BGC0002136: janustatin A biosynthetic gene cluster from Gynuella sunshinyii YC6258
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 5,869,722 - 5,941,646 nt. (total: 71,925 nt).
This entry is originally from NCBI GenBank NZ_CP007142.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002136
Short description janustatin A biosynthetic gene cluster from Gynuella sunshinyii YC6258
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (None)
  • Polyketide (Trans-AT type I, Other)
Loci NCBI GenBank: NZ_CP007142.1
Compounds
  • janustatin A
  • janustatin A'
  • janustatin B
  • janustatin C
Species Gynuella sunshinyii YC6258 [taxonomy]
References
Chemical products information
janustatin A
Copy SMILES
C25H37N1O6
janustatin A'
Copy SMILES
C25H37N1O6
janustatin B
Copy SMILES
C25H39N1O5
janustatin C
Copy SMILES
C25H39N1O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • YC6258_RS24365
  • WP_044619189.1
 5869722 - 5870321 (-) TetR/AcrR family transcriptional regulator
copy AA seq
copy Nt seq
  • YC6258_RS24370
  • WP_044619190.1
 5870486 - 5872549 (+) VIT and VWA domain-containing protein
copy AA seq
copy Nt seq
  • YC6258_RS24375
  • WP_044619191.1
 5872833 - 5873399 (-) PIN domain-containing protein
copy AA seq
copy Nt seq
  • YC6258_RS24380
  • WP_044619192.1
 5873406 - 5873858 (-) excisionase family DNA-binding protein
copy AA seq
copy Nt seq
  • YC6258_RS24385
  • WP_211264582.1
 5874327 - 5875361 (-) endonuclease NucS
copy AA seq
copy Nt seq
  • YC6258_RS24390
  • WP_044619193.1
 5875873 - 5876208 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24395
  • WP_044619194.1
 5876289 - 5876621 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24400
  • WP_044619195.1
 5876707 - 5877045 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24405
  • WP_052830551.1
 5877235 - 5878032 (+) DsbA family protein
copy AA seq
copy Nt seq
  • YC6258_RS24410
  • WP_044619196.1
 5878034 - 5878303 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24415
  • WP_044619197.1
 5878307 - 5880370 (+) thioredoxin family protein
copy AA seq
copy Nt seq
  • YC6258_RS24420
  • WP_052830552.1
 5880382 - 5880780 (+) cytochrome c
copy AA seq
copy Nt seq
  • YC6258_RS24425
  • WP_052830553.1
 5880816 - 5882171 (+) multicopper oxidase family protein
copy AA seq
copy Nt seq
  • YC6258_RS24430
  • WP_044619198.1
 5882234 - 5882548 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS29995
  • WP_144407739.1
 5882769 - 5883002 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24435
  • WP_044619199.1
 5882999 - 5883199 (+) ribbon-helix-helix protein, CopG family
copy AA seq
copy Nt seq
  • YC6258_RS24440
  • WP_211264583.1
 5883289 - 5884803 (+) DNA cytosine methyltransferase
copy AA seq
copy Nt seq
  • YC6258_RS24445
  • WP_044619200.1
 5884772 - 5886445 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24450
  • WP_044619201.1
 5886454 - 5888124 (+) DUF2357 domain-containing protein
copy AA seq
copy Nt seq
  • YC6258_RS24455
  • WP_044619202.1
 5888183 - 5888608 (+) DNA mismatch endonuclease Vsr
copy AA seq
copy Nt seq
  • YC6258_RS24460
  • WP_052830554.1
 5889233 - 5894203 (-) non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • YC6258_RS30000
  • WP_044619203.1
 5894200 - 5921646 (-) trans-acyltransferase polyketide synthase
  • Mutation phenotype: knock-out abolishes polyketide production
copy AA seq
copy Nt seq
  • YC6258_RS24470
  • WP_044619204.1
 5921724 - 5922122 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24475
  • WP_044619205.1
 5922208 - 5923602 (-) enoyl reductase
copy AA seq
copy Nt seq
  • YC6258_RS24480
  • WP_052830555.1
 5923595 - 5924527 (-) sterol desaturase family protein
copy AA seq
copy Nt seq
  • YC6258_RS24485
  • WP_052830556.1
 5925525 - 5926256 (+) sterol desaturase family protein
copy AA seq
copy Nt seq
  • YC6258_RS24490
  • WP_044619206.1
 5926550 - 5927104 (-) GNAT family N-acetyltransferase
copy AA seq
copy Nt seq
  • YC6258_RS24495
  • WP_044619207.1
 5927848 - 5928141 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24500
  • WP_044619208.1
 5928216 - 5929184 (-) helix-turn-helix domain-containing protein
copy AA seq
copy Nt seq
  • YC6258_RS24505
  • WP_044619209.1
 5929300 - 5929587 (-) DUF6150 family protein
copy AA seq
copy Nt seq
  • YC6258_RS24510
  • WP_044619210.1
 5929650 - 5930075 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24515
  • WP_144407741.1
 5930856 - 5931158 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS30435
  • WP_169749023.1
 5931783 - 5931956 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24525
  • WP_044619213.1
 5932019 - 5932444 (+) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24530
  • WP_044620402.1
 5932698 - 5933330 (-) class I SAM-dependent methyltransferase
copy AA seq
copy Nt seq
  • YC6258_RS24535
  • WP_044619214.1
 5933379 - 5933933 (-) GNAT family N-acetyltransferase
copy AA seq
copy Nt seq
  • YC6258_RS24540
  • WP_044619215.1
 5934029 - 5934538 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24545
  • WP_044619216.1
 5934610 - 5934975 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24550
  • WP_044619217.1
 5935079 - 5935369 (-) DUF3144 domain-containing protein
copy AA seq
copy Nt seq
  • YC6258_RS24555
  • WP_044619218.1
 5935552 - 5936628 (-) 3'-5' exonuclease
copy AA seq
copy Nt seq
  • YC6258_RS30745
  • WP_211264584.1
 5936972 - 5937265 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS30750
  • WP_211264585.1
 5937342 - 5937773 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24565
  • WP_044619219.1
 5937915 - 5938667 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24575
  • WP_044619221.1
 5939145 - 5939417 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24580
  • WP_044619222.1
 5939506 - 5940075 (-) hypothetical protein
copy AA seq
copy Nt seq
  • YC6258_RS24585
  • WP_044619223.1
 5940163 - 5940858 (-) hypothetical protein
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Trans-AT type I/Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Unknown
Polyketide-synthases
Genes Properties Modules
YC6258_RS30000 Synthase subclass:
Trans-acyltansferases: YC6258_RS30000
Module 1
Genes: YC6258_RS30000
Core domains: Thiolation (ACP/PCP), Ketosynthase
Scaffold-modifying domains: Methylation, GNAT
Module 2
Genes: YC6258_RS30000
Core domains: Thiolation (ACP/PCP), Thiolation (ACP/PCP), Ketosynthase
Scaffold-modifying domains: Methylation
Module 3
Genes: YC6258_RS30000
Core domains: Dehydratase, Thiolation (ACP/PCP), Ketosynthase
Module 4
Genes: YC6258_RS30000
Core domains: Ketoreductase, Thiolation (ACP/PCP), Ketosynthase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 5
Genes: YC6258_RS30000
Core domains: Thiolation (ACP/PCP), Ketosynthase
Scaffold-modifying domains: Methylation
Non-canonical activity:
  • Non-elongating
Evidence for non-canonical activity:
Module 6
Genes: YC6258_RS30000
Core domains: Thiolation (ACP/PCP), Thiolation (ACP/PCP), Ketosynthase
Scaffold-modifying domains: Methylation
Module 7
Genes: YC6258_RS30000
Core domains: Ketoreductase, Thiolation (ACP/PCP), Ketosynthase
KR-domain stereochemistry: L-OH
NRP-specific information
Subclass None
Cyclic? no
Release type
  • None
NRP-synthases
Gene Modules
YC6258_RS24460
Module 8
Condensation domain type: DCL
Module 9
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Entry added
  • Fix trans AT ID
  • Set status to pending, could not find a corresponding publication
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.