BGC0002164 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002164 (Epichloe festucae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	8,322	peramine	NRPS:Type I	100%

BGC0002164 - Region 1 - NRPS

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Location: 1 - 8,322 nt. (total: 8,322 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,323
Label		BGC0002164

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164	1.00	NRP	peramine	Epichloe festucae
BGC0002166	0.40	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0000900	0.35	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.34	NRP	dimethylcoprogen	Alternaria alternata
BGC0001517	0.28	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0001261	0.26	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.24	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002710	0.22	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001128	0.22	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307	0.22	NRP	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164	1.00	NRP	peramine	Epichloe festucae
BGC0002166	0.72	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0000900	0.68	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0001517	0.62	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0001261	0.60	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.57	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002710	0.56	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001128	0.55	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307	0.55	NRP	AbT1	Aureobasidium pullulans

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 8322:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-Arg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

perA

Search NORINE for peptide: strict or relaxed

AMP-binding (245..644): X

nrpys: Pyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVHHVTEINK
Nearest Stachelhaus code(s):: Pyr DVHHVTEINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1320..1720): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSDTGAPTK
Nearest Stachelhaus code(s):: Arg DVSDTGAPTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)