LOCUS       BGC0002139             22912 bp    DNA     linear   PLN 07-JAN-2021
DEFINITION  Aspergillus burnettii strain FRR 5400 scaffold_211, whole genome
            shotgun sequence.
ACCESSION   BGC0002139
VERSION     BGC0002139
KEYWORDS    .
SOURCE      Aspergillus burnettii
  ORGANISM  Aspergillus burnettii
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     Annotated using funannotate v1.5.2-3129958
            In Jan 2021 annotation was updated and SPNV01000328 sequence was
            updated.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:01:06
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22912
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[487:8476]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      488..8476
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..22912
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..22912
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002139"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22912
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(488..8476)
                     /locus_tag="ETB97_004590"
     mRNA            complement(join(488..999,1055..1779,1839..7097,7151..7438,
                     7503..8476))
                     /locus_tag="ETB97_004590"
                     /product="hypothetical protein"
     CDS             complement(join(488..999,1055..1779,1839..7097,7151..7438,
                     7503..8476))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (8-439). E-value:
                     7e-172. Score: 563.9. Matches aSDomain:
                     nrpspksdomains_ETB97_004590_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (552-869). E-value: 4.9e-90.
                     Score: 293.7. Matches aSDomain:
                     nrpspksdomains_ETB97_004590_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (941-1121). E-value: 9.3e-20.
                     Score: 63.5. Matches aSDomain:
                     nrpspksdomains_ETB97_004590_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1383-1589). E-value: 1.7e-74.
                     Score: 242.3. Matches aSDomain:
                     nrpspksdomains_ETB97_004590_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2118-2293). E-value: 1.9e-42.
                     Score: 137.1. Matches aSDomain:
                     nrpspksdomains_ETB97_004590_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2411-2486). E-value: 3.9e-12.
                     Score: 38.2. Matches aSDomain:
                     nrpspksdomains_ETB97_004590_PKS_PP.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR013217"
                     /db_xref="InterPro:IPR013968"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="InterPro:IPR020806"
                     /db_xref="InterPro:IPR020807"
                     /db_xref="InterPro:IPR020841"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR032821"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="InterPro:IPR036736"
                     /db_xref="PFAM:PF00106"
                     /db_xref="PFAM:PF00109"
                     /db_xref="PFAM:PF00550"
                     /db_xref="PFAM:PF00698"
                     /db_xref="PFAM:PF02801"
                     /db_xref="PFAM:PF08241"
                     /db_xref="PFAM:PF08242"
                     /db_xref="PFAM:PF08659"
                     /db_xref="PFAM:PF13489"
                     /db_xref="PFAM:PF13649"
                     /db_xref="PFAM:PF13847"
                     /db_xref="PFAM:PF14765"
                     /db_xref="PFAM:PF16197"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 75.8; E-value:
                     4.4e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ETB97_004590"
                     /note="EggNog:ENOG410PIJA; COG:I"
                     /product="hypothetical protein"
                     /protein_id="KAF5858310.1"
                     /sec_met_domain="itr_KS (E-value: 4.7e-176, bitscore:
                     574.7, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 7e-91, bitscore: 293.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.9e-39, bitscore:
                     124.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.4e-09, bitscore:
                     25.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPSRNEPIAIIGMGCRFPGEACSPSKLWDLLHNPRDVARDIPDS
                     RFNLDRFYHPTGSHHGTTNIRQAYLLSEDVREFDAKFFSVPPGEAEAIDPQQRLLLEVA
                     YEALESSGHTLADLSNSNTGAFVGLMSQDYFALNGQDVNSVPTYAASGTAASNASSRLS
                     YFFNWHGPSMTIDTACSSSLVAVNEAVQALRNGTSRVAVACGTNLCLSAFTFITLSKLS
                     MLSPTSRCHMWDADADGYARGEGVACVVLKTLSDAIADRDHIEAVIREVGVNHDGRTKG
                     LTMPSATAQAALIRETYARAGLDPTKEADRCQYFEAHGTGTKAGDPQEAEALMRAFFPE
                     SDSEGELFVGSIKTVVGHTEGTAGLAGLMKACLALRNATIPPNLLFNKLNPDLERFTSH
                     LRVPTANQPWPELPDGTPRRASVNSFGFGGTNAHCILETYDPPTASDPVTEIETATSGT
                     CCIPAVFSAASDSSLVTLLQSTLEFMDEDADVNMSGLAYNLSTKRSALQRRLAISAASI
                     DELRDKIKSTIEAASEKDATLPSTSALPETASLLGIFTGQGAQWQGMGSQLISSIPLAR
                     RTVEELDSSLASLPSYHSPSWTLRDVLTDSTAPVGKASLSQPLCTAVQVILVDLLRAAG
                     VKFQAVVGHSSGEIAAAYAAGFITAWDAIRIAYYRGFYADMAAGPAGEKGAMLAAGTSF
                     EDASELCQLDDFDGRICVAAHNSPSSVTLSGDIDAIALAQRVLEEEEKFARLLKVDTAY
                     HSNHMRKCSVSYLTALRNCNIQVQQPGLDAPQWFSSVRNGQVVNSLESLDSQYWVDNMV
                     QPVLFCPAVQTCLTSADKATNCAVEVGPHPALQGPAKDSILAAVDREIPYTGTLNRGKS
                     SAVAFSDALGFLWCRFGPAAVTLGAFQQTNHPDTPTTMIRGLPTYPWTHDRGYFAESRL
                     MKTFHNHPVPFHDLLGIQTADGATEEWRWRNILKMNELKWLSGHSLQGQVVFPATAYIC
                     LAMEAALQLAQGRPVKSIDLFDLEIRKAIAIHDSTGTELLTSMTKVSTLDTESEEITAD
                     FAAYSTISKDAANLALNCCGRVRVLLGEGEVSPSHFSPRLPPLGKLTAVDVDSFYQILR
                     DDFGFGYEGPFRALRNVSRKAGFATGTIRCERFDDSETSLLFHPGMLDSALQGLNAAHS
                     APGDGRLWTIVAPTFCRRISIIPGLCGSNMTDNVEIDCNITDPRDTHVTGDVEVFSEGF
                     KEKIIEVEGLTFSPFAGATVENDRYLFQESFLCLDKPNADVIFGDRQATPEESRKALDA
                     ERAAFYYLKTFHLSVSPEQRETLPWYRQALLKNAERLFHIVNDGKHPFASQTWISDTRE
                     DIFKMMDSYPPTDADFNLTKAVGEHLLLPSVLNGDTSILQYMTKDNYLEQYYVDAIGFQ
                     LLNFLIAGVMEQLCLKSPRMNFLEVGAGTGGATKAILEKIGYSYASYTYTDISSAFFGH
                     AADNFQSHASKMIFKTLDITKDPAGQDFTPLSYDVVVASNVLHATESLRSALEHTRKLL
                     RPGGYLVMVEIIRNDVMRHGLVMGGLPGWWVGENDGRYGGPSITLEQWDKVLRETGFSG
                     IETNSPMRDPVGVPGSIIVSRAENDHVSQLSRPLSSKPSTATDKAPLLVIGGSSPFVSP
                     FRDQLCLTLRRQFADVIKVDQFADLPPLPERYHVLSLTECDANLFEDMEESVFSNLKTV
                     LGSALSVLWLLRDRRSSNPHAGTTLGLFRTLFYEVPGTLLQTLDIDAVDMDDCSVIAES
                     MCQLRFQSDMARRGETDEIRWEFEPELVLKDGQFYVPRVRPHDGQNNRYNSSKRSITHD
                     VDVHTTPLALDLVDGSYMVREQHAIERDSPELVTVNVSCSFLSSIKTPVGYVFVSLGEN
                     VKTGEKTLCFTSRNGSIVKAPKSWTISLDEVEVDGQFMSFVIADLTVQWVLQMLPPTGT
                     VLAYEPDPVAASLLSRHLNRLGRKALFMTSSPEMSGRNWVYLHPNSTKRAIAALLPADV
                     TLYVDASGADESPSQSLGSKIATSLSSVCDKVKMSSLTASEASVLPHDAPKAITDLLRR
                     VASFASSLLSAQANPEGAPLDILPLKRVVANFAVPNPRSLVYWREDQYVPVSVEPVMQR
                     GDLFRPDRTYWLAGLAGDTGRSLADFMIAHNARNIVLSSRTPTVYEDWVQWHKSRGATV
                     RYFGGDITSFESMKQIHDAIKESMPPIGGVANGAMVLRDSSFMKMSFDDFQAVLGPKIQ
                     GTINLDRLFSDPNQPLDWFIGFSSVAGTVGNPGQSGYTAGNCFIKGLVDRRRKQGLAGS
                     VIDITRLVGLGFIERESHGRLTKEHQERLTTRSGTIAMSENDLHQLFAEAILSGRPDLG
                     LNPEIITGLAPITVEQSKDAYWKTNPRLSLLIREAGQGDTQGRDRGNAVPVRQLLEAAK
                     TMQDAAKVLSGAFKGKLQALKFLSDSDSLYDTTPLVDMGVDSLVAVEVRSWFLKELTVD
                     VPVMKILGGASITDLVEVVVQKLPQELLSRLDPEGQRQGSNGDVPATVADNNSVETTES
                     KTNGIDSAREIGSSGVNGTHDTDMDSTTDLNGTNGTAVIEEMLEHKTTNGVVPIIISAQ
                     EVA"
     aSDomain        complement(join(788..999,1055..1067))
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004590_PKS_PP.1"
                     /evalue="3.90E-12"
                     /label="ETB97_004590_PKS_PP.1"
                     /locus_tag="ETB97_004590"
                     /protein_end="2486"
                     /protein_start="2411"
                     /score="38.2"
                     /tool="antismash"
                     /translation="KVLSGAFKGKLQALKFLSDSDSLYDTTPLVDMGVDSLVAVEVRSW
                     FLKELTVDVPVMKILGGASITDLVEVVVQK"
     aSModule        complement(788..8452)
                     /complete
                     /domains="nrpspksdomains_ETB97_004590_PKS_KS.1"
                     /domains="nrpspksdomains_ETB97_004590_PKS_AT.1"
                     /domains="nrpspksdomains_ETB97_004590_PKS_DH.1"
                     /domains="nrpspksdomains_ETB97_004590_cMT.1"
                     /domains="nrpspksdomains_ETB97_004590_PKS_KR.1"
                     /domains="nrpspksdomains_ETB97_004590_PKS_PP.1"
                     /iterative
                     /locus_tags="ETB97_004590"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(1422..1779,1839..2005))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004590_PKS_KR.1"
                     /evalue="1.90E-42"
                     /label="ETB97_004590_PKS_KR.1"
                     /locus_tag="ETB97_004590"
                     /protein_end="2293"
                     /protein_start="2118"
                     /score="137.1"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="TYWLAGLAGDTGRSLADFMIAHNARNIVLSSRTPTVYEDWVQWHK
                     SRGATVRYFGGDITSFESMKQIHDAIKESMPPIGGVANGAMVLRDSSFMKMSFDDFQAV
                     LGPKIQGTINLDRLFSDPNQPLDWFIGFSSVAGTVGNPGQSGYTAGNCFIKGLVDRRRK
                     QGLAGSVIDITR"
     CDS_motif       complement(1461..1571)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0009"
                     /evalue="1.60E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="ETB97_004590"
                     /protein_end="2280"
                     /protein_start="2243"
                     /score="52.8"
                     /tool="antismash"
                     /translation="LDWFIGFSSVAGTVGNPGQSGYTAGNCFIKGLVDRRR"
     CDS_motif       complement(1907..2005)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0008"
                     /evalue="1.10E-10"
                     /label="PKSI-KR_m1"
                     /locus_tag="ETB97_004590"
                     /protein_end="2151"
                     /protein_start="2118"
                     /score="34.1"
                     /tool="antismash"
                     /translation="TYWLAGLAGDTGRSLADFMIAHNARNIVLSSRT"
     aSDomain        complement(3593..4210)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004590_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.70E-74"
                     /label="ETB97_004590_cMT.1"
                     /locus_tag="ETB97_004590"
                     /protein_end="1589"
                     /protein_start="1383"
                     /score="242.3"
                     /tool="antismash"
                     /translation="YMTKDNYLEQYYVDAIGFQLLNFLIAGVMEQLCLKSPRMNFLEVG
                     AGTGGATKAILEKIGYSYASYTYTDISSAFFGHAADNFQSHASKMIFKTLDITKDPAGQ
                     DFTPLSYDVVVASNVLHATESLRSALEHTRKLLRPGGYLVMVEIIRNDVMRHGLVMGGL
                     PGWWVGENDGRYGGPSITLEQWDKVLRETGFSGIETNSPMRDP"
     aSDomain        complement(4997..5536)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004590_PKS_DH.1"
                     /evalue="9.30E-20"
                     /label="ETB97_004590_PKS_DH.1"
                     /locus_tag="ETB97_004590"
                     /protein_end="1121"
                     /protein_start="941"
                     /score="63.5"
                     /tool="antismash"
                     /translation="HDLLGIQTADGATEEWRWRNILKMNELKWLSGHSLQGQVVFPATA
                     YICLAMEAALQLAQGRPVKSIDLFDLEIRKAIAIHDSTGTELLTSMTKVSTLDTESEEI
                     TADFAAYSTISKDAANLALNCCGRVRVLLGEGEVSPSHFSPRLPPLGKLTAVDVDSFYQ
                     ILRDDFGFGYEGPFRAL"
     CDS_motif       complement(5375..5452)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0007"
                     /evalue="6.90E-11"
                     /label="PKSI-DH_m2"
                     /locus_tag="ETB97_004590"
                     /protein_end="995"
                     /protein_start="969"
                     /score="34.5"
                     /tool="antismash"
                     /translation="WLSGHSLQGQVVFPATAYICLAMEAA"
     aSDomain        complement(5753..6703)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004590_PKS_AT.1"
                     /evalue="4.90E-90"
                     /label="ETB97_004590_PKS_AT.1"
                     /locus_tag="ETB97_004590"
                     /protein_end="869"
                     /protein_start="552"
                     /score="293.7"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="IFTGQGAQWQGMGSQLISSIPLARRTVEELDSSLASLPSYHSPSW
                     TLRDVLTDSTAPVGKASLSQPLCTAVQVILVDLLRAAGVKFQAVVGHSSGEIAAAYAAG
                     FITAWDAIRIAYYRGFYADMAAGPAGEKGAMLAAGTSFEDASELCQLDDFDGRICVAAH
                     NSPSSVTLSGDIDAIALAQRVLEEEEKFARLLKVDTAYHSNHMRKCSVSYLTALRNCNI
                     QVQQPGLDAPQWFSSVRNGQVVNSLESLDSQYWVDNMVQPVLFCPAVQTCLTSADKATN
                     CAVEVGPHPALQGPAKDSILAAVDREIPYTGTLNRG"
     CDS_motif       complement(5909..5956)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0006"
                     /evalue="1.90E-03"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="ETB97_004590"
                     /protein_end="817"
                     /protein_start="801"
                     /score="10.9"
                     /tool="antismash"
                     /translation="LDSQYWVDNMVQPVLF"
     CDS_motif       complement(6350..6457)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0005"
                     /evalue="1.50E-10"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="ETB97_004590"
                     /protein_end="670"
                     /protein_start="634"
                     /score="33.5"
                     /tool="antismash"
                     /translation="GVKFQAVVGHSSGEIAAAYAAGFITAWDAIRIAYYR"
     CDS_motif       complement(6653..6703)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0004"
                     /evalue="1.70E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ETB97_004590"
                     /protein_end="569"
                     /protein_start="552"
                     /score="17.2"
                     /tool="antismash"
                     /translation="IFTGQGAQWQGMGSQLI"
     aSDomain        complement(join(7043..7097,7151..7438,7503..8452))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004590_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="7.00E-172"
                     /label="ETB97_004590_PKS_KS.1"
                     /locus_tag="ETB97_004590"
                     /protein_end="439"
                     /protein_start="8"
                     /score="563.9"
                     /tool="antismash"
                     /translation="IAIIGMGCRFPGEACSPSKLWDLLHNPRDVARDIPDSRFNLDRFY
                     HPTGSHHGTTNIRQAYLLSEDVREFDAKFFSVPPGEAEAIDPQQRLLLEVAYEALESSG
                     HTLADLSNSNTGAFVGLMSQDYFALNGQDVNSVPTYAASGTAASNASSRLSYFFNWHGP
                     SMTIDTACSSSLVAVNEAVQALRNGTSRVAVACGTNLCLSAFTFITLSKLSMLSPTSRC
                     HMWDADADGYARGEGVACVVLKTLSDAIADRDHIEAVIREVGVNHDGRTKGLTMPSATA
                     QAALIRETYARAGLDPTKEADRCQYFEAHGTGTKAGDPQEAEALMRAFFPESDSEGELF
                     VGSIKTVVGHTEGTAGLAGLMKACLALRNATIPPNLLFNKLNPDLERFTSHLRVPTANQ
                     PWPELPDGTPRRASVNSFGFGGTNAHCILETY"
     CDS_motif       complement(join(7426..7438,7503..7537))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0003"
                     /evalue="8.10E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ETB97_004590"
                     /protein_end="329"
                     /protein_start="313"
                     /score="11.8"
                     /tool="antismash"
                     /translation="YFEAHGTGTKAGDPQE"
     CDS_motif       complement(7742..7780)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0002"
                     /evalue="3.90E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="ETB97_004590"
                     /protein_end="245"
                     /protein_start="232"
                     /score="13.5"
                     /tool="antismash"
                     /translation="WDADADGYARGEG"
     CDS_motif       complement(7922..7969)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ETB97_004590_0001"
                     /evalue="3.10E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="ETB97_004590"
                     /protein_end="185"
                     /protein_start="169"
                     /score="22.1"
                     /tool="antismash"
                     /translation="GPSMTIDTACSSSLVA"
     gene            9017..10150
                     /locus_tag="ETB97_004591"
     mRNA            join(9017..9561,9625..10150)
                     /locus_tag="ETB97_004591"
                     /product="hypothetical protein"
     CDS             join(9017..9561,9625..10150)
                     /NRPS_PKS="Domain: PKS_ER (21-251). E-value: 1.6e-22.
                     Score: 71.9. Matches aSDomain:
                     nrpspksdomains_ETB97_004591_PKS_ER.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="PFAM:PF00107"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 168.6; E-value: 3.3e-51)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ETB97_004591"
                     /note="EggNog:ENOG410PMNB; COG:C"
                     /product="hypothetical protein"
                     /protein_id="KAF5858311.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.6e-16, bitscore:
                     48.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELPFNQTAIVALDDGTLGLRNDVQMPSLEDDMILVRNAFVALN
                     PIDTKMVGKLASPGAIAGMDFAGEVISIGSKVQTAAPIKPGDRICGAVPGMHSLTPAVG
                     AFAQYVGATDLTTMKVPDYMSLEEAVTLGSGIGTIGLALFKSLDVPGSPWLPADKPVDV
                     LVYGGSTATGTLAIQLLKLSGLNPITTCSPTNFDLVKSYGATAVFDYRQETCADDIRKH
                     TRNSLKFVLDCISEPETMQFCYKCLGRSGGKYTALEPYPEFLHTRPKTVVPDWVLGPTL
                     LGKRLGWPEPFGGEGNEEYRKFGFQWFKLVQELLDQGKLKSHPHKIVGDSLGETLCGLG
                     LLKEKKVSGQKLVCRV"
     aSDomain        join(9080..9561,9625..9832)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ETB97_004591_PKS_ER.1"
                     /evalue="1.60E-22"
                     /label="ETB97_004591_PKS_ER.1"
                     /locus_tag="ETB97_004591"
                     /protein_end="251"
                     /protein_start="21"
                     /score="71.9"
                     /tool="antismash"
                     /translation="RNDVQMPSLEDDMILVRNAFVALNPIDTKMVGKLASPGAIAGMDF
                     AGEVISIGSKVQTAAPIKPGDRICGAVPGMHSLTPAVGAFAQYVGATDLTTMKVPDYMS
                     LEEAVTLGSGIGTIGLALFKSLDVPGSPWLPADKPVDVLVYGGSTATGTLAIQLLKLSG
                     LNPITTCSPTNFDLVKSYGATAVFDYRQETCADDIRKHTRNSLKFVLDCISEPETMQFC
                     YKCLGRSG"
     gene            10676..12412
                     /locus_tag="ETB97_004592"
     mRNA            join(10676..10754,10978..11223,11298..12412)
                     /locus_tag="ETB97_004592"
                     /product="hypothetical protein"
     CDS             join(10676..10754,10978..11223,11298..12412)
                     /codon_start=1
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="PFAM:PF00067"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 268.6; E-value: 1.8e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ETB97_004592"
                     /note="SECRETED:SignalP(1-17); EggNog:ENOG410PWHU; COG:Q"
                     /product="hypothetical protein"
                     /protein_id="KAF5858312.1"
                     /sec_met_domain="p450 (E-value: 3.8e-65, bitscore: 209.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISFLEFWLCTLTLASGGIVHQALTCVLFPDNAWVPLRELAETTP
                     NDGLLRIYSTLSGEALLVTSPPAIRDMLTVNAFDFAHQDLVKIAIKRFTGSNLGFLSND
                     EFKASFTVPHVRKLTSIFWAKAQEMVHCMSNELRADPFARINFREYVSRATLDNIGLAG
                     MGHDFQTLKQPDNDLRSHYRKLILDPTRVFSWVGLLSRYFDMRLLMRVPLKKLIEISQS
                     ANYLRAVTTAVIQDRSEKLVEAEDNRAKDIITVALASGVFDERHLVDHVMTFLTAGHES
                     TATAFEWTMYELGRRPEMQSRLRDELREAIGTDLAAVDFGLRVQNLPYLNAFCSEVLRC
                     YPFSPIIVKVAQQETTLMGQRIPKGTVVLYSAEVSNHDKTLWGPDADKFDPERWIGEGK
                     AKSGGASSNYAMLTFGAGPRNCIGANFARATLECLVAAVLSTFEIELVNPDTAGRLKFG
                     QTKKSAEGVYGRLKFVRPVEV"
     gene            12602..13888
                     /locus_tag="ETB97_004593"
     mRNA            join(12602..12887,13000..13647,13701..13888)
                     /locus_tag="ETB97_004593"
                     /product="hypothetical protein"
     CDS             join(12602..12887,13000..13647,13701..13888)
                     /codon_start=1
                     /db_xref="InterPro:IPR008183"
                     /db_xref="InterPro:IPR011013"
                     /db_xref="PFAM:PF01263"
                     /locus_tag="ETB97_004593"
                     /note="SECRETED:SignalP(1-19); EggNog:ENOG410PVFG; COG:G"
                     /product="hypothetical protein"
                     /protein_id="KAF5858313.1"
                     /transl_table=11
                     /translation="MNLWKLSVGILAAVKSVWTRGSPFAALTALWPTNEEGKFIIQSEG
                     IRLAFTNHGAALTNLWLNNTHGEEIDVVLGLDDARGYPSLQSNPFLNGVIVDGTIYPVT
                     ANAHNATSLFNGGDKGWGRQTWDIAVHINNSITFVLFDNRWNGFPGIFASCVTHTVTPY
                     EWRIAFGVTPLLKAGPINLSQQVFFNIDGFRNNASTSDASNSTVLDHRLRLPVSGMRFD
                     VDERGIPTGDMKSNREGKEFDFWSADKSIGDEVQKGNAGFDVTYALSHKPLGDKEDEPV
                     AILSSKLSGVTMELYTDQDALHVHTWDNNLGGLRLKKGQGAGKVAQHAAISLEMQDWPD
                     AVHHPEWRHRKTIWGMDGLYTRFATYKFSVEGK"
     gene            complement(13987..14739)
                     /locus_tag="ETB97_004594"
     mRNA            complement(13987..14739)
                     /locus_tag="ETB97_004594"
                     /product="hypothetical protein"
     CDS             complement(13987..14739)
                     /codon_start=1
                     /db_xref="InterPro:IPR005645"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="PFAM:PF02230"
                     /db_xref="PFAM:PF03959"
                     /locus_tag="ETB97_004594"
                     /note="EggNog:ENOG410PX4W; COG:S"
                     /product="hypothetical protein"
                     /protein_id="KAF5858314.1"
                     /transl_table=11
                     /translation="MNSETKPAIICLHGHGSSGEIFQAQSQNLTRVLSPHFRFLFLNSP
                     ITTAQAGVGVPLYYAHIKPHRRWHQDRNTIGLFDVTVEDVERERRVVRDSLKDVIERER
                     RNGPGAGVVGVMGFSQGTRVATAVCLDPELGRDIKFAIMICGICPSLPLSAAETQVSRP
                     LDIVSVHVQGIGDPWLAKGTRLSKQYFNQRLATVVRFKGGHEIPVKTGDVQNIAEVMAE
                     YRDRDRGEYDSVPAVEVASEVAARMVSA"
     gene            complement(15208..16616)
                     /locus_tag="ETB97_004595"
     mRNA            complement(join(15208..16133,16196..16616))
                     /locus_tag="ETB97_004595"
                     /product="hypothetical protein"
     CDS             complement(join(15208..16133,16196..16616))
                     /codon_start=1
                     /db_xref="InterPro:IPR001138"
                     /db_xref="InterPro:IPR036864"
                     /db_xref="PFAM:PF00172"
                     /locus_tag="ETB97_004595"
                     /note="EggNog:ENOG410PTH6; COG:S"
                     /product="hypothetical protein"
                     /protein_id="KAF5858315.1"
                     /transl_table=11
                     /translation="MMNGERKLRAACDRCHELKNRCTRTGGPESRCDRCERLDIDCVYN
                     TSARMGRPRVSRPGSENQKGASSARHSKRRAVQAGSQRGANAVPLPVDHVDLASAAHDR
                     SGGAGPGSGPSSGSEPDSPRNLEPVLGLLDPALLPAVVPGDNVIWDLGLYSPDFAHPAH
                     DDPTGGQGHGRGHGHAHQEYHQVESLQQKYKEVPDFSDSDLEMSEKGTVPIVKTTVADE
                     LLRLQFHLSNLLTGASESPTGHQPAIDEVMMVCKELLELLPIPARRSSSDYGTASKNMT
                     GTGPPFTPASVNAGHPDPCDGIGQPTQRGGPFDPLRINYITVLQVATSYAYALQLLDLA
                     VDNLKTRAGNLALVSLGTFNLASQPAMSTSVGAYMISSMVHQLRDAISLLTPEYQHQQG
                     RPPPHASSPPSGLQAAAAAANNSIHAAVDMISEKETSLLEKLAQVMINS"
     gene            18887..19781
                     /locus_tag="ETB97_004596"
     mRNA            join(18887..19228,19329..19781)
                     /locus_tag="ETB97_004596"
                     /product="hypothetical protein"
     CDS             join(18887..19228,19329..19781)
                     /codon_start=1
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR041698"
                     /db_xref="PFAM:PF08241"
                     /db_xref="PFAM:PF13649"
                     /locus_tag="ETB97_004596"
                     /note="EggNog:ENOG410PR7D; COG:S"
                     /product="hypothetical protein"
                     /protein_id="KAF5858316.1"
                     /transl_table=11
                     /translation="MTGGLNVKPITVMLECLNSRFPLASATGILDDGCGPGPIMTRIID
                     EFGKHLPAECTLTCSDFAPAMVDQVQEAKRRFVADEPGSVWGRVRTEVLDCMDLATVGD
                     GEMSHVAAGWSFFNASNPQKALSESLRVLQPGGVLAASSWAETDWLKILRTITKIDPAR
                     SPPAIPEDWAKAGNLVAQLEIAGYRDVDVHEVPVDIPFRSYASFVDVMMTRVTQMMTAS
                     QDLDERQKTLLRELMTEEMKGLCPTEPGVLKAVSLVAVGVKS"
     gene            complement(20197..22086)
                     /locus_tag="ETB97_004597"
     mRNA            complement(join(20197..20313,20375..20835,20913..21807,
                     21868..22086))
                     /locus_tag="ETB97_004597"
                     /product="hypothetical protein"
     CDS             complement(join(20197..20313,20375..20835,20913..21807,
                     21868..22086))
                     /codon_start=1
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="PFAM:PF06609"
                     /db_xref="PFAM:PF07690"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 323.7; E-value:
                     2.4e-98)"
                     /gene_kind="transport"
                     /locus_tag="ETB97_004597"
                     /note="TransMembrane:12
                     (i50-76o88-105i117-137o143-167i174-194o206-226i246-
                     265o277-294i314-334o354-372i381-399o520-542i);
                     EggNog:ENOG41KOG0254; COG:J"
                     /product="hypothetical protein"
                     /protein_id="KAF5858317.1"
                     /transl_table=11
                     /translation="MAASSPDEATRATKSERDADSPAQAQHATSDEVSTEDPETNANAM
                     HGFKLFAIFVGICFGAFLMSLDIFVIATAIPSITSDFKDTSQLAWYPAAYSLTTCALTP
                     LAGKLSSTFPLRWIYISFFSIFLVGSLVCGFAPNSNTFIAGRAIAGIGASGVASGGFVI
                     VLTVSPEKSKPLLLGICSSCFAMGLILAPVIGGAFTEKATWRWCFWVNLPPGALTLLSM
                     LCFFKPPSIQRDRTVVQRIMNLDLLGCAIFIPAIFMLLLAMMWGGTQKDWDSATIIGLF
                     VGSGVMLILFVCWEAHKGEGAMIPGNVVARRAVSFSVLFSFCHFGSLGILNYYLPEWFQ
                     AVQGASPLQSGTRVLAAVLSQIVGTLSAGVLARRIHYYNPWLYVGPLFMCTAAALYTQF
                     STFNTPSSHWIGFQVIQGLGVGMAQQMPSLIVQQAVRDKPELMPVAVSLNLFFQYLGAT
                     VTQVLGGIVFRSILASELANHAGLKAQQIALLSAAGTAKVRGTAEQRFPDLLNLVLESY
                     NTAITSTFFVAVATTTAAFFLAFGVKWERITDKKTTDPEEAEAEQQ"
ORIGIN
        1 gcttgcgaat ggtgcaccac ctgcatctga ccttaagcat acaagaactg ccccctcact
       61 gttctaaccg tcctctctcc caacttcttc gttccccctg aatcccctat tattctacac
      121 cctttcagtc actgcagctg tttcacgtgc ccctatagct acaccccctt ttctccatct
      181 gatttgacgg gtgtcttgac gttatgtaac tagttgacat caacagctga ttataaagca
      241 gatcgcaaaa ctggggtcgt tcggactcaa ttccaactct tctctggaaa tcacatccca
      301 gtgtcgagag gcgcgcgaat gcaaatatca ctgaaccaag ggcgaaagac ccattgcgat
      361 tctcaatttt gaaagcagta ggctcgtaat gactggtaag gatgggaatc tcattgcatt
      421 tggtggttta tagatcggta tatctaaaca actaatatta tcaaacatga gcacaaaatc
      481 ttcgatctta ggcaacctcc tgcgcactga taatgatcgg aacaacgcca ttcgtggttt
      541 tgtgctccaa catttcctcg ataaccgcgg tcccgttggt gccattgagg tccgtggtgc
      601 tatccatatc agtgtcgtga gtgccgttga caccactgga accaatttca cgagcgctgt
      661 caatgccgtt ggtctttgat tccgtcgttt ctactgagtt gttgtcagcg acagtagctg
      721 gcacgtcgcc attgctgccc tgacgctgcc cttcgggatc tagcctactc aatagctcct
      781 ggggaagctt ctgcacgaca acctccacca aatccgtgat ggaggcgccg cccagaatct
      841 tcatgactgg cacgtcgact gtgagctcct tcaagaacca agaccttact tccacagcta
      901 ccaggctgtc gacacccatg tccactagag gcgtagtgtc gtacaagctg tcagaatccg
      961 acaggaattt caacgcttgc agctttcctt tgaaggcacc taaacggact tgtcagggcc
     1021 cagataaggg gtattgaagc ataattttac gtacctgaaa gcaccttcgc cgcgtcttgc
     1081 attgtcttgg ccgcttctag cagttgtcgc acaggaaccg cgttgcccct gtctctgccc
     1141 tgtgtatcac cctgtcctgc ctctctgatc aacagcgaca acctcggatt ggtcttccag
     1201 tatgcgtcct tggactgctc aacagtgatg ggcgccagac ctgtaatgat ctccgggttg
     1261 agaccgagat ccggtcgtcc ggacaagatc gcctccgcaa acaactggtg caggtcattc
     1321 tcgctcatcg caatagtccc agaccgcgta gttagacgct cctggtgctc ctttgtcaga
     1381 cggccgtggc tttcacgctc gataaagccc agccccacta atcgagtgat gtcaatgact
     1441 gatccagcca ggccttgctt acgccgccgg tcgacaagtc ccttgatgaa acagtttcca
     1501 gcggtgtacc ccgattgtcc cgggttgccg acggtgccgg cgaccgaact gaacccgatg
     1561 aaccagtcga gtggttggtt ggggtcggag aagagccggt cgagattgat tgtgccttga
     1621 attttgggac ctaggaccgc ttggaaatcg tcgaagctca tcttcatgaa ggaactgtct
     1681 cgcagcacca tggcgccatt cgcaacaccg ccaatgggcg gcatggactc cttgatagcg
     1741 tcatggatct gtttcatgga ctcaaagctg gtgatatccc taagcaacaa aggtggttag
     1801 cgacgataag tttcaagcgg acgagtccat ttgcttaccc tccgaaatac ctcactgtgg
     1861 cacctcttga cttgtgccat tgcacccagt cctcgtagac ggtgggcgta cggctgctta
     1921 gcacaatatt ccgagcattg tgggcaatca tgaagtcggc cagggatcga ccagtgtctc
     1981 cggccagacc agctagccag taggtgcgat cgggacggaa cagatcacca cgttgcataa
     2041 cgggctcaac agagaccggc acgtattgat cctctcgcca gtaaacaagc gagcggggat
     2101 ttggcactgc aaagttcgca accacccgtt tgagcggtaa gatatcgagt ggtgcaccct
     2161 ctggatttgc ttgagcggat agcaaggagg aagcgaagga agcaacgcga cggagcagat
     2221 ctgtgatggc tttaggggca tcgtgcggaa gaacggacgc ttctgatgca gtcaggctag
     2281 acatcttgac tttgtcacag accgatgata gggaggtcgc aatcttggat ccgagacttt
     2341 gggaaggaga ttcgtcggct ccggaggcgt cgacatacag ggtaacgtcg gctggtaaga
     2401 gggcagcgat ggctctcttg gtgctgttag gatggaggta cacccagttt cggccggaca
     2461 tttccggact cgaagtcatg aaaagagcct tcctgccgag cctgttcaag tgccgagata
     2521 gcagagatgc tgcaactgga tctggctcgt atgccagcac agttcctgtg ggtggcagca
     2581 tttgcaacac ccattggact gtgagatcgg caatgacaaa cgacatgaat tgtccgtcaa
     2641 cctcgacctc gtcaagggat atcgtccagg atttgggggc cttgacaatg gacccgttac
     2701 ggctggtgaa acaaagtgtc ttttctcctg tcttgacatt ttctccgaga ctgacgaata
     2761 catatcccac gggagtcttt attgacgaca agaaagaaca agagacattg actgtaacca
     2821 gctcgggtga atctctctct atggcgtgct gctcccttac catgtacgag ccgtcgacca
     2881 gatctagagc caaaggcgtc gtgtgcacgt ccacatcgtg agtaattgat ctcttggatg
     2941 agttgtatcg attgttctgc ccatcatgcg gacgaactct tgggacataa aactggccgt
     3001 ccttgagaac aagttctggt tcgaactccc agcgaatctc atccgtctca ccacgtctgg
     3061 ccatatccga ctggaacctg agctggcaca ttgactctgc aatgactgag cagtcgtcca
     3121 tatcgacggc gtcaatatcc agagtctgca atagggtccc gggaacttcg taaaaaagtg
     3181 ttctgaaaag accgagcgta gttccggcat ggggattact cgatcgacga tcccggagca
     3241 accagagtac actcaatgca gagcctagca ctgtctttag attcgagaag acagactcct
     3301 ccatgtcctc gaacaagttt gcgtcgcact ccgtgagact gaggacatgg tagcgctcag
     3361 gaagcggagg cagatccgcg aactggtcaa ctttaatgac atctgcgaac tgccgcctca
     3421 gggtgagaca gagctggtcc ctgaacggcg atacaaatgg actgctacca cctataacaa
     3481 gtaatggagc tttgtctgtt gccgtactag gctttgagct gagaggcctg ctcaactggc
     3541 tgacgtgatc attttcagcc cgagaaacga taatcgatcc gggcacgccc accgggtccc
     3601 gcatgggcga attagtctcg ataccactga agccggtctc tcgaaggacc ttatcccatt
     3661 gttcaagagt aatacttggg cccccgtaac ggccatcgtt ctcaccgacc caccagcctg
     3721 ggagaccgcc catgacgaga ccatggcgca tcacgtcgtt gcggatgatc tcaaccatca
     3781 caagataacc accaggacgc aagagcttcc gtgtatgttc aagggcagat ctcaatgact
     3841 cggtcgcgtg caagacattg gaggcaacga caacatcata gctcagcggg gtgaagtctt
     3901 gtccagcagg gtccttcgtg atatccaagg tcttgaaaat catcttgctg gcgtgggatt
     3961 ggaagttgtc tgcagcatgg ccgaagaagg cactggaaat gtcggtatac gtataagatg
     4021 cataggagta cccgatcttc tccaggatcg ccttggtcgc gcctccagtt ccggcgccga
     4081 cttcaaggaa gttcattcgg ggagacttca agcaaagctg ttccatcacc ccggcaatca
     4141 agaagttcag cagctggaac ccgatggcat ctacatagta ctgctcaagg tagttatcct
     4201 tggtcatgta ttgcaggatg ctggtatctc cattcagcac cgaaggcaga agaagatgtt
     4261 ctccgacggc cttggtcagg ttgaaatcgg cgtctgtcgg aggatagctg tccatcatct
     4321 tgaatatatc ctctctggta tcacttatcc aagtctgcga ggcaaacgga tgtttcccgt
     4381 cattgacaat gtggaacagc cgctcagcgt tcttcagcaa agcctgtcga taccatggaa
     4441 gggtctcgcg ctgctccgga ctgaccgaga gatggaaggt cttgaggtag taaaacgccg
     4501 cgcgctcagc gtcaagggcc ttcctgctct cctcgggggt tgcctgtctg tccccaaaga
     4561 taacgtccgc gttcggctta tcaaggcaca gaaacgactc ctggaagaga taccggtcgt
     4621 tctcaacagt cgcgcccgca aaaggggaga aggtgagccc ctcaacctcg ataatcttct
     4681 ccttgaaacc ctccgagaag acctccacat ctccagtgac gtgcgtatcg cgaggatcag
     4741 tgatattgca gtcgatctca acattatccg tcatgttgct gccgcagagt ccagggatga
     4801 tcgagatccg acgacagaag gtcggcgcca cgatcgtcca gagccggcca tctcctgggg
     4861 cgctatgggc agcgttcaga ccctgcaggg cactatccag cataccggga tggaagagca
     4921 gagacgtttc agaatcgtcg aatctctcgc accgaattgt gcccgtcgcg aagccggctt
     4981 tacgggacac attcctgagc gcgcggaagg ggccctcgta tccgaatccg aagtcatcgc
     5041 gcaggatctg gtagaagctg tccacgtcta ctgcggtcag ttttccgagt gggggaagtc
     5101 taggtgagaa gtgggatggc gagacctcgc cctctcctag aagcacacgc acacgaccgc
     5161 agcagttgag tgcaaggttg gcagcgtctt tgcttatagt tgagtaggcc gcgaagtcgg
     5221 cggtgatttc ttccgactcg gtgtcgaggg tagacacctt ggtcatggat gtgaggagct
     5281 cggtgcctgt ggagtcgtgg atggcgatgg ctttgcggat ttcaaggtcg aagagatcga
     5341 tcgatttcac gggtctccct tgggccagtt gcagtgctgc ttccatggca aggcagatgt
     5401 aagctgttgc gggaaagacg acttggcctt gtagcgagtg tcccgacagc cacttgagtt
     5461 cgttcatctt caggatattc cgccacctcc attcctccgt tgctccgtct gccgtctgga
     5521 tgcctagtaa gtcatggaag ggcaccgggt ggttgtggaa ggtcttcatg agtcttgatt
     5581 cggcaaagta ccccctgtca tgagtccatg ggtatgttgg aagaccgcgg atcatcgtag
     5641 tcggagtatc cgggtgattt gtctgctgga acgctccgag cgtcacagca gcagggccaa
     5701 accgacacca aaggaatcca agggcgtcgg aaaatgccac cgcactgctc ttcccacggt
     5761 tcaaggtgcc agtatatggg atttcccgat ccacagcggc aagaatagaa tctttcgcag
     5821 gtccttgcaa agcaggatgc ggtcccacct ctacagcgca gttggtggct ttgtccgcag
     5881 atgtcaagca tgtttgaaca gctgggcaga ataacacggg ctgtaccatg ttatcgaccc
     5941 agtattggct gtccaggctc tccaggctat tgacgacctg accgtttcgg acgctgctga
     6001 accactgcgg tgcatcgagc ccgggctgct ggacttgtat gttgcagttt ctcaatgccg
     6061 taaggtaaga tacagagcat ttacgcatgt ggttcgagtg atacgccgtg tcgaccttta
     6121 aaagccgggc gaatttctcc tcctcttcta gcaccctctg tgccagggct atagcgtcga
     6181 tatcacccga cagagtcacg ctgctagggg agttatgggc agccacgcag atcctcccat
     6241 cgaagtcatc aagctggcaa agctcgctgg catcctcaaa ggaggtcccg gcagccagca
     6301 ttgcgccctt ctctcccgca ggcccggccg ccatatcggc gtagaatccc cggtagtatg
     6361 caatgcggat agcatcccat gcagtgatga agcccgccgc ataggcagca gcaatctctc
     6421 cagaggaatg cccaacaacg gcctggaact tgactcccgc agcgcggagc aggtcaacca
     6481 ggatgacttg gacagccgtg cagagaggct gcgaaagaga ggctttgccg acgggggcag
     6541 tgctgtcagt aagtacgtct cttagagtcc aggatgggct gtggtaggac ggtaagcttg
     6601 cgagagatga atccagctct tcgacggtcc tccgcgccag cgggatcgac gatatcagct
     6661 gggaccccat gccttgccac tgagcgccct ggccggtgaa aatgccgagc aatgaagcag
     6721 tttcaggtaa agcggaagtg gagggcaaag tagcgtcttt ctctgacgcg gcttctatcg
     6781 tggacttgat cttgtcccta agttcgtcga tcgatgcagc ggagattgca agtcttcgct
     6841 gcagggcaga tcgcttggtg cttaagttgt atgccagtcc actcatattg acatcggcgt
     6901 cctcgtccat gaattccagt gtcgactgca ggagtgtcac taacgagcta tcagatgctg
     6961 cagaaaatac agctggaata cagcatgttc ctgatgtggc cgtctctatt tcagtgactg
     7021 ggtcactggc cgttggtgga tcgtatgttt caagaatgca gtgagcgttg gtccctccaa
     7081 agccaaagct gttgacacta ttgtcacaca attagctgtt atccaaaggg gctgacaata
     7141 ttcaactaac ctagcccttc gaggtgtgcc atctggcaat tcgggccaag gttgattggc
     7201 cgtaggaaca cggagatgac ttgtgaaccg ttcaaggtca gggtttaatt tattgaacag
     7261 taaattgggg ggaatggttg cattgcgaag agcaagacaa gccttcatga gacctgccag
     7321 tcccgctgtg ccttcggtgt ggccgaccac ggttttgata gacccgacga agagttcgcc
     7381 ttcggagtca gactccggga aaaacgctct catcagggct tcggcttctt gagggtccct
     7441 aaacggggcc tattagtatt ttcggtttct aacagtgtac agatctctga ggctcaaccc
     7501 acccagcttt cgtccccgtg ccatgcgctt cgaaatactg acaccgatca gcctccttcg
     7561 tcggatccag cccagcgcgg gcataagtct ctcgaatgag cgccgcctgg gccgtagcac
     7621 tgggcatagt caaccccttc gtcctgccat cgtgattcac tcccacttcc cgaatcacgg
     7681 cttcgatatg gtccctgtct gcaatcgcat cgctgagggt cttcaaaaca acgcaagcaa
     7741 caccttcacc tcgggcgtag ccatctgcgt cggcatccca catgtgacat cgagacgtcg
     7801 gtgacaacat actgagcttg ctcagcgtga tgaacgtaaa ggccgacaaa cacaagtttg
     7861 tcccacaagc tacagcaacg cggctcgtgc cgtttcgaag ggcttgcact gcctcattca
     7921 cagcgacgag actggatgag caggcggtgt ctatcgtcat ggacgggcca tgccagttaa
     7981 agaagtaaga gagtcggctg gaggcattac tcgccgccgt accggacgca gcgtaagtcg
     8041 ggacggagtt cacatcctgg ccattaagcg cgaagtagtc ctgggacatg aggccgacaa
     8101 aggctcccgt attcgagttg gacaggtcgg ccagtgtatg gcctgaggat tcgagggcct
     8161 cgtaagcgac ctcgaggagc aggcgttgct gcgggtcgat ggcctctgct tcacctgggg
     8221 ggacggagaa gaattttgcg tcgaactcgc gcacgtcttc ggaaaggaga taggcctggc
     8281 ggatgttggt ggtaccgtgg tggctgccgg ttgggtggta gaagcggtcg aggttgaatc
     8341 gggagtcggg gatgtcgcgg gcgacgtcgc gcgggttgtg gaggaggtcc cagagtttgg
     8401 agggggagca ggcttcacct gggaagcggc agcccatgcc tatgatggct atgggttcat
     8461 ttctgctggg gtgcattgtg ggaggatgga tttagaactt gggtatgaga ggggagagat
     8521 gcttcgagac gaatagttga tcaagaaaat tgagtgaaat cctgcgtcct ggttgccaaa
     8581 ccacttctct acagttctct aactatatgt acagtataat acagcaatgc tatcaaagtg
     8641 gctggctatg ctaagattac aagaccacta gccctaagta cgccttgcgc gaacagatgt
     8701 tgccagagcg tggccaaggc cggctggggg ccgtaacgac aagacgcaat atatactccg
     8761 gttggtatac gaggaccggc aacttaatct gacagttgag aagttccgga gcttacctac
     8821 gtactaagaa ttatggattt atgagtgagt ttctggtgat cttacgctcg cccggagtgg
     8881 aggctttatt tcgatcctaa ccgtaaccat ggtacttatt gatacttatg agattcttag
     8941 cagcacatca agcattggaa cttcgtcgct aatttttgtc cttttccttt tcttgttact
     9001 tatttatttt cccactatgt ccgagctacc gttcaatcaa accgccatcg tcgctctcga
     9061 tgatggtaca ctcggcctac gcaacgatgt ccaaatgccc tccctagaag acgacatgat
     9121 cctagtgagg aacgccttcg tcgccctaaa cccaatcgac accaaaatgg tcggcaagct
     9181 cgcaagtccc ggcgcaatcg ccggaatgga tttcgcaggc gaagtcatct ccattgggtc
     9241 caaagtccaa accgccgcgc ccatcaagcc gggcgaccga atctgcggcg cagtgccggg
     9301 gatgcactct ctcactcctg cggtaggcgc ttttgcgcag tatgttggcg cgacggatct
     9361 tactaccatg aaggtcccgg attatatgtc ccttgaagaa gcggtaaccc tgggaagtgg
     9421 gattgggact attgggcttg cgctgtttaa gtcgctggat gttcctggtt cgccttggtt
     9481 gccggctgac aaaccggtgg atgtgctggt gtatggtggg agcactgcga ctgggactct
     9541 ggctattcag ttgcttaaac tgtacgttat agtaccgctc tgttatttcc ttagaagtaa
     9601 atacctacta actcaacctt ccagatcggg cctgaatccc ataacaacct gctcaccgac
     9661 caacttcgac ctcgtgaaat cctacggcgc cactgcagtc ttcgactacc gccaggagac
     9721 atgtgcagac gatatccgca agcacactcg aaactcactc aagttcgtcc tcgactgcat
     9781 ttccgagcca gagacaatgc agttctgtta caaatgcctc ggccggtcgg gggggaaata
     9841 caccgcattg gaaccctacc ctgagttcct gcatacccgg ccgaagacgg ttgtgccaga
     9901 ttgggtgctt ggtccgacgc tgcttgggaa aaggcttgga tggccagagc cgtttggtgg
     9961 ggaggggaac gaggagtata ggaagtttgg gttccagtgg tttaagctgg tgcaggagtt
    10021 gctggatcaa gggaagttga agtcacatcc gcataagata gtaggggaca gtcttgggga
    10081 gacgttgtgc ggtcttgggc ttcttaagga gaagaaagtc tctggtcaga agcttgtgtg
    10141 tcgcgtttga tgatatcaat gtcttgtact atgtcctagt taagctacgt atacatcagg
    10201 actgtcctca gcggaaatgc ataacgcatc aaaagactac agctgtccat acgaggtttc
    10261 gcctacgtaa tagaaaaata cataaatcat tgttttcgca ccgaaatagc agcctttact
    10321 attgcattgc ccattgctag taaagattga accaatagcc gtcatttatg agatcatatg
    10381 gtatcacctc cgagcagggt ggttgaagta tacgaccaat cgatggttta gtgtaatcgg
    10441 cagcctattg agtaatttag ccttgtctgc ctgccagatt tttccatccg caagaagtca
    10501 ccggtcctgt tgggctcaac accggcgcag ctaacacgcc ggcagcctgc aacaaatgag
    10561 aatggcttat atctagtctc tgtatcaaga acacacgctt gagtagctgg atgaactgtt
    10621 gccacatcta ttgaacaagt tattcaatca gtttctgttt cagcaaacct tcaggatgat
    10681 ctcttttctc gagttctggc tgtgtacgct tacactagcc tcgggcggaa tcgtccacca
    10741 ggctctcact tgcggtgagc atatagcact gctcttccga gtgctaggcg ctcatgtggt
    10801 tgcctttgtt gcctttgctg tgtattggat gatcctctac ccccgttatt tcacccccct
    10861 cggcaacatc cccactcctt cggtacgtat ccccatcaca tcacatcaca ttagacagag
    10921 acaaagacaa agctgacata tagtagcgtc gaagaatcct gacagggaac tacccagtcc
    10981 tgttccccga taacgcatgg gttcctctgc gggaactcgc cgaaaccacc cccaacgacg
    11041 gtctcctccg aatctactct acgttgagcg gcgaggccct cctggtgaca agcccgccgg
    11101 caatcagaga catgctcaca gtcaatgcct ttgacttcgc ccaccaggac ctcgtcaaga
    11161 ttgctatcaa gcgattcacg ggtagcaatc ttggtttcct tagcaatgat gaattcaagg
    11221 catgtaaaca acacgttgcc cctgggctac tagctgatca gagagaacac agctccaccg
    11281 caaaaacatg atgccagcat tcacagtccc acacgtccga aaattaacca gcatcttctg
    11341 ggccaaagct caggaaatgg tgcactgcat gtcgaacgag ctccgcgcag accccttcgc
    11401 ccggatcaac ttccgtgaat acgtgtctag ggctacactc gataacatcg ggctggcggg
    11461 gatgggccac gatttccaga cgctcaagca gcccgataac gacctgcgca gccactacag
    11521 gaaactgatc ctcgacccga cccgcgtgtt tagctgggtg gggctgctga gtcggtactt
    11581 cgacatgaga ctattgatga gggtgccgct gaagaagttg atcgagatct cgcaatcggc
    11641 gaactacctc cgtgctgtca cgacggcggt cattcaggac agaagcgaga agctagttga
    11701 ggctgaggat aacagggcta aggatatcat cactgtcgct ctcgcaagcg gtgtttttga
    11761 cgaacgccat ctagtcgacc acgtcatgac cttcctaaca gcgggccacg agtccaccgc
    11821 cacggccttt gaatggacga tgtacgagct aggccgccgg ccggagatgc agagccggtt
    11881 aagggacgag ctgcgagagg caataggcac ggatctggcg gctgtggact ttggattacg
    11941 ggtccagaat ctgccttact tgaatgcgtt ctgcagtgag gtgctccggt gctatccctt
    12001 ctcgccgatt atcgtaaaag ttgcacagca ggaaactacg cttatgggcc agcggatccc
    12061 caagggcact gttgtgctgt actcggctga ggtgtcgaac catgacaaga cgctttgggg
    12121 gccagatgcg gataagttcg atccggagcg gtggataggc gaggggaagg cgaagtctgg
    12181 tggtgcttcg agtaattatg ccatgcttac atttggcgcg ggtccacgga actgcattgg
    12241 agcgaatttt gccagggcga cgcttgagtg tcttgttgcg gcggtgttgt ctacgtttga
    12301 gattgagctt gtgaatcctg atacggcggg gaggttgaag ttcgggcaga cgaagaagtc
    12361 ggcagaaggg gtttacggaa ggcttaagtt tgtacgaccg gtggaagtct aaggactgga
    12421 agattgtttg gtataacctc cgtagcgtta gatgactacc ttagggttat ttatagggga
    12481 tgcagccgtc cgagcaaaaa gtcgccggtc agcaacaaaa cacatttatt aaatacaata
    12541 taaattataa agtcattctg aaaaaaggcc acgagcttaa cagtcgagtt gcagagcagc
    12601 aatgaacctc tggaaacttt cagtcggcat cctcgccgcc gtaaagtccg tctggacccg
    12661 cggcagccca ttcgccgcac tcacagccct atggccaaca aacgaagagg gcaaattcat
    12721 cattcaatcc gaaggcattc gactggcttt tacaaaccac ggcgcagccc ttacaaatct
    12781 ctggctgaat aatacccatg gtgaggagat cgatgttgta ctgggcttgg acgatgcgag
    12841 gggttatccg tcgctgcagt caaatccgtt tttaaatggg gttataggtg tgtgttatcg
    12901 accttaccct ttctctttct ttttttgcca gttaaataag ctgattgcgc aaacgacaag
    12961 gacgatacgc cggcttccta agcaactcca gctacccagt cgacggaaca atctaccccg
    13021 taaccgcaaa cgctcacaac gcgacctcgc tcttcaacgg cggagataaa ggctggggcc
    13081 gacagacctg ggacatcgca gtgcatatca acaatagcat tacattcgtt ctgtttgata
    13141 acaggtggaa tgggttccct gggatctttg cctcgtgcgt gacgcatacg gttacgccgt
    13201 atgagtggcg gattgccttt ggggttacgc cgttgctcaa ggcgggcccg attaatttga
    13261 gtcagcaggt tttctttaac attgatgggt ttaggaataa tgccagcacc agcgatgcta
    13321 gtaatagtac ggtgcttgat cataggctga ggcttcctgt ttccgggatg cggttcgatg
    13381 ttgatgagcg ggggattccg acgggcgata tgaagagtaa tagggagggg aaggagttcg
    13441 acttttggtc tgcggataag tctattggcg acgaggttca gaagggtaat gccggatttg
    13501 atgtgactta tgcgctctcc cataaaccgt tgggcgacaa ggaagatgag cctgtggcga
    13561 tcctctcctc gaagctgtct ggtgtcacca tggagcttta cacggaccag gacgctctcc
    13621 atgttcatac gtgggacaat aacttgggta atatgacatt tttctgtaga agttggagtc
    13681 acaactgata gtgtctacag gtgggttgcg gttgaagaaa ggtcaagggg caggcaaagt
    13741 cgctcagcac gcggcgatat ctctagagat gcaagactgg ccagatgcag tgcaccatcc
    13801 ggaatggaga cacaggaaga ccatttgggg gatggacgga ctatatacgc ggtttgcaac
    13861 gtacaagttc tcggtcgagg ggaaataaac atatagaagc cattggccta gtaattgctg
    13921 cagacagata tacatttata tagaagcaac cgtgtctacg aaactacaat ttgtaaacca
    13981 gtctctctag gcagatacca ttctagctgc aacctcactc gcaacctcaa cagccggcac
    14041 ggagtcatac tcaccacgat cccgatcccg atactccgcc ataacctcag caatattctg
    14101 cacatcgccc gtcttcaccg gaatctcatg ccccccctta aacctgacca ccgtcgcaag
    14161 cctctgatta aaatactgct tcgacaacct ggttccctta gccaaccacg gatcaccaat
    14221 cccctgaaca tggacagaca caatatctag cggccgcgat acctgcgtct cagcagcact
    14281 caacggcaac gaaggacaaa tcccacaaat cataatcgca aacttgatgt ccctccccag
    14341 ctcagggtca agacaaaccg ccgtcgcaac cctcgtcccc tgactaaacc ccataacgcc
    14401 gacaaccccg gcccccggtc catttcggcg ctcgcgctca ataacatcct tcaatgaatc
    14461 ccgtacaacc cggcgttcac gctcgacatc ttccactgtg acgtcgaata gcccgattgt
    14521 gtttctgtcc tgatgccacc gtctgtgcgg ctttatgtgt gcgtagtaga gcggcacgcc
    14581 gacgccagcc tgggccgttg tgatgggcga gttgaggaag aggaaacgga agtgggggga
    14641 taggactcgc gtgagatttt gggactgggc ttggaagatc tccccgctgc tgccgtggcc
    14701 gtggaggcag atgatagcgg gtttcgtttc tgagttcatt ttgtggctgg cctgtgtcgg
    14761 gttgggtgtt gctggtggtg gtggtgttaa tggattggag attggtgtgc agtgctggac
    14821 actggattga gtgcttagcc tagctggtct tttggatgga agcttgtctt ttgattttta
    14881 agaagcgtgc ctttaatagg acgccgtgtg tgctgtatta cttaacctcc ggacttattg
    14941 gggcagggca tttaccggac cggcgacttc tactgttgaa ggatgtgaga ttactctgtt
    15001 ggtttctcca cgggccggaa aagggtcatc agtaaaaatg gcgtacaatg gaggggtgat
    15061 aagggcctca gagacttgtt catggtactt aaacacactg ggatataacg ggaaatagaa
    15121 gttcgaagtc tgtctgattc tagttattgg gagtataaag tcacatatac caaccatatg
    15181 gtgaaacatt ccaaagccaa atcgtaacta tgaattaatc ataacctgcg ccaatttctc
    15241 gagtaaagac gtctctttct cagaaatcat atccaccgca gcgtgtatcg agttattcgc
    15301 agccgcagct gctgcctgca agccactcgg tggtgatgat gcatgcggtg gtggtcgccc
    15361 ctgctgatgc tgatattcag gcgtcaagag actaatagca tcacgcagct gatgaaccat
    15421 gctagaaatc atataagcac ccaccgaggt actcatggcc ggctgggatg caagattgaa
    15481 ggtacccagg ctaacgaggg ccagattccc agcgcgggtc ttgagattat ccacagcaag
    15541 gtccagcagc tgcagggcgt atgcgtacga tgtcgcgact tgtaagacgg tgatgtagtt
    15601 tatccttagt gggtcgaacg gccctcctcg ttgagttggc tggccaattc cgtcgcaggg
    15661 atcaggatgt ccggcattga cgctggctgg ggtgaatggc ggtcctgtcc cagtcatatt
    15721 cttacttgca gtaccgtagt ctgaagagga gcgacgggct gggatgggga gtagctctag
    15781 cagctctttg cagaccatca tgacctcgtc aatggccggc tggtgccctg tgggcgattc
    15841 gctcgcgcct gttaacagat tgctcaggtg gaactgcagc cgtaggagct catctgcgac
    15901 ggtagtctta acaataggga ctgtcccctt ttctgacatc tccaggtcgg aatcagagaa
    15961 atcaggaact tccttgtatt tctgttgcag gctctccact tgatgatatt cctggtgggc
    16021 gtgcccatgt ccacgtccgt gtccctgtcc gcccgttgga tcatcgtgag ccgggtgcgc
    16081 aaagtccggg gaatacagcc ctaggtccca gatcacattg tcgccaggta ccactggtca
    16141 cactctttag cgtttcggtt cctgcatgca gggtctgcgg gtgtatgtac gttacctgcg
    16201 gggaggagag caggatctag aagccctaac actggttcga gattgcgggg actatcaggt
    16261 tcagaaccac tactagggcc acttccagga ccggcaccgc cagatctatc gtgtgctgca
    16321 gaagctagat cgacatgatc aacaggaagc ggcactgcat tagcaccgcg ctggctcccg
    16381 gcctggacgg cccgtcgttt agagtgtctg gcggaggatg ctcctttctg gttctcagaa
    16441 cccggccgcg acactcgtgg acggcccatg cgcgcactgg tgttatacac gcagtctata
    16501 tcaagcctct cacaccggtc gcaccgactc tcaggcccac cggtgcgagt gcatcggttc
    16561 ttgagttcgt ggcagcggtc acatgccgcg cggagctttc gttcaccgtt catcatcttc
    16621 ttaacggcaa taaaacattc gcttagtgaa tgaacttagt gccttggaaa tcggcttata
    16681 aagaatggcc taaaggcccg ggccgttgcc ccgctcctgc ctttcgctct tctattttga
    16741 gagtactaca cgccttgatc attcccgcgg accaattgta caaaaggaac taggaactgt
    16801 tggatttcct tactgttagg tcaacagaat atgcctgcct tcttgtccaa tcattcattc
    16861 taaagaatac cttttaggaa tcaacctggt caatttagtc tggtatgtaa catactaaca
    16921 tgtagctgtg gagggaaatg taagctgcct gcgccacaaa ccaactttac agcctatcaa
    16981 ggtagattct gtgggagagg aggagcacta gttcactaga gtgggtaagc tgcctccaca
    17041 aatattaaat tctcatatac gtagtaggta tatcaggtca tcatatagtg tcgatatcga
    17101 atcgccatat agtactgata tcaaattgcc atatggcatc aatattaaat ggtcacatat
    17161 tattgatatc aactcatata ggaggatatg aatatcacta tatgtagata tatatccatt
    17221 ttagtaatgg gctacccccc agacaaacaa aaacaatctt tatatatgaa ttataaggat
    17281 acagagcaca gtaagcacta acttggtatc tacttgtaaa ggatccacga gacagggtag
    17341 atgagcctgt tgactaggta ggacttttgt aacgattagc agctgacgga gagattagta
    17401 agaagactcg atatatagta tcaagtagta aatcactaga taacaagact aatccttgta
    17461 ttcctaagtg ctcaacaagg gtgtctacat gtatcttcat ggaccatcca agatgttcgc
    17521 ggtggtgatt cgaaaacagg tcgagtgcat gaaacggtag gaagcaaccc cttgggggtg
    17581 ccacacaaca aagcaacggg aactgaaacc aatctgttac attaatatcc atacttacgg
    17641 cgattcaata tcaatactac atgaccattt gatatcccta ctgtatagcg attcgataat
    17701 aatactctag tgcttattca atacggacac tatatgatgt ctttgatact atatagtatt
    17761 tgatatcaga gtagtgcgtg cgagcgtaag gtgggaggga gtggtaggac gtatcacacc
    17821 gggaagtggg gtgggagcac ctggcatgga taatcatcgt aagaaaacca acaccattac
    17881 cagtctggct gatcgatcgg ccagtgagaa tcttagttcg tgccgcagtc ctgttggttg
    17941 ggatattata ccactaaccg acccttccac ctacacagtg tagtttcagg gtcgcacgct
    18001 agggcgaccc cgccagctca acgtaagggg ccatctcaac gtctaaggat atgtacttcg
    18061 tccggacgcc cttttagcat aatggtaatt ttactcgtcc actgtggttt tgaaagtgtc
    18121 agagatactc gttacaatgg tattccttcg ggagaggctg atctcagata gttgcatctt
    18181 ccttatctct cttttgggta cgaaactaag aatgcagtat atcacataaa tctaaccaat
    18241 ggaagtactc tgttcatcgg atttctaacc aaccgagctg cggcctacag agagcttagc
    18301 gccgcgagaa tgagattgat agtggattgt ccagaccggc ctaaagagag cctcgagctg
    18361 ctccaatggg gctattgggc aatgccattg tcccatttgg tctattgctg ccgcttgcgc
    18421 accgacccca aacaatcaga aacaaacaag cttgtctaag gccctctaga taggcttact
    18481 ttgcgtcggt atctgcggct ccatgccctt aaatgcggcc gccacacgga ggttttctct
    18541 gcctaccacc gctgaagtgt aaaagtcgcc ggatgggttg gacagtgata cagtttacag
    18601 gacatgcgtc aaaggaagga attagtgaat cctggagtgg gcgctgaaac tatcaaaatg
    18661 cccctcccag gccttcccaa cagtgaataa gccatcacat tcagaagaca ttcagaaatc
    18721 cagtcaacct caccgtcacc atcaccatta cccaaaatga cagtcacaag tttgtcttcc
    18781 tatccatcca tctcatcact acgcaaataa gcacactaac gcaaacatta cttcccccac
    18841 agcaaccccc gacgactgga aaaagaaggc atcaagctac aaatccatga ccggcgggct
    18901 aaacgtgaaa cccataaccg tgatgctgga gtgcctgaac tcgcgcttcc cactcgcatc
    18961 cgcaaccgga atcctcgacg acgggtgcgg gcctggtccc atcatgacgc ggattatcga
    19021 tgagtttggg aaacatcttc cggcagagtg taccctgacc tgctcggatt tcgcaccggc
    19081 gatggtcgac caggttcagg aggcgaagag gcgcttcgtc gctgatgagc cggggtcggt
    19141 ttggggtcgt gttaggaccg aggtcctgga ttgtatggac ttggctactg ttggggatgg
    19201 agagatgagt catgttgcgg ctggttgggt atgtatcttc ttttctttcc catttccatg
    19261 cttaccttga catacatcgt atgtgctcgt tcggatgcta attttttgtt gttttgtgtg
    19321 tgttgcagtc cttcttcaac gccagcaacc cccagaaagc gctctccgaa tccctacgcg
    19381 tcctccagcc aggcggcgtg ttagcagcct cgtcctgggc cgaaaccgac tggctcaaga
    19441 tcctgcggac aatcacgaag atcgacccgg cgcgcagccc gcccgccatc cccgaggact
    19501 gggcgaaagc aggtaatttg gtagcgcagc ttgagattgc ggggtaccgc gacgtcgatg
    19561 ttcatgaggt ccccgtcgat ataccgttcc gctcgtatgc gtcgtttgtg gatgtgatga
    19621 tgacgagggt tacgcagatg atgacggcga gccaggactt ggatgagagg cagaagacgt
    19681 tgctgaggga gttgatgacg gaggagatga agggcttgtg tccgactgag cctggggttc
    19741 tcaaggccgt ttcgttggtt gctgttgggg tgaaaagttg actatttatc atgtactttg
    19801 tattctcttg gctttcgtca gtgatggggt tccttggcta actagatgga gtcggcagga
    19861 actaaatcta ccttgggtta ttccactgac aagacgggct ccctagcttt agctgtattg
    19921 tacacttata aatgataagt tgtacccgtg gacagtaaag catattggca attactagtg
    19981 ccctttggct tatcatgaca agtaaatatt gacttcgcct tgttcaatcc agtacaatac
    20041 tacacaggta aaggcaaaag tgagaacacc ttgccggatg tttttcgtct actccgtatc
    20101 tcaacatcga tcgcttctcc gtccctccat tctataaacc cataaagacc actcgtactc
    20161 ttgagatcac aacccagtag aacagaattg acagctctac tgctgttcag cctcagcctc
    20221 ctctgggtca gtcgtctttt tgtcagtaat tctctcccac ttaactccga aggccaggaa
    20281 gaatgctgca gttgtcgtag caacagcaac aaactttcat gccatctggt tagtttcaat
    20341 cctcctacaa agccgtagcg gaaagggcac ttacaaaagt cgaagtaata gccgtattat
    20401 aagactccaa aaccaagttc aacaaatccg gaaacctctg ctccgcagta ccacgcacct
    20461 tcgccgtccc agcagcagac agcagcgcaa tctgctgggc tttcaagccc gcatggtttg
    20521 ccaattctga agccaggatc gaacgaaaca caatcccgcc aaggacctgc gtgactgtgg
    20581 cgcctaggta ctggaagaag agattcagcg acaccgcgac gggcataagc tctggcttgt
    20641 cgcgcacggc ttgctggact atgagcgatg gcatttgctg cgccatgccg acgccgagac
    20701 cctggatgac ctggaagcca atccagtggc tagatggggt attgaatgtt gagaattgcg
    20761 tgtagagggc tgcggcggtg cacatgaaaa ggggcccgac gtagagccac gggttgtagt
    20821 agtggattct tcgtgctgtg tcaacgctca gtgtcagctt ctacttgaac ttgatacatt
    20881 gacacgtaag acgtgagtgt gtaaagtcgt acctagaaca ccagcagaca gggttccgac
    20941 tatttgagaa agcaccgcgg ccaaaacccg cgtaccactt tgcaacggac tcgcgccttg
    21001 cacggcctgg aaccattcag ggagatagta gttcaagata ccgagagagc cgaagtggca
    21061 gaaagaaaac aagacactga acgagactgc ccgtctggcg acgacattcc ccggtatcat
    21121 cgcgccctcg cctttatggg cttcccagca aacaaagagg ataagcatca caccggagcc
    21181 cacaaacagc ccgatgattg tcgctgagtc ccaatccttc tgcgtcccac cccacatcat
    21241 agcaaggagc agcatgaaga tagccggaat gaaaattgca cacccgagga gatccaggtt
    21301 catgattcgc tggacaacgg tccgatcgcg ctgtatggac gggggtttga agaagcacag
    21361 catagagagc aacgtcagag cacctggggg aagattaacc cagaaacacc accgccaggt
    21421 tgccttctcc gtgaacgcgc cgccgattac gggtgctaga attagcccca tagcgaagca
    21481 gctgctgcat atgcctagca gcagtggttt cgatttctcc ggagaaacgg tgagaacgat
    21541 aacgaagccg ccacttgcga caccggatgc cccgatacct gcgattgcgc gacccgcgat
    21601 gaaagtgttg ctatttggcg caaagccgca gactagactg ccgactagga aaatggagaa
    21661 gaacgatatg tagatccagc ggagcggaaa cgtcgagctt agctttcctg ctagcggagt
    21721 caatgcgcat gttgtgagtg agtaggcagc cggataccag gccaattgcg acgtatcctt
    21781 gaagtcggac gtgatggatg ggattgccta gccgtgggga tcagatcatt gaagtttttc
    21841 gaatagcaac gggggtggta gtagtacagt tgcgatgaca aaaatatcca aggacatcag
    21901 gaacgcgccg aagcatatgc ctacgaaaat ggcaaagagc ttgaaaccgt gcatcgcgtt
    21961 cgcgtttgtc tctggatcct cagtgctgac ctcatcactg gtcgcatgct gggcttgggc
    22021 agggctgtcc gcatctcgtt ctgacttggt agctctcgtc gcctcatctg gggaagacgc
    22081 agccatattc gagatttagc agacggacca tgaaacgaga gtggcagaat gcatttggtc
    22141 ataggcaaat gatcaaatcc atgactgcgt gacgcacgga ctcggagtgt gttggaccgg
    22201 cgacattcgt ggcttgaaag tcgccggttt caaaggtaca tgatacatcc ccgttcagcc
    22261 gcatctctgg aagaacaata ctccaaaaca gttattttga gttagttatg cagatcaaac
    22321 tactgctact acctggctat atagcagatt aatgcaattg acgaggcttt gcaaggtttg
    22381 aaaggcaggg atttcctaca gcctggcaga aatgtctgct cacaaattgg ggatcataaa
    22441 tgagactatg gatctactca tcgcatgcac tttcagtatg ttgaccagct atataaacgg
    22501 gctatggtta cagtggttgg ttggttggtt gatggcattt acgctgaccc ctcgctagct
    22561 atggttacag ggatgattat gatgatgatg atgatgatga tttcatacgc tgacccctcg
    22621 ccctcagttg taaccctgaa ttgaggtaca agtgtgatga tactcatact aactatgtga
    22681 gcaggtacgg ctatttatag ccaaagtagc tgccttccta ctgtccagct caccagctgc
    22741 ctcctaggct aaccctggta gcctactact tcacatatag tgtatcatat ggtcatgtga
    22801 tcttgggatc caacactccc cctgtaccac ggccccgggt tgtggtacca tcaaaggatc
    22861 ccatatcctt attaagtgtt atactgttat gcagtacccc tttgaacagc tg
//
