BGC0002135 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002135 (Xenorhabdus bovienii SS-2004)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	11,508	bovienimide A	NRPS:Type I	100%

BGC0002135 - Region 1 - NRPS

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Location: 1 - 11,508 nt. (total: 11,508 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,509
Label		BGC0002135

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135	1.00	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.35	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001135	0.32	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128	0.32	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.31	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833	0.30	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132	0.30	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758	0.30	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844	0.29	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002437	0.28	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135	1.00	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.68	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001135	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128	0.65	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.64	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833	0.64	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132	0.64	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758	0.63	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844	0.63	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002437	0.62	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 11508:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Ala - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XBJ1_RS10015

Search NORINE for peptide: strict or relaxed

AMP-binding (490..884): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWLIGAVCK
Nearest Stachelhaus code(s):: Leu DAWLLGAVCK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1571..1968): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNNALTYK
Nearest Stachelhaus code(s):: Ala DLYNNALTYK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2638..3052): X

nrpys: Orn, Lys, Arg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DISNIGAITK
Nearest Stachelhaus code(s):: Hpg DIWHVGAITK (44% 8Å match)
Stachelhaus code match:: 70% (weak)