BGC0002129: metathramycin biosynthetic gene cluster from uncultured bacterium
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 42,302 nt. (total: 42,302 nt).
This entry is originally from NCBI GenBank MW512268.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002129
Short description metathramycin biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MW512268.1
via Heterologous expression, Gene expression correlated with compound production
Compounds
  • metathramycin
  • premetathramycin
Species uncultured bacterium [taxonomy]
References
Chemical products information
metathramycin Evidence: Mass spectrometry, MS/MS
Copy SMILES
C47H68O21
Chemical database entries
NPAtlas
premetathramycin Evidence: NMR, Mass spectrometry, MS/MS
Copy SMILES
C48H64O21
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QVQ68779.1
 1 - 984 (-) mmyE
    copy AA seq
    copy Nt seq
    • QVQ68780.1
    		 981 - 2054 (-) mmyD
      copy AA seq
      copy Nt seq
      • QVQ68781.1
      		 2121 - 3158 (-) mmyMI
        copy AA seq
        copy Nt seq
        • QVQ68782.1
        		 3211 - 4191 (-) mmyMII
          copy AA seq
          copy Nt seq
          • QVQ68783.1
          		 4407 - 5168 (+) mmyTII
            copy AA seq
            copy Nt seq
            • QVQ68784.1
            		 5284 - 7044 (+) mmyOII
              copy AA seq
              copy Nt seq
              • QVQ68785.1
              		 7094 - 8059 (+) mmyQ
                copy AA seq
                copy Nt seq
                • QVQ68786.1
                		 8052 - 9590 (+) mmyL
                  copy AA seq
                  copy Nt seq
                  • QVQ68787.1
                  		 9603 - 9884 (+) mmyO3
                    copy AA seq
                    copy Nt seq
                    • QVQ68788.1
                    		 9975 - 10670 (+) mmyHy
                      copy AA seq
                      copy Nt seq
                      • QVQ68789.1
                      		 10767 - 12392 (-) hypothetical protein
                        copy AA seq
                        copy Nt seq
                        • QVQ68790.1
                        		 12613 - 13242 (+) hypothetical protein
                          copy AA seq
                          copy Nt seq
                          • QVQ68791.1
                          		 13397 - 13513 (+) hypothetical protein
                            copy AA seq
                            copy Nt seq
                            • QVQ68792.1
                            		 13504 - 14190 (+) hypothetical protein
                              copy AA seq
                              copy Nt seq
                              • QVQ68793.1
                              		 14267 - 14710 (-) mmyX
                                copy AA seq
                                copy Nt seq
                                • QVQ68794.1
                                		 14756 - 15529 (-) mmyY
                                  copy AA seq
                                  copy Nt seq
                                  • QVQ68795.1
                                  		 15559 - 16788 (-) mmyOI
                                    copy AA seq
                                    copy Nt seq
                                    • QVQ68796.1
                                    		 16791 - 17540 (-) mmyTI
                                      copy AA seq
                                      copy Nt seq
                                      • QVQ68797.1
                                      		 17537 - 17788 (-) mmyS
                                        copy AA seq
                                        copy Nt seq
                                        • QVQ68798.1
                                        		 17851 - 19077 (-) mmyK
                                          copy AA seq
                                          copy Nt seq
                                          • QVQ68799.1
                                          		 19074 - 20336 (-) mmyP
                                            copy AA seq
                                            copy Nt seq
                                            • QVQ68800.1
                                            		 20377 - 20622 (-) hypothetical protein
                                              copy AA seq
                                              copy Nt seq
                                              • QVQ68801.1
                                              		 20747 - 21583 (+) mmyRI
                                                copy AA seq
                                                copy Nt seq
                                                • QVQ68802.1
                                                		 21674 - 22426 (-) mmyTIII
                                                  copy AA seq
                                                  copy Nt seq
                                                  • QVQ68803.1
                                                  		 22423 - 23685 (-) mmyC
                                                    copy AA seq
                                                    copy Nt seq
                                                    • QVQ68804.1
                                                    		 23682 - 24710 (-) mmyU
                                                      copy AA seq
                                                      copy Nt seq
                                                      • QVQ68805.1
                                                      		 24719 - 26251 (-) mmyV
                                                        copy AA seq
                                                        copy Nt seq
                                                        • QVQ68806.1
                                                        		 26351 - 27292 (+) mmyW
                                                          copy AA seq
                                                          copy Nt seq
                                                          • QVQ68807.1
                                                          		 27330 - 28595 (+) mmyGIV
                                                            copy AA seq
                                                            copy Nt seq
                                                            • QVQ68808.1
                                                            		 28616 - 29806 (+) mmyGIII
                                                              copy AA seq
                                                              copy Nt seq
                                                              • QVQ68809.1
                                                              		 29826 - 30968 (-) mmyGII
                                                                copy AA seq
                                                                copy Nt seq
                                                                • QVQ68810.1
                                                                		 31195 - 32358 (+) mmyGI
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • QVQ68811.1
                                                                  		 32607 - 33884 (+) mmyOIV
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • QVQ68812.1
                                                                    		 33951 - 36416 (+) mmrX
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • QVQ68813.1
                                                                      		 36422 - 37075 (+) mmyRII
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • QVQ68814.1
                                                                        		 37146 - 38108 (+) mmrAI
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • QVQ68815.1
                                                                          		 38120 - 38872 (+) mmrBI
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • QVQ68816.1
                                                                            		 39029 - 40000 (+) mmrAII
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • QVQ68817.1
                                                                              		 39993 - 40766 (+) mmrBII
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • QVQ68818.1
                                                                                		 41030 - 41785 (+) mmyRIII
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • QVQ68819.1
                                                                                  		 41847 - 42302 (-) mmyH
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    Biosynthesis information
                                                                                    Annotation changelog

                                                                                    Entry version: next

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2023-12-04
                                                                                    Fix compound evidence
                                                                                    • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-10-07
                                                                                    Update chemical activity to schema version 2.11
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-10-07
                                                                                    Changed chemical structures for compounds: metathramycin, premetathramycin.
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-10-07
                                                                                    Added NPAtlas links to compounds: metathramycin, premetathramycin.
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Submitted
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    Detailed domain annotation
                                                                                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                    A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                    Selected features only
                                                                                    Show module domains
                                                                                    Similar known gene clusters from MIBiG 4.0
                                                                                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                    Click on reference genes to show details of similarities to genes within the current region.
                                                                                    Click on an accession to open that entry in the MiBIG database.