BGC0002140: galtamycin C biosynthetic gene cluster from Streptomyces sp. MBT84
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Location: 1,882,327 - 1,923,787 nt. (total: 41,461 nt).
This entry is originally from NCBI GenBank JAHTGP010000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002140
Short description galtamycin C biosynthetic gene cluster from Streptomyces sp. MBT84
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Galtamycin C has been isolated before by Stroch et al., doi:10.1038/ja.2005.13"
Biosynthetic class(es)
  • PKS (Unknown)
Loci
JAHTGP010000001.1
1882327 - 1923787
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • galtamycin C
  • galtamycin D
Species Streptomyces sp. MBT84 [taxonomy]
References
Chemical products information
galtamycin C Evidence: NMR
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Chemical database entries
PubCHEM
ChemSpider
galtamycin D Evidence: NMR
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C31H31O11
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MBT84_08725
  • MBW8699674.1
 1882327 - 1883931 (+) putative multidrug-efflux transporter
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    • MBT84_08730
    • MBW8699675.1
    		 1884084 - 1884824 (-) hypothetical protein
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      • MBT84_08735
      • MBW8699676.1
      		 1884927 - 1886045 (-) NADH oxidase
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        • MBT84_08740
        • MBW8699677.1
        • bmr3_2
        		 1886151 - 1887731 (-) Multidrug resistance protein 3
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          • MBT84_08745
          • MBW8699678.1
          • azo1
          		 1887762 - 1888361 (-) FMN-dependent NADPH-azoreductase
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            • MBT84_08750
            • MBW8699679.1
            • tetR_5
            		 1888534 - 1889217 (+) Tetracycline repressor protein class E
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              • MBT84_08755
              • MBW8699680.1
              		 1889347 - 1890198 (+) hypothetical protein
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                • MBT84_08760
                • MBW8699681.1
                • otcC_2
                		 1890516 - 1891994 (+) Anhydrotetracycline monooxygenase
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                  • MBT84_08765
                  • MBW8699682.1
                  • tcmI_1
                  		 1892017 - 1892343 (+) Tetracenomycin F2 cyclase
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                    • MBT84_08770
                    • MBW8699683.1
                    		 1892340 - 1893620 (+) Actinorhodin polyketide putative beta-ketoacyl synthase 1
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                      • MBT84_08775
                      • MBW8699684.1
                      		 1893617 - 1894843 (+) Actinorhodin polyketide putative beta-ketoacyl synthase 2
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                        • MBT84_08780
                        • MBW8699685.1
                        		 1895028 - 1895297 (+) Oxytetracycline polyketide synthase acyl carrier protein
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                          • MBT84_08785
                          • MBW8699686.1
                          • actIII_1
                          		 1895547 - 1896332 (+) putative ketoacyl reductase
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                            • MBT84_08790
                            • MBW8699687.1
                            		 1896374 - 1897309 (+) putative polyketide cyclase
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                              • MBT84_08795
                              • MBW8699688.1
                              • otcC_3
                              		 1897312 - 1899309 (+) Anhydrotetracycline monooxygenase
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                                • MBT84_08800
                                • MBW8699689.1
                                • efpA_5
                                		 1899330 - 1900544 (+) putative MFS-type transporter EfpA
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                                  • MBT84_08805
                                  • MBW8699690.1
                                  • aknK
                                  		 1900603 - 1901895 (+) Aclacinomycin-T 2-deoxy-L-fucose transferase
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                                    • MBT84_08810
                                    • MBW8699691.1
                                    • novM_1
                                    		 1901921 - 1903135 (+) L-noviosyl transferase
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                                      • MBT84_08815
                                      • MBW8699692.1
                                      • rmlC_1
                                      		 1903117 - 1903698 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                        • MBT84_08820
                                        • MBW8699693.1
                                        • novM_2
                                        		 1903701 - 1904831 (+) L-noviosyl transferase
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                                          • MBT84_08825
                                          • MBW8699694.1
                                          • rmlA_1
                                          		 1904857 - 1905924 (+) Glucose-1-phosphate thymidylyltransferase
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                                            • MBT84_08830
                                            • MBW8699695.1
                                            • strE_1
                                            		 1905921 - 1906904 (+) dTDP-glucose 4,6-dehydratase
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                                              • MBT84_08835
                                              • MBW8699696.1
                                              • tal_2
                                              		 1906894 - 1907955 (+) dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(P)(+))
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                                                • MBT84_08840
                                                • MBW8699697.1
                                                • rfbE
                                                		 1907952 - 1909256 (+) GDP-perosamine synthase
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                                                  • MBT84_08845
                                                  • MBW8699698.1
                                                  • rfbB
                                                  		 1909302 - 1910066 (+) dTDP-glucose 4,6-dehydratase
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                                                    • MBT84_08850
                                                    • MBW8699699.1
                                                    		 1910134 - 1911105 (+) hypothetical protein
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                                                      • MBT84_08855
                                                      • MBW8699700.1
                                                      		 1911171 - 1912571 (+) hypothetical protein
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                                                        • MBT84_08860
                                                        • MBW8699701.1
                                                        • gfo_3
                                                        		 1912568 - 1913524 (+) Glucose--fructose oxidoreductase
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                                                          • MBT84_08865
                                                          • MBW8699702.1
                                                          • psf-1
                                                          		 1913559 - 1914284 (+) 4'-phosphopantetheinyl transferase psf-1
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                                                            • MBT84_08870
                                                            • MBW8699703.1
                                                            • accD5_1
                                                            		 1914299 - 1915891 (+) putative propionyl-CoA carboxylase beta chain 5
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                                                              • MBT84_08875
                                                              • MBW8699704.1
                                                              		 1915931 - 1916596 (+) hypothetical protein
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                                                                • MBT84_08880
                                                                • MBW8699705.1
                                                                • aknOx
                                                                		 1916755 - 1918341 (+) Aclacinomycin-N/aclacinomycin-A oxidase
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                                                                  • MBT84_08885
                                                                  • MBW8699706.1
                                                                  		 1918459 - 1918896 (+) hypothetical protein
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                                                                    • MBT84_08890
                                                                    • MBW8699707.1
                                                                    		 1918999 - 1919229 (+) hypothetical protein
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                                                                      • MBT84_08895
                                                                      • MBW8699708.1
                                                                      • yycF_1
                                                                      		 1919451 - 1920215 (-) Transcriptional regulatory protein YycF
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                                                                        • MBT84_08900
                                                                        • MBW8699709.1
                                                                        • korA_1
                                                                        		 1920781 - 1922700 (+) 2-oxoglutarate oxidoreductase subunit KorA
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                                                                          • MBT84_08905
                                                                          • MBW8699710.1
                                                                          • korB_1
                                                                          		 1922693 - 1923787 (+) 2-oxoglutarate oxidoreductase subunit KorB
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                                                                            Biosynthesis information
                                                                            Annotation changelog

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Submitted
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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