BGC0002148: guanitoxin biosynthetic gene cluster from Sphaerospermopsis torques-reginae ITEP-024
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Location: 3,534,861 - 3,547,442 nt. (total: 12,582 nt).
This entry is originally from NCBI GenBank CP080598.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002148
Short description guanitoxin biosynthetic gene cluster from Sphaerospermopsis torques-reginae ITEP-024
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
CP080598.1
3534861 - 3547442
via Enzymatic assays, Gene expression correlated with compound production, Heterologous expression
Compounds
  • guanitoxin
Species Sphaerospermopsis torques-reginae ITEP-024 [taxonomy]
References
Chemical products information
guanitoxin [synonyms: anatoxin-a(S)] Evidence: NMR [1]
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C7H17N4O4P1
Chemical database entries
CyanoMetDB CyanoMetDB_0313
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • K2F26_16450
  • QYX30480.1
  • gntJ
 3534866 - 3535615 (-) guanitoxin forming phosphate O-methyltransferase
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    • K2F26_16455
    • QYX30481.1
    • gntA
    		 3535878 - 3536681 (+) heme dependent pre-guanitoxin N-hydroxylase
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      • K2F26_16460
      • QYX30482.1
      • gntB
      		 3536705 - 3537661 (+) L-arginine gamma (S) hydroxylase
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        • K2F26_16465
        • QYX30483.1
        • gntC
        		 3537813 - 3538925 (+) PLP-dependent (S)-gamma-hydroxy-L-arginine cyclodehydratase
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          • K2F26_16470
          • QYX30484.1
          • gntD
          		 3538922 - 3539965 (+) L-enduracididine beta-hydroxylase
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            • K2F26_16475
            • QYX30485.1
            • gntE
            		 3539980 - 3541290 (+) PLP-dependent transaminase
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              • K2F26_16480
              • QYX30486.1
              • gntF
              		 3541494 - 3542318 (+) pre-guanitoxin forming N-methyltransferase
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                • K2F26_16485
                • QYX30487.1
                • gntG
                		 3542324 - 3543358 (+) PLP-dependent aldolase
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                  • K2F26_16490
                  • QYX30488.1
                  • gntH
                  		 3543550 - 3544791 (+) MBL fold metallo-hydrolase
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                    • K2F26_16495
                    • QYX30489.1
                    • gntI
                    		 3544854 - 3545771 (+) pre-guanitoxin N-oxide kinase
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                      • K2F26_16500
                      • QYX30490.1
                      • gntT
                      		 3546079 - 3547437 (+) MATE family efflux transporter
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                        Biosynthesis information

                        Biosynthetic paths

                        guanitoxin
                        Show structure
                        Pathway: GntB > GntC > GntD > GntG > GntE > GntF > GntA > GntI > GntJ [1]
                        Precursor
                        pre-guanitoxin
                        Show structure
                        Pathway: GntB > GntC > GntD > GntG > GntE > GntF [1]
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-08-18
                        MIBiG v4 annotathon
                        • (ID: 5YHEW7BMWFDRKNSFQDCWZN7L)
                        • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
                        • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Entry added
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Cleaned up synonym list
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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