LOCUS       BGC0002154              7323 bp    DNA     linear   CON 14-MAR-2015
DEFINITION  Magnaporthe oryzae 70-15 chromosome 2, whole genome shotgun
            sequence.
ACCESSION   BGC0002154
VERSION     BGC0002154
KEYWORDS    .
SOURCE      Pyricularia oryzae 70-15
  ORGANISM  Pyricularia oryzae 70-15
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Sordariomycetidae; Magnaporthales; Pyriculariaceae;
            Pyricularia.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:03:33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7323
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7323
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[337:7126]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      338..7126
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..7323
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..7323
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002154"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7323
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(232..7143)
                     /locus_tag="MGG_07219"
     mRNA            complement(join(232..379,449..6349,6413..6704,6816..7143))
                     /locus_tag="MGG_07219"
                     /product="conidial yellow pigment biosynthesis polyketide
                     synthase"
     CDS             complement(join(338..379,449..6349,6413..6704,6816..7126))
                     /NRPS_PKS="Domain: SAT (13-251). E-value: 5.8e-86. Score:
                     279.8. Matches aSDomain: nrpspksdomains_MGG_07219_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (390-823). E-value:
                     8e-139. Score: 455.0. Matches aSDomain:
                     nrpspksdomains_MGG_07219_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (919-1219). E-value: 1.8e-93.
                     Score: 305.0. Matches aSDomain:
                     nrpspksdomains_MGG_07219_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1299-1616). E-value: 4.8e-122.
                     Score: 399.1. Matches aSDomain:
                     nrpspksdomains_MGG_07219_PT.1"
                     /NRPS_PKS="Domain: ACP (1669-1737). E-value: 3.5e-17.
                     Score: 54.4. Matches aSDomain:
                     nrpspksdomains_MGG_07219_ACP.1"
                     /NRPS_PKS="Domain: PP-binding (1796-1862). E-value:
                     1.8e-12. Score: 39.5. Matches aSDomain:
                     nrpspksdomains_MGG_07219_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (1939-2171). E-value:
                     9.3e-44. Score: 142.4. Matches aSDomain:
                     nrpspksdomains_MGG_07219_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 73.5; E-value:
                     2.3e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="MGG_07219"
                     /product="conidial yellow pigment biosynthesis polyketide
                     synthase"
                     /protein_id="EHA55627.1"
                     /sec_met_domain="itr_KS (E-value: 2e-156, bitscore: 507.0,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.2e-95, bitscore: 305.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-14, bitscore:
                     40.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTTIKMADKLAFLLFGDQSLDTHGFLAEFYRHEDRGILAKAFLD
                     QAAQALRKEIERLPRLERSRLPVFRTLQQLNERYHAQITKHSGLDGALLCVAQLAHYID
                     HAEKNHEDVTQHDKTYLVGLCSGLFAASAIASTPSLSSLVPVAVQTVLMAFRTGAHVAA
                     LAERLEPVSERSESWTYIVPGFTEEAAQKEIAGFHESHGIPQASQVYVSASSSANVAIS
                     GPPTTLKAFRAATSSLTKATAIPVYGPYHAPHLHRPEDVDNILGLNNPEMIDTFLNTKP
                     RSSVMSCLTGTWFNESTTRALFAAVVSEILTQTLRFHNVLDGCLNLARGFDGKSCLIIP
                     FGPTQHAATLANLLKAETNLDIILRKAPQISKESTDSVIGNHGRGSRDKLAIVGMAGRF
                     PDAASHEKLWELLSKGLDVHRVVPADRFPVETHYDPNGKVINSSHTPYGCWIEKPGMFD
                     PRFFNMSPREAFQTDPMQRMALTTAYEALEMSGYVPNRTPSTRLDRIGTFYGQTSDDWR
                     EINAAQEVDTYYITGGVRAFGPGRINYHLGFSGPSLNVDTACSSSAAAMNVACSSLWAR
                     DCDTAIVGGLSCMTNPDIFAGLSRGQFLSKKGPCATFDNNADGYCRGDSCASVIVKRLD
                     DAIADHDRVLAVILGTATNHSADAISITHPHGPTQSLLSSAILDDAGVDPLDVDYVEMH
                     GTGTQAGDGTEMVSVTNVFAPANRKRPADRPLYLGAVKANLGHGEAASGVTALCKVLLM
                     LQKNAIPPHVGIKKGSVINKTFPKDLGERNVNIAFHLTPFKRSDGKPRRVFINNFSAAG
                     GNTGLLLEDAPPVEPATQDPRNVHVITITGKSKSAMIHNAERLIQFMDDNDDTPISHVA
                     YSTTARRIQHYWRMNVTAQDLGEAKQALKNRLQENFVPVSPEPPKVAFMFTGQGSHYAG
                     LGKELYANHAVFRQAINEFDRISQIHGFPSFMPLVDGSEPDVAKLEPLIVQLGLCCFEM
                     ALAKLWASWGVKPAAVMGHSLGEYAALHVAGVLSASDTIYLVGARAKLLVEKCTAGTHA
                     MLAVMGSVSTVQEALGERADSTNVACINGPRETVLSGEASEMAEIAQQLGAAGFKCTQL
                     KVPFAFHSAQVDPILDDFEKLARSVRFNTPKVPVISPLLGKLVDDEPINPKYLRDHARD
                     AVDFLGGLVSAQSAGAIDEKTVWLEVGPHPVCANMVKAAFGVSTVAVPTLRRNEATYKT
                     LSASLCTLHTAGLNIDWNEYHNDFLSSVRHLDLPSYAFDEKNYWLQYEGDWCLSKNRIA
                     KALPAAAAVAKPKLETTTVQKVVREEIKGDVAVVEIESNLSREDLRGVVSGHLVNGAPL
                     CPSSLYGDMAITTCQYAYKLLRPESENIGVNVAHMEVPKTLIFDDAAESHILRLTVTAN
                     AAQNSADLVFHTGEGAKRVDHANCKVYFGNTEDWQGEFDRVSYLIKSRVDGLIDSEKDG
                     KASKIGRGLAYKLFAALVDYTPRYRGMEEVVLDSETCEATAQVKFQTTEADGNYVFSPY
                     WIDSLCHISGFIINGTDAVDSREQVFISHGWGSLRFSELPVASKKYRSYIRMQPIKGNK
                     VYAGDVYVFDGEKIIGVCGDLKFQAIPRKVLNMMLPPRGAAAIAAPARAAPAPAAKPAA
                     KEKKTSSTKEKSKSVTPKNIGKVNQKLASVVTQVLDILAKEVGVSHDELADNIAFTDLG
                     VDSLMSLTVSGRIREDMDLSIDSHAFVDHPTIGAFKAFLAQFEGPGGAMEDSSSSSSSV
                     SGDMDSESDVTTPADESDTASVKGEKMDGKATATDTNELQEAIRNTIATEMGMDVEEII
                     AAPDLASLGMDSLMSLQILGTLREKTGMDVPSDLFVSNPSLKDVERALGIVPAAPKRPA
                     AQAAPAKSKASKSEKVKPCPPTTSIPPSQVTATIYKPPRPTEILDTMPHRKATSVLLHG
                     SHKTATRHLFMVPDGSGCATSYTEMCNVGPNYAVWGLFSPFMKTPEEYNCGVYGMAAKF
                     IEEMKRRQPVGPYSLAGWSAGGVIAFEIVNQLIKAGDEVENMIIIDAPCPVTIEPLPKS
                     LHAWFASIGLLGDGDADKIPSWLLPHFAASVTALSNYTAEPIPKDKCPKVMAIWCEDGV
                     CHLPTDPRPDPYPSGHALFLLDNRVDFGPNRWDEYLDGSKMTMRHMPGNHFSMMHGAMA
                     KQLQGFMQEALQ"
     aSDomain        complement(join(371..379,449..1135))
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_Thioesterase.1"
                     /evalue="9.30E-44"
                     /label="MGG_07219_Thioesterase.1"
                     /locus_tag="MGG_07219"
                     /protein_end="2171"
                     /protein_start="1939"
                     /score="142.4"
                     /tool="antismash"
                     /translation="RHLFMVPDGSGCATSYTEMCNVGPNYAVWGLFSPFMKTPEEYNCG
                     VYGMAAKFIEEMKRRQPVGPYSLAGWSAGGVIAFEIVNQLIKAGDEVENMIIIDAPCPV
                     TIEPLPKSLHAWFASIGLLGDGDADKIPSWLLPHFAASVTALSNYTAEPIPKDKCPKVM
                     AIWCEDGVCHLPTDPRPDPYPSGHALFLLDNRVDFGPNRWDEYLDGSKMTMRHMPGNHF
                     SMMHGAMAKQ"
     aSModule        complement(371..1564)
                     /domains="nrpspksdomains_MGG_07219_PP-binding.1"
                     /domains="nrpspksdomains_MGG_07219_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="MGG_07219"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       complement(881..955)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MGG_07219_0006"
                     /evalue="1.90E-12"
                     /label="NRPS-te1"
                     /locus_tag="MGG_07219"
                     /protein_end="2024"
                     /protein_start="1999"
                     /score="39.5"
                     /tool="antismash"
                     /translation="QPVGPYSLAGWSAGGVIAFEIVNQL"
     aSDomain        complement(1367..1564)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_PP-binding.1"
                     /evalue="1.80E-12"
                     /label="MGG_07219_PP-binding.1"
                     /locus_tag="MGG_07219"
                     /protein_end="1862"
                     /protein_start="1796"
                     /score="39.5"
                     /tool="antismash"
                     /translation="EAIRNTIATEMGMDVEEIIAAPDLASLGMDSLMSLQILGTLREKT
                     GMDVPSDLFVSNPSLKDVERA"
     aSDomain        complement(1742..1945)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_ACP.1"
                     /evalue="3.50E-17"
                     /label="MGG_07219_ACP.1"
                     /locus_tag="MGG_07219"
                     /protein_end="1737"
                     /protein_start="1669"
                     /score="54.4"
                     /tool="antismash"
                     /translation="TQVLDILAKEVGVSHDELADNIAFTDLGVDSLMSLTVSGRIREDM
                     DLSIDSHAFVDHPTIGAFKAFLA"
     aSModule        complement(1742..5782)
                     /complete
                     /domains="nrpspksdomains_MGG_07219_PKS_KS.1"
                     /domains="nrpspksdomains_MGG_07219_PKS_AT.1"
                     /domains="nrpspksdomains_MGG_07219_PT.1"
                     /domains="nrpspksdomains_MGG_07219_ACP.1"
                     /iterative
                     /locus_tags="MGG_07219"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(2105..3055)
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_PT.1"
                     /evalue="4.80E-122"
                     /label="MGG_07219_PT.1"
                     /locus_tag="MGG_07219"
                     /protein_end="1616"
                     /protein_start="1299"
                     /score="399.1"
                     /tool="antismash"
                     /translation="TTTVQKVVREEIKGDVAVVEIESNLSREDLRGVVSGHLVNGAPLC
                     PSSLYGDMAITTCQYAYKLLRPESENIGVNVAHMEVPKTLIFDDAAESHILRLTVTANA
                     AQNSADLVFHTGEGAKRVDHANCKVYFGNTEDWQGEFDRVSYLIKSRVDGLIDSEKDGK
                     ASKIGRGLAYKLFAALVDYTPRYRGMEEVVLDSETCEATAQVKFQTTEADGNYVFSPYW
                     IDSLCHISGFIINGTDAVDSREQVFISHGWGSLRFSELPVASKKYRSYIRMQPIKGNKV
                     YAGDVYVFDGEKIIGVCGDLKFQAIPRKVLNMMLPP"
     aSDomain        complement(3296..4195)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_PKS_AT.1"
                     /evalue="1.80E-93"
                     /label="MGG_07219_PKS_AT.1"
                     /locus_tag="MGG_07219"
                     /protein_end="1219"
                     /protein_start="919"
                     /score="305.0"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="MFTGQGSHYAGLGKELYANHAVFRQAINEFDRISQIHGFPSFMPL
                     VDGSEPDVAKLEPLIVQLGLCCFEMALAKLWASWGVKPAAVMGHSLGEYAALHVAGVLS
                     ASDTIYLVGARAKLLVEKCTAGTHAMLAVMGSVSTVQEALGERADSTNVACINGPRETV
                     LSGEASEMAEIAQQLGAAGFKCTQLKVPFAFHSAQVDPILDDFEKLARSVRFNTPKVPV
                     ISPLLGKLVDDEPINPKYLRDHARDAVDFLGGLVSAQSAGAIDEKTVWLEVGPHPVCAN
                     MVKAAFGVSTVAVPTLRRN"
     CDS_motif       complement(3842..3958)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MGG_07219_0005"
                     /evalue="6.10E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="MGG_07219"
                     /protein_end="1037"
                     /protein_start="998"
                     /score="53.7"
                     /tool="antismash"
                     /translation="GVKPAAVMGHSLGEYAALHVAGVLSASDTIYLVGARAKL"
     CDS_motif       complement(4145..4192)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MGG_07219_0004"
                     /evalue="1.30E-04"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="MGG_07219"
                     /protein_end="936"
                     /protein_start="920"
                     /score="14.7"
                     /tool="antismash"
                     /translation="FTGQGSHYAGLGKELY"
     aSDomain        complement(4484..5782)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="8.00E-139"
                     /label="MGG_07219_PKS_KS.1"
                     /locus_tag="MGG_07219"
                     /protein_end="823"
                     /protein_start="390"
                     /score="455.0"
                     /tool="antismash"
                     /translation="AIVGMAGRFPDAASHEKLWELLSKGLDVHRVVPADRFPVETHYDP
                     NGKVINSSHTPYGCWIEKPGMFDPRFFNMSPREAFQTDPMQRMALTTAYEALEMSGYVP
                     NRTPSTRLDRIGTFYGQTSDDWREINAAQEVDTYYITGGVRAFGPGRINYHLGFSGPSL
                     NVDTACSSSAAAMNVACSSLWARDCDTAIVGGLSCMTNPDIFAGLSRGQFLSKKGPCAT
                     FDNNADGYCRGDSCASVIVKRLDDAIADHDRVLAVILGTATNHSADAISITHPHGPTQS
                     LLSSAILDDAGVDPLDVDYVEMHGTGTQAGDGTEMVSVTNVFAPANRKRPADRPLYLGA
                     VKANLGHGEAASGVTALCKVLLMLQKNAIPPHVGIKKGSVINKTFPKDLGERNVNIAFH
                     LTPFKRSDGKPRRVFINNFSAAGGNTGLLLEDAP"
     CDS_motif       complement(4838..4885)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MGG_07219_0003"
                     /evalue="2.20E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="MGG_07219"
                     /protein_end="705"
                     /protein_start="689"
                     /score="10.7"
                     /tool="antismash"
                     /translation="YVEMHGTGTQAGDGTE"
     CDS_motif       complement(5081..5116)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MGG_07219_0002"
                     /evalue="2.10E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="MGG_07219"
                     /protein_end="624"
                     /protein_start="612"
                     /score="11.4"
                     /tool="antismash"
                     /translation="FDNNADGYCRGD"
     CDS_motif       complement(5237..5305)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MGG_07219_0001"
                     /evalue="1.80E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="MGG_07219"
                     /protein_end="572"
                     /protein_start="549"
                     /score="16.9"
                     /tool="antismash"
                     /translation="GPSLNVDTACSSSAAAMNVACSS"
     aSDomain        complement(join(6200..6349,6413..6704,6816..7087))
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MGG_07219_SAT.1"
                     /evalue="5.80E-86"
                     /label="MGG_07219_SAT.1"
                     /locus_tag="MGG_07219"
                     /protein_end="251"
                     /protein_start="13"
                     /score="279.8"
                     /tool="antismash"
                     /translation="LLFGDQSLDTHGFLAEFYRHEDRGILAKAFLDQAAQALRKEIERL
                     PRLERSRLPVFRTLQQLNERYHAQITKHSGLDGALLCVAQLAHYIDHAEKNHEDVTQHD
                     KTYLVGLCSGLFAASAIASTPSLSSLVPVAVQTVLMAFRTGAHVAALAERLEPVSERSE
                     SWTYIVPGFTEEAAQKEIAGFHESHGIPQASQVYVSASSSANVAISGPPTTLKAFRAAT
                     SSLTKATAIPVYGPYH"
ORIGIN
        1 gtggttagtg tgtgagtagt ttctccaaaa atgtcaaaag aaacaagcca aaaaatatga
       61 catgagaaat aataaaatcc acaaaactcg ctttgctcgt aaggtaaaac aagaaaacag
      121 gataatacca tcaaggcttc taatgatata aaaaaggaaa ataaaaaaac aacactatta
      181 gtttgacggg ctctttttct gccaagaaga cttagtcacg tcccataagg cccccgttcg
      241 acgtcatgat aacacagaat tagaaaataa aagaaatgtt gataacagcg aatgtcatat
      301 gcgcgtatga gtttgtcaag agatggttgc tgtgcattta ttgcagagcc tcttgcatga
      361 aaccttgaag ctgcttggcc tgttgagtga gggtatggtt agcgtctgaa gtacaaggca
      421 tggatgggag tgtcgaggtg cgacttacca tagcgccgtg catcatcgaa aagtggttac
      481 cgggcatgtg cctcatggtc atcttgctgc catcgaggta ctcgtcccag cggttggggc
      541 caaagtcgac cctgttgtcg aggaggaaga gggcgtgtcc cgaggggtaa gggtcaggcc
      601 tggggtcggt gggaaggtgg cagacaccat cctcgcacca gatggccatg accttggggc
      661 acttgtcctt ggggatcggc tcggctgtgt agttggagag ggccgtgacc gaagcggcaa
      721 agtggggcag gagccacgag gggatcttgt ccgcgtcgcc gtcgcccagc aggccgatgg
      781 atgcgaacca ggcgtgcagg gacttgggga ggggctcaat ggtcacgggg caaggagcgt
      841 cgatgatgat catgttctca acctcgtcgc cggccttgat gagctgattg acaatctcaa
      901 aggcgatgac accaccggcg gaccagccag caaggctgta gggtccgacg ggctggcggc
      961 gcttcatctc ctcgatgaac ttggccgcca tgccgtagac accgcagttg tactcctcgg
     1021 gggtcttcat gaagggcgag aagagacccc agacggcgta gttgggaccg acattgcaca
     1081 tctcggtgta cgaggtggcg cagccgcttc cgtcgggtac catgaagagg tggcgggtgg
     1141 cggtcttgtg gctaccatgc agcagcaccg atgtggcctt gcggtgaggc attgtgtcga
     1201 ggatctcggt ggggcggggt ggcttgtaga tggtggccgt cacctgagat ggggggatcg
     1261 aggtggtggg tgggcaaggc ttgaccttct cagacttgga agccttggac ttggcggggg
     1321 cagcctgagc ggcagggcgc tttggggcag ccgggacgat gcccagagca cgctcgacgt
     1381 ccttcagcga agggttggag acaaagaggt ccgaggggac atccatgcca gtcttctccc
     1441 tgagggtgcc caggatctga agactcatga gcgagtccat acccaagctg gccaagtcgg
     1501 gggcggcgat gatctcctca acgtccatgc ccatctcggt ggcaatggtg ttgcggatag
     1561 cctcctggag ctcgttggtg tcagtagcag tagccttgcc gtccatcttc tcacccttga
     1621 ccgaggcagt atcgctctcg tcagcagggg tggtgacgtc cgactcggag tccatgtcac
     1681 ccgagacgga agagctgctg ctggagctgt cctccatggc gccgccgggg ccctcgaact
     1741 gagcaaggaa ggccttgaaa gcaccaatgg tagggtggtc gacaaaggcg tgcgagtcga
     1801 tgctcaggtc catgtcctca cgaatgcgac cactgacagt aagcgacatc agcgaatcga
     1861 cacccagatc ggtgaaggca atgttgtcag caagctcgtc gtggctgaca ccaacctcct
     1921 tggcgaggat gtcgagcacc tgcgtgacga ccgaggcgag cttctggttg accttgccga
     1981 tgttcttggg ggtcacgctc ttgctcttct ccttggtgga ggaggtcttc ttctccttgg
     2041 cagccggctt ggcagcggga gcaggagcag cgcgggcggg ggcggcaatg gcagcagctc
     2101 cacgcggggg cagcatcatg ttgaggacct tgcgggggat ggcctggaac ttcaggtcac
     2161 cgcacacgcc gatgatcttc tcgccgtcaa agacgtagac gtcaccagcg tagaccttgt
     2221 tacccttgat gggctgcatg cggatgtagc tgcggtactt cttggaggca acagggagct
     2281 cagagaacct gagcgagccc catccgtggg agatgaagac ctgctcgcgc gagtcgacag
     2341 cgtcggttcc gttgatgatg aagcccgaga tgtggcacag actgtcgatc cagtaggggc
     2401 tgaagacgta gttgccatcg gcctcggtgg tctggaactt gacctgagca gtagcctcgc
     2461 aagtctcgct gtcgaggacg acctcctcca taccgcggta gcggggagtg tagtcgacca
     2521 gtgcggcgaa cagcttgtaa gccaagccac ggccgatctt ggatgccttg ccatccttct
     2581 cagagtcaat gagaccgtca acgcgagact tgatgaggta agagacgcgg tcgaactcgc
     2641 cctgccagtc ctcagtgttg ccaaagtaga ccttgcagtt ggcgtggtca acacgcttgg
     2701 caccctcgcc agtgtggaag accaggtcag cgctgttctg ggcagcattg gcagtgactg
     2761 tgagcctcag gatgtggctc tcagcagcgt cgtcgaagat gagggtcttg ggaacctcca
     2821 tgtgagcgac gttgacacca atgttctcag actcgggacg gagcagcttg taggcatatt
     2881 gacaagtagt gatggccatg tctccataca gcgaagaagg gcagagagga gcaccgttga
     2941 ccaagtgacc ggaaacgacg ccacgaaggt cctcgcggga caggttggac tcgatctcga
     3001 cgacggcaac atcacccttg atctcctcgc ggacaacctt ctgcacggtg gtcgtctcga
     3061 gcttgggctt ggcgacggca gcagcagcag gcagggcctt ggcgatgcgg ttcttgctga
     3121 gacaccagtc tccctcgtac tggagccagt agttcttctc gtcgaaagca tacgagggga
     3181 gatccaagtg cctgacggaa gagaggaagt cgttgtggta ctcgttccag tcaatgttca
     3241 gaccagcagt gtggagagtg cagagactgg cgctcagggt cttgtaagtg gcctcgttgc
     3301 ggcgaagagt ggggacagcg acggtcgaga cgccgaaagc agccttgacc atgttggcgc
     3361 agacggggtg ggggccgacc tcgagccaga cagtcttctc atcgatggcg ccggctgact
     3421 gggcagaaac aagcccgcca aggaagtcaa cagcatcacg agcatgatcg cgcaggtact
     3481 tggggttgat gggctcatcg tcaacgagct tgccaaggag gggcgagatg acggggacct
     3541 tgggggtgtt gaagcggaca gagcgggcca gcttctcaaa gtcatcaagg atggggtcga
     3601 cctgggccga gtggaaggcg aagggcacct tgagctgagt gcacttgaag ccagcggcac
     3661 caagctgctg agcgatctca gccatctcag aagcctcacc actgagaacc gtctcgcggg
     3721 gtccgttgat gcaagcaacg ttggtagagt cggcgcgctc tccaagagcc tcctggacag
     3781 tggagacgga tcccatgaca gccaacatgg cgtgggtgcc ggcagtgcac ttctcaacga
     3841 gaagcttggc acgagcacca acgaggtaga tggtgtcgct ggcagacaga acaccggcaa
     3901 cgtggagagc agcgtactcg cccaggctgt ggcccatgac cgcagcaggc ttgacacccc
     3961 aagaagccca gagcttggcc aaggccatct cgaagcagca gagaccaagc tggacgatga
     4021 ggggctcgag cttggcgaca tcaggctcgc tgccgtcgac cagaggcatg aagctcggga
     4081 agccgtggat ctgcgagatc ctgtcgaact cgttgatggc ctggcggaag acagcgtggt
     4141 tggcgtacag ctcctttcca agaccagcgt agtgagagcc ctggccagtg aacatgaagg
     4201 caaccttggg aggctcgggg gagacgggaa caaagttctc ctgcaggcgg ttcttgaggg
     4261 cctgcttagc ctcacccaga tcctgagcag tcacgttcat gcgccagtag tgctggatgc
     4321 gacgagcggt ggtggaatag gcaacgtgag agatgggagt gtcatcgttg tcatccatga
     4381 actggatgag cctctcggcg ttgtggatca tggccgactt ggacttgcca gtgatggtga
     4441 tcacgtggac gttgcggggg tcctgagtcg caggctcaac gggaggagca tcctcaagca
     4501 gcagaccggt gttaccacca gcagcgctga agttgttgat gaaaaccctg cggggcttgc
     4561 catccgacct cttgaagggg gtcaagtgga aagcaatgtt gacgttgcgc tcaccaaggt
     4621 ccttggggaa ggtcttgttg atgacggatc ccttcttgat accgacgtgg ggaggaatgg
     4681 cgttcttctg gagcatgaga agaaccttgc acagagccgt gacacccgat gcggcctcac
     4741 cgtgacccag gttggccttg acggcaccaa ggtacagggg tctgtcagca ggtctcttcc
     4801 tgttggcagg agcaaagacg ttggtgactg agaccatctc tgttccgtca ccggcctgag
     4861 taccggtacc gtgcatctcg acgtagtcaa catcgagagg gtcaacacca gcatcgtcca
     4921 ggatagcaga cgacagaagc gactgcgtag gaccgtgagg gtgggtgatg gagatggcat
     4981 cagccgagtg gttggtggca gtgcccagga tgacagcgag aacgcgatca tggtcggcaa
     5041 tggcatcgtc gagcctcttc acaatgactg aggcgcaact gtcaccacgg cagtatccat
     5101 cggcattgtt gtcgaaggtg gcacaggggc ccttcttgga aaggaactgt ccacgagaca
     5161 gacccgcgaa aatgtcgggg ttggtcatgc aggacagacc accaacaatg gcggtgtcac
     5221 agtcacgggc ccacagcgaa gagcaggcaa cgttcatggc agcggcactg gaagagcagg
     5281 cagtgtccac gttcagcgaa ggaccgctga agccaaggtg gtagttgatt ctaccggggc
     5341 cgaaggctcg gacacctccc gtgatgtagt aggtgtcgac ctcctgggcc gcgttgatct
     5401 cacgccagtc atcggaagtc tgaccgtaga aggtaccgat acggtccagc ctggtcgagg
     5461 gtgtcctgtt gggcacgtaa ccgctcatct cgagagcctc gtaggcggtt gtcagggcca
     5521 tcctctgcat ggggtcggtc tggaaagcct cacgcggtga catgttgaag aaacgagggt
     5581 cgaacatgcc aggcttctca atccagcagc cgtaaggggt gtgactggag ttgataacct
     5641 tgccgttagg gtcgtagtga gtctcgaccg ggaaacgatc ggcagggacg acgcggtgaa
     5701 cgtctagtcc cttggaaaga agctcccaca gcttctcgtg gctggcagca tcggggaaac
     5761 gaccggccat accgacaatg gccagcttgt cacggctgcc acggccatgg tttccaatga
     5821 ccgagtcggt gctctccttg gatatttgcg gggccttgcg gaggatgatg tccaggttgg
     5881 tctcagcctt gaggaggttg gcgagagtgg cggcgtgctg tgtggggccg aaggggatga
     5941 tgaggcacga ctttccgtca aaaccacgag ccagatttaa gcagccgtcg agcacgttgt
     6001 gaaacctcag ggtctgggtg agaatctcgg agacgacagc ggcgaagaga gcgcgggtgg
     6061 tggactcgtt gaaccaggtg ccagttaggc aggacatgac ggaggagcgg ggcttggtgt
     6121 tgaggaaggt gtcaatcatc tcggggttgt tgaggcccag gatgttgtcg acatcctcag
     6181 ggcggtggag gtggggggcg tggtacgggc cgtagaccgg gatggccgtg gccttggtga
     6241 gggagcttgt ggcggccctg aaagccttga gtgtggtggg agggccagag atggcgacat
     6301 tagcggacga gctggcgctt acgtacacct ggctcgcttg ggggataccc tgatggtggg
     6361 agacctgtta gctgatgatc tagggtgagc tggtcgagga ggttatgctt acatgtgact
     6421 cgtggaatcc agcgatttcc ttttgtgcgg cctcctcagt gaagccggga acaatgtaag
     6481 tccagctctc ggagcgctcg ctgaccggct ccagcctttc ggcgagggcg gcaacgtgtg
     6541 caccggtccg gaaagccatg agaactgttt gcacggcgac cggaacaaga gaagacaatg
     6601 atggggttga agcgattgcg gacgcagcga agaggcctga gcagagaccg acaaggtagg
     6661 ttttgtcatg ctgtgtgaca tcttcatggt tcttctctgc gtggctacaa gggaggagaa
     6721 ttgctcaggt tagttgtact gttggaatca agcaagcagc caagcaagcg acgaggctgt
     6781 gggaggtagg tagatcgtgt gatgaatcaa catactcaat gtagtgagcg agctgggcaa
     6841 cacatagaag agcaccgtcg aggccggagt gcttggtgat ttgagcatga taccgctcgt
     6901 ttagttgttg cagtgtgcgg aacacgggca gcctcgacct ctccagcctt ggtagccttt
     6961 cgatctcttt cctcagagct tgggcggcct ggtcgagaaa ggccttggcg agtattcccc
     7021 gatcctcgtg acggtagaac tcggcgagga atccatgagt gtccagagat tggtctccga
     7081 agaggaggaa agccagcttg tccgccattt tgatggttgt cagcatgtat tcctctagag
     7141 tcgagatcgt gcgtgtcgag atactgggaa aacgaggaaa tgtatggagg taccatcgac
     7201 gaagcttata tatctaaact atcactcccg ggcccggggg ctaagtgaac tgggtcatac
     7261 caaaaatacc atccgagatg gcagatcgtc cgtcggtgtg tatgcttcct agtccgagca
     7321 ggt
//
