LOCUS       BGC0002164              8322 bp    DNA     linear   PLN 09-FEB-2012
DEFINITION  Epichloe festucae EF100, EF101, EF102, perA, EF103, EF104, EF105,
            EF106, EF107, EF108, EF109 genes, complete cds.
ACCESSION   BGC0002164
VERSION     BGC0002164
KEYWORDS    .
SOURCE      Epichloe festucae
  ORGANISM  Epichloe festucae
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
            Epichloe.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:04:23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 14488
            Orig. end    :: 22810
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..8322
                     /gene="perA"
     subregion       1..8322
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8322
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1..8322
                     /NRPS_PKS="Domain: AMP-binding (245-644). E-value: 1.7e-82.
                     Score: 269.0. Matches aSDomain:
                     nrpspksdomains_perA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (779-848). E-value: 3.7e-19. Score:
                     60.6. Matches aSDomain: nrpspksdomains_perA_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (887-1158). E-value:
                     1.1e-52. Score: 170.9. Matches aSDomain:
                     nrpspksdomains_perA_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1320-1720). E-value:
                     9.4e-84. Score: 273.2. Matches aSDomain:
                     nrpspksdomains_perA_AMP-binding.2"
                     /NRPS_PKS="Domain: nMT (1822-2046). E-value: 5.4e-93.
                     Score: 303.2. Matches aSDomain: nrpspksdomains_perA_nMT.1"
                     /NRPS_PKS="Domain: PCP (2272-2339). E-value: 1.4e-15.
                     Score: 49.1. Matches aSDomain: nrpspksdomains_perA_PCP.2"
                     /NRPS_PKS="Domain: NAD_binding_4 (2399-2620). E-value:
                     1.5e-50. Score: 163.5. Matches aSDomain:
                     nrpspksdomains_perA_NAD_binding_4.1"
                     /codon_start=1
                     /gene="perA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     181.7; E-value: 4.6e-55)"
                     /gene_kind="biosynthetic"
                     /product="peramine synthetase"
                     /protein_id="BAE06845.2"
                     /sec_met_domain="PP-binding (E-value: 4.7e-18, bitscore:
                     51.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1e-48, bitscore:
                     152.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.1e-98, bitscore:
                     314.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.7e-52, bitscore:
                     163.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAEPFDEVDEYTTYPSLPASVICPVADTKTRYELSWQPSGHHPQ
                     EEGDDCAVVTLVYAAWALMASRMTSSERVVFDTIDGRPDRPAARPLRVLCASSQTVGEY
                     LQALRAHTSSEESYMASPDCKSKRHPTSSTLIATRTSGDAKSSNGTIGNGLPSLAGYPL
                     VLDLQLRGSRLQATAMSDSRCTEPWIVFRLLIRLEYCMKGLHEADSRTRLADIDLMSPD
                     DVEQIWKWNGTLPAAVERCMHDMFEDQVYSQPLALAVDAWDGRLTYKELDELSEKLAGH
                     LIDADVGPEVIVPLCFEKSMWMPIAMLGVLKAGGSFTLLEPSFPEQRLRTIVEKVNASV
                     MISSPSNMSLSSRLLKRVVELDSCSVKSFSAHPSRPRNSQPSSTAMFAVFTSGSTGVPK
                     GAILTHTNYSSALAYQLQPLGFTKDSRVFDFASYAFDVSVHNVFATLTSGACLCIPSDE
                     DRHNDISKVMVDMRVTISHLTPSVTRLIDPDSQPFLKTMVFTGEPLSVDDATRWWGKVD
                     VVNEYGPAECTINTVNSRPISPEAATNIGLPVGVAAWITDPENHQVLVPIGCVGELLVE
                     GPLVGRGYIGDPIKTAASFIQDPKWLLRGVSGHPGRKGRLYKTGDLVRYCADGSLSYLG
                     RKDAQVKIRGQRVHLGDVEHWTQVCMPEAQRVFADVIEPQAISPVPTLAVFVQSPEMGE
                     NTATNERPVQIRALRADVQAKLSQHLPSYMVPTVSFWMETLPMTPTGKMDRRMLRRIGS
                     SFSAEQLAQARADRRDGPKRQPTCEMEERMRNIWARVLGMLPQDIHLESNFFHLGGDSI
                     ASMRVVAYARRLGIQVMVADVFQHPSLHDLAKNCSQTLARAPEDIPAFSLLGPHFNHAL
                     FVQDMSTRYALDPMTIQDAYPCTRLQEGLMFLTSKRPGDYIEQNVLELARDLSLEGLRN
                     AWEQAVKAMPILRTRIAQHNHVGLVQLVLDDTADWDEAKGLEKYLAADRKRSMGLGEPL
                     SRFALVRDEEGTCKWLVWTIHHAIYDGWSIRLVTDAVAEAYGGRSIPQGPQFQAFIKYV
                     QDQDERAAVNYWQRNLQGFDSAPFPPNVPSVDQPVADAAVAHSFATPSGAHGCITTSML
                     IRAAWALVVGRMANSNDVVFGSTLHGRNAAVNGLDEMVAPTIATIPVRVRFCSTQYVPS
                     YLQAITQEAAEMMPYEQTGLQRIAALSSDAEKACKFQTHVVIQPEDCIPGRSLLGQWRS
                     DSQDQWFSTYALTVEVWLRSDDIFASAMFDSRTIQSWVVTGMLQRLEWTMHQLHHATPS
                     QTLGEINMSSAEDLEQIWQWNERVPEPVNRCIHDLLADQVQARPDSPAICAWDGELTYR
                     KLDELSTRMSHSLLQLGAGFHKGLVPLCFDKSMWTAVAILGVLKAGVGFILLDPHLPEQ
                     RMRDIVDQVGSKVIVTCPTREILCSRLAEATVAISWDYFSGQLDWTQQELPSVSPSSTA
                     YVVFTSGSTGTPKGVVVTHANAVSAQHHQLEPMGHTPESRLFDFASYSFDVSISNIVSM
                     LACGGCLCVPSESDRTDDMEKSIVSLRVNALDLTPSTLQLLSPERLPAVRQLTLGGEPL
                     READVEKWCGKTRICNAYGPSECTPTATINSNAMEPQMATHIGKGAGVVTWIVDADDHD
                     ELLPLGCTGELLLEGPLVGRGYFNDSAKTAAAFIEDPKWLLRGSISHPGRQGRLYKTGD
                     LVKYNRDGSLAFVGRKDTQVKVRGQRVEPGEIEAVLRSHESVDGAVVVFHRLTDQELWL
                     AAFVTTREDDGKIPQSQSLAHDETQLKQKRIQAWEEEFEGETYLAIGATEAENIGRDFV
                     GWSSMYDGSEINKVEMNEWLDDTIATMLNGGPAGHVLEIGSGSGMMLFNLANHSLQSYI
                     GVDPAMRAVDFTTKAAKSVPDLADKVNVFKGTAEDIMNLDMPIHSELAVMNSVVQYFPS
                     QDYLFNIIQHLASLGSIKTIFVGDIRSHALHKEFMARRALHIAGKDASREEFSGIMENL
                     LKGEPELLVDPGFFTSLPHRIHGVTHVEILPKRMKATNELSSYRYAAVLHVNSHGEQAK
                     DGRAQDIGADEWIDYVSNGLDRQAVSGLLGTASRVAISNIPYSKTIYEREIVNAVEASK
                     NIPKLERESEWLAAALQASQEHSSLCAFDLAELAQLAGYRVECSWARQYSQRGGLDAVF
                     YCGGSGTDSERRTLFRFPTDHEGRPCHVLSTNPLEQQRKSKLRGDLEQLLRSKLPSYMV
                     PQAIKILDKMPVNHTGKIDRSMLSESLQQKAPPTARKRLPSTAPERAMQQIWSKVLSIE
                     SSQIGLDDGFIKLGGNSLSAMKVVSMAREEGIRLEVADMFHHSTTSIAHLLQTAAAGVS
                     ESGAALPGVTSDRLLSDLARYDCTIAMAQSEAANKRLSATSHGGIRDTRLTVVLTGANG
                     FIGTQILRQLLDHGRFSRVIAIVRGTSASKARQRAIDAAKNAQWWSEFYSSELEVWRGD
                     LALPRLGLGKENWNTLADGTVDVFIHNGASVHFMKSYSALQAANVESTAQVLRVAAENP
                     SMRVVYVSSARCCDPELEREEDVAKALADRPNGYTTTKFIAEALVKRAAARGLGRRDQF
                     AVVSPGLVVGTPTEGVANADDWLWRMTAACIRVGVVNGEESDNWIPIADAAATATTVIE
                     TSLGRSSGIVTQVKGGLTMGEFWETLRAIGYTLRGEDSSTCMAAIRQDVEKNRDTHPLG
                     ALSDMLQDLADTARSQWADSWRTGGLSSPARLKLALVKSAGFLSKVGVLPLPDGNDEPA
                     QARENLRAFTRSGG"
     aSDomain        736..1932
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_AMP-binding.1"
                     /evalue="1.70E-82"
                     /label="perA_AMP-binding.1"
                     /locus_tag="perA"
                     /protein_end="644"
                     /protein_start="245"
                     /score="269.0"
                     /tool="antismash"
                     /translation="FEDQVYSQPLALAVDAWDGRLTYKELDELSEKLAGHLIDADVGPE
                     VIVPLCFEKSMWMPIAMLGVLKAGGSFTLLEPSFPEQRLRTIVEKVNASVMISSPSNMS
                     LSSRLLKRVVELDSCSVKSFSAHPSRPRNSQPSSTAMFAVFTSGSTGVPKGAILTHTNY
                     SSALAYQLQPLGFTKDSRVFDFASYAFDVSVHNVFATLTSGACLCIPSDEDRHNDISKV
                     MVDMRVTISHLTPSVTRLIDPDSQPFLKTMVFTGEPLSVDDATRWWGKVDVVNEYGPAE
                     CTINTVNSRPISPEAATNIGLPVGVAAWITDPENHQVLVPIGCVGELLVEGPLVGRGYI
                     GDPIKTAASFIQDPKWLLRGVSGHPGRKGRLYKTGDLVRYCADGSLSYLGRKDAQVKIR
                     "
     aSModule        736..2544
                     /complete
                     /domains="nrpspksdomains_perA_AMP-binding.1"
                     /domains="nrpspksdomains_perA_PCP.1"
                     /locus_tags="perA"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       922..960
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0001"
                     /evalue="4.90E-01"
                     /label="NRPS-A_a2"
                     /locus_tag="perA"
                     /protein_end="320"
                     /protein_start="307"
                     /score="4.6"
                     /tool="antismash"
                     /translation="LGVLKAGGSFTLL"
     CDS_motif       1159..1215
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0002"
                     /evalue="4.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="perA"
                     /protein_end="405"
                     /protein_start="386"
                     /score="19.2"
                     /tool="antismash"
                     /translation="FAVFTSGSTGVPKGAILTH"
     CDS_motif       1561..1593
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0003"
                     /evalue="3.50E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="perA"
                     /protein_end="531"
                     /protein_start="520"
                     /score="7.2"
                     /tool="antismash"
                     /translation="EYGPAECTINT"
     CDS_motif       1696..1785
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0004"
                     /evalue="3.80E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="perA"
                     /protein_end="595"
                     /protein_start="565"
                     /score="41.6"
                     /tool="antismash"
                     /translation="PIGCVGELLVEGPLVGRGYIGDPIKTAASF"
     CDS_motif       1897..1962
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0005"
                     /evalue="1.90E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="perA"
                     /protein_end="654"
                     /protein_start="632"
                     /score="32.8"
                     /tool="antismash"
                     /translation="YLGRKDAQVKIRGQRVHLGDVE"
     aSDomain        2338..2544
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_PCP.1"
                     /evalue="3.70E-19"
                     /label="perA_PCP.1"
                     /locus_tag="perA"
                     /protein_end="848"
                     /protein_start="779"
                     /score="60.6"
                     /tool="antismash"
                     /translation="EERMRNIWARVLGMLPQDIHLESNFFHLGGDSIASMRVVAYARRL
                     GIQVMVADVFQHPSLHDLAKNCSQ"
     aSDomain        2662..3474
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.10E-52"
                     /label="perA_Condensation_DCL.1"
                     /locus_tag="perA"
                     /protein_end="1158"
                     /protein_start="887"
                     /score="170.9"
                     /tool="antismash"
                     /translation="QDAYPCTRLQEGLMFLTSKRPGDYIEQNVLELARDLSLEGLRNAW
                     EQAVKAMPILRTRIAQHNHVGLVQLVLDDTADWDEAKGLEKYLAADRKRSMGLGEPLSR
                     FALVRDEEGTCKWLVWTIHHAIYDGWSIRLVTDAVAEAYGGRSIPQGPQFQAFIKYVQD
                     QDERAAVNYWQRNLQGFDSAPFPPNVPSVDQPVADAAVAHSFATPSGAHGCITTSMLIR
                     AAWALVVGRMANSNDVVFGSTLHGRNAAVNGLDEMVAPTIATIPVRVRF"
     aSModule        2662..7860
                     /complete
                     /domains="nrpspksdomains_perA_Condensation_DCL.1"
                     /domains="nrpspksdomains_perA_AMP-binding.2"
                     /domains="nrpspksdomains_perA_nMT.1"
                     /domains="nrpspksdomains_perA_PCP.2"
                     /domains="nrpspksdomains_perA_NAD_binding_4.1"
                     /locus_tags="perA"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2731..2838
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0006"
                     /evalue="8.30E-06"
                     /label="C2_DCL_024-062"
                     /locus_tag="perA"
                     /protein_end="946"
                     /protein_start="910"
                     /score="18.1"
                     /tool="antismash"
                     /translation="YIEQNVLELARDLSLEGLRNAWEQAVKAMPILRTRI"
     CDS_motif       3025..3090
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0007"
                     /evalue="2.60E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="perA"
                     /protein_end="1030"
                     /protein_start="1008"
                     /score="20.1"
                     /tool="antismash"
                     /translation="IHHAIYDGWSIRLVTDAVAEAY"
     CDS_motif       3370..3465
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0008"
                     /evalue="5.30E-11"
                     /label="C5_DCL_263-294"
                     /locus_tag="perA"
                     /protein_end="1155"
                     /protein_start="1123"
                     /score="35.0"
                     /tool="antismash"
                     /translation="DVVFGSTLHGRNAAVNGLDEMVAPTIATIPVR"
     aSDomain        3961..5160
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_AMP-binding.2"
                     /evalue="9.40E-84"
                     /label="perA_AMP-binding.2"
                     /locus_tag="perA"
                     /protein_end="1720"
                     /protein_start="1320"
                     /score="273.2"
                     /tool="antismash"
                     /translation="ADQVQARPDSPAICAWDGELTYRKLDELSTRMSHSLLQLGAGFHK
                     GLVPLCFDKSMWTAVAILGVLKAGVGFILLDPHLPEQRMRDIVDQVGSKVIVTCPTREI
                     LCSRLAEATVAISWDYFSGQLDWTQQELPSVSPSSTAYVVFTSGSTGTPKGVVVTHANA
                     VSAQHHQLEPMGHTPESRLFDFASYSFDVSISNIVSMLACGGCLCVPSESDRTDDMEKS
                     IVSLRVNALDLTPSTLQLLSPERLPAVRQLTLGGEPLREADVEKWCGKTRICNAYGPSE
                     CTPTATINSNAMEPQMATHIGKGAGVVTWIVDADDHDELLPLGCTGELLLEGPLVGRGY
                     FNDSAKTAAAFIEDPKWLLRGSISHPGRQGRLYKTGDLVKYNRDGSLAFVGRKDTQVKV
                     R"
     CDS_motif       4147..4188
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0009"
                     /evalue="1.70E-01"
                     /label="NRPS-A_a2"
                     /locus_tag="perA"
                     /protein_end="1396"
                     /protein_start="1382"
                     /score="6.0"
                     /tool="antismash"
                     /translation="LGVLKAGVGFILLD"
     CDS_motif       4381..4440
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0010"
                     /evalue="5.90E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="perA"
                     /protein_end="1480"
                     /protein_start="1460"
                     /score="31.1"
                     /tool="antismash"
                     /translation="AYVVFTSGSTGTPKGVVVTH"
     CDS_motif       4789..4815
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0011"
                     /evalue="1.70E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="perA"
                     /protein_end="1605"
                     /protein_start="1596"
                     /score="5.3"
                     /tool="antismash"
                     /translation="YGPSECTPT"
     CDS_motif       4924..5013
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0012"
                     /evalue="1.50E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="perA"
                     /protein_end="1671"
                     /protein_start="1641"
                     /score="39.7"
                     /tool="antismash"
                     /translation="PLGCTGELLLEGPLVGRGYFNDSAKTAAAF"
     CDS_motif       5125..5190
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_perA_0013"
                     /evalue="3.50E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="perA"
                     /protein_end="1730"
                     /protein_start="1708"
                     /score="38.2"
                     /tool="antismash"
                     /translation="FVGRKDTQVKVRGQRVEPGEIE"
     aSDomain        5467..6138
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_nMT.1"
                     /domain_subtypes="nMT"
                     /evalue="5.40E-93"
                     /label="perA_nMT.1"
                     /locus_tag="perA"
                     /protein_end="2046"
                     /protein_start="1822"
                     /score="303.2"
                     /tool="antismash"
                     /translation="GSEINKVEMNEWLDDTIATMLNGGPAGHVLEIGSGSGMMLFNLAN
                     HSLQSYIGVDPAMRAVDFTTKAAKSVPDLADKVNVFKGTAEDIMNLDMPIHSELAVMNS
                     VVQYFPSQDYLFNIIQHLASLGSIKTIFVGDIRSHALHKEFMARRALHIAGKDASREEF
                     SGIMENLLKGEPELLVDPGFFTSLPHRIHGVTHVEILPKRMKATNELSSYRYAAVLHVN
                     SH"
     aSDomain        6817..7017
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_PCP.2"
                     /evalue="1.40E-15"
                     /label="perA_PCP.2"
                     /locus_tag="perA"
                     /protein_end="2339"
                     /protein_start="2272"
                     /score="49.1"
                     /tool="antismash"
                     /translation="ERAMQQIWSKVLSIESSQIGLDDGFIKLGGNSLSAMKVVSMAREE
                     GIRLEVADMFHHSTTSIAHLLQ"
     aSDomain        7198..7860
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_perA_NAD_binding_4.1"
                     /evalue="1.50E-50"
                     /label="perA_NAD_binding_4.1"
                     /locus_tag="perA"
                     /protein_end="2620"
                     /protein_start="2399"
                     /score="163.5"
                     /tool="antismash"
                     /translation="LTGANGFIGTQILRQLLDHGRFSRVIAIVRGTSASKARQRAIDAA
                     KNAQWWSEFYSSELEVWRGDLALPRLGLGKENWNTLADGTVDVFIHNGASVHFMKSYSA
                     LQAANVESTAQVLRVAAENPSMRVVYVSSARCCDPELEREEDVAKALADRPNGYTTTKF
                     IAEALVKRAAARGLGRRDQFAVVSPGLVVGTPTEGVANADDWLWRMTAACIRVGVVNG"
ORIGIN
        1 atggacgcgg agccttttga tgaggttgat gagtacacga cctatcccag tctcccggcg
       61 tctgtcattt gtccagtggc ggacaccaag actcggtacg aactctcatg gcagccgtcc
      121 ggccatcatc cacaagaaga aggcgatgac tgcgctgtgg tgacattggt atatgctgct
      181 tgggcactca tggcgagccg aatgacgagc tcggagcgag ttgtctttga cacaatcgac
      241 ggcaggccgg atcggccggc ggcgaggcca ttgcgtgtcc tatgcgcctc tagtcagact
      301 gttggcgagt atttgcaggc cttgagagca cataccagct ccgaggaaag ctatatggct
      361 tcgccggact gcaaaagcaa aagacatcca acatcgagca ctctcattgc tacgaggacc
      421 agcggcgacg ccaaaagcag caatggcacc atcggaaacg gccttcccag ccttgcgggg
      481 taccctttgg tgctcgactt gcagctgcga ggatctcggc tacaagcgac agccatgtcc
      541 gattctaggt gcaccgaacc gtggattgtg ttcaggctac tcatacgcct agagtactgc
      601 atgaaggggc tccatgaagc ggactcgaga acgcgtctag ctgacatcga cctcatgtca
      661 ccggacgacg tggagcaaat atggaaatgg aacggcactc tccctgcggc ggtggagcgc
      721 tgcatgcacg acatgtttga agatcaggtc tattcgcagc cactggccct ggcagtcgat
      781 gcatgggacg gccgattgac ctataaggag ctggatgaac tctccgagaa actggccggc
      841 cacctcatag acgcggacgt cgggcccgag gtgatcgttc cgctatgctt cgaaaaatcc
      901 atgtggatgc cgatcgccat gctgggtgtt ctcaaggccg gcggatcgtt tacccttctg
      961 gagccctcgt ttcctgagca gcgcctgagg accatcgtgg aaaaggtcaa cgcgagcgtg
     1021 atgatctctt caccctcgaa tatgtcgctg agttctagac tgttgaagag ggtcgtagag
     1081 ctcgactctt gctccgtaaa atcattttct gcgcatccaa gtcgtccacg gaactcacag
     1141 ccttcatcaa cggcaatgtt tgccgtcttc acttccggga gcaccggagt gcccaagggg
     1201 gcgatactca cgcacaccaa ctactcttcc gccctcgctt atcagcttca gccacttggt
     1261 ttcaccaagg attctagagt atttgacttt gcctcctacg cctttgacgt ctccgttcat
     1321 aacgtgtttg cgactctcac atcaggagcg tgtttgtgca ttccctctga tgaagaccgc
     1381 cataacgaca tctccaaggt catggtcgac atgcgcgtca cgatttccca tttaacaccc
     1441 tcagtcacgc ggctgataga cccagattca caaccttttc taaagacgat ggtgtttacc
     1501 ggcgagcctc tgtctgtgga cgatgctacc cgatggtggg gaaaggtcga cgtcgtcaac
     1561 gaatatgggc ctgcagagtg caccatcaac actgtcaaca gccgacctat cagtcctgaa
     1621 gctgctacga acatagggct gccggttgga gtggccgctt ggattaccga cccggaaaac
     1681 catcaagtac tcgttccgat cggctgtgtt ggggaactgc ttgtggaggg tccgctagtc
     1741 gggcgtggat acattggcga ccccatcaag accgccgctt cgttcatcca agatccaaag
     1801 tggctgttgc gtggtgtttc cggccacccg ggtcggaaag gtcggctgta caagaccgga
     1861 gacctcgtcc gatactgtgc agatggaagt ctcagctact tgggccggaa ggacgcccag
     1921 gttaagatcc gcggccagag agtgcatctc ggcgacgtcg agcattggac tcaagtgtgc
     1981 atgcctgaag cgcagcgagt ttttgctgat gttatagaac ctcaagccat cagcccagtt
     2041 ccaactttgg ctgtgttcgt acagtccccg gagatgggcg agaacacggc aacgaatgaa
     2101 cgccccgtcc agatacgggc gctacgagct gatgtacagg ccaagctgtc tcagcatctg
     2161 ccctcgtaca tggttcccac ggtgtctttc tggatggaaa cgctgcccat gacgccgacc
     2221 ggcaagatgg accgaaggat gctgcgaaga ataggctcct cgttctccgc cgagcagctc
     2281 gcccaagcca gggcggaccg ccgggatggc ccaaaaaggc aaccgacttg cgagatggaa
     2341 gagcgcatga gaaacatctg ggcccgcgta ttgggcatgc tgccgcagga cattcatctg
     2401 gaaagcaact tcttccacct cggcggcgat tctattgcat cgatgagggt tgtagcgtat
     2461 gcccgcaggc ttggaatcca ggtcatggtt gcggatgtat tccagcatcc gtctctccac
     2521 gacttggcca agaattgctc ccaaactctt gcaagggctc cagaagacat ccccgcgttc
     2581 agcctcttgg gcccccattt caatcacgcc ttgttcgtcc aggacatgtc tacccggtac
     2641 gccctggacc ccatgacgat ccaagacgca tatccctgca cgcggctcca ggagggcctc
     2701 atgttcttga cctccaagcg acctggcgac tatattgagc agaatgtcct cgagctggct
     2761 cgggacttgt cactggaggg cttgcgcaat gcatgggagc aggcagtcaa ggccatgccg
     2821 attctacgaa cccggattgc acagcataac catgttggcc tggtacagct ggtcctggac
     2881 gatacagctg actgggatga agcaaaaggg ctggaaaaat atctcgccgc cgacagaaag
     2941 cgctcgatgg ggctggggga gccgctgtcg cgatttgcgt tggttagaga cgaggagggt
     3001 acgtgcaagt ggttggtgtg gacaatccat cacgccattt atgatggctg gtccattcgc
     3061 ctcgtcactg atgctgtcgc cgaggcatat gggggacgga gcattcccca aggaccgcag
     3121 ttccaggctt tcataaagta cgtccaggac caagacgaga gagcggcagt gaactactgg
     3181 caacggaacc tgcagggctt cgactcagct cctttcccac caaatgtgcc gtcggtcgac
     3241 cagcctgtcg cagacgcggc tgttgcgcac agctttgcca ctccaagcgg tgcccacgga
     3301 tgcatcacaa catccatgct catcagggcg gcgtgggcct tggtcgtcgg acgaatggcc
     3361 aactcgaatg atgtagtctt cggctctacc ctccacggtc gcaatgcggc cgtgaacggc
     3421 ctagatgaaa tggtggcccc gacaattgcg acaatcccag tgcgcgtgag gttctgcagc
     3481 acccagtacg tgcccagcta tctccaggcc atcacacagg aagccgccga gatgatgccc
     3541 tacgagcaga cgggtctgca gaggatcgcc gccttgtctt ctgatgcaga gaaggcctgc
     3601 aagttccaga cccatgtcgt cattcaaccc gaggattgca tcccgggcag aagccttcta
     3661 ggccagtggc ggagcgacag ccaggaccag tggttcagca cgtatgcgtt gacggttgaa
     3721 gtatggctgc ggtcggatga catctttgcc tcagccatgt ttgactcgag gacgattcag
     3781 tcgtgggtgg tgacaggcat gctgcagcga ctggagtgga ctatgcacca gctccaccat
     3841 gccacacctt cacagacctt gggcgaaatc aacatgtcgt cggcagagga cttggaacag
     3901 atttggcagt ggaacgagag agttcccgaa ccagtgaatc gatgtatcca cgacctactc
     3961 gccgaccaag tccaagcccg gccagacagt cctgccattt gcgcatggga tggagagctg
     4021 acgtaccgca agctggacga actttcgacc aggatgtcac actcactact gcagcttggt
     4081 gccggcttcc ataaaggtct ggtgcctctt tgttttgaca agtccatgtg gacagcggtg
     4141 gccatcctcg gcgtcctcaa ggctggtgtc ggctttatcc tccttgatcc acatcttcca
     4201 gagcagagga tgcgagacat tgtcgatcaa gtcggaagca aagtcatcgt aacttgtccc
     4261 accagagaga tcctgtgctc gcggctggca gaagcgacgg tcgccatcag ctgggactac
     4321 ttttctggcc agcttgattg gacgcagcaa gagcttccat ctgtcagtcc gtcatcaacc
     4381 gcatacgtcg tcttcacctc tggaagtacg ggaacaccaa aaggcgtcgt ggtaacgcac
     4441 gcaaacgccg tctctgctca gcaccatcag ctcgagccca tgggacacac accggaatca
     4501 aggctgttcg actttgcctc gtacagtttc gacgtctcca tcagcaacat cgtttctatg
     4561 ctggcttgcg gcggttgtct ttgcgtcccc agcgagagtg accgcacaga tgacatggag
     4621 aagagtatcg tgtctctacg cgtgaatgcg cttgacctga cgccgtctac cttgcaactt
     4681 ctttctccag agagactccc cgcggtgcgt cagctgacac tgggcggcga gcctctacgc
     4741 gaggcggacg ttgagaagtg gtgtggcaaa acacgtatat gtaacgcata tgggccgagc
     4801 gagtgcacac cgaccgccac catcaactcc aatgcgatgg aacctcaaat ggcgacccac
     4861 attgggaaag gtgcaggcgt tgtgacgtgg atcgttgatg ccgacgacca tgacgagctg
     4921 ctgccactgg ggtgtaccgg cgagctgctt ctagagggac ctcttgtcgg tcgaggttat
     4981 ttcaacgact cagccaagac agcagcagcg tttattgaag accctaagtg gttgttaagg
     5041 ggatccatct ctcaccccgg tcggcaaggc agactgtaca agaccggcga cttggtcaag
     5101 tacaaccgtg acggctccct tgcgtttgtc ggccgcaaag acactcaagt taaggtcaga
     5161 gggcagcgtg tcgagccagg agaaatcgaa gcggttctgc ggagccacga gagcgtggac
     5221 ggcgctgtgg ttgtctttca ccgtctgact gaccaggagc tgtggcttgc tgcgtttgtc
     5281 actacgcgcg aggacgatgg caaaatacca cagagccaat cacttgctca cgatgagaca
     5341 caattaaagc agaaaaggat tcaggcctgg gaagaggagt tcgaaggcga gacttatctg
     5401 gccatcggcg ccaccgaggc cgaaaacatc ggacgggact tcgtcgggtg gtcgtccatg
     5461 tacgatggaa gtgagataaa caaagtcgag atgaacgaat ggctggacga caccattgct
     5521 accatgttga acggcgggcc cgccggccat gttctcgaaa tcgggtccgg gtcgggcatg
     5581 atgctcttca atttggccaa ccacagccta cagagctaca taggcgtgga tccggccatg
     5641 cgagctgtcg actttacaac caaagccgcc aagtccgtcc cggatcttgc agacaaggtc
     5701 aacgtgttca agggcacagc cgaggatatc atgaacctcg acatgcccat ccactccgaa
     5761 cttgccgtca tgaattccgt cgtccagtac ttcccaagcc aagactatct cttcaacatc
     5821 atccagcatc tggccagctt gggaagcatc aagaccatct tcgtaggtga catccgctct
     5881 catgcgcttc acaaggaatt catggcaagg cgtgctctgc acattgccgg caaagacgca
     5941 tctcgggaag agttcagtgg gatcatggag aacctcctca aaggcgagcc agaactgctt
     6001 gtagatcccg ggtttttcac cagcttgccc caccgcatac atggcgtgac acatgtcgag
     6061 atcttgccca agaggatgaa ggccaccaac gagctcagca gctaccgcta cgcagcggtg
     6121 ttgcatgtca attcccatgg cgagcaggcg aaagatggcc gcgctcagga tattggtgcg
     6181 gacgagtgga ttgactacgt gtccaacggt ctcgaccgtc aggccgtatc gggcctcttg
     6241 ggcaccgcat ccagagtggc cataagcaac atcccctaca gcaagacaat ctacgaaaga
     6301 gaaattgtca atgctgtcga ggcgtccaag aatattccca agttggagcg cgagagtgaa
     6361 tggctcgcag cggctcttca ggcatcgcag gaacactcat cgctatgtgc ttttgatctt
     6421 gccgagcttg cgcagctggc gggctacaga gtcgaatgca gctgggctcg acagtactca
     6481 caacgcggtg ggttggacgc tgtattctac tgcggcggga gcggcacaga cagtgagagg
     6541 aggaccttgt tccgatttcc cactgatcat gaaggccggc cctgccatgt gctcagcaca
     6601 aacccgctgg aacagcagcg caagagcaaa ttgcgcggag atcttgagca gctgctacgg
     6661 tccaagctgc cttcttacat ggtgccgcaa gccatcaaga tcttggacaa aatgccggtc
     6721 aaccacaccg gcaaaatcga tcgctccatg ttgtctgaga gcctgcagca aaaggcaccg
     6781 ccgacggcaa ggaagcgact gccatcaacg gcaccggaga gggcgatgca gcaaatctgg
     6841 tcaaaggtcc tgagtatcga gtcgagtcag attggtttgg acgatggatt catcaagctg
     6901 ggtggtaact cgctcagcgc catgaaggtg gtcagcatgg cccgggagga aggcatcagg
     6961 ctggaggtgg ccgacatgtt ccatcactcc acaaccagca ttgcccactt gcttcagaca
     7021 gcagctgcgg gcgtttctga atcaggagct gctttgccag gtgtcacttc ggatcgtctt
     7081 ctgtcggacc ttgcccgata cgattgcacc atcgccatgg cgcagtctga ggctgctaat
     7141 aagcgtttga gtgcgacgtc gcacgggggt attcgtgaca ctcggctcac cgttgtgcta
     7201 acgggagcca acggcttcat tggcacccag attctccgcc agcttctcga tcatggccgc
     7261 ttcagtcgtg tgattgctat tgtcaggggt acttctgcaa gcaaggccag acagcgagct
     7321 atcgacgctg cgaaaaacgc tcagtggtgg tccgagtttt atagcagcga gctagaggta
     7381 tggcgtggag acctggcgct gccgaggctg ggtctcggaa aagaaaactg gaacactctt
     7441 gcagatggta ctgtggatgt tttcatacac aacggggcgt cggtgcattt catgaagagc
     7501 tactctgctc tccaggcggc caacgtcgag tcaaccgccc aggtccttcg cgtggctgct
     7561 gaaaacccct ccatgagggt tgtctacgtt tctagtgcgc gatgctgcga ccctgagctc
     7621 gagcgtgagg aggacgtggc aaaggcgctc gccgacaggc ccaacggcta caccacgacc
     7681 aagtttattg ccgaggccct ggtgaagcgt gctgcggcgc gaggtctagg cagacgagat
     7741 cagttcgcag ttgtcagccc tggtctcgtc gtgggcacac cgaccgaagg tgtcgcgaat
     7801 gccgacgact ggctgtggag gatgaccgcc gcctgtatac gggtaggcgt cgtcaatggc
     7861 gaggagtccg acaattggat ccccatagcc gatgccgctg ccacggcgac gactgtcata
     7921 gaaacttcat tggggcgctc atcaggcatt gtgacccaag tcaaaggcgg gctcaccatg
     7981 ggcgagtttt gggagactct acgcgcgata gggtacaccc tgaggggcga agactcgagc
     8041 acgtgcatgg cggcgattcg ccaggatgta gagaaaaaca gagacacaca tccgctcgga
     8101 gcgctgtcag atatgctcca agatctggct gataccgcca ggtctcaatg ggcagacagt
     8161 tggcggactg gtggcctttc gtctcctgcc aggcttaagt tggcactggt gaagagcgcg
     8221 ggattcttga gcaaagttgg cgtcttgccc ttgccagatg gcaacgacga acccgcgcag
     8281 gcaagagaaa acctgcgtgc tttcacaaga tctggaggct ag
//
