LOCUS       BGC0002130             29760 bp    DNA     linear   BCT 18-NOV-2021
DEFINITION  Streptomyces cacaoi strain CA-170360 cacaoidin biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0002130
VERSION     BGC0002130
KEYWORDS    .
SOURCE      Streptomyces cacaoi
  ORGANISM  Streptomyces cacaoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:00:05
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..29760
                     /country="South Africa"
                     /db_xref="taxon:1898"
                     /isolation_source="rhizosphere"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces cacaoi"
                     /strain="CA-170360"
     misc_feature    1..29760
                     /note="cacaoidin biosynthetic gene cluster"
     protocluster    1..29760
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7256:10697]"
                     /cutoff="20000"
                     /detection_rule="(APH and HopA1)"
                     /neighbourhood="20000"
                     /product="lanthipeptide-class-v"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7257..10697
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APH and HopA1)"
                     /neighbourhood="20000"
                     /product="lanthipeptide-class-v"
                     /protocluster_number="1"
     cand_cluster    1..29760
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APH and HopA1)"
                     /kind="single"
                     /product="lanthipeptide-class-v"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..29760
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002130"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..29760
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-v"
                     /region_number="1"
                     /rules="(APH and HopA1)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(475..1200)
                     /gene="caoR1"
     CDS             complement(475..1200)
                     /codon_start=1
                     /gene="caoR1"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 80.1; E-value:
                     2.2e-24)"
                     /gene_kind="regulatory"
                     /product="DNA response regulator"
                     /protein_id="QKI29061.1"
                     /transl_table=11
                     /translation="MLHEAFQQNGHRQHSTERQPQTVAVATESEIVRLGLFSMLDLASD
                     FQPLRHRVTPGTAVSGEYPVDFVIAEFDGHFVDDLKELTEKCRNDSISVLLLVSSTDRE
                     ELDLAIQVPAQGFLLLAELTPDELNTALSKVAAGSVHLPPVFANRLLTRARREESSALS
                     PQGRTTLTPRELQTLELLVEGLSNKQIARRLAISQHGAKRLVANVLSKLNCHNRTMAAA
                     VALRERLVSRPGSRARETR"
     misc_feature    complement(910..912)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1953..2531
                     /gene="caoR2"
     CDS             1953..2531
                     /codon_start=1
                     /gene="caoR2"
                     /product="XRE family transcriptional regulator"
                     /protein_id="QKI29062.1"
                     /transl_table=11
                     /translation="MGRPETVIDPTEGPVQQFSMELRELRRKAGSPTYREMSKRVHYSV
                     AALSEAARGTRRPTLEITRAFVEACAGDVPHWEERWRKLNAELGIDEEAGEAGEVREGA
                     VRAVRPRVPLSAPSQAVPNQGVPKRQVPKQGVPRQAVPGRVQGTRLPAWREVRTRAGGG
                     PAVRYAATAACAAAFVAGVVMGGRNAARR"
     gene            2528..3763
                     /gene="cao3"
     CDS             2528..3763
                     /NRPS_PKS="Domain: NAD_binding_4 (148-263). E-value:
                     5.8e-10. Score: 30.5. Matches aSDomain:
                     nrpspksdomains_cao3_NAD_binding_4.1"
                     /codon_start=1
                     /gene="cao3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 79.9;
                     E-value: 3.6e-24)"
                     /gene_kind="biosynthetic-additional"
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="QKI29063.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.2e-87, bitscore:
                     281.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRARGTGRTDETGRGEEPGRTEDAGRTRPGRTDVTSGGEDTGRP
                     DGTGRNESTGRTGPGRTGSADGRGDTGLDGPGRTETGRGGEGVGRADGGTGAGGPLRAP
                     RVRWVVVGAGGLLGREMTGFLGERGDDVVALPRRALDITDAGACAAVIRRGDVVVNAAA
                     WTAADDAELDEDRAFTANAYGPAVLARTCAAAGARLVHVSTDYVFHEAPGGPHDAAPTP
                     YAEDDLPRPRSAYGRTKAAGEWAVQALCPDHLIVRTAWLYGRYGACFPLSIARRLREHG
                     EVRVVDDQFGQPTWTRDVARLVVELVLAAAPSGTYHATAAGWTSWHAFARAVAAADGAD
                     PALVRPATTAGIGRRAPRPAFSALGHDAVHRVAAAGADVAPIGPWQERWSYASALVLGA
                     LGPGPERADAAH"
     aSDomain        2972..3316
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cao3_NAD_binding_4.1"
                     /evalue="5.80E-10"
                     /label="cao3_NAD_binding_4.1"
                     /locus_tag="cao3"
                     /protein_end="263"
                     /protein_start="148"
                     /score="30.5"
                     /tool="antismash"
                     /translation="AAVIRRGDVVVNAAAWTAADDAELDEDRAFTANAYGPAVLARTCA
                     AAGARLVHVSTDYVFHEAPGGPHDAAPTPYAEDDLPRPRSAYGRTKAAGEWAVQALCPD
                     HLIVRTAWLYG"
     gene            3887..4936
                     /gene="cao4"
     CDS             3887..4936
                     /codon_start=1
                     /gene="cao4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 243.3; E-value:
                     6.7e-74)"
                     /gene_kind="biosynthetic-additional"
                     /product="methyltransferase"
                     /protein_id="QKI29064.1"
                     /transl_table=11
                     /translation="MATEIPPQVRDLLKKADLLPPTAIRIAATLRIADHIADGVRDPAG
                     IAERAGAQRVPMERLLRYLATIDVLCETDDGGYDVTGTGALLRSGAGLREALDIDGLMG
                     RGESATPFLLHTLRTGKSAYAGVHGREYWEDVNAEPVFREQLKALGHSGLAWEGERIVK
                     EYPWSGVGHVVDVGGNKGQLLVALLSEFSHLRGTLVELPNLVELATEDFARAGLQDRCT
                     AVVGDFFAELPAGADVYVLSGVLADWDDEDAVRILRRCAEACGTRGRILLADIDLVLDM
                     PDPADQAAAELRTMATVPGIGRDVDGVKELAGRAGLDITWEGEASAIRSLLELTPRTGT
                     AQAAPDGGA"
     gene            complement(5029..6009)
                     /gene="cao5"
     CDS             complement(5029..6009)
                     /NRPS_PKS="Domain: NAD_binding_4 (6-192). E-value: 3e-16.
                     Score: 51.1. Matches aSDomain:
                     nrpspksdomains_cao5_NAD_binding_4.1"
                     /codon_start=1
                     /gene="cao5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     296.7; E-value: 3.6e-90)"
                     /gene_kind="biosynthetic-additional"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="QKI29065.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.1e-24, bitscore:
                     75.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.7e-16,
                     bitscore: 49.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.4e-16, bitscore:
                     51.1, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYRVLVTGGAGFIGSCYVRALLNGELGAAAPAADAAVTVLDKFT
                     YAAHPANLPSGDGRCTVVEGDICDADLVRGLVAGTDLVVNFAAETHVDRSIRDGGDFVR
                     SNSLGVETLARACLDARVPRLVQVSTDEVYGSIAHGAWDESAPVAPNSPYAAAKAGGDL
                     VALSYARTHGLPVSVTRYSNTYGPRQFPEKLIPLFVTNLLRGRQVPLYGDGRNVREWIH
                     VSDHCRAVHLVAERGAPGEVYHVAGDTRLTNRALTKLLLELLGAGPERIAHVADRKGHD
                     LRYALDGGRLAALGHRPRVPFRAGLADTVEWYRDHPEWWQPLLPD"
     aSDomain        complement(5434..5991)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cao5_NAD_binding_4.1"
                     /evalue="3.00E-16"
                     /label="cao5_NAD_binding_4.1"
                     /locus_tag="cao5"
                     /protein_end="192"
                     /protein_start="6"
                     /score="51.1"
                     /tool="antismash"
                     /translation="VTGGAGFIGSCYVRALLNGELGAAAPAADAAVTVLDKFTYAAHPA
                     NLPSGDGRCTVVEGDICDADLVRGLVAGTDLVVNFAAETHVDRSIRDGGDFVRSNSLGV
                     ETLARACLDARVPRLVQVSTDEVYGSIAHGAWDESAPVAPNSPYAAAKAGGDLVALSYA
                     RTHGLPVSVTRYSNTYGPRQFPE"
     gene            complement(6006..7073)
                     /gene="cao6"
     CDS             complement(6006..7073)
                     /codon_start=1
                     /gene="cao6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 327.2; E-value:
                     1.5e-99)"
                     /gene_kind="biosynthetic-additional"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="QKI29066.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 9.1e-13, bitscore:
                     39.7, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLAGGSGTRLRPITHTRAKQLVPVANKPVLFYGLESIRNAG
                     ITEVGLVVGDTAPAIEEAVGDGSAFGLQVTYLRQEAPLGLAHAVRIARGYLGDEPFVMY
                     LGDNFLVGGITELVRSFDPAVHDALVLLTPVPDPEMFGVAEVRAGRVVRLVEKPAEPPS
                     DLALVGVYLFSSAVHEAAAEIKPSWRGELEITDAIQWLIDRGRPVASTTVEGYWKDTGD
                     VESILEVNGRLLDRRGDETAVHGDVDAVSELTGGVRVAAGARIRRSRIAGPVDIAAGTL
                     IEDCSIGPWTSIGEGCRLRGSGLRRSIVLAHASIAGAHGIESSLIGHCAEIASDGDRGA
                     PRRTLVLGDHSKVRI"
     gene            7257..8291
                     /gene="cao7"
     CDS             7257..8291
                     /codon_start=1
                     /gene="cao7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-v: HopA1"
                     /gene_kind="biosynthetic"
                     /product="hypothetical protein"
                     /protein_id="QKI29067.1"
                     /sec_met_domain="HopA1 (E-value: 4.5e-49, bitscore: 157.3,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILHDAVSTDWLNGALDGIRLARDLRSAAVGDRQIADDSPHELSK
                     KLSVALYEVLHAGIGERSAAPPLPRRDSACDRALARAVPHREVSVRVRVLTGDVVPAAE
                     AAPAGLAGTPRGPDGADGERLLVEREGVRVWVPCTALAGGPASWRPGAVVRMRATSRRP
                     MLSPGFFFVEGTRRPHPGDPGLRVYVHLEDFDSATAVWEAVLADLEAAGAAYRAKVIST
                     RTGYPRFDALVLYLGRDSWHLHPRIARLAGDMPGVGDATSVFARRLRPGVALAWEPSDP
                     RTGMRGLSFGQHRASAVAHGLVRSVREGTPAGQAVREALLEANIDPDRPARNCDSPDPA
                     ARGE"
     gene            8304..9455
                     /gene="cao8"
     CDS             8304..9455
                     /codon_start=1
                     /gene="cao8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /product="glycosyltransferase family 2"
                     /protein_id="QKI29068.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.9e-29,
                     bitscore: 93.5, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGNTPDTRSPGTEPEYVTLRAARRTAGKSRIDVICPTHNRSTRI
                     RPTLDSVLAQSVGDWRLVVVSDGSTDDTEDVVRAYDDPRIALLRCPPHGHPGGPRNIGL
                     HHAGAPFAAYIDHDDTWRPDHLAVLLEMLESGAQAAATGCRRLTPEGGVEDVGAVDMVW
                     HPEIQALAGLNEPSRVGHVRELVPRVGGWTQADHGFEDWDLWWRMAEQGIRFTTDARRT
                     VQMRQTHGTRRETITAKYAITVARTSTREVAEAVVERLREPRTARRMRDGARADLAAWH
                     TRLAATPDYVVPRGHTVAALRDACLERVARMENQHGYQSVFTGPKGDGWALFLTLWCTQ
                     PAHASRVSGLLARRDVRQRAVLAELVEECERHAGRGSGHRVGS"
     gene            9555..10697
                     /gene="cao9"
     CDS             9555..10697
                     /codon_start=1
                     /gene="cao9"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-v: APH"
                     /gene_kind="biosynthetic"
                     /product="phosphotransferase"
                     /protein_id="QKI29069.1"
                     /sec_met_domain="APH (E-value: 1.6e-14, bitscore: 45.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSVKSQRGVHPASGELDRVPAVGALLARLGLGEFEENSVDSRP
                     GRNDIWCGTTTTGASVFVKRMTGDPFDIQQRTRRLLSFETALRAFFPFPRESGAALDAP
                     RLLGHDAEAAVFAFTRVTDGEPGNDLMIERRLDEDTARRCGRAVAHLHSLRPGEAAQLD
                     DSVPLFPSLKLLEGIPDTMFDLLGTAELQMWRLLQTDDELRGAVARLLRREREAPRVPV
                     HCDLRLDQFLIAGEHLTLTDWEELRLGDPARDVGAFIGECLYRSVLDIVSGRGEVDFTA
                     ASLTVEDVLRRGVERIRARQPLMAAFTAGYAQGRPGRDPRLAARAAAFAGWHLIDRMIA
                     TAHFRPRLLGIERAAAGIGRTALLDPDRFVGSLGLEPLLN"
     gene            10775..10936
                     /gene="caoA"
     CDS             10775..10936
                     /codon_start=1
                     /gene="caoA"
                     /product="cacaoidin precursor peptide"
                     /protein_id="QKI29070.1"
                     /transl_table=11
                     /translation="MGEVVEMVAGFDTYADVEELNQIAVGEAPESSAPCTIYASVSASI
                     SATASWGC"
     gene            11058..12809
                     /gene="cao11"
     CDS             11058..12809
                     /codon_start=1
                     /gene="cao11"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 302.4; E-value:
                     1.1e-91)"
                     /gene_kind="transport"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QKI29071.1"
                     /transl_table=11
                     /translation="MERTHSEEQLGITRELVNRQPWLIAGIVLLSVVSTLGTLALPLTA
                     ARLISAMQRGGSTLVPVLLMVGAGLAAAAAHALSTYLLSRVGEQMVGRVRSRFMAHSLR
                     LPLSVVRREGQGTLAARLGTDGLQMKAVVDVGVLQLPMAIITVTGTAVIMAVLDWVLLL
                     YLVASFALSVGGVVVIIKVMRKRFMALQMSVAKMTQVFMNALEALPTIKAYRAEQRTSR
                     ELAALAQDTADLGVTTTRLASLLFPVINLGQQIALVTVIVAGGVRLNSGLLTLPDLAAF
                     LLYMLQLTAPLLLVAMGVGSLQAGLASRDRFRAIFATPTEESADAAAPAPRTAPSEETP
                     AAAVRFEGVTFSYESQPALRAVDFTIPRRGMTALVGMSGAGKTTVLSLIERFISADSGT
                     VRVLGEDVTRWRVADLRAHMAYVDQKFTLLSDTIRANLTLGTSSPPPDDRLMAALAEVG
                     MEDAVRALPGGLDARLDEGTDISGGQRQRLALARAILAEGELVLLDEPSSQLDSVNEML
                     LRDSIRRMADDRALLVVAHRLSTVQDADHIIVLDRGQVVADGTHHELMARSPEYSLLVR
                     GQLLSSV"
     gene            12995..13945
                     /gene="cao12"
     CDS             12995..13945
                     /codon_start=1
                     /gene="cao12"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083:oxidoreductase (Score: 129.5; E-value: 2.9e-39)"
                     /gene_kind="biosynthetic-additional"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="QKI29072.1"
                     /transl_table=11
                     /translation="MELSVITPVVPTRPERLVRIAALAERTRSGRLWCGQSMTLEQHHL
                     YAYLTGLGFRIEAGLGVSLMPFRHPLQGALEARSIAATTGRPVIAGFGPGATALQASMH
                     GEPYARPLRAAREYLTVVRTLLDGRPCRQEGDYFSFTGELMPMPTPRIDVGLGVLRPGM
                     ARLAGEVADVAITWLAPAPYLHDVVRPALEEGAQRAGRPVPKLVAVVPMALDRPDRDPA
                     VLARTPHLRFPHYQDMLRRAGVDVNGEDPDATAAALVDGDVFLVGDPSALDKKLDAHRA
                     AGVDELVVNLAGVAMHEGPTAAAADLEEILAGVDR"
     gene            13942..14745
                     /gene="caoD"
     CDS             13942..14745
                     /codon_start=1
                     /gene="caoD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /product="cypemycin decarboxylase"
                     /protein_id="QKI29073.1"
                     /sec_met_domain="Flavoprotein (E-value: 8.1e-23, bitscore:
                     71.6, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADPAGVPEVDTSVRSVFGFSRLLVVGTGSVSVSELPFWIGWLR
                     SSFSDLELRVAVTRSAERFVTRTALALRAEREVVRDAWPEEETGGLPLHAELAEWAEAV
                     VVYPATMNFLARLALGMADTPVMIACQCTTAPIALAPMPPPGGARSAAYTRHVAELESR
                     DNVVVVPARSAARPGRRQDSAVIPPLLDVLKAVGGLRADGPGTPDDRGERDDQGARGDQ
                     GDRGDRGDRGERGGRDERGEQGERSGPAADGPYSREEPPAAWARV"
     gene            14730..15635
                     /gene="cao14"
     CDS             14730..15635
                     /codon_start=1
                     /gene="cao14"
                     /product="hypothetical protein"
                     /protein_id="QKI29074.1"
                     /transl_table=11
                     /translation="MGARMTTETGRAPVLAFATGLLRTTVYEQDDGRYRWERARGDAAP
                     AAFRYPDETLLPVLTAAESAGARFVLAADGTEPRRYTAPGWQSCAHRLLVGGHQACAAV
                     TGPLAGAGGLLRAVHDQLPPPGAAPPPGLLRLSAWLDGTAERPDAARSAEFLRPLLGAP
                     GWARLRAWSDEALQDRSAALHGAPGLGALVPGEGTGTGLLVGEDVAAGPPLWDLGWIVG
                     ELMEFQWRLAAKGGTQVWHELLRSLLRAYGVSENTGLRRMAVLRIALHLHDFIAYVGWD
                     QREFARAAAFLGHLIKESRE"
     gene            15632..18229
                     /gene="cao15"
     CDS             15632..18229
                     /codon_start=1
                     /gene="cao15"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /product="Zn-dependent peptidase"
                     /protein_id="QKI29075.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 4.7e-18, bitscore:
                     56.4, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTTVPAATAAPGSSTVTRARLPNGLRVVVETVPGAPRAAVSVH
                     YGVGYRAEPPGRAGFAHLFEHLMTQGSESLPGRAYIDRLLAAGGNGNASTHQDYTDFHQ
                     VVPHEWLERALFCEADRMRAPVLTEHALAGQLAAVAWEIKGRIHDRPHGGLPWPLLPGV
                     LFSAFPNAHDGYGDLRELAGTTVAECAAFFERHYGPGNAVLTVLAPQHPDEVLDMAGHH
                     FAGIAARPVPDRPSLAEPAAHEDRIRTVTGPGSGATAVAVGHRLPDPAAELPGYLAHLA
                     LAGLASRRPVHVPGAPPVPLRARCGFFAPLDALDPDALVCTATVPGDVPPRTVAEAVRA
                     SLREAAADPRPDDVAAVGAGWRRTHDDLLARCRARGRTELLFGDPSLVDEVPRLLARLG
                     PDDVTAAASGLDGSPCAVLAVVPGGGRPAAAPLPDGLLGSGPPAPDPAPAPLDSAPAPA
                     WPALGTRHAPSVRGLRETTLGNGLRVTAVRAGHAPLVEARLRFPDSGARAADEAVLESA
                     AALLRARCAGGPWSVRSDGIRLTMTGSAPADRTEHLLAQLRAVLVPPLTSPLASPPASP
                     RRPLRARTENDLAWHVLAGRTRGEAAAACAVPDGATLVVVGAAGPDDVASAASRLLGPW
                     QAGPRRRTAPDTAPRAGLRILPPDAHTPVAFLGLCAPDPTPHAAPGTPTDATRGEAARF
                     LAVGVLGGQPGSRFASLSGAAGAPLTGGFALAGRDVLFGAGRVLVSAGMPPGTVRAGVA
                     AVCGQLRLLAADPPTAAEVRRVAEFGAGQLSGVFDSQAALADHLVRAGAQGQSARTLLD
                     LPRALRETGVEEVAEAARRLFGEARFTGVLRAGAEEAEQARQAAAAVCGEVTA"
     gene            18226..19305
                     /gene="cao16"
     CDS             18226..19305
                     /codon_start=1
                     /gene="cao16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /product="glycosyltransferase family 2"
                     /protein_id="QKI29076.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.5e-29,
                     bitscore: 92.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTEVLREATGSRRPRIDIICPTYNRSTAIRPTLTGVLEQSVGD
                     WRLLVVSDASSDDTEDVVLGCRDPRIALLRSERHGHPGGPRNVGLAHARAPYIAYLDHD
                     DLWEPHHLRTLLEQLERGAEIVATGATYIDHEGRETGRTEPADMVWHPDLQAVYALFEP
                     ARVGHVRGVVESVGGWTTDTAGFEDWDLWWRLGEAGHAFQPVLERTAVIYRGSDTRTES
                     VRARYAIPVGRTDSEDAARGCLDALADDGTRDRLAALYAADFADWWDALARDDRFRTAP
                     GTARAEVLGALRERSDGARTHVFTQLRHARRRDGHLLYDPAWCTSKDQAARMSAVMRDR
                     DVRQREFLHGLLARGASGG"
     gene            complement(19310..19456)
                     /gene="cao17"
     CDS             complement(19310..19456)
                     /codon_start=1
                     /gene="cao17"
                     /product="hypothetical protein"
                     /protein_id="QKI29077.1"
                     /transl_table=11
                     /translation="MAHSTDRARRSGTAHGRARPRSARRFPRPTVEAISAAARVVTLIW
                     RPR"
     gene            19660..20637
                     /gene="cao18"
     CDS             19660..20637
                     /codon_start=1
                     /gene="cao18"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 192.2; E-value:
                     1.8e-58)"
                     /gene_kind="transport"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QKI29078.1"
                     /transl_table=11
                     /translation="MAVQNNLRRPGEHPPEAPEREPAVDVRGLRMRYGTHDVLNGVDLR
                     VEQGEVLVLLGPNGAGKTTTVEILEGFRGRSSGEVSVLGVDPDRGNEAWRARLGVVLQS
                     WRDHAKWRVRELLAHFAAHYAPYGTPERPRPRDVDELLETVGLTEQADAKVGSLSGGQR
                     RRMDVAVGIVGRPELLFLDEPTAGFDPVARRDFHALVQRLAGEEGTTILLTTHDLDEAE
                     KLADRILILSGGTIVAGGSPAALAAQLESDAEVRWTHRGERHVTFTPDGTGFARKLFER
                     HGEEIEDLQVRRPGLEEVYLEMVRLHESGRAEEAAGSIPLRRQQ"
     gene            20634..21494
                     /gene="cao19"
     CDS             20634..21494
                     /codon_start=1
                     /gene="cao19"
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 75.7; E-value: 5.6e-23)"
                     /gene_kind="transport"
                     /product="ABC transporter permease"
                     /protein_id="QKI29079.1"
                     /transl_table=11
                     /translation="MSADTRTAQTLRLGAERGWREFRGLLASGNELFSAVVMSLAFVLV
                     VFFQRNETLEDTGISTATAALPGIVAMMLVYNGLVGTATYLTTEREDGTLLRAKALPGG
                     IASYLWGKTVFMLLNTLLSVVLVLVAGLLLFDGVADGLADGGPQMLGMMVLGLAACLPI
                     GAILGTWFDNPRTAIGSLMIPFMGLTVISGVLMPVSWMPDWVQTLVQFTPLYWLGLGMR
                     AAMLPDTMLALEIGGSWRVPETLGVLALWAVAGFALALVLLRRMTRTVNGATLDESRLK
                     AMQRV"
     gene            21487..21819
                     /gene="caoR3"
     CDS             21487..21819
                     /codon_start=1
                     /gene="caoR3"
                     /product="XRE family transcriptional regulator"
                     /protein_id="QKI29080.1"
                     /transl_table=11
                     /translation="MSDGAESPTGKKVRKAGKASKPGQPGRGAATGDKSSERIYNRIAL
                     MRIERGISRRQLADALDVHYQTVGYLERGEYSPSLHLALRIAAYYGTSVESVFALEPFP
                     RIGSEE"
     gene            21825..22373
                     /gene="cao21"
     CDS             21825..22373
                     /codon_start=1
                     /gene="cao21"
                     /product="hypothetical protein"
                     /protein_id="QKI29081.1"
                     /transl_table=11
                     /translation="MTPENAVGGRDGERDGRQDRLRAKVESEKVRRRWMSRRRRRPLVV
                     AEAVSAVLFAGGIRLLAGGENRLVGLLVVVVTGGLLAVVGTQIGLASRFRSDYHDLDER
                     QRAEQARARLLGDRVTNVALAVAFVAALLLSGLTDEVDMAAVPPAAFLLLALNVFFPAA
                     WLTWTQPAESDDEPDEEEF"
     gene            complement(22465..23082)
                     /gene="caoR4"
     CDS             complement(22465..23082)
                     /codon_start=1
                     /gene="caoR4"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 67; E-value: 4.8e-20)"
                     /gene_kind="regulatory"
                     /product="TetR family trancriptional regulator"
                     /protein_id="QKI29082.1"
                     /transl_table=11
                     /translation="MVNPENPRPSGATARGTDGNRRAELVEAAVDHVTAHGIGDLSLRR
                     LGAAIGVSHRMLIHYFGTREQLLVEVVRRSERRQRELLSRLHAEPGRSPAEVARLLWRE
                     LSDPRLAGRERLFFEICGYALRGRPEAVRVLDGIVADWLEPLVAAEVAAGADAGTARNR
                     ARLGLATVRGLLLDLLATGDRAGVDAALEEFLRLFYPPERPG"
     gene            23099..23593
                     /gene="cao23"
     CDS             23099..23593
                     /NRPS_PKS="Domain: Polyketide_cyc2 (13-155). E-value:
                     1.5e-13. Score: 43.2. Matches aSDomain:
                     nrpspksdomains_cao23_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene="cao23"
                     /product="SRPBCC family protein"
                     /protein_id="QKI29083.1"
                     /transl_table=11
                     /translation="MVHDVCTVWYMRPVTVAIDVPHTPAQIYDFLDVMAHHERFTDHYL
                     TNWRYSGPGRGTGACATVTAALGGTRTDVTIEVVEAEAPRRIVERNVSAGGRRRAHGTY
                     TIEPLETGRSRVSFTYSWLRAPLADRLLAPFVRGAMRNANRTVMRRLAEELARHAAGGG
                     S"
     aSDomain        23138..23563
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cao23_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.50E-13"
                     /label="cao23_Polyketide_cyc2.1"
                     /locus_tag="cao23"
                     /protein_end="155"
                     /protein_start="13"
                     /score="43.2"
                     /tool="antismash"
                     /translation="VTVAIDVPHTPAQIYDFLDVMAHHERFTDHYLTNWRYSGPGRGTG
                     ACATVTAALGGTRTDVTIEVVEAEAPRRIVERNVSAGGRRRAHGTYTIEPLETGRSRVS
                     FTYSWLRAPLADRLLAPFVRGAMRNANRTVMRRLAEEL"
     gene            23816..25069
                     /gene="cao24"
     CDS             23816..25069
                     /codon_start=1
                     /gene="cao24"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 166.5;
                     E-value: 1.8e-50)"
                     /gene_kind="biosynthetic-additional"
                     /product="glycosyltransferase family 4"
                     /protein_id="QKI29084.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.1e-38,
                     bitscore: 121.0, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHISFLIFSAYGMGGTVRTTFNLAQALAEQHEVEVVSVFRYRDKP
                     FFEPGNGVRLRSLVDMRRHRPGYQGDDPEHALPATVFPAADGNYKQHSALTDRLIGEHL
                     ATTEADVVIGTRPGLNVHVARQTRRGPVRLGQEHLTLATHSARLKRVLRSNYPRLDAVT
                     TVTEADARDYRKHMWLPGVHVQSLPNSVPEPAVSPADGSGKWVVAAGRLAPAKRYDVLV
                     RAFAEVVSERPDWGLRIYGHGREEGKLRKLIDELGLYNHVFLMGSANPIEAEWVKGAIC
                     AVTSSLESFGMTIVEAMRCGLPVVATDCPHGPKEIIRDGEDGLLVPTGDVRAISGALLR
                     LIDDEGLRTRMGKAALTASARFDPAEVAARYEELLTSLVNHRPGAVHRARGNLLGGAYA
                     AKDRIRQGVSHALEGARS"
     gene            25066..26028
                     /gene="cao25"
     CDS             25066..26028
                     /codon_start=1
                     /gene="cao25"
                     /product="hypothetical protein"
                     /protein_id="QKI29085.1"
                     /transl_table=11
                     /translation="MIQEHLGTPPRAVPAPAPHRAGAPATRRIDHARADCTADSRGGLA
                     FAVRLFDETAADVPAHEAPESAAVLLRLRQQHGPDATVRLPLARAEAGETLHATLAGTA
                     LLREGRWDAHLDLGDEVLLRLLPGMNDLRSLAAGATFPAHAWLGVRIPYTTKHGNLSVR
                     AWLRRPHAEAGALHLADGVMELHGTFHGVRLDTTAHLEARPRDAAAAPVRVPVRPDTEE
                     HPGQATAPGDGPEGRHPVRGFTTELPLDALLSFGGVWDLWLRPAENEEPVRVARILDDV
                     LNKKRVFSYPAQQVTDGDGTAHPVRPYYTVNNNLSVEVG"
     gene            complement(26191..26292)
                     /gene="cao26"
     CDS             complement(26191..26292)
                     /codon_start=1
                     /gene="cao26"
                     /product="hypothetical protein"
                     /protein_id="QKI29086.1"
                     /transl_table=11
                     /translation="MRIRRIVPTVLLAAMVCIPYVFLASQGGSPAAA"
     gene            complement(26421..29471)
                     /gene="caoR5"
     CDS             complement(26421..29471)
                     /codon_start=1
                     /gene="caoR5"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     528.9; E-value: 4.4e-160)"
                     /gene_kind="regulatory"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="QKI29087.1"
                     /transl_table=11
                     /translation="MELRIQLFGAVSLQVGGEQIPLGTPKERLALAALAWDADRTVSVD
                     TLVRRLWDDLTPAKPREALYPHISRIRKALSAHHHEGAAAVISTTHAYTLRADPDAVDL
                     RRYLALLDQAREWADAAGDREALGALKTASSLWVGEPLAGLPGAWADHIRGVMEEKRLA
                     VSLLQADITMRSGHYAEAVADLRPLAPLHTTKQSFAGRLALALHGSGRTDEAAALLQRT
                     ARQLRRTSGTEPGEELRRVHHGILAGTPARTLLPSPPMPSPRHHSVTVPPDTLPAEVPY
                     VGREGELEQLADAADTREASALAAVITGMPGSGKSTLAVHAAHRMRDRFPDGQLFVNLR
                     GHVPQQSPMTVTEVLRELLRVLDGAPTGLPQEPGELARRWRSAIRDRRIVAVLDDASSI
                     DQVLPLLPGTSPALLLITSRRRLDALPGARHVALDVLPRTDSVAFLRRALKERAPTATQ
                     ADTLARLCGDLPLALALATRRLLSRPAWGVADLIQRFEQAPARLPELRDSHHAAAQAFE
                     VSYQALTPTQQRVFRLLGLHPGAEFGTAAVAALSGLPHHETELVLEELLACHLLSEPAP
                     HRYRQHDLLREYASALAASSPAADNEAALGRLIRYYLRTADQADRCAYPHRLRMEPAAG
                     TTGGRMWQRDEAQQWFTAEGPNLLAILERVRVHGAPHELAISAHVLAGFLNVEGYLNTA
                     VPLLRTAAAHWEGTGQSKAHGRALIDLGTACAGAGKYDEAFHSAQKALHLSQNEDEELR
                     AEALHQMSIIRWHTAQHAEALDLQQRALRIRLSTSDRLQQGRSFNVMGMLSLRLERHKD
                     ALKYFLEGRARFHDAEDSRGEFIALHNLAELYRESGDLDNAIGAYQRAIKISDPRSGGT
                     AQYAILQMNLADTLRARGRPGDALALYGKALPAVHSSGDRRSEAIARTGIGRALDAMGD
                     SERALPHHTAALAISRSIGAVLEQCQALRALGEAETATGRLPQARAHLEASLALSRQIA
                     ARTEEAMALRALSQAHHRGQQPPHPER"
ORIGIN
        1 ccggccgtcg gtccgtggcg gtcccgccac ggtgcgtgta cggacgccgg cgcccggcgg
       61 tgagcgcccg tgacgtgctg cgaccagttc tgcgaccgct tccgcgccca ccgcgctgct
      121 gccgcgcgct gctgggcgcc gtccggatcg acggcgagcg tccgcgccat gcctgcctcc
      181 tccgcacacg ggtccggcgg ggagccggtt cctccaggct gacgcggaaa cgccgctgtg
      241 tcgatttgtc cctctgtctc cctgctgttg ctgtctccct gctgttgtgg gtgtccgtcg
      301 tgtggtgtcg tgcggcccgt tgcgagtacg gcggcgccgc tgcgggtgct gcgtcgtcgc
      361 cctggccgta tgggctgtcc cggccgcccg ggcggtcccg gctgccccgg ccgccgcggt
      421 ggtcccggtg gtcccggtgg tcaggtcagt tgcggtaccc cggccgtccc cgggtcatct
      481 cgtctcgcgg gcacgggagc cggggcggct cacgaggcgt tcgcgtagcg ccacggccgc
      541 cgccatggtg cggttgtggc agttgagctt gctcagcacg ttcgccacca gccgtttcgc
      601 gccgtgctgc gagatggcca ggcgacgggc gatctgcttg ttcgacagcc cctcgaccag
      661 cagttccagg gtctgtagct cgcgcggggt gagcgtcgtc cggccctggg gtgacagggc
      721 ggaggactcc tcacggcggg cccgggtcag cagcctgttg gcgaacacgg gcggcaggtg
      781 cacggaaccg gcggccactt tgctgagggc cgtgttgagt tcgtcgggag tcagctccgc
      841 cagcaggaga aatccctgtg cggggacctg aatcgccagg tcgagttcct cgcggtcggt
      901 ggaactcact aacagcagca cggagatgct gtcgttcctg cacttctccg tgagttcctt
      961 gaggtcgtcg acgaagtgcc cgtcgaattc ggcgatgacg aagtccaccg ggtactcacc
     1021 ggacacggcg gtgcccggcg tgacccggtg acgcagcggc tggaaatcgg atgcgaggtc
     1081 gagcatgctg aacaggccga gccggacgat ttcgctctcg gtggcgaccg ccacggtctg
     1141 cggctgacgc tccgtgctgt gctgtcgatg gccgttctgc tgaaatgctt cgtgcagcaa
     1201 agctccccct tcgaaggtca agtgcccatg atctcggtgg tctgtgatct tcagcgccgg
     1261 gccgtggcgc atcccccgtg ggcacgaagc atggagattg gcatcttgct caccatcgca
     1321 tccgttttcc cccgtgtcac gccactcttc acatgctgat cgaagggacg agccggtacg
     1381 agtcggaacc cgtgcccggg tccccggacg gccgcgcgcg ccgccggtgt gggctgcccg
     1441 atcggctacc cccggcgggg agatgggcca cgcccgtgtg gagaggtgca agcgggtcgt
     1501 gcggggctgc aaggcgttgc cggggcggcc gagaatccca gacaggggcg cggggcgggc
     1561 aagtcgaccg gttcttccgg taattgtctt ggcaagagag gaaaagccgg acacgctttc
     1621 ctcgccgagt tccgcccccg acgacttccg cacgtcggag cggatccgga cgtgcgggga
     1681 gcgccagcgg gccggcggcg acacggggga gctgaaggca cgtgcaccac ggggtggttc
     1741 gcggacacat gtgcgggcgg ggccgcccgc cggggacggc gcggccgtcc gcacccgccg
     1801 tcggatcgtc gacgtgcgcg cgagaccgct cccgacgccc gcgcccggtg ccggtgcgcg
     1861 accggtacgg gcccaaaggt ccggtggaca ccacgccgcg gaaatcgagc acttcgcgct
     1921 cgcgcggaaa gcacacaacg gggaggcagc acatgggaag gcccgaaaca gtgatcgatc
     1981 cgacggaagg gccggtgcag caattttcca tggagctgag agagctgcgg cgaaaggcgg
     2041 gaagccccac ctaccgggaa atgtccaagc gggtccacta ctcggtggcg gccctttccg
     2101 aggcggcacg gggaacgcgc cgccccaccc tggagatcac ccgcgctttc gtggaggcgt
     2161 gcgcgggtga tgtcccgcac tgggaggagc gctggcggaa actcaacgcg gaactcggga
     2221 tcgacgagga ggcgggagag gccggcgaag tcagggaggg ggccgtgcgc gcggtgcggc
     2281 cgcgggtgcc gctgtcggcg ccgagccagg cggtgccgaa tcagggagtg ccgaagcggc
     2341 aagtgccgaa gcagggagtg ccgaggcagg cggtgccggg ccgggtgcag gggacgcggc
     2401 tgccggcgtg gcgggaggtg cggacacgtg ccggcggcgg gcccgctgtc cggtacgcgg
     2461 cgaccgccgc ctgcgccgcc gccttcgtgg ccggtgtcgt catgggcggc cgaaacgcgg
     2521 cccgccgatg agccgggcgc ggggcaccgg ccgtaccgat gaaacgggcc ggggcgagga
     2581 gcccggccgg accgaggacg cgggccgaac ccggcccggg cgtacggacg tcacgagcgg
     2641 tggcgaggac accggccgtc ccgacggcac cggccggaac gagagcaccg gccgaaccgg
     2701 gcccgggcgt acgggaagcg ccgacggtcg cggggacacg ggccttgacg ggcctggccg
     2761 gacggagacc ggcaggggtg gcgagggcgt cggtcgtgcg gacgggggga cgggtgcggg
     2821 tggaccgctg cgggcgccgc gggtgcggtg ggtggtggtg ggtgccggtg ggctgctggg
     2881 gcgggagatg accgggttcc tgggcgaacg cggcgacgac gtcgtcgcac tgccgcgccg
     2941 tgcactggac atcaccgacg ccggggcctg cgccgcggtg atccggcgcg gcgacgtcgt
     3001 cgtcaacgcc gccgcctgga cggctgccga cgacgccgaa ctggacgagg accgcgcctt
     3061 cacggccaac gcgtacggtc cggcggtcct cgcccgtacc tgcgcggcag cgggcgcgcg
     3121 gctcgtccac gtgtcgacgg actacgtgtt ccacgaggcg ccgggcggtc cgcacgacgc
     3181 cgctcccacc ccgtacgccg aggacgatct gccgcgtccg aggtccgcgt acggccgtac
     3241 caaggcggcg ggggagtggg cggtccaggc actgtgcccg gaccatctga tcgtgcggac
     3301 cgcgtggctg tacggcagat acggcgcctg ctttccgctg agcatcgcgc ggcggctgcg
     3361 tgagcacggt gaagtgcggg tggtcgacga ccagttcggc cagcccacct ggacgcgtga
     3421 tgtggcgcgg ctcgtcgtcg agctggtgct cgccgcggcg ccgtcgggca cgtaccacgc
     3481 gaccgccgcc ggctggacgt cgtggcacgc gttcgcccgt gccgtcgccg ccgcggacgg
     3541 cgccgacccc gctctggtgc gcccggcgac caccgcgggg atcgggcgcc gggcgccccg
     3601 gccggcgttc tccgcgctcg gtcacgacgc cgtgcaccgg gtcgccgccg ccggggcgga
     3661 cgtcgccccc atcggcccct ggcaggaacg ctggtcgtac gcgtccgcgc tggtcctcgg
     3721 cgcgctcggc ccgggcccgg aacgggcgga cgccgcgcac tgaccgtctg cccgaggacc
     3781 gcccgacgac cgtccgagga cgtttagacg accgttcgac gaccggacac cgcacggggc
     3841 cgcgggcccg tgcggccacc gaccgcacca ggtgaggagc acacgtatgg caaccgagat
     3901 acccccgcag gtcagggacc tgttgaagaa ggccgacctg ttgccgccga cggcgatcag
     3961 gatcgccgcg accctgcgca tcgccgacca catcgccgac ggcgtacgcg acccggcggg
     4021 catcgcggag cgcgccggtg cccaacgggt gcccatggag cggttgttgc gctatctggc
     4081 caccatcgac gtgctgtgcg agaccgacga cggcgggtac gacgtcaccg ggaccggcgc
     4141 cctgctgcgc tccggggccg ggctgcggga ggcgctcgac atcgacggcc tcatgggccg
     4201 cggcgagagc gccacgccct tcctcctgca cacgctgcgc accgggaagt ccgcgtacgc
     4261 cggggtccac ggccgcgagt actgggagga cgtcaacgcc gagccggtgt tccgggagca
     4321 gttgaaggcc ctcggccact cggggctcgc ctgggagggg gagcggatcg tcaaggagta
     4381 cccctggtcc ggcgtcgggc acgtcgtcga cgtcggcggc aacaaggggc agttgctcgt
     4441 cgcgctgttg agcgagttct cccatctgcg cggcaccctc gtcgagttgc cgaacctggt
     4501 cgagctggcc accgaggact tcgcccgggc cgggctccag gacaggtgca ccgcggtcgt
     4561 cggcgacttc ttcgcggaac tgcccgcggg cgccgatgtg tacgtcctct cgggcgtcct
     4621 cgccgactgg gacgacgagg acgcggtacg gatcctgcgc cgctgcgccg aggcgtgcgg
     4681 tacgcgcggc aggatcctgc tggccgacat cgatctggtg ctcgacatgc ccgatcccgc
     4741 cgaccaggcc gcggcggaac tgcgcaccat ggccaccgtg ccgggcatcg gccgggacgt
     4801 cgacggggtg aaggaactgg ccgggcgggc cgggctcgac atcacgtggg agggggaggc
     4861 cagcgccatc cggtcgctgc tggagctgac gccgcggacc ggcaccgcgc aggcggcacc
     4921 ggacggaggg gcgtagcgca cacggagacg agccgccccg cctggcgtcg gcacccggcg
     4981 cacggaccgc tcggtgccgg cgccctggcc ggtgcggtgc ccgccgggtc agtccggcag
     5041 cagcggctgc caccactcgg ggtggtcgcg gtaccactcg acggtgtcgg ccagcccggc
     5101 acggaagggc acccggggcc ggtggcccag ggcggcgagc cggccgccgt ccagcgcgta
     5161 ccgcaggtcg tgccccttgc ggtcggccac gtgcgcgatc cgctccgggc cggcgcccag
     5221 caactccagc agcagcttcg tcagcgcacg gttcgtcagc cgggtgtcgc ccgcgacgtg
     5281 gtacacctcg ccgggtgcgc cgcgctcggc gacgaggtgg acggcccggc agtggtcgct
     5341 gacgtggatc cactcccgga cgttgcgccc gtccccgtac agcggcacct gccgtccccg
     5401 cagcaggttc gtcacgaaca gcgggatcag cttctccggg aactgccgcg gcccgtaggt
     5461 gttcgagtag cgcgtcacgc tgacgggcag gccgtgcgtg cgggcatagg acagggcgac
     5521 gaggtcgccg cccgccttcg ccgctgcgta cggcgagttc ggtgcgacgg gcgccgactc
     5581 gtcccacgcg ccgtgcgcga tcgagccgta gacctcgtcg gtggacacct gcaccaggcg
     5641 cggcacccgg gcgtcgaggc acgcccgcgc cagcgtctcc accccgaggg agttgctgcg
     5701 gacgaagtcg ccgccgtccc ggatcgagcg gtccacatgg gtctccgccg cgaagttgac
     5761 caccaggtcc gtgccggcga cgagcccgcg caccagatcc gcgtcgcaga tgtcgccctc
     5821 gaccaccgtg caacggccgt cgccggacgg gaggttggcg gggtgcgccg cgtaggtgaa
     5881 cttgtcgagg acggtcaccg ccgcgtccgc cgccggtgcc gccgccccca gttcgccgtt
     5941 cagcagcgcc cgcacgtagc acgagccgat gaatccggcc ccgccggtga cgagcacccg
     6001 gtaggtcata tccgcacctt gctgtggtcg cccagcacca gcgtgcggcg cggcgccccg
     6061 cggtcgccgt ccgacgcgat ctccgcacag tggccgatga gggaggactc gatgccgtgc
     6121 gcgccggcga tgctggcgtg cgcgagcacg atggagcggc gcaggccgct gccgcgcagc
     6181 cggcagccct ccccgatgga ggtccacggt ccgatggagc agtcctcgat gagggtgccg
     6241 gccgcgatgt cgacgggccc ggcgatgcgc gagcgccgta tccgggcgcc cgcggccacc
     6301 cggacgccgc cggtcagctc gctcaccgcg tcgacgtccc cgtggacggc ggtctcgtcg
     6361 cccctgcggt ccagcagccg gccgttgacc tccaggatgg actcgacgtc gccggtgtcc
     6421 ttccagtagc cctccaccgt cgtggacgcc acggggcggc cccggtcgat cagccactgg
     6481 atggcgtcgg tgatctccaa ctccccgcgc cacgagggct tgatctccgc ggcggcctcg
     6541 tgcacggcgg agctgaacag atagacgccg acgagcgcga gatcgctcgg cggctccgcc
     6601 ggcttctcca cgagccggac gacccgcccg gcacggacct ccgcgacgcc gaacatctcc
     6661 ggatcgggga cgggcgtcag cagcaccagc gcgtcgtgga cggctgggtc gaaggagcgg
     6721 accagttcgg tgatgccgcc caccaggaag ttgtcgccca ggtacatgac gaacggctcg
     6781 tcgcccagat aaccgcgtgc gatccgcacc gcgtgcgcga ggcccagcgg cgcctcctgc
     6841 cgcagatacg tcacctggag accgaacgcc gaaccgtcgc ccaccgcttc ctcgatggcc
     6901 ggcgcggtgt cgccgacgac gaggccgacc tcggtgatgc ccgcgttccg gatggattcc
     6961 agcccgtaga agagcacggg tttgttggcg accgggacga gttgtttggc ccgggtgtgg
     7021 gtgatcggtc ggagccgggt accgctgccc cctgcgagaa cgagcgcttt cactgcacca
     7081 cctcgatgac cctggcggcc gcacgggaat tcccggccgc ccaggcggtc attctcggcc
     7141 gcccgctgaa ttgtccgcaa tcgcctgccg ggccaccgtt gtctgcggat tgtgcgtgcg
     7201 gttgtccggg tggcccggcg cttgcagata acccggtgct cggggaagtt cggcatgtga
     7261 tccttcatga cgccgtatcg acggactggc tgaatggcgc actcgacgga attcggctcg
     7321 cgcgcgatct gcgttcggcg gcggtcgggg accggcagat cgcggacgat tcgccgcacg
     7381 aactgagcaa gaaactctcc gtcgctctgt acgaggtgct gcacgccggc atcggtgaac
     7441 ggtccgccgc gccgccgctg ccccgccgcg actccgcgtg cgaccgggcg ctggcccggg
     7501 cggtgccgca ccgcgaggtg tccgtgcgcg tgcgggtcct caccggggac gtcgtgcccg
     7561 cggccgaggc ggcaccggcc ggcctcgccg gaacgccgcg ggggccggac ggcgcggacg
     7621 gcgaacgcct cctcgtggaa cgtgagggcg tccgggtgtg ggtgccgtgt acggcgctcg
     7681 ccggcgggcc cgcgtcctgg cggccgggcg ccgtcgtgcg gatgcgggcc acgtcccggc
     7741 ggccgatgct ctccccgggt ttcttcttcg tcgagggcac ccgcaggccg caccccggcg
     7801 acccgggcct gcgcgtctat gtgcacctgg aggacttcga ctccgcgacc gccgtctggg
     7861 aggccgtgct cgccgatctg gaggccgccg gcgccgccta ccgcgccaag gtcatctcca
     7921 cccgcaccgg ctatccgcgc ttcgacgcgc tcgtgctgta cctgggccgc gactcctggc
     7981 acctgcatcc caggatcgcc cgcctggccg gggacatgcc gggcgtgggc gacgccacct
     8041 cggtgttcgc ccgccggctg cgccccgggg tcgccctggc ctgggagccg tccgaccccc
     8101 gcaccggcat gcgcgggctg agcttcggcc agcaccgggc ctccgccgtc gcacacggcc
     8161 tggtccgctc cgtacgcgag ggcacacccg cgggccaggc cgtccgcgag gcgctgctgg
     8221 aggccaacat cgacccggac cggcccgcca ggaactgcga cagccccgac ccggcagcgc
     8281 gcggcgagtg aggacggcac ccgatgaacg gcaacacgcc agacacccga agcccgggca
     8341 cggagcccga gtacgtcacg ctccgcgcgg cccggcggac ggccgggaaa tcccggatcg
     8401 acgtcatctg ccccacccac aacaggtcca cccgcattcg gccgaccctc gacagcgtgc
     8461 tcgcccagtc cgtcggcgac tggcgcctcg tcgtcgtctc cgacggctcg accgacgaca
     8521 ccgaggacgt ggtgcgcgcc tacgacgatc cgcggatcgc cctgctccgc tgcccgcccc
     8581 acgggcaccc gggcggcccg cgcaacatcg gactgcacca cgccggcgcg ccgttcgccg
     8641 cgtacatcga ccacgacgac acctggcggc ccgaccatct cgcggtgctg ctggagatgc
     8701 tggaatccgg ggcgcaggcg gcggccacgg gctgccggcg gctcaccccg gagggcggcg
     8761 tcgaggacgt cggggccgtc gacatggtgt ggcacccgga gatccaggcg ctcgccgggc
     8821 tcaacgagcc gtcccgggtg gggcacgtac gcgaactggt gccccgggtg ggcggctgga
     8881 cgcaggccga ccacgggttc gaggactggg acctgtggtg gcgcatggcg gagcagggca
     8941 tccggttcac caccgacgcc cgccgtaccg tgcagatgcg ccagacgcac ggcacccgcc
     9001 gcgagacgat caccgccaag tacgccatca ccgtggcgag gaccagcacc cgcgaggtgg
     9061 cggaggccgt ggtggagcgg ctgcgcgaac cccgcacggc gcggcgcatg cgggacggcg
     9121 cccgcgccga cctcgccgcc tggcacaccc ggctggccgc gacgcccgac tacgtcgtcc
     9181 cgcgcgggca cacggtcgcc gcgctgcgcg acgcgtgcct ggagagggtg gcccggatgg
     9241 agaaccagca cggctaccag tcggtgttca ccggccccaa gggcgacggc tgggcgctgt
     9301 tcctcaccct ctggtgcacc cagccggcac acgcctcccg tgtctccggg ctgctcgccc
     9361 ggcgcgatgt gcgccagcgc gccgtcctgg cggaactcgt cgaggaatgc gagcggcacg
     9421 cggggcgggg gagcgggcac cgtgtcggtt cctgagcagc ggagcgcgga cgcgttgtcc
     9481 acacctggtt gtccagggcg gaaggggcga atcggcgctt gtggacaact tttcaccggg
     9541 gggagtgtgg cggcgtgacg gtttcagtga agtcccagcg cggtgtgcac ccggcgtccg
     9601 gggaactcga ccgggttccc gccgtgggcg cgctgctcgc ccggctcggg ctgggcgaat
     9661 tcgaggagaa ctccgtggat tcccgccccg gccgcaacga catctggtgc ggtacgacca
     9721 ccacgggcgc ctcggttttc gtcaagcgta tgaccgggga tccgttcgac attcagcagc
     9781 ggacgcggcg gctgctctcc ttcgaaaccg cgctgcgcgc cttcttccct ttcccgcggg
     9841 aaagcggtgc cgcactcgat gcgccgcgcc tgctcggaca cgacgccgaa gccgccgtct
     9901 tcgccttcac ccgtgtcacg gacggcgagc cgggcaacga cttgatgatc gagcggcgcc
     9961 tggacgagga caccgcgcgc cgctgcggcc gagccgtcgc gcatctgcac tccctgcggc
    10021 ccggggaggc cgcccaactg gacgactccg tcccgctgtt cccctccctg aagctgctgg
    10081 agggcattcc ggacacgatg ttcgacctgc tcggcacggc ggaactccag atgtggcggc
    10141 tgctccagac cgacgacgaa ctgcgcggag ccgtcgcgcg gttgctgcgc cgggagcggg
    10201 aggcaccacg ggtgccggtg cactgcgacc tgcggctgga tcagttcctc atcgccgggg
    10261 agcacctcac cctcaccgac tgggaggaac tgcggctcgg cgaccccgcc cgcgacgtgg
    10321 gcgccttcat cggcgaatgc ctctaccgct ccgtcctcga catcgtctcc ggccgcggcg
    10381 aggtggactt cacggcggcg tcgctgacgg tggaggacgt gctgcgccgc ggcgtggagc
    10441 gcatccgcgc gcggcagccg ctcatggcgg cgttcaccgc cggctacgcg cagggccgcc
    10501 ccggccgtga cccgcggctc gccgcccgcg ccgccgcctt cgccggctgg catctgatcg
    10561 accggatgat cgccaccgcg cacttccggc cgcggctgct cggcatcgag cgggcggcgg
    10621 ccggcatcgg caggaccgcc ctgctcgacc cggacaggtt cgtcggatca ctgggccttg
    10681 agcccttgct gaactgattg cagggcgcgg gtgagtaccg cacccgtgcc ctgttttcag
    10741 atcagccatc gagagcgcaa agggggtgaa cagcatggga gaggtcgtcg agatggtggc
    10801 cggcttcgac acctacgcgg atgtcgagga gctgaaccag atcgcggtcg gcgaggcgcc
    10861 ggagtcctcc gctccgtgca ccatctacgc atcggtcagc gcgtccatca gcgccaccgc
    10921 ttcctggggc tgctgatcga gatctgatcc agcatcccgg aacacaccgg taatcaaccc
    10981 tgcccatccg tcggttcgcg gaaacgcgga gcgcggatgg gcagggctcc cgacacggtc
    11041 cgagaaagcc ggggaacatg gaacgtacgc actccgagga gcagctgggc atcacccgcg
    11101 agctggtcaa ccggcagccc tggctgatcg ccgggatcgt gctgctgtcc gtcgtctcga
    11161 cgctcggcac gctcgccctg ccgctgaccg ccgcccggct catctccgcc atgcagcgcg
    11221 gcggttccac actcgttccg gttctgctca tggtgggcgc gggcctggcc gccgccgcgg
    11281 cgcacgccct gtccacgtat ctcctctccc gcgtgggcga gcagatggtc ggcagggtcc
    11341 gcagccgctt catggcgcac tccctccggc taccgctgtc cgtcgtgcgg cgcgagggtc
    11401 agggcacgct cgccgcccgg ctcggcaccg acggcttgca gatgaaggcc gtcgtcgacg
    11461 tcggagtgct gcaactgccg atggcgatca tcacggtgac cggcaccgcc gtcatcatgg
    11521 ccgtcctcga ctgggtgctg ctgctctacc tggtggcgtc cttcgccctg tccgtgggcg
    11581 gcgtcgtcgt gatcatcaag gtgatgcgca agcgcttcat ggcgctccag atgagcgtgg
    11641 cgaagatgac ccaggtcttc atgaacgccc tggaggcgct gcccaccatc aaggcgtacc
    11701 gcgcggaaca gcgcacgtcc cgggagctcg ccgcgctcgc ccaggacacg gccgacctgg
    11761 gcgtgacgac cacccggctg gcgtccctgc tgttcccggt gatcaacctg ggccagcaga
    11821 tcgcgctggt gacggtcatc gtcgccggcg gcgtacggct caacagcggc ctgctcaccc
    11881 tgcccgacct cgccgccttc ctcctctaca tgctgcaact gacggcgccg ctgctgctgg
    11941 tcgccatggg agtgggcagc ctccaggcgg ggctcgcctc ccgggaccgg ttccgggcga
    12001 tcttcgccac ccccaccgag gagtccgcgg acgcggccgc ccccgcgccc cggaccgccc
    12061 cgtccgagga gacaccggcg gcagccgtcc ggttcgaggg cgtcaccttc tcctacgagt
    12121 cccaaccggc cctgcgcgcg gtcgacttca ccattccgcg ccgcggcatg accgcgctcg
    12181 tcggtatgtc cggcgcggga aagacgaccg tgctctcgct catcgagcgg ttcatcagcg
    12241 cggacagcgg caccgtccgg gtcctgggcg aggacgtcac ccgctggcgc gtcgccgacc
    12301 tgcgggccca tatggcctat gtggaccaga agttcacgct cctcagcgac accatccgcg
    12361 ccaacctcac cctcggcacg agcagtccgc cgcccgacga ccggctgatg gccgccctgg
    12421 ccgaggtcgg catggaagac gcggtacgcg ctctgcccgg cgggctcgac gcacggctgg
    12481 acgagggcac cgacatctcc ggcggccagc ggcagcgcct cgcgctggcc cgcgcgatcc
    12541 tcgccgaggg cgaactggta ctcctcgacg agcccagctc ccagctcgac agcgtcaacg
    12601 agatgctgct gcgcgactcc atccggcgca tggccgacga ccgcgccctg ctcgtcgtcg
    12661 cccaccggct gtccaccgtg caggacgccg accacatcat cgtcctcgac cgcggccagg
    12721 tggtggccga cggcacgcac cacgaactca tggccaggtc accggagtac agcctgctgg
    12781 tccgcggcca actgctcagc agcgtctaga ccgccccggc ccggacgccc cggccgaacg
    12841 gcgctcggca accgcacaac ggccgcgtgc gagacgcgag caagccgcac ggaagacgcg
    12901 agcacgccgc acgcgagccg cacggaagac gcacggaaga cgcacgcgag ccgcacgcaa
    12961 gacgcacgga agacgcgcga ggaaggagac accggtggag ctgtccgtca tcacccccgt
    13021 cgtgcccacc cggccggaac gcctcgtcag gatcgcggcc ctggccgagc ggacacgcag
    13081 cggacggctg tggtgcggcc agagcatgac gctcgaacag caccatctgt acgcgtacct
    13141 gaccggcctc ggcttccgta tcgaggccgg actcggcgtc tccctcatgc cgttccggca
    13201 ccccctccag ggcgcgctgg aggcccgctc gatcgccgcc accaccggcc ggccggtcat
    13261 cgccggattc ggcccgggcg cgaccgcgct ccaggcgtcg atgcacggcg agccgtacgc
    13321 cagaccgctg cgcgcggccc gcgagtacct caccgtcgtc cgcaccctgc tcgacggccg
    13381 cccctgccgc caggagggcg actacttctc cttcaccggc gagctgatgc cgatgcccac
    13441 cccgcgtatc gatgtcggcc tcggcgtgct gcgccccggt atggcccggc tggcgggcga
    13501 ggtggccgac gtcgccatca cctggctcgc cccggcgccg tacctccacg acgtggtgcg
    13561 gcccgcgctg gaggagggcg cgcagcgggc gggccggccg gtgccgaagc tggtggcggt
    13621 cgtgccgatg gcgctcgacc gcccggaccg cgaccccgcc gtcctcgccc gcacccccca
    13681 tctgcgtttc ccgcactacc aggacatgct gcgccgggcc ggtgtggacg tgaacggcga
    13741 ggacccggac gcgaccgcgg cggccctcgt ggacggcgat gtgttcctgg tgggcgatcc
    13801 ctcggcgctg gacaagaagc tcgacgcgca ccgcgcggcc ggcgtcgacg aactggtggt
    13861 gaacctcgcc ggtgtcgcga tgcacgaggg acccacggcg gccgccgcgg acctggagga
    13921 gatcctggcg ggggtggacc ggtgacggcg gacccggccg gtgtgccgga ggtggacacc
    13981 tccgtacgct cggtcttcgg cttctcacgg ctgctcgtcg tgggcaccgg ctccgtcagc
    14041 gtctccgaac tgcccttctg gatcggctgg ttgaggtcct cgttcagcga cctggagctg
    14101 cgggtggcgg tgacgcgcag cgccgagcgg ttcgtgaccc gtaccgcgct cgccctgcgc
    14161 gccgagcgcg aagtggtgcg cgacgcctgg ccggaggagg agaccggcgg gctgccgctg
    14221 cacgcggagc tggcggagtg ggcggaggcc gtcgtggtct accccgccac catgaacttc
    14281 ctggcccggc tggcactcgg gatggccgac acccccgtga tgatcgcctg ccagtgcacc
    14341 acagcgccga tcgcgctcgc gcccatgccg ccgcccggcg gcgcccggag cgccgcctac
    14401 acccggcacg tcgcggaact ggagtcccgg gacaacgtcg tggtggtccc ggcgcgcagc
    14461 gctgcccggc ccggacggcg gcaggacagc gccgtcatcc cgccgctgct ggacgtgctg
    14521 aaggccgtcg gcggcctgcg cgccgacgga ccgggcacgc cggacgaccg cggcgagcga
    14581 gacgaccaag gagcccgagg cgaccaagga gaccgcggcg accgcggcga ccgcggcgag
    14641 cggggcggcc gggacgagcg cggtgagcag ggggagcgga gcggcccggc cgcggacggg
    14701 ccgtactccc gggaggagcc accggccgca tgggcgcgcg tatgaccacg gagaccggcc
    14761 gcgccccggt gctggcgttc gcgacggggc tgctgcgcac caccgtgtac gagcaggacg
    14821 acggccgcta ccgctgggag cgcgcccggg gcgacgcggc gcccgccgcg ttccgctacc
    14881 cggacgagac actcctgccg gtcctgaccg ccgccgagtc cgccggcgcc cgcttcgtcc
    14941 tcgccgccga cggcaccgaa ccgcgccgct acaccgcccc cggctggcag tcgtgcgccc
    15001 accggctgct ggtgggcggc caccaggcgt gcgccgccgt caccggcccg ctcgccggcg
    15061 ccggcggact gctgcgcgcc gtgcacgacc agctgccccc gcccggcgcc gccccgccgc
    15121 ccggcctgct gcgcctgtcc gcctggctgg acggcaccgc cgagcggccc gacgcggcgc
    15181 gctccgccga gttcctgcgg ccgctgctcg gcgcgcccgg ctgggcacgg ctgcgcgcgt
    15241 ggtccgacga ggcgctccag gaccggtcgg cggcgctgca cggggcgccc ggcctgggcg
    15301 cgctcgtgcc gggcgagggc accggtaccg ggctgctcgt cggcgaggac gtggcggccg
    15361 gaccaccgct gtgggacctc ggctggatcg tcggcgaact gatggagttc cagtggcggt
    15421 tggccgccaa gggcggcaca caggtctggc acgagctgct gcggagcctg ctgcgcgcgt
    15481 acggcgtctc cgagaacacc gggctgcgcc gtatggccgt gctgcggatc gccctgcatc
    15541 tgcacgactt catcgcctat gtgggctggg accagcggga gttcgcccgc gccgccgcct
    15601 tcctggggca tctgatcaag gagagtcgcg agtgacgcgc acgaccgtgc ccgccgcaac
    15661 cgccgcgccc ggcagctcca ccgtcacccg cgcgaggctg ccgaacggcc tgcgggtggt
    15721 ggtggagacc gtccccggag cgccccgcgc ggcggtgagc gtccactacg gggtgggcta
    15781 ccgggcggag ccgcccggca gggccggctt cgcgcacctc ttcgagcacc tcatgacgca
    15841 gggcagcgag tccctgccgg ggcgcgccta catcgaccgg ctgctggccg cgggcggcaa
    15901 cggcaacgcc tcgacccacc aggactacac cgacttccac caggtcgtcc cgcacgagtg
    15961 gcttgagcgg gcgctgttct gcgaggccga ccgcatgcgc gcccccgtcc tcaccgagca
    16021 cgccctcgcc ggccaactcg cggcggtggc ctgggagatc aagggccgca tccacgaccg
    16081 gccgcacggc ggcctgccct ggcccctgct gcccggtgtg ctcttctccg ccttccccaa
    16141 cgcacacgac ggatacggcg atctgcgtga gctggccggg acgacggtgg ccgagtgcgc
    16201 cgcgttcttc gagcggcact acggccccgg caacgccgtg ctgaccgtcc tcgccccgca
    16261 acaccccgac gaggtgctgg acatggccgg acaccacttc gccggcatcg ccgcgcggcc
    16321 cgtccccgac cggccgtcgc tggcggaacc cgcggcgcac gaggaccgga tccgcacggt
    16381 gaccggcccg ggcagcggcg cgaccgccgt cgccgtcggc caccgcctgc ccgatcccgc
    16441 cgccgaactg ccgggctatc tggcccatct cgccctggcc gggctcgcgt cccggcggcc
    16501 ggtccacgtc cccggggcgc cgccggtgcc gctgcgcgcc cggtgcggct tcttcgcgcc
    16561 gctcgacgcg ctcgacccgg acgcgctcgt ctgcaccgcc accgtccccg gcgacgtgcc
    16621 gccccggacc gtcgccgagg ccgtccgcgc gagcctgcgg gaggccgccg ccgacccgcg
    16681 ccccgacgac gtcgccgctg tcggcgccgg atggcggcgc acgcacgacg acctcctcgc
    16741 ccgctgccgg gcccgcggca ggaccgagct gctgttcggc gacccgtcgc tggtggacga
    16801 ggtgccccgg ctgctggcac ggctcgggcc cgacgacgtc acggccgcgg cctcggggct
    16861 cgacggatcg ccgtgcgcgg tgctcgccgt cgtacccggc ggcggccggc cggccgccgc
    16921 gccgctcccc gacgggctgc tcggctccgg cccgcccgcg cccgatccgg cgcccgctcc
    16981 gctcgactcg gcgcccgccc ccgcctggcc tgcgctcggc acacgccacg cgccgtccgt
    17041 gcggggcctg cgggagacga cgctcggcaa cggcctgcgc gtgacggcgg tccgtgccgg
    17101 gcacgccccg ctcgtcgagg cccggctgcg ctttcccgac agcggcgccc gcgccgccga
    17161 cgaggccgta ctggagtcgg ccgccgccct gctgcgcgca cgctgcgccg gcggcccgtg
    17221 gtccgtccgc agcgacggga tccggttgac catgacgggc agcgcaccgg ccgaccggac
    17281 cgagcacctg ctcgcgcaac tccgcgccgt cctcgtcccc ccgctcacct ccccgctcgc
    17341 ctccccgccc gcgtcccccc gccgcccgct gcgggcgcgc acggagaacg acctggcctg
    17401 gcacgtcctc gccgggcgga cgcggggcga agcggcagcg gcgtgtgccg tcccggacgg
    17461 cgccaccctc gtggtggtcg gcgccgccgg gccggacgac gtggcctccg cggcctcccg
    17521 gctgctgggc ccgtggcagg ccggaccgcg ccggcggacc gcaccggaca ccgcaccgcg
    17581 ggcgggcctg cgcatcctgc cgcccgacgc gcacaccccg gtggcgttcc tcggcctgtg
    17641 cgcccccgac cccacgcccc acgccgcgcc cgggacgccc accgacgcca cccgcggcga
    17701 ggccgcgcgc ttcctcgcgg tcggcgtgct cggcggtcag cccggctccc gcttcgcctc
    17761 gctgagcggg gccgccggtg cgccgctcac cggggggttc gccctcgccg gccgtgacgt
    17821 cctcttcggc gccggccgcg tgctcgtctc cgccgggatg cctcccggca cggtgcgggc
    17881 cggagtggcc gccgtctgcg ggcagctgcg gctgttggcg gccgacccgc cgaccgcggc
    17941 ggaggtccgc cgcgtggccg agttcggcgc cgggcagctg agcggggtct tcgactccca
    18001 ggcggccctc gccgaccacc tggtgcgggc cggcgcgcag gggcagtccg cgcggacgct
    18061 gctggacctg ccgcgggccc tgcgcgagac cggtgtcgag gaggtggccg aggccgctcg
    18121 acggctgttc ggcgaggcgc ggttcacggg agtgctgcgc gccggcgccg aggaggcgga
    18181 gcaggcgagg caggcggcgg ccgccgtgtg cggagaggtg acggcatgac gggaaccgag
    18241 gtactgcgcg aggccaccgg cagccgcagg ccgcgcatcg acatcatctg cccgacctac
    18301 aaccgctcga cggcgatccg gccgacgctc accggcgtcc tggagcagag cgtcggcgac
    18361 tggcggctcc tcgtcgtgtc ggacgcctcc agcgacgaca ccgaggacgt ggtgctcggc
    18421 tgccgcgatc cccggatcgc cctgctgcgc agcgagcgcc acggccatcc cggcggtcca
    18481 cggaacgtgg gcctcgccca cgcccgcgcc ccgtacatcg cctacctcga ccacgacgac
    18541 ctatgggagc cgcaccatct gcgcacgctg ctggagcagt tggagcgcgg agccgagatc
    18601 gtggccaccg gcgccaccta catcgaccac gaggggcggg agaccggccg caccgagccc
    18661 gccgacatgg tctggcaccc ggatctacag gcggtctacg cgctgttcga gccggccagg
    18721 gtcggacacg tgcgcggcgt cgtcgagtcc gtcggcggct ggacgacgga caccgccggc
    18781 ttcgaggact gggacctgtg gtggcgcctg ggcgaggcgg gccacgcctt ccagccggtc
    18841 ctggagcgca ccgcggttat ctaccggggc agcgacaccc gtaccgaatc ggtacgcgcc
    18901 cgctacgcga tcccggtcgg ccgcaccgac agcgaggacg ccgcacgcgg ctgcctcgac
    18961 gcgctggccg acgacggcac ccgcgaccgg ctcgccgccc tgtacgcggc cgacttcgcc
    19021 gactggtggg acgccctggc gcgcgacgac cggttccgta cggcccccgg aacggcccgt
    19081 gccgaggtgc tcggcgcgct gcgcgagcgg tcggacgggg cgcggaccca tgtgttcaca
    19141 caactgcggc acgcgcgccg ccgcgacggc catctgctct acgacccggc ctggtgcacc
    19201 tcgaaggacc aggcggcacg gatgagcgcc gtcatgcggg accgggacgt gaggcagcgg
    19261 gagttcctgc acgggctgct cgcccggggc gcctccggcg gctgacgggc taccggggcc
    19321 gccagatcag cgtgaccacc cgtgccgcgg cagagatcgc ctccacggtc ggccggggga
    19381 agcggcgcgc ggagcggggc cgggcgcggc cgtgtgccgt gccgcttcgc cgtgcccggt
    19441 cggtgctgtg ggccatggac gtgccacctc cgagaagacg ccgccgggtc cggcgggacc
    19501 gtgcctgccc ccgaagcctc ccgccgcggc ggtcccgggg ggatacccga acgggcccgc
    19561 cggccgggca ccccggcgct gtcgatagca acctctagat ggaatgtagt aggtgtgcta
    19621 tctctagaag tagacctgag acgaggggga aggtgtcgta tggcggtgca gaacaacctt
    19681 cgacggccgg gtgagcaccc gcccgaagcg ccggagcgcg aaccggcggt cgacgtacgc
    19741 ggcctgcgga tgcgctacgg gacgcacgac gtcctcaacg gcgtggacct ccgggtcgag
    19801 cagggcgagg tgctggtgct cctcgggccc aacggcgcgg gcaagaccac caccgtcgag
    19861 atcctcgaag gcttccgcgg cagatcgtcc ggcgaggtgt ccgtgctggg cgtcgacccg
    19921 gaccggggca acgaggcgtg gcgggcccgc ctgggcgtgg tcctgcaatc ctggcgcgac
    19981 cacgcgaaat ggcgggtacg ggaactcctc gcgcacttcg ccgcccacta cgccccgtac
    20041 ggcacaccgg agcgcccccg cccccgcgac gtggacgaac tcctcgaaac cgtcgggctc
    20101 accgagcagg cggacgccaa ggtgggctcg ctctccggtg gccagcggcg gcgcatggac
    20161 gtcgccgtcg ggatcgtcgg ccgccccgag ctgctgttcc tcgacgaacc caccgcgggc
    20221 ttcgacccgg tggcgcggcg ggacttccac gcgctggtgc agcgcctcgc gggcgaggag
    20281 ggcaccacga tcctcctcac cacccacgac ctcgacgagg ccgagaagct ggccgaccgc
    20341 atcctgatcc tctccggcgg cacgatcgtc gccggcggca gccccgccgc actggccgcc
    20401 cagctggaga gcgacgccga ggtgcgctgg acccaccgcg gcgagcggca tgtgaccttc
    20461 accccggacg gcaccggctt cgcccggaag ctgttcgagc gtcacggcga ggagatcgag
    20521 gacctccagg tccgcaggcc cggcctggag gaggtctatc tggagatggt gcggctgcac
    20581 gaatccggcc gggccgaaga ggccgcgggc agcatccccc tgaggaggca gcagtgagcg
    20641 cggacacgcg tacggcccag accctccgcc tcggcgcgga gcgcgggtgg cgggagttca
    20701 gaggactgct cgccagcggc aacgaactct tcagcgccgt cgtcatgtcg ctggccttcg
    20761 tcctcgtcgt gttcttccag cggaacgaga ccctggagga caccgggatc agcacggcca
    20821 cggcggccct gccgggcatc gtggcgatga tgctcgtcta caacgggctc gtcggcaccg
    20881 ccacgtatct gacgacggaa cgcgaggacg gcacgctgct gcgcgccaag gcgctgcccg
    20941 gcggaatcgc ctcctatctg tggggcaaga cggtcttcat gctgctgaac acgctgctgt
    21001 ccgtcgtgct cgtcctcgtc gccggactgc tgctgttcga cggcgtcgcg gacggcctcg
    21061 ccgacggcgg cccgcagatg ctcggcatga tggtgctcgg cctcgccgcg tgcctgccca
    21121 tcggcgcgat cctcggcacc tggttcgaca atccgcgcac cgcgatcggc tctttgatga
    21181 tccccttcat ggggctgacg gtgatctccg gcgtgctcat gccggtgtcc tggatgccgg
    21241 actgggtgca gacgctggtg cagttcaccc cgctgtactg gctcggcctc ggcatgcggg
    21301 ccgccatgct gccggacacg atgctggccc tggagatcgg cgggagctgg cgggtgcccg
    21361 agaccctcgg agtcctcgcc ctgtgggccg tggcaggctt cgccctcgcg ctcgtcctgc
    21421 tgcggcggat gacgcgtacg gtcaacgggg ccaccctgga cgaatcgaga ctgaaggcga
    21481 tgcagcgtgt ctgacggtgc ggaatcaccg acgggaaaga aggtgcgcaa ggcgggcaag
    21541 gcgagcaaac cgggtcagcc gggccggggc gccgcgaccg gggacaagtc ctcggagcgc
    21601 atctacaaca gaatcgcgct catgcgcatc gaacggggca tctcccggcg gcagttggcc
    21661 gacgcgctcg atgtccacta ccagaccgtg ggctatctgg agcggggcga gtacagcccc
    21721 agcctgcatc tggcgctgcg gatcgccgcg tactacggca cctcggtgga gtcggtcttc
    21781 gcgctggagc cgttccccag aatcggaagt gaggagtgac gcgcgtgacg ccggagaacg
    21841 ccgtcggagg ccgggacgga gaacgggacg gccggcagga caggctgcgg gccaaggtcg
    21901 agtcggagaa ggtgcgcagg cggtggatgt cccggcgccg ccggcgtccg ctcgtcgtcg
    21961 ccgaggcggt gtccgccgtg ctcttcgccg gcggcatccg gctgctggcg ggcggggaga
    22021 accggctcgt cggcctgctc gtggtcgtcg tcaccggcgg gctgctcgcg gtggtgggca
    22081 cccagatcgg cctcgccagc cgcttccgct ccgactacca cgacctggac gaacgccagc
    22141 gcgccgagca ggcccgtgcc cggctgctgg gcgaccgtgt gaccaacgtg gccctcgccg
    22201 tcgccttcgt ggccgccctc ctgctgagcg gcctcaccga cgaggtggac atggccgccg
    22261 tacccccggc cgccttcctg ctgctggccc tgaacgtctt cttcccggcc gcctggctga
    22321 cctggaccca gccggccgag agcgacgacg agccggacga ggaggagttc tgagagggga
    22381 gccatcgagg cgggcggcca cggaagtgcc cgccccggcc cgggtgttcg cggacgaccc
    22441 cgccgccccg cgcggcgctc ccgttcaccc gggtcgctcc ggcgggtaga acagtcggag
    22501 gaactcctcc agcgccgcgt cgactccggc gcggtcgccg gtggcgagca gatcgagcag
    22561 caggccgcgg acggtggcga gtcccagtct cgcgcggttg cgggccgtgc cggcgtccgc
    22621 gcccgcggcg acctcggcgg ccacgagcgg ctccagccag tccgccacga tcccgtccag
    22681 gacccggacg gcctcggggc gcccccggag cgcgtatccg cagatctcga agaagagccg
    22741 ctcccgcccg gccagccgcg ggtcggacag ctcccgccag aggagccgcg cgacctcggc
    22801 gggggagcgg cccggttccg cgtgcagccg ggacagcagc tcgcgctggc gccgctccga
    22861 tcgccggacg acctcgacga gcagttgctc cctggtgccg aagtagtgga tgagcatccg
    22921 gtggctgacg ccgatcgcgg caccgagacg gcgcaggctc agatccccga tgccgtgcgc
    22981 cgtgacatgg tcgacggccg cttccaccag ttccgcgcgt cggttcccgt ccgtaccgcg
    23041 cgcggtcgcg ccggaaggcc gcgggttctc cggattcacc accgagggag cgtaccaagt
    23101 ggtacacgac gtctgtaccg tctggtacat gagacctgtc accgtagcga tcgatgttcc
    23161 gcacacgccc gctcagatct acgacttcct cgatgtcatg gcacaccacg agcgcttcac
    23221 cgaccactac ctgaccaact ggcgctacag cggccccggc cggggcacgg gagcgtgcgc
    23281 cacggtcacc gccgcactgg gcggaaccag gaccgacgtc accatcgagg tcgtcgaggc
    23341 cgaggcgccc cggcgcatcg tcgagcggaa cgtcagcgcc ggcggccggc gccgggcgca
    23401 cggcacctac accatcgaac cgctggagac cgggcggagc cgcgtctcgt tcacctactc
    23461 ctggctgcgc gccccgctcg ccgaccggct gctggcgccg ttcgtccggg gtgcgatgcg
    23521 gaacgccaac cgcacggtca tgcgacgtct ggccgaggag ctggcccgcc acgcggccgg
    23581 tggcgggagc tgacaccgcc cggcggggaa gcgggcccat ggcctgttac agagtgcgga
    23641 caagaacccg tgaacaaacc cgtgccgctt gtcatcacag tgaacgtacc gggcggagaa
    23701 aacgccccgg gaccgacacc gcacgacgta cgggatgaca tctcgcctca tcgctgtggt
    23761 ggcgggatgt cagctgtcgg tcgggcatgt gcctttttga cgagtgggag gggatatgca
    23821 catctctttc ttgatcttca gtgcgtacgg gatgggggga accgtccgta ccaccttcaa
    23881 tctggcgcag gcgctggccg agcagcacga ggtggaggtc gtgtccgtct tccggtaccg
    23941 ggacaagccg ttcttcgaac cgggcaacgg tgtgcggctg cggtcgctgg tcgacatgcg
    24001 gcggcacaga ccgggctacc agggcgacga tcccgaacac gccctccccg ccaccgtctt
    24061 ccccgcggcc gacggcaact acaagcagca cagcgcgctg acggaccgcc tgataggtga
    24121 acacctggcc actaccgagg ccgacgtcgt catcggcacc cggcccggac tcaatgtgca
    24181 cgtcgcccgg cagacgcgcc gcggccccgt gcgcctgggc caggaacacc tcacgctggc
    24241 cacccactcc gcacggctga agcgggtgct gcgcagcaac tacccccggc tggacgccgt
    24301 caccacggtg accgaggccg acgcccggga ctaccgcaag cacatgtggc tgcccggtgt
    24361 gcacgtccag tccctgccca acagcgtgcc cgagccggcc gtcagccccg ccgacggcag
    24421 cggcaaatgg gtcgtcgccg ccggccggct cgccccggcc aagcgctacg acgtgctcgt
    24481 acgcgccttc gccgaggtcg tcagcgagcg ccccgactgg gggctgcgca tctacggcca
    24541 cggccgtgag gaaggcaagc tgcgcaagct catcgacgaa ctgggcctct acaaccatgt
    24601 gttcctgatg ggctcggcca accccatcga ggcggagtgg gtgaagggcg cgatctgcgc
    24661 ggtcacctcc agcctcgaat ccttcgggat gaccatcgtc gaggccatgc ggtgcgggct
    24721 cccggtcgtg gccaccgact gcccgcacgg gcctaaggag atcatccgcg acggcgagga
    24781 cggtctcctg gtgcccaccg gcgatgtgcg cgccatctcc ggtgcgctgc tgcgcctcat
    24841 cgacgacgag ggcctccgga cgcggatggg taaggccgcg ctcaccgcgt cggcgcggtt
    24901 cgaccccgcg gaggtggccg cccgctacga ggaactgctg acctcgctgg tgaaccaccg
    24961 gcccggcgcg gtccaccggg cgcgcggcaa tctgctcggc ggagcgtacg cggccaagga
    25021 caggatccgg cagggagtca gccacgcgct ggaaggagca cggtcatgat tcaggaacac
    25081 ctcggcacac cgccccgcgc cgtaccggcg ccggccccgc accgcgccgg cgctcccgcc
    25141 actcgccgca tcgaccacgc ccgcgccgac tgcacggccg acagccgcgg cgggctcgcc
    25201 ttcgcggtgc ggctcttcga cgagaccgcg gcggacgtcc cggcccacga ggcgccggag
    25261 tccgcggccg tccttctgcg cctgcgacag cagcacggcc cggacgccac cgtccggctg
    25321 ccgctcgccc gtgcggaggc gggcgagacg ctccacgcga cgctggccgg caccgcgctg
    25381 ctgcgcgaag ggcgctggga cgcccatctc gacctgggcg acgaggtgtt gctgcgcctg
    25441 ctgcccggca tgaacgatct gcgctccctc gccgccggtg cgaccttccc ggcacacgcc
    25501 tggctcggcg tgcggatccc ctacaccacc aagcacggca atctctccgt ccgcgcctgg
    25561 ctgcgccgcc cgcacgcgga ggcgggcgcg ctgcacctgg cggacggcgt catggagctg
    25621 cacggcacct tccacggtgt gcgcctcgac accaccgcac acctggaggc gcgcccccgc
    25681 gacgccgcgg ccgcacccgt gcgcgtcccc gtgcgcccgg acaccgagga acacccagga
    25741 caggcgaccg cacccggcga cggccccgaa ggacggcacc cggtacgcgg cttcaccacc
    25801 gaactgcccc tggacgccct gctgtccttc ggcggcgtat gggacctgtg gctgcgcccc
    25861 gccgagaacg aggagccggt acgcgtcgcc cgcatactcg acgacgtcct gaacaagaag
    25921 cgggtcttca gctacccggc ccagcaggtg acggacggcg acggcaccgc ccacccggtg
    25981 cggccgtact acacggtcaa caacaatctg tcggtggagg tggggtagcg gggctgtcgc
    26041 accgggggcc ccttcggacg gtacgggcgg gccctcgtac acccttcgac ggtcgcctcc
    26101 ggcgtcgcag gatcgccccg atcaactgcg gggcaggggg ctgaggaacg ggcgagtgca
    26161 cggacgccgt caggcacccg tgcacgtggg tcacgccgcg gccgggctcc cgccctggga
    26221 tgccaggaag acgtacggga tgcacaccat cgctgccagc aggacggtcg ggacgatacg
    26281 gcgtatgcgc atggcgctgc tcctcgaggg ttgagtgtcg gaactcaccc atgatcaccc
    26341 gcaggtgctg ctgtgtccag cggggtcata gtctcaactg cggctcagag gagctgagtt
    26401 gtgaaggttc agtcgtggta ctagcgttcc ggatggggag gttgctggcc cctgtggtgt
    26461 gcctgggaca gagcgcggag ggccatggcc tcctcggtac gagccgcgat ctgtcggctg
    26521 agggcgaggc ttgcctccag atgggcacgg gcctggggga gccgtccggt tgcggtctcc
    26581 gcctcaccga gggctcggag cgcctggcac tgttccagta cggcgccgat ggagcgtgag
    26641 atggccaaag ccgccgtgtg atgaggcaga gctcgttcgc tgtctcccat cgcgtcaaga
    26701 gcccggccga tccccgtgcg ggcgatggcc tcactgcgcc gatctccgct ggagtgcacg
    26761 gcgggcaggg ctttgccgta cagggccagg gcgtcgccgg gccgaccgcg ggcccggagc
    26821 gtatccgcca gattcatctg gaggattgcg tactgtgctg ttccaccact tcgggggtcg
    26881 gagatcttga tggctctttg ataggcgccg atggcgttgt ccaggtcgcc cgattcccgg
    26941 tacagctcgg cgaggttgtg gagagcgatg aattctccac gcgaatcttc cgcgtcgtgg
    27001 aagcgggcac gtccttcgag gaagtatttg agagcgtctt tgtggcgctc cagccgaagg
    27061 gagagcattc ccatcacgtt gaagcttcgg ccctgctgaa gccggtccga ggtggacagg
    27121 cggatgcgca gggcacgttg ctggagatcg agtgcctcgg catgctgggc tgtgtgccag
    27181 cgaatgatgg acatctgatg gagagcttcg gcccggagtt cttcgtcctc gttctgggac
    27241 agatgcaggg ccttttgcgc actgtggaag gcttcgtcgt actttcctgc tcccgcgcag
    27301 gcagtgccga gatcgatcaa cgctcgtccg tgcgccttgc tttgccccgt gccttcccaa
    27361 tgggccgcag ctgtacgaag cagtgggacc gcggtgttga ggtagccttc gacgttcagg
    27421 aatcctgcca ggacatgggc cgaaatcgcg agctcgtgcg gtgcgccgtg gacacggaca
    27481 cgctccagaa tggccagcag gttggggcct tcggcggtga accactgctg ggcttcgtcg
    27541 cgttgccaca tgcgaccgcc ggtcgtgccg gcggccggtt ccatgcgcag ccggtgcggg
    27601 taggcacatc ggtccgcctg gtcggcggtg cgcaggtagt agcggatcaa tcggccgagt
    27661 gccgcctcgt tgtctgcggc ggggctgctc gcagcgagag ccgaggcgta ctcgcgtagc
    27721 agatcgtgct gacggtagcg gtgcggggcg ggctccgaga gcagatggca ggcgagcagt
    27781 tcctcgagca ccagctccgt ctcgtgatgg ggcaggcccg agagcgcagc cacagcggcg
    27841 gtgccgaact cggcgccggg atgcagaccg agaaggcgga agaccctctg ctgcgtcggt
    27901 gtgagggcct ggtaggacac ttcgaaggcc tgcgctgccg cgtggtggga atcgcgcagc
    27961 tccggcagcc gggctggtgc ctgctcgaag cgctgaatca ggtcggcgac gccccacgcc
    28021 ggtctggaga gcagtcgtcg ggtggcaagt gccagtgcga gaggcaggtc cccgcacagt
    28081 cgcgcgagtg tgtcggcttg cgtggccgtg ggcgcgcgtt ccttcagagc gcgtcgtagg
    28141 aaggcgaccg agtcggtgcg gggcagcacg tccagcgcga cgtgtcgggc tcctggaagg
    28201 gcgtcgagcc ggcgtctgct cgtgatgagc agcagggcgg gggacgtgcc ggggaggagc
    28261 ggcaggacct ggtcgatgct ggaggcatcg tccagtacgg ccacgattct gcggtcgcgg
    28321 atcgcgctgc gccatcgtct ggcgagttcg ccgggttcct gggggagccc ggtcggcgcc
    28381 ccgtccagga cgcgcaacag ctctctgagg acctcggtga cggtcatggg ggattgctgc
    28441 ggtacatggc cacgcagatt gacgaagagc tgaccgtcgg ggaaccggtc ccgcatccgg
    28501 tgcgcagcgt gcacggcgag ggtgctctta cccgagccgg gcattccggt gatcactgcg
    28561 gcgagcgcgg atgcctcccg tgtgtccgct gcatcggcca actgctccag ttccccctct
    28621 cttcccacgt aggggacttc ggctggcagc gtgtccggcg gcacggtgac gctgtggtga
    28681 cggggggacg gcatgggtgg tgagggaagc agcgtacggg cgggcgtgcc ggccaggatg
    28741 ccgtggtgaa cgcgccgaag ttcttcaccc ggctcggttc cggaagtccg gcgcagctga
    28801 cgcgctgtcc gctgcagcaa ggcagccgcc tcgtcggtgc gaccgctccc gtgcagcgcc
    28861 agggccagcc gcccggcgaa cgactgcttt gtcgtgtgca gcggagccag cgggcgaagg
    28921 tccgcaacgg cctccgcgta gtgaccgctc cgcatcgtga tgtccgcctg cagcaaggag
    28981 accgccaggc gcttctcctc catgacaccg cgtatgtggt cggcccaagc gccgggcaga
    29041 ccggccagtg gttcgcccac ccacagggag gacgctgtct tcagcgcacc gagcgcctcc
    29101 ctgtccccgg cggcgtcagc ccattcgcgt gcctggtcga gcagcgccag atagcgccgc
    29161 agatccaccg catccgggtc cgcccggagc gtgtaggcgt gcgttgtgct gatcactgcg
    29221 gcagcgcctt cgtggtgatg tgcggacagc gccttgcgta tgcgggagat gtgcgggtac
    29281 agggcttcgc gtggtttggc gggagtgaga tcgtcccaaa ggcgccgtac aagcgtgtcc
    29341 acactcaccg tccggtcggc gtcccaggcc agcgcggcga gcgccaagcg ctctttgggc
    29401 gttcccagtg ggatctgctc tcccccgacc tgcaatgaga ccgcgccgaa cagctgtatg
    29461 cggagttcca ccagcgacct cccgccggta cgcacatccg gttcggagag gatgtcacga
    29521 gtgtattctc atggccatgt cacagtgggg agcggctgaa agactacgcc cgtccaacag
    29581 tcgggtgatc gtggtgtgtt ggagcgggta agggactgat cgggaaggtc tcagcagtat
    29641 gtgcccggtc cggcatggca ggaagatccg gcaggggaga gatcgccgtg cacgaagcag
    29701 atatggctgc ggctctgtta tcggccatga tttctcatcg acccctccac gtgtctccgc
//
