BGC0002136: janustatin A biosynthetic gene cluster from Gynuella sunshinyii YC6258
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Location: 5,869,722 - 5,941,646 nt. (total: 71,925 nt).
This entry is originally from NCBI GenBank NZ_CP007142.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002136
Short description janustatin A biosynthetic gene cluster from Gynuella sunshinyii YC6258
Status Quality: questionable
The quality level of this entry.

Status: pending
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
NZ_CP007142.1
5869722 - 5941646
via Knock-out studies
Compounds
  • janustatin A
  • janustatin A'
  • janustatin B
  • janustatin C
Species Gynuella sunshinyii YC6258 [taxonomy]
References
Chemical products information
janustatin A Evidence: NMR, Mass spectrometry, Total synthesis
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C25H37N1O6
janustatin A' Evidence: NMR, Mass spectrometry
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C25H37N1O6
janustatin B Evidence: NMR, Mass spectrometry
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C25H39N1O5
janustatin C Evidence: NMR, Mass spectrometry
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C25H39N1O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • YC6258_RS24365
  • WP_044619189.1
 5869722 - 5870321 (-) TetR/AcrR family transcriptional regulator
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    • YC6258_RS24370
    • WP_044619190.1
    		 5870486 - 5872549 (+) VIT and VWA domain-containing protein
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      • YC6258_RS24375
      • WP_044619191.1
      		 5872833 - 5873399 (-) PIN domain-containing protein
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        • YC6258_RS24380
        • WP_044619192.1
        		 5873406 - 5873858 (-) excisionase family DNA-binding protein
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          • YC6258_RS24385
          • WP_211264582.1
          		 5874327 - 5875361 (-) endonuclease NucS
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            • YC6258_RS24390
            • WP_044619193.1
            		 5875873 - 5876208 (+) hypothetical protein
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              • YC6258_RS24395
              • WP_044619194.1
              		 5876289 - 5876621 (+) hypothetical protein
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                • YC6258_RS24400
                • WP_044619195.1
                		 5876707 - 5877045 (+) hypothetical protein
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                  • YC6258_RS24405
                  • WP_052830551.1
                  		 5877235 - 5878032 (+) DsbA family protein
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                    • YC6258_RS24410
                    • WP_044619196.1
                    		 5878034 - 5878303 (+) hypothetical protein
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                      • YC6258_RS24415
                      • WP_044619197.1
                      		 5878307 - 5880370 (+) protein-disulfide reductase DsbD family protein
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                        • YC6258_RS24420
                        • WP_052830552.1
                        		 5880382 - 5880780 (+) c-type cytochrome
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                          • YC6258_RS24425
                          • WP_052830553.1
                          		 5880816 - 5882171 (+) multicopper oxidase family protein
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                            • YC6258_RS24430
                            • WP_044619198.1
                            		 5882234 - 5882548 (-) hypothetical protein
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                              • YC6258_RS29995
                              • WP_144407739.1
                              		 5882769 - 5883002 (+) hypothetical protein
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                                • YC6258_RS24435
                                • WP_044619199.1
                                		 5882999 - 5883199 (+) ribbon-helix-helix protein, CopG family
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                                  • YC6258_RS24440
                                  • WP_211264583.1
                                  		 5883289 - 5884803 (+) DNA cytosine methyltransferase
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                                    • YC6258_RS24445
                                    • WP_044619200.1
                                    		 5884772 - 5886445 (+) hypothetical protein
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                                      • YC6258_RS24450
                                      • WP_044619201.1
                                      		 5886454 - 5888124 (+) DUF2357 domain-containing protein
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                                        • YC6258_RS24455
                                        • WP_082070878.1
                                        		 5888108 - 5888608 (+) very short patch repair endonuclease
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                                          • YC6258_RS24460
                                          • WP_052830554.1
                                          		 5889233 - 5894203 (-) non-ribosomal peptide synthetase
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                                            • YC6258_RS30000
                                            • WP_044619203.1
                                            		 5894200 - 5921646 (-) trans-acyltransferase polyketide synthase
                                            • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f816fc91f10>
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                                            • YC6258_RS24470
                                            • WP_044619204.1
                                            		 5921724 - 5922122 (-) hypothetical protein
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                                              • YC6258_RS24475
                                              • WP_044619205.1
                                              		 5922208 - 5923602 (-) enoyl reductase
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                                                • YC6258_RS24480
                                                • WP_052830555.1
                                                		 5923595 - 5924527 (-) sterol desaturase family protein
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                                                  • YC6258_RS24485
                                                  • WP_052830556.1
                                                  		 5925525 - 5926256 (+) sterol desaturase family protein
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                                                    • YC6258_RS24490
                                                    • WP_044619206.1
                                                    		 5926550 - 5927104 (-) GNAT family N-acetyltransferase
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                                                      • YC6258_RS24495
                                                      • WP_044619207.1
                                                      		 5927848 - 5928141 (+) hypothetical protein
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                                                        • YC6258_RS24500
                                                        • WP_044619208.1
                                                        		 5928216 - 5929184 (-) helix-turn-helix domain-containing protein
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                                                          • YC6258_RS24505
                                                          • WP_044619209.1
                                                          		 5929300 - 5929587 (-) DUF6150 family protein
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                                                            • YC6258_RS24510
                                                            • WP_044619210.1
                                                            		 5929650 - 5930075 (+) hypothetical protein
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                                                              • YC6258_RS24515
                                                              • WP_144407741.1
                                                              		 5930856 - 5931158 (-) hypothetical protein
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                                                                • YC6258_RS30435
                                                                • WP_169749023.1
                                                                		 5931783 - 5931956 (-) hypothetical protein
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                                                                  • YC6258_RS24525
                                                                  • WP_044619213.1
                                                                  		 5932019 - 5932444 (+) hypothetical protein
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                                                                    • YC6258_RS24530
                                                                    • WP_044620402.1
                                                                    		 5932698 - 5933330 (-) class I SAM-dependent methyltransferase
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                                                                      • YC6258_RS24535
                                                                      • WP_044619214.1
                                                                      		 5933379 - 5933933 (-) GNAT family protein
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                                                                        • YC6258_RS24540
                                                                        • WP_044619215.1
                                                                        		 5934029 - 5934538 (-) hypothetical protein
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                                                                          • YC6258_RS24545
                                                                          • WP_044619216.1
                                                                          		 5934610 - 5934975 (-) hypothetical protein
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                                                                            • YC6258_RS24550
                                                                            • WP_044619217.1
                                                                            		 5935079 - 5935369 (-) DUF3144 domain-containing protein
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                                                                              • YC6258_RS24555
                                                                              • WP_044619218.1
                                                                              		 5935552 - 5936628 (-) 3'-5' exonuclease
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                                                                                • YC6258_RS30745
                                                                                • WP_211264584.1
                                                                                		 5936972 - 5937265 (-) hypothetical protein
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                                                                                  • YC6258_RS30750
                                                                                  • WP_211264585.1
                                                                                  		 5937342 - 5937773 (-) hypothetical protein
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                                                                                    • YC6258_RS24565
                                                                                    • WP_044619219.1
                                                                                    		 5937915 - 5938667 (-) hypothetical protein
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                                                                                      • YC6258_RS24575
                                                                                      • WP_044619221.1
                                                                                      		 5939145 - 5939417 (-) hypothetical protein
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                                                                                        • YC6258_RS24580
                                                                                        • WP_044619222.1
                                                                                        		 5939506 - 5940075 (-) hypothetical protein
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                                                                                          • YC6258_RS24585
                                                                                          • WP_044619223.1
                                                                                          		 5940163 - 5940858 (-) hypothetical protein
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                                                                                            Biosynthesis information

                                                                                            Biosynthetic modules

                                                                                            Name
                                                                                            1
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, methyltransferase, other (GNAT), carrier (ACP)
                                                                                            Name
                                                                                            2
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, methyltransferase, carrier (ACP), carrier (ACP)
                                                                                            Name
                                                                                            3
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, dehydratase, carrier (ACP)
                                                                                            Name
                                                                                            4
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                                                                                            Name
                                                                                            5
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, methyltransferase, carrier (ACP)
                                                                                            Name
                                                                                            6
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, methyltransferase, carrier (ACP), carrier (ACP)
                                                                                            Name
                                                                                            7
                                                                                            Type
                                                                                            pks-trans-at
                                                                                            Genes
                                                                                            YC6258_RS30000
                                                                                            Substrates
                                                                                            Integrated Monomers
                                                                                            Domains
                                                                                            ketosynthase, ketoreductase, carrier (ACP)
                                                                                            Annotation changelog

                                                                                            Entry version: 2

                                                                                            Date
                                                                                            Changes
                                                                                            Submitters
                                                                                            Reviewers
                                                                                            2022-10-07
                                                                                            Update chemical activity to schema version 2.11
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                            Entry version: 1

                                                                                            Date
                                                                                            Changes
                                                                                            Submitters
                                                                                            Reviewers
                                                                                            2022-09-15
                                                                                            Entry added
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            2022-09-15
                                                                                            Fix trans AT ID
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            2022-09-15
                                                                                            Set status to pending, could not find a corresponding publication
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            Detailed domain annotation
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