BGC0002143 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002143 (Streptomyces sp. CA-256286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,519	High	griseusin	PKS

BGC0002143 - Region 1 - T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 72,519 nt. (total: 72,519 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,520
Label		BGC0002143

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

JHY03_07040: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

JHY03_07060: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

JHY03_07080: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

JHY03_07110: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

JHY03_07150: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

JHY03_07280: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

JHY03_07300: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: PPTase acyltransferase aminotransferase glycosyltransferase methyltransferase transferase

JHY03_06920: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

JHY03_06940: methyltransferase

smcogs: SMCOG1089: methyltransferase

JHY03_07030: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

JHY03_07070: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

JHY03_07140: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

JHY03_07170: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

JHY03_07240: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

JHY03_07250: methyltransferase

smcogs: SMCOG1248: methyltransferase

JHY03_07270: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase hydrolase

JHY03_07130: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

JHY03_07190: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase dehydratase

JHY03_07010: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

JHY03_07050: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

JHY03_07230: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

JHY03_07200: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

JHY03_07210: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002143.2	1.00	PKS	griseusin	Streptomyces sp. CA-256286
BGC0000231.5	0.77	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.67	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001239.3	0.67	other (other)	biotin	Aspergillus nidulans
BGC0001723.5	0.63	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000278.3	0.62	PKS	urdamycin	Streptomyces fradiae
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002143.2	1.00	PKS	griseusin	Streptomyces sp. CA-256286
BGC0000231.5	0.77	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.67	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001239.3	0.67	other (other)	biotin	Aspergillus nidulans
BGC0001723.5	0.63	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000278.3	0.62	PKS	urdamycin	Streptomyces fradiae
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72519
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 682.2; E-value: 4.5e-208)
Product molecular weight(s):: acetyl-CoA_8: 503 Da
acetyl-CoA_9: 545 Da

JHY03_07040: KR C9 (Score: 486.3; E-value: 4.8e-149)
JHY03_07050: CYC C7-C12 (Score: 496.2; E-value: 6.5e-152)
JHY03_07060: KR (Score: 119.8; E-value: 3.6e-37)
JHY03_07080: KR (Score: 123.5; E-value: 2.7e-38)
JHY03_07100: CYC C1-C18|C2-C19 (Score: 175.7; E-value: 1e-54)
JHY03_07130: CYC C5-C14 (Score: 473.5; E-value: 5.4e-145)
JHY03_07200: KS (Score: 769.9; E-value: 1.3e-234)
JHY03_07210: CLF 8|9 (Score: 682.2; E-value: 4.5e-208)
JHY03_07220: ACP (Score: 119.6; E-value: 1e-37)
JHY03_07230: CYC C7-C12 (Score: 305.5; E-value: 7.6e-94)
JHY03_07270: GT (Score: 340.5; E-value: 3.9e-104)
JHY03_07280: KR (Score: 155.4; E-value: 5e-48)