BGC0002147 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002147 (Streptomyces sp. CB02009)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	28,788	bohemamine A/bohemamine B/bohemamine C	NRPS:Type I	100%

BGC0002147 - Region 1 - NRPS

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Location: 1 - 28,788 nt. (total: 28,788 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,789
Label		BGC0002147

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002147	1.00	NRP	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009
BGC0001873	0.42	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001534	0.41	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001535	0.37	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001736	0.33	NRP	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002474	0.32	NRP	agrobactin	Agrobacterium tumefaciens
BGC0000457	0.32	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002284	0.31	Other	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131	0.30	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002147	1.00	NRP	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009
BGC0001873	0.73	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001534	0.72	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001535	0.70	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001736	0.66	NRP	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002474	0.65	NRP	agrobactin	Agrobacterium tumefaciens
BGC0000457	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002284	0.64	Other	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131	0.63	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28788:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AMK27_13910

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AMP-binding (459..868): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1529..1931): X

nrpys: 5Me-Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFISQLLK
Nearest Stachelhaus code(s):: 5Me-Pro DVQFISQLLK (100% 8Å match)
Stachelhaus code match:: 100% (strong)