BGC0002167 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002167 (Aspergillus flavus NRRL3357)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	15,099	actinopolymorphol C/morpholine containing hemiacetal piperazine compound/piperazine compound 2/piperazine compound 1/3-(p-hydroxyphenyl)-1,2-propanediol/N,N-dioxide containing derivate/O-sulfonated actinopolymorphol C/C-3 sulfonylated derivative	NRPS:Type I	100%

BGC0002167 - Region 1 - NRPS-like

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Location: 1 - 15,099 nt. (total: 15,099 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 15,100
Label		BGC0002167

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002167	1.00	NRP	actinopolymorphol C, morpholine containing hemiacetal piperazine compound, piperazine compound 2, piperazine compound 1, 3-(p-hydroxyphenyl)-1,2-propanediol, N,N-dioxide containing derivate, O-sulfonated actinopolymorphol C, C-3 sulfonylated derivative	Aspergillus flavus NRRL3357
BGC0002736	0.31	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002276	0.27	NRP	choline	Aspergillus nidulans FGSC A4
BGC0001475	0.25	Terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001775	0.24	Terpene	sespendole	Cordana terrestris
BGC0001616	0.24	NRP, Polyketide	himeic acid A	Aspergillus japonicus
BGC0001516	0.22	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0002602	0.22	Alkaloid	aspergillic acid	Aspergillus flavus
BGC0002295	0.21	NRP, Saccharide	minimycin	Streptomyces hygroscopicus
BGC0000375	0.20	NRP	indigoidine	Streptomyces chromofuscus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002167	1.00	NRP	actinopolymorphol C, morpholine containing hemiacetal piperazine compound, piperazine compound 2, piperazine compound 1, 3-(p-hydroxyphenyl)-1,2-propanediol, N,N-dioxide containing derivate, O-sulfonated actinopolymorphol C, C-3 sulfonylated derivative	Aspergillus flavus NRRL3357
BGC0002736	0.64	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002276	0.60	NRP	choline	Aspergillus nidulans FGSC A4
BGC0001475	0.59	Terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001775	0.57	Terpene	sespendole	Cordana terrestris
BGC0001616	0.57	NRP, Polyketide	himeic acid A	Aspergillus japonicus
BGC0001516	0.55	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0002602	0.55	Alkaloid	aspergillic acid	Aspergillus flavus
BGC0002295	0.54	NRP, Saccharide	minimycin	Streptomyces hygroscopicus
BGC0000375	0.53	NRP	indigoidine	Streptomyces chromofuscus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 15099:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

G4B84_009366

Search NORINE for peptide: strict or relaxed

AMP-binding (25..425): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFAFGAIFK
Nearest Stachelhaus code(s):: Phe DVFALGAVYK (76% 8Å match); Ac-OH-Orn DVFALGAVNK (38% 8Å match)
Stachelhaus code match:: 70% (weak)