgaccgc gtcctgcggg acggtcacac
     1501 gggcagtggc tcccggaact ccgccaggta gggactcacg tcgacctgga tcgaggcgcc
     1561 gcgagtgcgg ccgtaacgtt cgacgatgcc ggccaggtac gtactgatct cctcgcgcat
     1621 ctcctcggtg cccggcagcg cggcggcgcc gtcgacgagg cgcgccaccc actgggcctg
     1681 ggcctccacc agccgggtga gggcacccgc gggccgcacc agtcccacga agtacagacc
     1741 gggccggtcg gccgggacga tccgccggta gagctcgacc gcgccgtcgg ccgcgaccgg
     1801 gcagcccggg ggcaggaagg ggaaggtcat gtggaatccg gtgcagtaga cgaccgtgtc
     1861 ggcggcctcg gagctgccgt ccgtgaacac gacccggtcg ctctcgaacg aggcgatcgc
     1921 gggcttcggg gtcaccgcac cgtgccggat ccggctgagg atctcgtccg agagggtcgt
     1981 cgcggaggag aggatcgggt ggtcgggctc gggcaggccg tagtccgaca gcctgccccg
     2041 ggccaccagc agggcctgct ccacccacct gcgccgctcg gcgaagggca tctcgttcca
     2101 ccacggggct tcggcgatct cgtcgaggga catcccgaag acctgcttgg gcacgatgtg
     2161 cagcccccgg cgcaccgaca gcagggtccg ctccgcgtgc cgggagaggt ccgccgcgat
     2221 gtccaccgcg gaggccccga ggcccaccac gacgacgcgc cggccggcga agtcgccgcc
     2281 gtcgcggtag tcgagggagt gaagaatcgt tccggcaaag gagtcggcgc cggccggaag
     2341 gggatcgggc agggccgggt cggtgtggtg ccccgaggcg acgaccacct gctcgaaccg
     2401 gcgtgcggac tgcgcgccgt ccgcgtcccg gctgacgacc gtccagctgc cgtccgagtc
     2461 ctggcgcacg gacagcacct cggtccgcag ctccacgtgg tcgaggagcc ccgcccactc
     2521 ggcgaaggac cgcagatagg cggcgacctg gtcgtgccgg ggatagaggg ggtagtcgga
     2581 cggcatcggg aagtccgcgt aaccggtcag ctgcctggcg gtgttcaggt gcagggactg
     2641 atagcccgga ccccgctcac cggcccccgg ctgacgccag atcccgccga cgtcgggcgc
     2701 cttctccagg cagacgaagg agatgccgcg ctccttcagg gcatggccca tcgccagccc
     2761 cgacaggcct gcaccgatca cacacacacg cacgggatgt ccccccagga tgtactcaac
     2821 ctcccccgat catgtcttta ctgcccatcc gtttcttctc gcacaccggc acgaccggtg
     2881 aacggacgtg tccgtgctca cgtttcacgc gccccgctgg tcccacaccc ggcggatctt
     2941 gccgagcgag cgctccaggg tttccggctc cacgacctcc acctccacgg tcacgcccac
     3001 accgtccttg acgccctggg cgatcgccct cgcggcggca tcgcgctgct cgggagcggc
     3061 gtcgggccgg gcctccaccc gcaccgtcat gtggtccatg cggccgcgtt cggtgagccg
     3121 catctggaag tgcggggcga cgcccggcgt gcgcagcacg atctcctcga cctgggtggg
     3181 gaagacgttc accccgcgca ggatgatcat gtcgtcgcag cggccggtga ccttccgcat
     3241 ccggcggaag gcggggcgcg cggtgcccgg cagcaggcgg gtcaggtcgc gcgtgcggta
     3301 gcggatcacc gggagcgcct ccttggtgag ggaggtgaag acgatctcgc cctcctcgcc
     3361 cccgggcagc acggcgtccg tgagcgggtc cacgacctcg gggtagaagt ggtcctccca
     3421 gatgtgcagc ccgtccttgg tctcgacgca ctcctgtgcc acgccggggc cgatcacctc
     3481 ggacaggccg tagatgtcga cggcgtggat gtccatgcgc tcctcgatct cgcgccgcat
     3541 ctcctcggtc cacggctcgg cgccgaagat gccgacctgg agggagctgg tgcgcggatc
     3601 gacgccctgg cgctcgaact cgtcgagcag ggtgagcatg taggacgggg tgaccatgat
     3661 gatctcgggc cggaagtcct ggatgatctg cacctggcgc gccgtcatgc cgccggaggc
     3721 cgggatcacc gtgcacccgg cgcgctcggc cccgtagtgg gcaccgagac cgccggtgaa
     3781 caggccgtag ccgtaggaga tgtggacctt gtggccgggg cggccgcccg cggcgcggat
     3841 cgaacgggct accacgtccg cccacatgga caggtcgttc tcggtgtacc cgacgacggt
     3901 ggcgcggccg gtggtgccgc tggaggcgtg cacgcgccgc acgtcggcca tcgggacggc
     3961 gaacatgccg aaggggtagg tgtcccgcag gtccgccttg gtggtgaagg ggaacctgga
     4021 caggtcggcc aggctgcggc agtcgtcggg ggtcaccccg gcggcgtcga acttcttgcg
     4081 gtacagctcc acgttgtcgt aggcgtgccg cagggtcgcg cgcaggcggt cgagctggag
     4141 ctcccggagc tgctcgcggg acaggcgctc ggcgtcgtcc agcaggtcgt gggggagggg
     4201 ctcgccccgt cggggtgccg gggccgtccc ggtcgtcggc tcgctgctca tcgcgactcc
     4261 ttcgtcgtgc ccggcgtctc gcgcgccgtg tcctgccgcg cgtcgcggct gcctgcgtcg
     4321 tcccgcgcac tccggtcgcg cccgtcgtcc cgcacgctgc ggctgcgccc ccggaactcc
     4381 gcgaccacct cgtcgccgcg ccgcacgctc acgtcgtaga tcccgctgcg tccgtaccgg
     4441 acccgctcct cggcgcgggc cacgagcacg tcgccctcgc gggccggggc gacgaagacg
     4501 atgtcggcgc cggccgccac ggtcaccggc ccgtggctgt tgcaggcgca ggcgaaggcg
     4561 gtgtcggcca gcaggaaaag gaaccctccg tgggcgatcc ggtgtccgtt caccatcgcc
     4621 ggggtcacgg tcatacggac cagcgcggtc ccctcaccgt gctccaccag ctcgatcccg
     4681 agcccccggg aggcctcgtc cgcggagaac atcgcctccg tcggcgtctg ctcagtggcc
     4741 tgcgacaccg tatccaccac cttgtctccc gaccgaccat tcggttagca cgcggcaagg
     4801 tcaagtaatc cagccacgcg acgggactgt caagagtgtg gccggcgagg tccggctctt
     4861 gcccggcgca cggaaacacg tcacactgat accgaacgaa tggtcggttg ggaagctggt
     4921 gacgatgacc acgacacacg ccgccgaggc gccgcccccg gacgcgccgg acgggctcca
     4981 ggagcacttc gacgcgacga tcgcgcgcga ccagcgcatc gagccgcggg actggatgcc
     5041 cgacgggtac cgcaagacgc tggtacggca gatcgcccag cacgcgcact cggagatcat
     5101 cggcatgcag cccgagggcg agtggatcac ccgggccccg tcgctgcgcc gcaaggcgat
     5161 cctgttcgcc aaggtccagg acgaggccgg gcacgggctg tacctgtact cggcggccga
     5221 gacgctcggc gcggaccgcg acgacctcac cgagcggctg atcgaggggc gccagaagta
     5281 ctcgtcgatc ttcaactacc cgaccctgag cttcgccgac gtcggcgtga tcggctggtt
     5341 cgtggacggc gccgcgatct gcaaccaggt gccgctgtgc cgcagctcct acgggcccta
     5401 cgcgcgcgcg atggtgcgca tctgcaagga ggagtccttc caccagcggc agggctacga
     5461 gctgctgatg acgatgatgc gcggcaccga cgcccagcgc gagatggtcc aggacgcggt
     5521 gaaccgctgg tggtggccgt ccctgatgat gttcggcccg cccgacgacg cctcgcccaa
     5581 ctcggcgcgc tccatggcct ggaagatcaa gcggcacagc aacgacgaac tgcgccgccg
     5641 cttcgtcgac atgaccgtcc cgcaggccga gaagctcggc gtcaccctgc ccgacccgga
     5701 gctgcgctgg aacgaggaga gcggtcacca cgacttcggc acccccgact gggacgagct
     5761 gatgcgcgtc atcaagggcg acggcccctg caacgaccgg cggatggagc ggcggcgcac
     5821 cgcccacgag gagggcgcct gggtgcgtga ggcggccacc gcccacgccg ccaaacaggc
     5881 cgcccgcgcg gagaagggag cggtggcatg acccccgaga cggcccggaa gcccgacggg
     5941 cggggctggc cgctgtacga ggtgttcgtg cgcggcaagc gcggcctcaa ccacgtccac
     6001 gtcggctcgc tgcacgccgc cgacgacgcc atggcgctca cccacgcccg cgacctctac
     6061 acccggcgca acgagggcgt gagcatctgg gtggtgcgct ccgagcacat cgccgcctcc
     6121 acccgggacg agaaggaccc cttcttcgcc cccagcgccg acaaggtcta ccgccacccg
     6181 accttctacg acatccccga cgacgtcccg cacatctagg agcagggtat gagcgacgac
     6241 cacgtctacc tcaccctggc cgaggggcac gaggacgaca cccgctgggc ctacggcacc
     6301 ggcttcgagg acccgctgca cggcgtcgac accaccgtgc ccgagggcgt cgacgccaca
     6361 gcgctggccg ccgagtgcgt cgcgctcgcc gacgacgccc tggtgagcgc ccagcggctg
     6421 gccgagtggg tcacccgggc gccggagctt gaggaggagg tggcgctggc caacatcggg
     6481 ctcgacctgc tcggccaggc ccgcctgctg tactcgcgcg ccggtcaggc cgacggcacc
     6541 ggccgcggcg aggacgcgta cgcctacttc cgcgatgccg gcgacttccg caacgtccgc
     6601 ctgaccgaac tcccgggcgg cgacttcgcg ttcgccgtcg tgcggctgct ggtgctctcc
     6661 agctggcggc tggcccactt ccggcggctg gagacacacc ccgacccggt gctcgcggcg
     6721 gtcgccgcca agggcgtcaa ggagctgacc taccaccggc agtacgccgc cgagtggtgc
     6781 gtgcgcctgg gcgacggcac cgacgagtcg caccgccgga tgcgcgccgc actggacgag
     6841 gtcgccccgt acctgggtga gctgcacacg gcgtacgacg tccgggacga ggtcgccgac
     6901 gacctgcgcc aggtcacgga ggccgccggg ctgcccctgc ccgtgtaccg gccgctgccc
     6961 ggctcgggcc gggccggcga gcacaccgaa cacctggcgc cgctcctgac cgagctgcag
     7021 ggcatcgccc gcgcccaccc ggaggcgaca tggtgacccg ggacccggcg ctcgcggacg
     7081 cgcgccgcgc ccggcacgtc gccgagcagg tgcccgaccc cgagctgccc atgctgaccc
     7141 tcgccgacct cggcgtgctg cgcgacgtcg aggtggacgg ggacggcacc gtggtcgcca
     7201 gcctgacccc cacctactcg ggctgcccgg ccatggccga gatgcgggcg gacgtcgccg
     7261 cgcggctgcg cgcggcgggc tacccgcgtg tggagatccg caccgtcctg gacccgccct
     7321 ggaccagcga ctggatcacc gagtccggcc gcggcaagct cgccgagcac ggaatcgccc
     7381 cgcccggcgc cgcaccccgc ggcccggtct ccctggtgct gtcgcccacc cggcccgcgg
     7441 tgccctgccc ccgctgcggc tcggcggaca ccgaggagac ctcccgcttc gccgccacgt
     7501 cctgcaaggc gctgtggcgc tgccgggcct gccgcgagcc gttcgagtac gtcaaggaga
     7561 tctgatggcc ccgaccgccc ccgtcccggc ggccccggtg cgcacccgcc gccggcccgc
     7621 cttccaccgt ctgcgcgtcg cggccgtcga gcggctgtgc gcggacgcgg cggccgtgag
     7681 cttcgagatc cccgacgagc tggccgggga gttcgtcttc gcgcccggtc agtcgctcac
     7741 cctgcggcgc gaggtggacg gccgggacga gcgccgctcc tactcgatct gcgcaccggc
     7801 cggttcggcg ccgcgcatcg gggtccgcgt ggtgccgggc ggactgttct cggcgtggct
     7861 ggtcgacgag gtgcggccgg gcgacaccgt cgaggtgatg gcgcccaccg gcctgttcac
     7921 acccgacctt tccacccccg gccaccacgt cctggtcgcg gccggttcgg gcatcacgcc
     7981 gatggtgtcc atcgccgagt cggtgctcgc cgccgacgac cgctccaccg tcaccctctt
     8041 ctacggcaac cgccgcacgg acaccgtgat gttcgccgac gagctggccg acctgaagga
     8101 cctccacccg acccgcttcc acctcgccca cgtgctctcc cgtgaacccc gggaggccga
     8161 ggtgctctcc ggccgcctgg acgcaggacg gctcgcggcg ctcgtcggct ccctggtgga
     8221 cgtggagcgg gcagatcact ggtggctgtg cggaccgcag ggcatggtcg ccgacgccca
     8281 gcaggtcctg accggcctcg gcgtcccggc cgggcgcgtc caccgggagc tgttctacgc
     8341 cgacgacgag cccgtgcggg aggtgcgcca cgaggagagc ggccccgagg gccccgtcag
     8401 tgaggtcacg atcaccctgg acggccgctc gacgacctcc tcgctctccc gcgagcggtc
     8461 ggtgctcgac ggggcccagc agacccgccc cgacctgccc ttcgcctgca agggcggggt
     8521 ctgcgggacc tgccgggcgc tcgtcaccga cggcagtgtc gacatgcgcc gcaactacgc
     8581 gctcgaaacc gccgaggtcg acgcgggcta cgtgctgacc tgccagtcgt acccggtctc
     8641 cgagaagctg accgtggact acgacagctg ac
//
