LOCUS       BGC0002168             34234 bp    DNA     linear   PLN 29-JAN-2021
DEFINITION  Aspergillus stellatus strain NBRC 32302 calbistrin A biosynthetic
            gene cluster, complete sequence.
ACCESSION   BGC0002168
VERSION     BGC0002168
KEYWORDS    .
SOURCE      Aspergillus stellatus (Emericella variecolor)
  ORGANISM  Aspergillus stellatus
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:04:52
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 34234
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..34234
                     /culture_collection="NBRC:32302"
                     /db_xref="taxon:1549217"
                     /mol_type="genomic DNA"
                     /organism="Aspergillus stellatus"
                     /strain="NBRC 32302"
     protocluster    1..34234
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[5737:14604]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5738..14604
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..34234
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..34234
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002168"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..34234
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            <101..>1414
                     /gene="calC'"
     mRNA            <101..>1414
                     /gene="calC'"
                     /product="transcription factor CalC'"
     CDS             101..1414
                     /codon_start=1
                     /gene="calC_"
                     /product="transcription factor CalC'"
                     /protein_id="QQW45465.1"
                     /transl_table=11
                     /translation="MSDQQTQAQQPPKKRAACDRCRTQKLRCLRVSGHPNDHCIRCVRS
                     QMECITSSSKRPGRPRNSTNTPRQQQPTPSPNTGIETNPALPAIDIPPQSLENVDDWFN
                     FGSLDTDYEICSAPWTSVDSGFESGFPMEGVATSMSSLSTPPLQTASTPAFLTTMPTHT
                     PIHDHFQDDPCDHLPLLAPQPFAANFDHGLHLSQLQRELSKQLYTLTSMPWDMTKVMQL
                     TCFQAPGTSAPSSPSQDDLKSNPLAKIAKTSAEFAQLLCSVQSPIAGDGGSNTSKASSP
                     LSSIHPRLSMPDLLTILSCHMLTISIYDSIFSHFTEQASHNPGAVNIVLQSAPKLYLGG
                     IAVPPRLELLSHLLYCITASQLRPIEMLLGLPDECCVSLKRNSASKDKQTGLFSGQSGQ
                     LLFSTLMQVETERATEDRGGLGVIESLKEKIRLIQGLE"
     misc_feature    101..34134
                     /note="calbistrin A biosynthetic gene cluster"
     gene            <2269..>4275
                     /gene="calB'"
     mRNA            join(<2269..2565,2616..2692,2743..2794,2844..3042,
                     3093..3832,3880..>4275)
                     /gene="calB'"
                     /product="major facilitator superfamily transporter CalB'"
     CDS             join(2269..2565,2616..2692,2743..2794,2844..3042,
                     3093..3832,3880..4275)
                     /codon_start=1
                     /gene="calB_"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 334; E-value:
                     1.8e-101)"
                     /gene_kind="transport"
                     /product="major facilitator superfamily transporter CalB'"
                     /protein_id="QQW45466.1"
                     /transl_table=11
                     /translation="MNDEPVALQTWSRPNTRESDARTQNTEESSRAPWTQQEHGSTARV
                     IEKPGDEESSAADPPAEAAAVQAPGVTGFKLFGILASVTLSAFLMLLDGSIIGVAIPNI
                     TSQFHSIHDVGWYTAAYQLSSAALQPLSGKIYTSYNTKWTYLFFFFLFEVGSLICGVAN
                     SSSTLIGGRAVAGIGSSGLLNGGMTIIAGAVPLEKRPVYTGVYLGISQLGIVCGPLIGG
                     ALTQYTTWRWCFYINLPVGAVVAVLLLFLRVPELTKKEPFSLALVKKTLPDLDLIGFTL
                     FAPAAIMALLGLYYGGNEYAWDSSVVIGLFVGAAATITVFGIWEWKMGDRAMIPTSMVS
                     HHIVWTSAINGGTLVASILTASQYLPIYFQGVRGYGAAMSGVNTLPGILSQLLTVIISG
                     GVVQKVGYYLPFAAAGSAISAVGNGLVTLFRPDTPTDKWIGYQIVLGSGRGIGMQMGII
                     AIQNLLPPEKIPVGIAFMIFCQNFAGAVFVVVGEVIFTQELVKEIVKYAPSVSVEAAEA
                     AGASADSVRALVPEGSPELAGVLMAFSNSVDKVFYLLMALCLLGFVAAFGMGWVDIRKN
                     KKPAAEEEDK"
     gene            <5738..>14604
                     /gene="calA'"
     mRNA            join(<5738..6158,6211..6468,6534..13076,13124..>14604)
                     /gene="calA'"
                     /product="polyketide synthase CalA'"
     CDS             join(5738..6158,6211..6468,6534..13076,13124..14604)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (7-442). E-value:
                     1.7e-164. Score: 539.6. Matches aSDomain:
                     nrpspksdomains_calA__PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (550-866). E-value: 3.4e-78.
                     Score: 254.9. Matches aSDomain:
                     nrpspksdomains_calA__PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (941-1110). E-value: 4e-14.
                     Score: 45.2. Matches aSDomain:
                     nrpspksdomains_calA__PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1377-1577). E-value: 1.4e-75.
                     Score: 246.0. Matches aSDomain: nrpspksdomains_calA__cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2115-2289). E-value: 1.6e-51.
                     Score: 166.7. Matches aSDomain:
                     nrpspksdomains_calA__PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2405-2478). E-value: 3.3e-11.
                     Score: 35.3. Matches aSDomain:
                     nrpspksdomains_calA__PKS_PP.1"
                     /NRPS_PKS="Domain: TD (2583-2815). E-value: 1e-56. Score:
                     183.7. Matches aSDomain: nrpspksdomains_calA__TD.1"
                     /codon_start=1
                     /gene="calA_"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 213.9; E-value:
                     6.5e-65)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase CalA'"
                     /protein_id="QQW45467.1"
                     /sec_met_domain="itr_KS (E-value: 3.1e-171, bitscore:
                     559.5, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 7.9e-79, bitscore: 254.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4.4e-46, bitscore:
                     146.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-07, bitscore:
                     21.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.8e-40, bitscore:
                     128.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKINEPIAIVGSACRFAGGASSPSKLWELLNNPRDVRSDIPTSR
                     FNKDNYYHPNSAFHGHSNIQHSYLLEEDVAAFDTEFFGIKPVEAKAIDPQQRLLMETVY
                     EGLESAGLTIDSLKGSDTAVYVGLMCGDYEASVLRDLKTAPVYTATGIGRSILSNRVSY
                     FFNWHGPSMTIDTACSSSLVAVHLAAQALRNGESRVALACGSNLLLGPENYIMESKLKM
                     LSPDGRSKMWDKDANGYARGDGVAACILKTLSAAIEDGDHIECIIRETGVNQDGATTGI
                     TMPSATAQRALIEATYEKAGLDLSKAIDRPQFFEAHGTGTPAGDPIEAEAISKAFFGEQ
                     YGTKVAEEPLYVGSIKTILGHTEGTAGVAALLKASLALQNSTVPPNMLLNTLSETVAPF
                     TKNLEILKAPKAWPSVESGQPRRASVNSFGFGGTNAHAILESYEPARLENGGADSSAQF
                     TPFVFSALSRGSLKETLAAYADYIEANPAISLRDLAYTLQARRTAFPYRVSFAAQSADD
                     LVSKIRAEIEGTKTEELGVRLASTNDKRRKIIGVFTGQGAQYARMGAELLEQSATARKM
                     IAELQTHLEQLPEDLRPDFSLEEELRRAKEDSRVLTGAFSFLSTVVQLILVDLLKLAGV
                     EFDAIVAHSSGEMAAAYAAGRLSARDAMCVAYFRGRFASKMVSPNGADKTGAMLAAGMS
                     EEDAVALCEDEMFAGRLCVAAINSSSSVTISGDEDAIDEFKMILDDENKFNRKLRVDRA
                     YHSNHVSKHLADYVELVRRAGVKALEPGEGAPLWISSVYGREVTSDMGLSDEYWGASVA
                     RGVSFYPALKIILEGGEYQAALEVGPHPALKGPASQTIQELGKAIPYFGVLNRGSDATV
                     AFATSLGSLWTRVGGEQLDLTNFEKEVNDNKSALQVLKGLPRYQWNHEGSYWHEPRASK
                     KHKAQTQPFNSLLGTMMPDSAAHHLSWGNLLRASEIEWASGHQVQSQTVFPAAGYICTA
                     FEGARVLAGDRDVRLFELKDFVIHQALTFASDDAGIEVQSSLSDIQNVSKDRLVAKFTY
                     SASIGEEDLDLVAEGELHIVFGPASEATLPKRASKQPHMISVDNERFYTFLATLGYGFE
                     GPFKSLHTLRRKLGSSSCSVHSISREGVFGQPLLVHPAELDGGIQSLILAYSYPDDDQL
                     LNMHLPTSMKSIRVNPTLCQSMTDITTDGRLGTRRSAGFNGDVSLFTNDSACAAIQIQG
                     LELKPLGALTAKDDRKVFSKYEWVKNRLDGDLAADDTNVTKHHEDVLEGLERISTFYLN
                     KLDAEVPMDSPLRKEGPHMHYLNYAHHIVELIQNGEHKVAKHDWLSDSLEDLHRKTGHL
                     KDLIDYDMMHLVGQQMPRVLRGETNMLEEMRVSNILDNYYKGAFGSREAGLWIGKIISQ
                     LAERYPHLNILEVGAGTGGATTRVLQGLNNKFLSYTFTDVSSGFFEGAAEMFSEQKDRM
                     VFKTFDCGQDPVAQGYAEGTYDVIVAFLVIHATPDLDLTMRNIRKLLKPGGFLIVGEGT
                     NNGQPYGSAGFIFGSLPGWWLGADSGRPLSPFVSYSEWERLLRGSGFSGIDSTAPQAFQ
                     DVLGMTVFAAQAVDDRVNFIREPTNPEVVAKSAAAIEYPIEKLVVIGGSTDKTRSLVSS
                     ITETLKKSAVNLYTFETLTGVDFSLVDANAIVVSLSELDKPVFEDLTPEEWAAFKTLFS
                     CPTKLFWVTSGRLSEVPFSNMTVGFARTAVFETPALRFQNVDFTDLSTVKAQDLVEKVL
                     RFHASASTLPPDVKQLAWPLEPEILVKEDGEELVPRLRHINARNDRYNSARRPITNETD
                     ITKYPAALFNDGEGWKLKELSPWAIPAETPETITLEVSHAVLSAVRTSYGHQFLVFGTD
                     SKTQGRFMALVPSLLSVVTIAKESAVPVPKAAATDAELQASLAACLISMAVVDPLVDGD
                     TLVVHNATELLANTISTHAASKKVHAVFVADSSNADAPEAWAKLEPYMTQSEIADILPA
                     NTACFVDFSVQGSENASSIIAGLPIHCRKENVSTLYSPIGWESVSVSAASALGQLLQRA
                     WFYAQQETLAHKKDAIAPQTVSIADLLEGSNPEDPATVIDWTLSKTHPVHVSRLDSGAF
                     FKGDKTYWLCGLSGALGVSLVDWMIERGAKCLVLTSRNPNISPDWIAAHKKNGVNVTIV
                     PCDVTNEPALRAAHKFIVETQPPIAGVLNGAMVLRDVSIANMSFELMSDVFRPKVYGSI
                     HLDRIFKDTPLDFFILFSSINCVIGNLGQANYAAANTFMCSLAAQRRKRGLAATALNVG
                     AIIGAGYMERESSKALDLTVSKMALMHLSEQDYHQLFAEGIDAGRPDSVDEAELTTGLL
                     DIPAAEDDENTPKWHSNPAFLDFIVHQVEKNGADAGNEVIASVQDQLAACKSRTDVLAV
                     VKARFAMQLRNVLQMTTADEDLMALRSRDIGLDSLISVDIRSWFLKNFEVSVPVLKIMG
                     NDTMAELADLVADQCPESLLPGLGGDGEAPVPVEDTPAVSVTPTVVVKAADDATSSSDS
                     NDGTPAESVHGGSTGRTTPVTMEPPQMVKGPLRIDWSKEIVLPQAAKISTERAPAARPQ
                     NVVLTGVSGLLGRNLLNSLLADSSVKKVFCIAVRRLNERINELPKDARVQYFAGDLETP
                     RLGLSERDATEIFSQADVVIHNGADTSHLKFYPEIKAANTGSTKELISLCISRKVPIHY
                     LSTVGVALFGNYKSFPEVSVAEHQPPVDGSHGYVAAKWASERLLEEVKKEAGLNVWIHR
                     PSTIIREGSDATNAAAQIDWMNALVEYMRKTRAVPVLKNLRGALDFVYVKNATDSILST
                     VFSNKQQGVVYTHQVGDIVAPLEDLKEFVAKDTGAVNVQELPVELWSQKAVEAGLNRGV
                     AALIDSMDDPGQPHYPRMLKAAQ"
     aSDomain        join(5759..6158,6211..6468,6534..7180)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.70E-164"
                     /label="calA__PKS_KS.1"
                     /locus_tag="calA_"
                     /protein_end="442"
                     /protein_start="7"
                     /score="539.6"
                     /tool="antismash"
                     /translation="IAIVGSACRFAGGASSPSKLWELLNNPRDVRSDIPTSRFNKDNYY
                     HPNSAFHGHSNIQHSYLLEEDVAAFDTEFFGIKPVEAKAIDPQQRLLMETVYEGLESAG
                     LTIDSLKGSDTAVYVGLMCGDYEASVLRDLKTAPVYTATGIGRSILSNRVSYFFNWHGP
                     SMTIDTACSSSLVAVHLAAQALRNGESRVALACGSNLLLGPENYIMESKLKMLSPDGRS
                     KMWDKDANGYARGDGVAACILKTLSAAIEDGDHIECIIRETGVNQDGATTGITMPSATA
                     QRALIEATYEKAGLDLSKAIDRPQFFEAHGTGTPAGDPIEAEAISKAFFGEQYGTKVAE
                     EPLYVGSIKTILGHTEGTAGVAALLKASLALQNSTVPPNMLLNTLSETVAPFTKNLEIL
                     KAPKAWPSVESGQPRRASVNSFGFGGTNAHAILESY"
     aSModule        5759..14346
                     /complete
                     /domains="nrpspksdomains_calA__PKS_KS.1"
                     /domains="nrpspksdomains_calA__PKS_AT.1"
                     /domains="nrpspksdomains_calA__PKS_DH.1"
                     /domains="nrpspksdomains_calA__cMT.1"
                     /domains="nrpspksdomains_calA__PKS_KR.1"
                     /domains="nrpspksdomains_calA__PKS_PP.1"
                     /domains="nrpspksdomains_calA__TD.1"
                     /final_module
                     /iterative
                     /locus_tags="calA_"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       6294..6341
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0001"
                     /evalue="3.60E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="calA_"
                     /protein_end="184"
                     /protein_start="168"
                     /score="21.9"
                     /tool="antismash"
                     /translation="GPSMTIDTACSSSLVA"
     CDS_motif       6548..6586
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0002"
                     /evalue="3.30E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="calA_"
                     /protein_end="244"
                     /protein_start="231"
                     /score="10.8"
                     /tool="antismash"
                     /translation="WDKDANGYARGDG"
     CDS_motif       6794..6838
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0003"
                     /evalue="1.60E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="calA_"
                     /protein_end="328"
                     /protein_start="313"
                     /score="11.0"
                     /tool="antismash"
                     /translation="FEAHGTGTPAGDPIE"
     aSDomain        7505..8452
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__PKS_AT.1"
                     /evalue="3.40E-78"
                     /label="calA__PKS_AT.1"
                     /locus_tag="calA_"
                     /protein_end="866"
                     /protein_start="550"
                     /score="254.9"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: mxmal"
                     /tool="antismash"
                     /translation="VFTGQGAQYARMGAELLEQSATARKMIAELQTHLEQLPEDLRPDF
                     SLEEELRRAKEDSRVLTGAFSFLSTVVQLILVDLLKLAGVEFDAIVAHSSGEMAAAYAA
                     GRLSARDAMCVAYFRGRFASKMVSPNGADKTGAMLAAGMSEEDAVALCEDEMFAGRLCV
                     AAINSSSSVTISGDEDAIDEFKMILDDENKFNRKLRVDRAYHSNHVSKHLADYVELVRR
                     AGVKALEPGEGAPLWISSVYGREVTSDMGLSDEYWGASVARGVSFYPALKIILEGGEYQ
                     AALEVGPHPALKGPASQTIQELGKAIPYFGVLNRG"
     CDS_motif       7508..7552
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0004"
                     /evalue="1.20E-04"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="calA_"
                     /protein_end="566"
                     /protein_start="551"
                     /score="14.8"
                     /tool="antismash"
                     /translation="FTGQGAQYARMGAEL"
     CDS_motif       7754..7852
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0005"
                     /evalue="9.50E-09"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="calA_"
                     /protein_end="666"
                     /protein_start="633"
                     /score="27.8"
                     /tool="antismash"
                     /translation="GVEFDAIVAHSSGEMAAAYAAGRLSARDAMCVA"
     aSDomain        8678..9184
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__PKS_DH.1"
                     /evalue="4.00E-14"
                     /label="calA__PKS_DH.1"
                     /locus_tag="calA_"
                     /protein_end="1110"
                     /protein_start="941"
                     /score="45.2"
                     /tool="antismash"
                     /translation="LLGTMMPDSAAHHLSWGNLLRASEIEWASGHQVQSQTVFPAAGYI
                     CTAFEGARVLAGDRDVRLFELKDFVIHQALTFASDDAGIEVQSSLSDIQNVSKDRLVAK
                     FTYSASIGEEDLDLVAEGELHIVFGPASEATLPKRASKQPHMISVDNERFYTFLATLGY
                     GFEGPF"
     CDS_motif       8762..8833
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0006"
                     /evalue="1.10E-08"
                     /label="PKSI-DH_m2"
                     /locus_tag="calA_"
                     /protein_end="993"
                     /protein_start="969"
                     /score="27.6"
                     /tool="antismash"
                     /translation="SGHQVQSQTVFPAAGYICTAFEGA"
     aSDomain        9986..10585
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.40E-75"
                     /label="calA__cMT.1"
                     /locus_tag="calA_"
                     /protein_end="1577"
                     /protein_start="1377"
                     /score="246.0"
                     /tool="antismash"
                     /translation="ILDNYYKGAFGSREAGLWIGKIISQLAERYPHLNILEVGAGTGGA
                     TTRVLQGLNNKFLSYTFTDVSSGFFEGAAEMFSEQKDRMVFKTFDCGQDPVAQGYAEGT
                     YDVIVAFLVIHATPDLDLTMRNIRKLLKPGGFLIVGEGTNNGQPYGSAGFIFGSLPGWW
                     LGADSGRPLSPFVSYSEWERLLRGSGFSGIDSTAPQA"
     CDS_motif       12200..12298
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0007"
                     /evalue="3.30E-12"
                     /label="PKSI-KR_m1"
                     /locus_tag="calA_"
                     /protein_end="2148"
                     /protein_start="2115"
                     /score="39.0"
                     /tool="antismash"
                     /translation="TYWLCGLSGALGVSLVDWMIERGAKCLVLTSRN"
     aSDomain        12200..12721
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__PKS_KR.1"
                     /evalue="1.60E-51"
                     /label="calA__PKS_KR.1"
                     /locus_tag="calA_"
                     /protein_end="2289"
                     /protein_start="2115"
                     /score="166.7"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="TYWLCGLSGALGVSLVDWMIERGAKCLVLTSRNPNISPDWIAAHK
                     KNGVNVTIVPCDVTNEPALRAAHKFIVETQPPIAGVLNGAMVLRDVSIANMSFELMSDV
                     FRPKVYGSIHLDRIFKDTPLDFFILFSSINCVIGNLGQANYAAANTFMCSLAAQRRKRG
                     LAATALNVGAI"
     CDS_motif       12569..12679
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calA__0008"
                     /evalue="2.40E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="calA_"
                     /protein_end="2275"
                     /protein_start="2238"
                     /score="68.4"
                     /tool="antismash"
                     /translation="LDFFILFSSINCVIGNLGQANYAAANTFMCSLAAQRR"
     aSDomain        join(13070..13076,13124..13335)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__PKS_PP.1"
                     /evalue="3.30E-11"
                     /label="calA__PKS_PP.1"
                     /locus_tag="calA_"
                     /protein_end="2478"
                     /protein_start="2405"
                     /score="35.3"
                     /tool="antismash"
                     /translation="VKARFAMQLRNVLQMTTADEDLMALRSRDIGLDSLISVDIRSWFL
                     KNFEVSVPVLKIMGNDTMAELADLVADQ"
     aSDomain        13651..14346
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calA__TD.1"
                     /evalue="1.00E-56"
                     /label="calA__TD.1"
                     /locus_tag="calA_"
                     /protein_end="2815"
                     /protein_start="2583"
                     /score="183.7"
                     /tool="antismash"
                     /translation="VVLTGVSGLLGRNLLNSLLADSSVKKVFCIAVRRLNERINELPKD
                     ARVQYFAGDLETPRLGLSERDATEIFSQADVVIHNGADTSHLKFYPEIKAANTGSTKEL
                     ISLCISRKVPIHYLSTVGVALFGNYKSFPEVSVAEHQPPVDGSHGYVAAKWASERLLEE
                     VKKEAGLNVWIHRPSTIIREGSDATNAAAQIDWMNALVEYMRKTRAVPVLKNLRGALDF
                     VYVKNATDSI"
     gene            complement(<15268..>16802)
                     /gene="calD'"
     mRNA            complement(join(<15268..16521,16575..>16802))
                     /gene="calD'"
                     /product="acyltransferase CalD'"
     CDS             complement(join(15268..16521,16575..16802))
                     /codon_start=1
                     /gene="calD_"
                     /product="acyltransferase CalD'"
                     /protein_id="QQW45468.1"
                     /transl_table=11
                     /translation="MGLFSSEKPVQQPPKVPTDEVIPLNAADDTDVLRSVCVVLSYRFD
                     DVLDPEKLKSSYEKLLDRPGWRKIGARLRLNPNGRLEYHIPEKYDETRPIVTWSHVTHD
                     MSITEHPLASKLPRPTTKPAVVGDPHDFDELTCSPDAPKTLDDYLSRDVPQTCLHVVSF
                     NDSTLISISLPHTLTDGTGGAQIYRCWALVLQGREDEVPDFHGYDSDPLATFGDKSSEE
                     YMFAPQLLTGWRKWLFIAYQIYDGWRYKTSSRIMCVPGPYMAAQRKKAIEEIRADTGND
                     KAFVSDNDVLTAWFTRLEAGHFPKNSNLTVRIMNAFALAAVLGNDHLPTTKAFISNAAT
                     EIYTFFTVRELFTKPLSQLAWKIRQSMMTGGTREQVEALQAVKKQTLAREGHTWPMFGD
                     ASMEMMSYSNWTKGKYFETDFSAAMTRVGFPENRRAEKPGYASMVQFNAWSTKFDLRNL
                     MPIMGKDAAGNYWLQGPLRDVVWRRIERELKAAKD"
     gene            <17376..>19160
                     /gene="calE'"
     mRNA            join(<17376..17750,17801..17900,17951..18019,18085..18687,
                     18739..>19160)
                     /gene="calE'"
                     /product="cytochrome P450 monooxygenase CalE'"
     CDS             join(17376..17750,17801..17900,17951..18019,18085..18687,
                     18739..19160)
                     /codon_start=1
                     /gene="calE_"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 147.7; E-value: 8.7e-45)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase CalE'"
                     /protein_id="QQW45470.1"
                     /sec_met_domain="p450 (E-value: 7.2e-47, bitscore: 149.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLQLDNITTTDSFDTAPETRPYISIIVLVTGLIAVIVSTLLKEN
                     PLANVPLVTEKAWWDITGKKAKDNFTANARAVIRQGFEKVGFLKPYRIISDQGEMLILP
                     PAMAHDIRNIDALSHAVFMKETTCAEVPGFEPYLESTGTTLLIDMTKTKLISAMKPLTY
                     PLSKTCANACKDLFTSENDWKEVTLKDELLDLVARLSSVIFLGDEEVSQDPAWLKITKE
                     YTVDSFIAFHQLRPYPAFLRSFVAKFLPQARKVLGQLREAESIIEPIIERRRAEKAANP
                     EAYKDRNDSIEWLEQVAQEKGIKYSPPAMQLTLALSAIHTTTDLLTTTMYEILQHPETI
                     QLLRDEVKAVVGDGKLKHSSLYNLKLMDSVIKEAQRLKPVLSINMVRTATEDIDLPDGF
                     HIPMGTRLGVSSHASWDPKIFPNPEKFDPFRFVRLREQPGQENVWQLTTTRPEQIAFGH
                     GQHACPGRFLAANEVKIALCHLLLKHDWELSSITMPKAISHGIMLDSDPTVKVKVRSRV
                     PDVEL"
     gene            complement(<19518..>21341)
                     /gene="calF'"
     mRNA            complement(join(<19518..20778,20824..21024,21070..>21341))
                     /gene="calF'"
                     /product="FAD-linked oxidoreductase CalF'"
     CDS             complement(join(19518..20778,20824..21024,21070..21341))
                     /codon_start=1
                     /gene="calF_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 297.5;
                     E-value: 4.4e-90)"
                     /gene_kind="biosynthetic-additional"
                     /product="FAD-linked oxidoreductase CalF'"
                     /protein_id="QQW45469.1"
                     /transl_table=11
                     /translation="MLAKLFLLSLSLLSPALGLVPRQAPSSSCKAFPGDAAWPSAGAWN
                     ALNRTVGGRLIATVPLPSVCHQTPFGTFNEDACAAMKTEWLEDTTFINHPAEVMNPPTQ
                     NYSCVPFTSSSQACNMGNYASYSINVTGADDVIAGIKFARENNVRLVIKNTGHDFSGKS
                     TGPGALSLWTHNLNTTKIIENYEGAGYSGPAAKLGAGVISGQVYEVVGAAGYRVMGGTC
                     PTVGLAGGYTSGGGHSLLNGAYGMAADAVLEWEVITADGKHLTASQSENSDLYWALSGG
                     GAGTYAVVLSMTTKVFADGPIGSGILMFNITANATEDYWGAIEDLWMFLPEFVDAGPNS
                     WDFALTAAGFQAYAITVPDKNGTEVQSLLQPWLSSVSRRGIQYSFIPTDSDNYLEYFSS
                     RFGPGIAGAGPATVQLTSRLIPRAAMYNKTETKVIVDALRQVVELDPEASLGCHALNVA
                     NVEHPDNAVLPAWREAIATCNIVTYWDWDISEAEMWEKKDLLVDTLIPGLEEATPGSGT
                     YLNEIDAGWKGDWITELYGENYDRLLSIKNKYDPQHVFYARTAIGSASWTSDATGRLCR
                     V"
     gene            <21745..>25153
                     /gene="calG'"
     mRNA            join(<21745..21859,21905..22020,22067..22102,22152..22844,
                     22895..>25153)
                     /gene="calG'"
                     /product="bifunctional cytochrome P450/NADPH-P450 reductase
                     CalG'"
     CDS             join(21745..21859,21905..22020,22067..22102,22152..22844,
                     22895..25153)
                     /codon_start=1
                     /gene="calG_"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 294.6; E-value: 2.4e-89)"
                     /gene_kind="biosynthetic-additional"
                     /product="bifunctional cytochrome P450/NADPH-P450 reductase
                     CalG'"
                     /protein_id="QQW45471.1"
                     /sec_met_domain="p450 (E-value: 7.2e-82, bitscore: 265.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKLSNIPQPPGVPFLGNLFDIDMELPLQSLYDLGAKHGEIYRMK
                     FPGHTFIIACSYDMVNEFCDEKRFPKTIFALKEMRHAMHDGLFTAIDGETEPAWAIAHR
                     ILVPAFGPSSLRMMYDGMYDIASQLALKWARYGGEAITVTDDFTRLTLDTIALCSMDFR
                     FNSYYKEGVHPFVEAMGDFLTESGDRARRLPIPSFFYRGKDKKFFGDIEVMRRTANEIL
                     QERKKEKNLDTRKDLLSAMLNGVDPKTGKKMTEESILDNLITFLIAGHETTSGMLSFAL
                     YHLMKDPDCYRKAQQEVDSVCGKTPIRFDQLNKLGYISAVLRETLRLTPPLPVFNVAPK
                     KDEIVGGQYVIKEGELVIVLIGASQMDPKVFGADVGVFKPERMLDENFNKLNKEFPNAW
                     KPFGNGTRGCIGRPFAWQEALLVLAMLLQNFDFEFDDPSYTLTLKQTLTVKPANFKVKA
                     IPRDGLRAFEMQNRLAGMSVSTKTTSGAAANGTAAPVSGGTGKPMKIFYGSNSGTCQSM
                     AERLAADAFSHGFSATTVDCVDNATAQLPKDEPVVIITASYEGQPPDNAAKFVPWLEGL
                     KEDSKELKDVNYAVFGCGHHDWSATFHRIPKLVDYTIDKHGGNRVAALGLTDVAQGNEM
                     TDFEAWEDNILWPALMEKYGAEAPQGPSLSVEVSTPRKSTLRQDVKEAAVVSTSVLTSE
                     DALIKKKHIEIELPSDMTYKAGDYLAVLPVNPPDQVHRVMRHFHLPRDAHLTISSKAVT
                     SLPSDGPMPAVDIFGSYVELAQAATKRDIQTLIDAAKDEKTKTKLAALATDEEYASTII
                     ASRLSVLDLLESNPDIKLPISAFLRMLPPMRVRQYSIGSSPVWSKNRVILTYTVLDEPR
                     IGTDGKRHVGVATNYMSTLQAGDVVHVAVRPSHAAFHLPADAGRTSMVMIAAGTGVAPF
                     RGFIQERAGMKGAGRKIAPATLYFGCRQPGQDDLYRSDLDNWESSGVVDVRRTFSRQVE
                     ASEGHKYVQDRLWQERKEIMSLWDQGAMIYICGGRAMGESAKEMMIEILYDAKKEKGEE
                     TSKEEVAKWFEGLKNTRYAVDIFD"
     gene            <25603..>26803
                     /gene="calH'"
     mRNA            join(<25603..26391,26444..26566,26615..>26803)
                     /gene="calH'"
                     /product="trans-acting methyltransferase CalH'"
     CDS             join(25603..26391,26444..26566,26615..26803)
                     /NRPS_PKS="Domain: cMT (168-350). E-value: 1.2e-78. Score:
                     256.0. Matches aSDomain: nrpspksdomains_calH__cMT.1"
                     /codon_start=1
                     /gene="calH_"
                     /product="trans-acting methyltransferase CalH'"
                     /protein_id="QQW45472.1"
                     /transl_table=11
                     /translation="MASIDLSNWQTVDLQWTPDSTPTPVSQLLHPTRESQSEQEMIARM
                     WVLCAIQMQEKLKSATCTKPHFEKYRNWLASEYERFKQPGYPQVPDSGDLVALSDGERL
                     KAMNEMRERVKDTYLWPVIEGPWRVYDNVVDIVEGRVKLVKVLLKDGLLEKFYDWANSL
                     SEVRPLINLMGRTNPGLRILEIGAGTGGTTARVFEGLNPDAGKQLYSSYVFTDISPLFF
                     DSAKRRFEAYDNVEYRALDISKDPVEQGFEAGAYDVVIASNVLHATPCLVETLKNVRTL
                     LQPKGFLFNQELSPPGKYVDFMVGLLPGWWLGEADGRAGGPCIPPAEWDRRLKQAGFEG
                     LHAVGLDSEPPFYYNANMLARVAASD"
     aSDomain        join(26107..26391,26444..26566,26615..26752)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calH__cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.20E-78"
                     /label="calH__cMT.1"
                     /locus_tag="calH_"
                     /protein_end="350"
                     /protein_start="168"
                     /score="256.0"
                     /tool="antismash"
                     /translation="LINLMGRTNPGLRILEIGAGTGGTTARVFEGLNPDAGKQLYSSYV
                     FTDISPLFFDSAKRRFEAYDNVEYRALDISKDPVEQGFEAGAYDVVIASNVLHATPCLV
                     ETLKNVRTLLQPKGFLFNQELSPPGKYVDFMVGLLPGWWLGEADGRAGGPCIPPAEWDR
                     RLKQAGFEGLHAVGLDSEP"
     gene            complement(<26879..>27907)
                     /gene="calI'"
     mRNA            complement(<26879..>27907)
                     /gene="calI'"
                     /product="short-chain dehydrogenase/reductase CalI'"
     CDS             complement(26879..27907)
                     /NRPS_PKS="Domain: PKS_KR (40-194). E-value: 7.7e-07.
                     Score: 21.0. Matches aSDomain:
                     nrpspksdomains_calI__PKS_KR.1"
                     /codon_start=1
                     /gene="calI_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     136.5; E-value: 1.8e-41)"
                     /gene_kind="biosynthetic-additional"
                     /product="short-chain dehydrogenase/reductase CalI'"
                     /protein_id="QQW45473.1"
                     /transl_table=11
                     /translation="MSLDRYAAFHAETPQGRGDGRPTAEQILRDQEPLGDWSDKVILIT
                     GGTAGLGAESTRVLHKTGAKIFIMGRDAVKGQKLADNISAVNPQFPPIEVITMDQSSLQ
                     SVHDGAAEFLKKSGRKLNVFMANAGIVASPVKETKDGFEAVFAINYLSTFLLTQLLAPA
                     LEASTTPEFKSRLVVVSSAGHRAGNVDPEKYNFMGEGYDPSKAYARSKSAAILMANEFE
                     RKYGSRGVHALSLNPGIIMDTEISRDMPGTKESRRPMYYKMEPLLASWEKDVEQGAATQ
                     VWASIAKELEGKGGLYLDDVQVAKEAKFEGQMCLPGWKPWIWDEEMAARLWKDSLEMVG
                     LA"
     aSDomain        complement(27326..27787)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calI__PKS_KR.1"
                     /evalue="7.70E-07"
                     /label="calI__PKS_KR.1"
                     /locus_tag="calI_"
                     /protein_end="194"
                     /protein_start="40"
                     /score="21.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VILITGGTAGLGAESTRVLHKTGAKIFIMGRDAVKGQKLADNISA
                     VNPQFPPIEVITMDQSSLQSVHDGAAEFLKKSGRKLNVFMANAGIVASPVKETKDGFEA
                     VFAINYLSTFLLTQLLAPALEASTTPEFKSRLVVVSSAGHRAGNVDPEKY"
     CDS_motif       complement(27695..27784)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calI__0001"
                     /evalue="1.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="calI_"
                     /protein_end="71"
                     /protein_start="41"
                     /score="14.2"
                     /tool="antismash"
                     /translation="ILITGGTAGLGAESTRVLHKTGAKIFIMGR"
     gene            <28360..>29605
                     /gene="calJ'"
     mRNA            join(<28360..28450,28494..>29605)
                     /gene="calJ'"
                     /product="esterase CalJ'"
     CDS             join(28360..28450,28494..29605)
                     /codon_start=1
                     /gene="calJ_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 156.1; E-value: 2e-47)"
                     /gene_kind="biosynthetic-additional"
                     /product="esterase CalJ'"
                     /protein_id="QQW45474.1"
                     /transl_table=11
                     /translation="MADFDALLADYTKKENPKVHGAIFKCVDGQGNEIYSKVAGWDSVE
                     PNAAPLTEDVVLKVASATKLITSIALLQCVDKGLIGLDEPLGKHVPELADKQILIDVKD
                     LEFVHEPSKVPITARHLLTHTSGFGYRFTHRLLRMRAEAKTAAGEKPSLRITERYEMPL
                     VFEPGTGWLYGCSLDWAGVTVSRLNGGITLEQYFVENIWKKLGLSAPFPCFNIATHPEY
                     NARTMGGAMRTPDGRLQPNNTWAFDNPEDQDGGSGLSCTAKDYVAVLADLISDSPKLLS
                     PGIIAEMFVPQLQPKSVPVEQMLGLRPAWDTVSGPIAEDAINHGLGGIVTTGDVAEIGQ
                     PKGMLGWGGASNIVWWVNRDLRVAGFFATQQAPFGNPTVTALVNAWKKDFWTQFKNKEN
                     A"
     gene            complement(<29623..>30757)
                     /gene="calK'"
     mRNA            complement(join(<29623..30157,30204..>30757))
                     /gene="calK'"
                     /product="trans-acting enoylreductase CalK'"
     CDS             complement(join(29623..30157,30204..30757))
                     /NRPS_PKS="Domain: PKS_ER (33-217). E-value: 1.9e-14.
                     Score: 45.3. Matches aSDomain:
                     nrpspksdomains_calK__PKS_ER.1"
                     /codon_start=1
                     /gene="calK_"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 142.6; E-value: 2.6e-43)"
                     /gene_kind="biosynthetic-additional"
                     /product="trans-acting enoylreductase CalK'"
                     /protein_id="QQW45475.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.7e-12, bitscore:
                     35.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPPTQTAIVQIAKGDSSEIPLVVSKSAPIPQVQSENHVLVKVLA
                     VALNPNDHKMVTHFNTAGSIAGCDFCGVVASSNAPLGLTEGTRVCGALFPYSPADPDNG
                     SFAQYCVVDARLLVKVPDTWSDLEAASLGVGWSTISLAFSDPNALGLEGLPTQPTHQNK
                     EPVLVYGGGTASGTLACQLLKLMNYTPIAIASNRSAELATEYGAAGTASYTSKDCVDTV
                     KSIAGKPIRKVLDCITDAESAAMCYSAMARTGGNYACLEECPEAWRSRRIVKVKEVMGF
                     QVLGVDINLGDSTYTRLGDQKLFTIGTQWAREFETLMATGQLKAHPLRELPGGFDAIIE
                     GLNMLRKGEVRGQKLVVKIPQN"
     aSDomain        complement(join(30061..30157,30204..30658))
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calK__PKS_ER.1"
                     /evalue="1.90E-14"
                     /label="calK__PKS_ER.1"
                     /locus_tag="calK_"
                     /protein_end="217"
                     /protein_start="33"
                     /score="45.3"
                     /tool="antismash"
                     /translation="QSENHVLVKVLAVALNPNDHKMVTHFNTAGSIAGCDFCGVVASSN
                     APLGLTEGTRVCGALFPYSPADPDNGSFAQYCVVDARLLVKVPDTWSDLEAASLGVGWS
                     TISLAFSDPNALGLEGLPTQPTHQNKEPVLVYGGGTASGTLACQLLKLMNYTPIAIASN
                     RSAELATEYGAAGTASYTSKD"
     gene            <31080..>32775
                     /gene="calL'"
     mRNA            join(<31080..31255,31311..32503,32555..>32775)
                     /gene="calL'"
                     /product="cytochrome P450 monooxygenase CalL'"
     CDS             join(31080..31255,31311..32503,32555..32775)
                     /codon_start=1
                     /gene="calL_"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 93.5; E-value: 2.3e-28)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase CalL'"
                     /protein_id="QQW45477.1"
                     /sec_met_domain="p450 (E-value: 1.4e-30, bitscore: 96.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAELGPLVWGVAACIALAIFIPKWIGKGAKEPPSLGGWMIANTY
                     QYMTDMHGFLQRVASAQRKSKIVKFRLGPKKIYMVSGEQNIQAINKPSHSISPDVFFLE
                     VMANVWGARKDEVSKFANDKSGRSKNPVPGHDVKPGQPRLWHGQHHVYSEYLQRADHAN
                     ALSDKYYELFSDRLKKQPLGEWQEIRLSEFFESEMAEAALVALMGPRIVKLNPGFWPAM
                     WEFARLAPRLMWGLPRWVNPKPWEIREQFHGMCRRYLDSAEKEFDWNGPDTDSEWEPHY
                     GSRMARELIGWAKNNLSPETTAGMVATFIFGTNANSVPLSTWAMMELIADPELYKAVHE
                     ECIAASTVDPATGERVFNPQKLLGMPLLQSVYIETLRLHVSINVTREVTQPITLDGHLL
                     TPGSLIQAPSQIGQYNEAVWASEGHPASQFWAGRNLKHENGKAEFTMAGRTTSFFPFGG
                     GPSICPGRVFAKQEILMTIAALVTRFEIELIDWVHPDGTKSDRPAQNDQSYIGAVGIPP
                     DRDMKVRWKRLW"
     gene            complement(<33127..>34134)
                     /gene="calM'"
     mRNA            complement(join(<33127..33473,33524..34033,34080..>34134))
                     /gene="calM'"
                     /product="short-chain dehydrogenase/reductase CalM'"
     CDS             complement(join(33127..33473,33524..34033,34080..34134))
                     /NRPS_PKS="Domain: PKS_KR (15-182). E-value: 2e-11. Score:
                     36.0. Matches aSDomain: nrpspksdomains_calM__PKS_KR.1"
                     /codon_start=1
                     /gene="calM_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     152.5; E-value: 2.4e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="short-chain dehydrogenase/reductase CalM'"
                     /protein_id="QQW45476.1"
                     /transl_table=11
                     /translation="MNPVNTKPYQLPADATWFVTGCSSGIGRAIAEHVAAQPGHRLIAT
                     ARDPASLSYLQDSASILKLGLDVTKPESVDAAFKAAAAHFGDSYYLDVVVNNAGYSLSG
                     DTESVTEGEMHEAFETNFFGLVRVSLKAIEVMRQSKEKRGGLIFNISSLAGICAFPGHA
                     FYHASKFAVEGWSESVAREVHPDWNINFCIVEPSAVKTNFETTSKKRTAPHEAYAGADM
                     PARQLEMFVKKGLAAGVGFEPSAVAKVLYQVASRNEKVPLRLPLSATAVKLITAKLQGQ
                     LQDLETTAELSAIDVGQAQFKV"
     aSDomain        complement(join(33543..34033,34080..34089))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_calM__PKS_KR.1"
                     /evalue="2.00E-11"
                     /label="calM__PKS_KR.1"
                     /locus_tag="calM_"
                     /protein_end="182"
                     /protein_start="15"
                     /score="36.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TWFVTGCSSGIGRAIAEHVAAQPGHRLIATARDPASLSYLQDSAS
                     ILKLGLDVTKPESVDAAFKAAAAHFGDSYYLDVVVNNAGYSLSGDTESVTEGEMHEAFE
                     TNFFGLVRVSLKAIEVMRQSKEKRGGLIFNISSLAGICAFPGHAFYHASKFAVEGWSES
                     VARE"
     CDS_motif       complement(join(33948..34033,34080..34089))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_calM__0001"
                     /evalue="4.00E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="calM_"
                     /protein_end="47"
                     /protein_start="15"
                     /score="19.5"
                     /tool="antismash"
                     /translation="TWFVTGCSSGIGRAIAEHVAAQPGHRLIATAR"
ORIGIN
        1 cctttaatag ccgctgttcc tgcttccttt gcccttctgc agctgcagct acgtccactg
       61 cacacgagtt gtctgattgc tcactttagg gtcattcaac atgtccgatc aacaaacaca
      121 agcccaacaa cctcccaaga agcgcgctgc ttgcgatcgc tgccgtacgc agaagctccg
      181 atgtctgcgc gtctccggcc atccgaatga tcactgtatc cgctgcgtgc gctcgcagat
      241 ggaatgcatt accagttcgt ctaaacgtcc tggtcgtccc aggaattcga ctaatacccc
      301 ccgtcaacaa caaccgacgc cgagtccgaa taccggcatc gaaacaaacc ctgccttgcc
      361 cgccatcgat atacctcctc aatccctcga gaatgtcgac gactggttca attttggttc
      421 cttggataca gactatgaga tctgctctgc tccctggacc tcagttgatt cgggcttcga
      481 atcagggttc cccatggaag gcgtcgccac atcgatgtct tcactatcca cgcctcccct
      541 gcaaacggct tccactcctg ctttcctcac taccatgcca acgcataccc ctatccacga
      601 ccactttcaa gatgacccgt gtgaccatct gccactgctg gctcctcaac cttttgcggc
      661 aaacttcgat cacggccttc acctttccca attacaacgc gaactttcca aacagttata
      721 cactctcacg tccatgcctt gggacatgac caaggttatg caattgactt gcttccaagc
      781 tcctggtacc tcggccccct ccagtcccag ccaggatgat ctgaagtcga acccgctggc
      841 aaagatcgcc aaaacgtctg ccgagtttgc gcagcttctc tgctctgtgc aatctcctat
      901 cgctggcgat ggagggagca atacgtccaa ggcttcgagt ccgttgtctt ctattcatcc
      961 gcgcctcagc atgccggacc tcctcaccat cttgtcctgt catatgttga cgatttccat
     1021 ttatgattcc atcttctccc attttaccga acaagcatcc cataatcccg gcgcagtgaa
     1081 tatcgtcttg cagtctgcgc caaagctcta cctcggcggt atcgcggttc ctcctcgatt
     1141 ggagcttttg agccacctgc tctactgcat cacggcgagc caacttcggc caatcgagat
     1201 gctgttaggc cttcccgacg aatgctgcgt gtcgctaaaa cgcaattccg caagcaaaga
     1261 taagcagact gggctgttca gcgggcagag tggccaattg ctcttctcca ctctgatgca
     1321 agtcgagact gagagggcga cagaggatcg cggtggcttg ggggtgatcg aatcgctgaa
     1381 ggagaagata cgcctgattc aagggctcga atgatgacga ttttcctatg ttcctataat
     1441 gtttgacgat caagaattta gtatagacaa tgaacatcaa atagcattca actcaaccct
     1501 aattctcttc cacttcttct tcctcctctt cctcccctca actcccacct acccaacaac
     1561 catcgtgacc tcaaattgct tttttgaatc taagaactct ataattgtgt aactacaacc
     1621 tctactcggt aaattctcgg acagtgtccg aatggcagtt cggccccaaa aaaggctgca
     1681 ccgctagttt cagctgcagc gctaagcact tgacgatact agcaacaaag ggactcagac
     1741 tcaacaacca agcttcgtgc tgtggatcag ccatgcacag ccaagctcaa agatgtcagg
     1801 gcccccaagg accaaagaga cacttcctta gctcgcaatg ctagcttact ggtcagactg
     1861 gcttgtcaaa ggatgccccg tggagccagc gatcgccagt caagaatgac cgattggcca
     1921 ggcttatcgg gaatttcggt ccctccctaa ggcgctatac tgcgtttggt gcgatgtgca
     1981 gatcgataat ggagtgcttt tgcttgttag ggcgtagtgc tgactgactg gctaagggct
     2041 gggggctatt gtgttcggcg ttaccctggc tgtgtgcgtg aaggcagatt ggctggggag
     2101 ccctcactca gtcactttgg tttctcctct gacgcaaact ctgctggagg gccctttgtt
     2161 actgctgtcg aaacaagccc ttttcaatcg ccccctgccg gctgttcgcc tcctcctcgt
     2221 ttgtcatcgt agctgtacgt atcttgtctc actgctatcg ctgtcaagat gaacgacgag
     2281 cctgtcgcgc tgcagacctg gagccgtccc aacacgcgcg agtcggacgc cagaacgcaa
     2341 aacacagagg agtcctcccg cgccccctgg acgcagcagg agcatggcag tacagcgaga
     2401 gtgattgaga agcccggaga tgaggagagc tcggcggcgg atcctcctgc tgaggctgcg
     2461 gcggtccagg ctcctggtgt cactggcttc aagctgtttg gcattctggc cagtgttacc
     2521 ttgtctgcgt ttttgatgtt gctggatggg tctattattg gtgtggtagg ttgcttacca
     2581 tctctccgcg ttgtgggttg aactcaccgt tgcaggccat ccccaacatc accagtcagt
     2641 ttcactcgat tcatgatgtc ggatggtata ccgctgcgta tcagctatct aggtaagtct
     2701 cttcatctat cccgaactac tacgaagctc atcgtcgcct agtgctgccc tccagcccct
     2761 ctccggcaag atatacacct cctacaacac caaggttcgt cgcccaccca tcactaagtg
     2821 agggagctaa caaagtatga aagtggacat acctcttctt cttcttcctc ttcgaagtcg
     2881 gatcgctcat ctgcggtgtc gccaactcct catccaccct aatcggaggc agagccgtcg
     2941 caggcatcgg cagttcagga ctcctcaatg gcggaatgac aatcatcgcg ggcgcagtgc
     3001 ccctggaaaa gcgacctgtc tataccggtg tctaccttgg aagtatgcac gcgctaaaac
     3061 cctactttca gttgtctcgc taacgaggat agtctcccaa ctcggcatcg tctgcggtcc
     3121 cctcatcgga ggtgccttga cccagtacac aacctggcgc tggtgtttct acatcaacct
     3181 gcccgtcggc gccgtcgtcg cagttctcct cctcttcctg cgtgtgcctg aactcactaa
     3241 gaaggaaccg ttctcgcttg cgctcgtcaa gaagacactt ccggatctcg atctcatcgg
     3301 gtttacgctc tttgcgccgg cggccatcat ggcgctgctg ggtctatact acggtggcaa
     3361 cgagtacgcg tgggatagtt ccgttgttat tggattgttt gtcggcgccg cagcaacaat
     3421 cacagtcttt ggaatctggg aatggaagat gggtgatcgt gctatgatcc ctacgtcgat
     3481 ggtcagccac catattgtct ggacgagtgc tattaacggc ggaacactcg tcgcttcgat
     3541 tctcacggct tcgcagtatc tgcctattta cttccagggt gttcgtgggt atggggctgc
     3601 gatgagtggt gttaataccc tccctggtat tcttagccag ttgctcactg ttattatttc
     3661 tggtggtgtt gtacagaaag ttggctatta tcttcctttt gctgcggcgg ggagtgccat
     3721 cagtgcggtt ggtaatgggc ttgttacgct gttcaggccg gatacgccta cggataagtg
     3781 gattgggtat cagatcgttt tgggaagtgg tcgcggtatt ggaatgcaga tggttggtcc
     3841 aattctctct ttttattgtt cttaactgat ggtttctagg ggattatcgc catccagaac
     3901 ctcctccccc ccgagaaaat ccccgtcgga attgcgttca tgatcttctg tcagaacttt
     3961 gctggtgcgg tcttcgtcgt ggtcggggag gtcatcttta cacaggaatt ggtcaaggag
     4021 attgtcaagt acgctccctc tgtctccgtc gaagctgctg aggctgctgg tgcgagtgcc
     4081 gactctgtgc gcgcgcttgt tcctgagggt agccctgagc tggctggcgt cttgatggcc
     4141 ttctcgaaca gtgttgacaa ggttttttac ctgctaatgg ctttgtgtct gctgggattt
     4201 gttgctgcgt ttggtatggg ctgggtggat atcagaaaga acaagaagcc tgctgctgag
     4261 gaggaggata aatgagtgag agagcagaag tagtatttgt ctaattgttg agcttctata
     4321 ttttgagcgt tttggatagt ttgagataga ttggtgttga aggcgttgat gaataaaatt
     4381 tatctaaagg gaaatatctt gactcttcat ttggaacttt ccatatacat acagatttat
     4441 gtaaatatat cctcatacgc ataatgactg gtttttgtat tgcttgatcg tagtgttgct
     4501 atgcgaaatg ccagtgtact tgaagcgaca aagttatata tattttgacc acgcggctaa
     4561 atccccaaca acgcttccag tttggcccat cacctgttga tccatgaatc aagacataat
     4621 tatctagatg tatgtatgtc gatatacatt tctacaaagt attgtttggg ttattctaca
     4681 ttttaaagat attctaaaga aagcaaaagt actgtcttcc ccagcaacga catcgaagcc
     4741 tcaggccact tctacaccga tcacccaaga acaaccataa gccacatgca gatacttcgg
     4801 ccgacccaag aaaagaccaa gaacatggcg atccttagat cgagcttagt cggcgataac
     4861 aacggttgag atgggggtta gcgccagtgg cagtgacagg ggccgcctcg tataagctac
     4921 actccaccaa gctgaatggc gatcgccgtc tgtctggctg gaacatagtc cctatttcta
     4981 gagtgtagga acacgtacag agtacagtac agtacggccg tgcagcgtat ggagtagcgg
     5041 ctgaagctga ggcaggcaag gtccacaaga gtcgggtaat agggctccac cactatagac
     5101 cactccaccg aacagacgac agacgagata ccagccgcgt ggcagctggg atgtcttgga
     5161 gttactagtt agagctcaag ctaaggtcgt aatctgcaca agctcgatct gcctgcagga
     5221 ttcctggacc ccaactgagc tgcactgtgt attcccgagc gctcggagca tatcccatac
     5281 tccccccgga ggctgtgggc gaaatggccg aacgctttcg cgaattcggt caatctccct
     5341 gtcaatcgtc cggctagtct ggcgttggtc agtgattggt tcatggacag gtggaggact
     5401 cgccttcgcc acgggatcct gaaggccgtt ctccgtatag gcaatttcgc tatcgatgct
     5461 tgttgtttgg cccccatgcc ggagtaatac tgcagcaggt tctatggacg tgatacaggg
     5521 ctggatgtag tagtatggct gagtcttggg gctggccgat agattgaact gagatgtcct
     5581 ctttaaagag ggtgttgctg ctcgattgat agaaaggaca gcccagccag ccctacacgt
     5641 tcaacacccg tgactcctgc tctatcttat attcagtctt ttcaactata ccacaagaca
     5701 atcatctcct tctttacctt cttacctcta atccaccatg tccaagatca acgagcccat
     5761 tgccattgtc ggcagcgcct gtcgctttgc cggaggagcc tcgtccccct cgaagctgtg
     5821 ggagttgctc aacaaccctc gcgatgtccg cagcgatatc cccacgagca ggttcaacaa
     5881 ggataactac taccatccta actctgcctt ccacgggcac agcaacatcc agcactccta
     5941 cctgctcgag gaggatgtcg cggcgtttga caccgagttc tttggtatca agcctgtgga
     6001 ggcaaaggcc attgatcccc agcagcggtt actcatggag accgtctatg agggtcttga
     6061 gtctgcgggt ctgactattg attctctgaa gggaagtgat accgccgtct atgttggttt
     6121 gatgtgcggt gactacgagg ccagtgtgct tcgcgactgt atgctcctca cctctgccct
     6181 tccccctgat aaagtactta actcttctag taaaaaccgc ccccgtctac acggccaccg
     6241 gtattggacg gtctatcctg tccaaccgtg tgtcctactt cttcaactgg catggacctt
     6301 ccatgaccat cgacactgcc tgttcctcct ctctcgttgc cgttcacctt gcagcgcagg
     6361 cactgcgaaa tggtgaatcg cgcgtcgctt tggcttgcgg atccaacttg ttgttgggtc
     6421 ctgagaatta cattatggaa agcaagctga agatgttgtc tcctgatggt aagccttgcc
     6481 ttgtgtctct gataccctct atcaatggtg actgacctat atttgctgta taggccgcag
     6541 taagatgtgg gacaaggacg ccaacggata cgcgcgaggt gacggtgtcg cagcctgtat
     6601 tctcaagaca ttgagcgctg ccatcgaaga cggcgaccac atcgaatgta tcatccgcga
     6661 gaccggcgtg aaccaggacg gtgctacaac cggtatcacc atgcccagcg ccaccgccca
     6721 gcgtgccctc atcgaagcca catatgagaa ggccggcctt gacctgtcca aggctatcga
     6781 ccgtcctcag ttcttcgagg cccacggtac cggtacgcct gcgggtgatc ccatcgaggc
     6841 ggaggccatc tccaaggctt tcttcggtga gcagtatggc accaaggttg ctgaggagcc
     6901 gctttacgtc ggttcgatca agaccattct cggacacact gagggtacgg ctggtgttgc
     6961 ggctctgttg aaggcgtcgc tcgccctgca gaacagcact gttccaccca acatgctcct
     7021 caacaccctg agtgagactg ttgctccctt caccaaaaac ttggagatcc tcaaggcgcc
     7081 caaggcctgg ccgtcggttg aatccggcca gccccgtcgt gccagtgtga actccttcgg
     7141 tttcggtggt accaacgcgc acgcgattct cgagagctac gagcctgctc gcctggaaaa
     7201 tggcggtgcg gactcctctg ctcaattcac tccttttgtc ttctctgcac tttctcgtgg
     7261 atcgctcaag gagactctcg ctgcctacgc cgactacatc gaggcgaacc ctgctatcag
     7321 cctccgcgac cttgcttaca ctctacaggc tcgccgcact gccttcccct accgtgtctc
     7381 tttcgctgct cagagtgcgg atgacctcgt ttctaagatc cgcgctgaga tcgagggtac
     7441 caagaccgag gagctgggtg ttcgcctggc ctctaccaac gacaagcgcc gcaagatcat
     7501 cggtgtcttc actggtcagg gtgcccagta cgctcgcatg ggtgctgagc tgctcgagca
     7561 gtctgctact gctcgcaaga tgattgccga gcttcagact cacctcgagc agctccccga
     7621 ggacctccgt cccgacttct cccttgagga ggagcttcgc cgtgctaagg aggactcgcg
     7681 cgttctcact ggtgccttct cgttcctctc tactgttgtc cagcttatcc tcgttgacct
     7741 gctcaagctc gctggtgtcg agttcgatgc aatcgtcgct cactcctctg gtgaaatggc
     7801 tgctgcgtat gctgctggtc gtctgagcgc ccgtgatgcc atgtgtgtcg cttacttccg
     7861 tggtcgcttt gcctccaaga tggtctctcc aaatggcgcc gacaagactg gtgctatgct
     7921 tgcggctggt atgtctgagg aagatgcagt agccctctgc gaggacgaga tgttcgctgg
     7981 tcgtctttgc gttgctgcta tcaactcttc ctcctccgtt accatctccg gtgacgagga
     8041 cgccattgac gagttcaaga tgattcttga tgacgagaac aagttcaacc gcaagcttcg
     8101 tgttgaccgt gcttaccact ctaaccacgt ctctaagcac ctcgctgact atgttgagct
     8161 tgttcgtcgc gctggtgtca aggctcttga gcctggtgag ggtgctcctc tctggatttc
     8221 gtctgtctac ggccgcgagg tcacttccga catgggattg agcgatgagt actggggtgc
     8281 cagtgttgct cgcggcgtct cgttctaccc tgctctcaag atcatccttg agggtggcga
     8341 gtaccaagct gctcttgagg ttggtcctca ccctgccctc aagggccctg ccagccagac
     8401 catccaggag ctcggcaagg cgatccccta ctttggtgtt ctcaaccgtg gctctgatgc
     8461 tactgttgcc tttgccacga gccttggatc gctctggacc cgcgttggag gcgagcagct
     8521 tgacctgacc aacttcgaga aggaagtcaa cgacaacaag tctgcccttc aggtcctcaa
     8581 gggtctcccc cgttaccagt ggaaccacga gggctcctac tggcatgagc cccgagcctc
     8641 caagaagcac aaggcccaga ctcagccctt caactcgctc ctcggtacca tgatgcccga
     8701 cagcgctgcc caccacctca gctggggtaa cttgctccgt gccagcgaga tcgagtgggc
     8761 ttctggtcac caggtccaga gccagactgt cttccctgct gccggataca tctgtactgc
     8821 ctttgagggt gcccgtgtcc ttgctggcga ccgtgacgtg cgcctcttcg agctcaagga
     8881 ctttgtcatt caccaggctt tgacctttgc ctctgacgac gctggtattg aggttcagtc
     8941 ttcactctct gacatccaga acgtcagcaa ggaccgcctt gtcgccaagt tcacttactc
     9001 tgcctccatt ggcgaggagg atcttgacct tgtcgctgag ggtgaactgc acattgtctt
     9061 tggccctgcc tctgaggcga ctctccccaa gcgcgcctcc aagcagcctc atatgatctc
     9121 cgtcgacaac gagcgcttct acaccttcct tgctacgctt ggctacggat tcgagggtcc
     9181 cttcaagtcg ctgcacactc tgcgcagaaa gcttggatcc agctcttgct ctgtccactc
     9241 gatctcgcgc gagggtgtct ttggccagcc tctgcttgtc caccctgctg agcttgacgg
     9301 tggtattcaa tcgcttatcc tggcttacag ttaccctgat gatgaccagc tgctgaacat
     9361 gcacttgcct actagcatga agagcattcg tgtcaaccct accctgtgcc agtccatgac
     9421 tgatatcacc actgacggca gacttggtac caggcgctct gctggcttca acggagacgt
     9481 cagcctgttc accaacgact ctgcctgcgc cgctatccag atacagggtc ttgagctgaa
     9541 gccccttggt gctctcacgg ccaaggatga ccgcaaggtc ttctccaagt acgagtgggt
     9601 gaagaaccgt ctggacggtg acctcgctgc tgacgacacc aacgtcacca agcaccacga
     9661 ggatgtcctt gagggtctcg agcgcatctc gaccttttac cttaacaagc ttgatgctga
     9721 ggttcctatg gactcgcctc ttcgcaagga gggtcctcac atgcattacc tcaactacgc
     9781 ccaccacatt gtcgagctca tccagaacgg cgagcacaag gttgctaagc acgactggct
     9841 cagtgattcc cttgaggacc tgcaccgcaa gactggtcac ctcaaggact tgatcgacta
     9901 cgacatgatg catctcgttg gacagcagat gccccgtgtc ctccgtggcg agaccaacat
     9961 gctcgaagag atgcgtgtct ccaacatcct ggacaactac tacaagggcg cctttggatc
    10021 ccgcgaggct ggtctctgga ttggcaagat catctcccag cttgcggagc gttaccctca
    10081 cctgaacatc cttgaggtcg gtgctggtac cggtggtgct acgactcgtg tcctgcaggg
    10141 tctgaacaac aagttcctct cttacacctt tactgatgtc tcgagtggtt tcttcgaggg
    10201 tgcggccgag atgttctctg agcagaagga ccgcatggtc ttcaagactt tcgactgtgg
    10261 ccaggatcct gttgctcaag ggtacgccga gggaacttac gatgtcatcg ttgctttctt
    10321 ggtcattcac gcgacccctg accttgacct gacgatgcgc aacatccgca agctgctaaa
    10381 gcctggtggt ttcttgattg tcggtgaggg taccaacaac ggccagccct acggaagcgc
    10441 cggtttcatc tttggctctc tgcctggttg gtggcttggt gctgactctg gtcgtcctct
    10501 gtctcctttc gtctcttatt cggagtggga gagactcctc cggggcagcg gattctctgg
    10561 cattgattcc accgctcctc aggccttcca ggatgtcctt ggtatgactg tctttgctgc
    10621 tcaggctgtc gatgaccgcg tcaacttcat ccgcgagcct accaaccctg aagtcgtggc
    10681 caagagcgct gctgccatcg agtaccccat cgagaagctc gtcgtcatcg gaggcagcac
    10741 tgacaagact cgctcccttg tctcgtccat cactgagacc ctcaagaaga gcgctgtcaa
    10801 cctctacacc ttcgagaccc taactggcgt cgacttcagc cttgttgacg cgaatgcgat
    10861 tgtggtcagc ttgtctgagc tggacaagcc tgtcttcgag gacttgactc ccgaagagtg
    10921 ggctgctttc aagactctct tctcatgccc taccaagctc ttctgggtca ccagcggcag
    10981 actgtccgag gttcccttct ccaacatgac tgttggtttc gctcgtactg cggtctttga
    11041 gactcccgcc ctgcgcttcc agaatgtcga cttcactgac ctttccaccg tcaaggctca
    11101 ggatctcgtc gagaaggtcc tccgcttcca tgcttcggcc agcactctgc ctccggacgt
    11161 caagcagctc gcttggcccc ttgagcctga gatcctcgtc aaggaggatg gtgaagagct
    11221 tgtccctcgt ctccgccaca tcaatgcccg taacgaccgt tacaactctg ctcgccgccc
    11281 catcaccaac gagaccgaca tcaccaagta tcctgccgcc ttattcaacg atggtgaggg
    11341 ctggaagctg aaggagttgt ccccctgggc tattcccgcc gagactcccg agaccatcac
    11401 tcttgaagtc agccacgctg tgctctctgc cgtccgcacc tcgtacggtc accagttcct
    11461 ggtctttgga acggactcca agactcaagg tcgcttcatg gctcttgttc ccagcctcct
    11521 gtctgtcgtg actatcgcca aggagtccgc tgtccctgtt cccaaggccg ctgctaccga
    11581 tgctgagctc caggcttctc ttgctgcttg cctcatttcc atggctgtcg tcgaccccct
    11641 tgttgatggc gacactctgg ttgtgcacaa cgcgaccgag ctccttgcca acaccatctc
    11701 gactcacgct gccagcaaga aggtccatgc cgtctttgtc gccgactcca gcaatgccga
    11761 tgctcctgag gcctgggcca agttggagcc ttacatgacc cagtccgaga ttgcggatat
    11821 cctccctgcc aacactgcct gcttcgttga cttctctgtc caggggtccg agaacgcctc
    11881 gtccattatc gctggtcttc ccatccactg ccgcaaggag aatgtctcca ctctttactc
    11941 tcccatcggc tgggagagcg tctccgtctc cgcggcctct gccctcggcc agcttctcca
    12001 gcgcgcttgg ttctacgctc agcaggagac tcttgctcac aagaaggacg ctatcgctcc
    12061 tcagacagtc agcatcgccg accttctcga gggctccaac cccgaagacc ccgcgaccgt
    12121 catcgactgg actctctcca agactcaccc cgtccacgtc agccgtctcg actccggtgc
    12181 cttcttcaag ggcgacaaga cctactggct gtgcggtctc tccggtgccc ttggtgtctc
    12241 gctggttgac tggatgatcg agcgcggtgc caagtgcctc gtcctgacca gtcgtaaccc
    12301 caacatctcg cctgactgga tcgccgcgca caagaagaac ggcgtcaatg tcacaatcgt
    12361 cccttgcgac gttaccaacg agcctgccct ccgtgctgcc cacaagttca tcgtcgagac
    12421 ccagcctcct atcgctggtg tcctcaacgg tgccatggtt ctccgtgatg tctcgattgc
    12481 caacatgtcc tttgagctca tgagcgatgt cttccgtccc aaggtgtacg gttctattca
    12541 cctcgaccgc atcttcaagg atactccttt ggacttcttc atcctgttct cctccattaa
    12601 ctgtgttatt ggaaacctgg gacaggccaa ctacgctgct gccaacacct tcatgtgcag
    12661 tcttgctgct cagcgtcgca agcgtggtct ggctgctact gctctcaacg tcggtgccat
    12721 tatcggtgct ggttacatgg agcgtgagtc cagcaaggct cttgacctga ctgtctccaa
    12781 gatggctctc atgcatcttt ccgagcagga ctaccaccag ctgttcgctg agggtattga
    12841 cgcaggtcgt cctgactctg tggatgaggc cgaactcacc actggtctac tggatattcc
    12901 tgctgccgag gacgacgaga acacgcccaa gtggcactct aacccggcct tcctcgactt
    12961 tatcgttcac caggtcgaga agaacggcgc cgacgctgga aacgaggtca ttgcctctgt
    13021 tcaagaccag ctcgctgctt gcaagtcccg cactgatgtc cttgctgttg tcaagggtaa
    13081 gttattcaca ctctttcgca tggttccaga ctgacacgaa cagctcgctt cgccatgcaa
    13141 ctccgcaacg tcctccagat gaccaccgcc gacgaggacc tcatggctct ccgcagccgt
    13201 gacattggtc ttgactcgct catctcagtc gacatccgtt cttggttcct caagaatttc
    13261 gaggtcagcg tccccgtcct caagatcatg ggtaacgaca ctatggccga gctggccgac
    13321 cttgtcgccg accagtgccc cgagtccctt ctccctggtc tcggtggtga cggtgaagcc
    13381 cctgttccgg tcgaggatac tcctgccgtc tctgtgactc ctaccgttgt tgtcaaggct
    13441 gctgatgatg ccacctcctc ctctgactcc aacgatggta cccctgctga gtccgttcac
    13501 ggcggatcga ccggtcgcac gacgccagtc accatggagc ctcctcagat ggtgaagggt
    13561 cctctgcgca tcgactggtc gaaggagatt gttcttcccc aggctgctaa gatttccact
    13621 gagcgcgcgc ccgctgctcg tccccagaac gttgttctca ccggtgtcag cggtctgctc
    13681 ggtcgcaacc tcctcaacag cctgctcgcc gactcttccg tcaagaaggt cttctgtatc
    13741 gccgtccgtc gcctcaacga gcgcatcaac gaacttccca aggatgcccg tgtccagtac
    13801 ttcgccggtg acctcgagac cccccgcctc ggcctctccg agagggacgc gaccgagatc
    13861 ttcagccaag cagatgtcgt gatccacaat ggcgctgaca cctcgcatct caagttttac
    13921 cccgagatca aggccgccaa caccggatcg accaaggaac tcatctcgct ttgtatctcc
    13981 cgcaaggtgc ccatacacta cctttcgacg gtcggagttg ccctctttgg caactacaag
    14041 tctttccctg aggtatcagt cgcggagcat cagcctcccg tcgatggatc gcacggatac
    14101 gtcgcagcca agtgggcgag tgagcggttg ttggaggagg tgaagaagga agcgggtctc
    14161 aacgtctgga ttcatcgtcc atcgacgatc atccgtgagg gatctgacgc gacgaacgcg
    14221 gctgcgcaaa tcgactggat gaatgcgctt gtcgagtaca tgaggaagac gcgtgcggtg
    14281 cctgtgttga agaacctgcg gggtgcgctg gactttgttt atgtcaagaa cgcgacggac
    14341 agtattctgt cgacggtgtt tagcaacaag cagcagggag ttgtttacac tcaccaagtt
    14401 ggagatattg ttgctccatt ggaggacctg aaggagtttg tggccaagga cactggagct
    14461 gtgaatgtgc aggagttgcc agtggaattg tggtcgcaaa aggcagtcga ggcgggattg
    14521 aaccgcggtg ttgctgcgct cattgactcg atggacgacc ctggccagcc tcactaccct
    14581 cgcatgttga aggctgctca atagagcatt gtatataata taggagttgg gttaatcaat
    14641 gatttggttt atttgcagtc ttcttgtttc gtagatttct tcgtcagtcg tatcttcagt
    14701 aaaagatcgt gcggtgtcgt agtggaggtt atatatattt tcgcgacaag ccgaagactt
    14761 cttggaaaac gatcaccaca gcaccaaggg atctcatctg gacaaaatag atacttccaa
    14821 ctctcttaat tataacactg cttataaaaa gcagaaaaat atctactatg gcataagcac
    14881 cataaaaaca atatgatatt ccatcaacaa aaacagcaaa aagatatgac aagggtggga
    14941 ttcgaaccca cgccaaatta atgacgcgga aacttgtgat tacaagagga ggttcgccta
    15001 ttggtgtacc ttaaccgcgc gccttagacc gctcggccac cttgcctaat catgtgatag
    15061 atgcaacatt ttgacgcact ataacccaaa tttgcatccc gcacacagta ggtttgcagt
    15121 cttgctcctg tcagctacac tgtcttccgt cgtctcctct gctacgcgct accaacacta
    15181 gacacaactt gcacagaaca tctattattc aacctaataa tatcaacaag ccaaccaatt
    15241 actcctaaca aacaatgaaa tctatctcta atcctttgcc gccttcaact ccctctcaat
    15301 cctcctccaa acaacgtctc tcaacggccc ctgcagccaa taatttcctg ccgcgtcttt
    15361 acccatgatg ggcatcagat tcctcaggtc aaacttggtc gaccacgcat tgaactgtac
    15421 catcgatgcg taccctggct tctcagcacg gcggttctca gggaacccca cgcgcgtcat
    15481 ggccgctgaa aagtctgtct cgaagtactt tcctttcgtc cagttcgagt agctcatcat
    15541 ctccattgat gcgtcgccga acatcggcca ggtgtgtccc tcccgagcta gggtttgctt
    15601 cttgacggct tgcaaggcct cgacttgctc acgcgtgccg ccggtcatca tgctttgccg
    15661 gattttccag gcaagctgac taaggggctt ggtgaagagt tcgcgcaccg tgaagaaggt
    15721 atagatctct gtggcggcat tggagatgaa cgctttggtt gtggggaggt ggtcgttgcc
    15781 cagcacagca gccaaggcga acgcgttcat gatgcgaacg gtgaggttcg agttcttggg
    15841 gaagtggccg gcttccagac gtgtgaacca ggctgtgagc acatcgttgt cggagacaaa
    15901 ggccttgtcg ttgccggtat ctgcgcgaat ctcttcaatg gccttcttgc gttgcgcagc
    15961 catgtagggc ccgggaacgc acatgatgcg cgacgacgtc ttgtaccgcc agccatcata
    16021 gatctggtac gcaatgaaca gccattttct ccagccggtt agcagctggg gggcgaacat
    16081 gtactcctcg ctggatttgt cgccaaaggt ggctaggggg tcgctgtcgt agccgtggaa
    16141 gtcggggacc tcgtcttcgc ggccttgcag cacgagcgcc cagcagcggt agatttgggc
    16201 accgcctgtt ccgtctgtga gagtgtgcgg cagagagatg gagatcaggg ttgagtcgtt
    16261 gaaggaaaca acgtgcagac atgtttgagg aacatctcgg gagaggtagt cgtccagcgt
    16321 cttgggagcg tcgggactgc acgtcaactc gtcgaaatcg tgcggatcac cgacaactgc
    16381 aggttttgtt gttggtcggg gcagtttcga ggccagaggg tgttcggtga tggacatgtc
    16441 gtgcgtgaca tgtgaccagg tcacaattgg tcgcgtctca tcgtacttct cggggatgtg
    16501 atattccagt cgtccattgg gctgcacgaa cctctgttag agaccattcg cgacatttgg
    16561 ttatttgaac gtacattgag tcgcaaacgc gcgccaatct tgcgccagcc tggtcggtcc
    16621 agcagcttct cgtaggagct cttcagcttc tccggatcaa gcacatcatc gaagcgatac
    16681 gacagaacca cgcagacact gcgaagcaca tcggtgtcgt cggcagcatt caacggaatc
    16741 acctcgtccg tcgggacctt gggtggctgc tgcaccggct tttcgctgct gaagagaccc
    16801 attgtgctgt actgttgaag ttgctagtgg gaggagaact gagattatcg taaggaagta
    16861 caggatacca agatcttgac atgcgacagg tctatagtct atagtccagc atggtaagca
    16921 gactgccgat cggacagcct caactacagc ccccaccgca attcgggaat tttgacagtg
    16981 aacagtactc gggaatattt atgggggccg tctgacagcc gatatctatc ttcagttatt
    17041 tactagcgag tctagacagt tcccggggct gtacaaaacc gccgatcagc tgtgctccag
    17101 acccacagcc atctagtgag ccctatcccc attgacaata tcgccaacct gattgtacga
    17161 gtaccaagac cctgtcaaaa cttccgacgg cttgggtcga ttgggctttt ccgctgcatc
    17221 ctattggata gacttactgt cggcagttgt gctattcagc cggacgttga actaaaaaac
    17281 agtgcacatc gtaggctgtt gtagttcttc tgctctctgc tctgcttgaa acttcctgcg
    17341 ccatactgtt ttgcatcaac tgcagtaaca acatcatgga tctgcagctt gacaacatca
    17401 ctacgacgga cagcttcgac actgctcctg aaacccgtcc gtacatctcc attatcgttc
    17461 tcgttaccgg cctaattgcg gtgattgtct ctacactgct caaggagaac ccgctcgcaa
    17521 atgttcccct cgtcacagaa aaagcctggt gggatatcac cggcaagaaa gcaaaggata
    17581 acttcactgc caatgcgcgt gccgttattc gccagggttt cgagaaggtt ggcttcttga
    17641 agccctaccg tatcatctcc gaccaaggag agatgctcat cttacccccg gctatggcgc
    17701 acgacatccg taacattgac gcgctgagtc acgccgtctt tatgaaagag gtaggaaaat
    17761 cttaactcag actgacctcg aaatccagct aacgttgcag acaacatgcg ccgaagtccc
    17821 tggtttcgag ccctacctcg agtccaccgg aaccactctc ctgattgaca tgacaaagac
    17881 gaagctgatt agcgctatga gtatgtttcc cggatgataa ccgctaggaa gaagttactg
    17941 atcactttag aacccctgac atatcccctg tccaagacct gcgcaaacgc ctgcaaagac
    18001 ctcttcactt cagagaacgg taagtcaacc acaccaaacc atgtacctag ccaagcatag
    18061 atactaactt atgaaaatga ttagactgga aagaagtaac cctaaaagac gaactcctcg
    18121 acctcgtcgc ccgcctctcc tccgtcatct tcctcggcga cgaagaagtc tcgcaagacc
    18181 cagcgtggct caaaatcaca aaggaataca ccgtcgactc cttcatcgcc ttccaccagc
    18241 tccgtcccta cccagccttt ctccgttcct tcgtcgcaaa gttcctccct caagcgcgta
    18301 aagtcctcgg tcaactccgc gaagccgagt ccattattga accgatcatt gagcgtcgtc
    18361 gtgccgagaa ggctgccaac cctgaggcgt acaaggatcg caatgactcg attgagtggc
    18421 ttgagcaggt tgcgcaggag aaggggatca agtactcgcc tcctgctatg cagcttactc
    18481 ttgcgctttc ggcgattcat accactactg atttgctcac gacgaccatg tatgagattt
    18541 tgcagcatcc tgagactatt cagttgctga gggacgaggt taaggctgtt gttggtgatg
    18601 ggaagctgaa gcactcttct ctctacaatc tcaagctcat ggacagtgtg attaaggagg
    18661 cgcagcgatt gaagcctgtc ttgtcgagta agtctaacca ccttccctaa gatatggaat
    18721 cgaaactaat tggctcagtc aacatggtcc gcaccgcaac cgaagacatc gaccttcccg
    18781 acggcttcca tatccccatg ggcacacgtc tcggcgtctc cagccacgcc tcctgggacc
    18841 ccaagatctt ccccaacccc gagaaattcg accccttccg cttcgtccgt ctgcgcgagc
    18901 agcctggcca ggagaacgtc tggcaactta cgactacgcg ccccgaacaa atcgcctttg
    18961 gtcacggcca gcacgcctgc cctggacgct tcctggctgc taacgaggtt aagattgccc
    19021 tttgccatct gttgctcaag catgattggg aactgagctc gattacgatg cccaaggcta
    19081 tttcgcatgg tattatgttg gattcggatc cgactgttaa ggttaaggtg cgtagtcgcg
    19141 tgcctgatgt tgagttgtag aggatgggct ggagtgtttg aaatgctggg acggacgttt
    19201 ggattttgct ggaatgttat gtgctgttag ttcaacacaa tttaggttgg ttcttgaata
    19261 tgcattctct attgtcgaat gcgcgatgat taaccagtac ggagtatata gcctttgtta
    19321 aattatgact gctagctcgg tgatctgagt aaacaaagat gttgcgggtt tcatgaaatg
    19381 taatatccag gttacaggtt gaggatatat tataataagc aaagtatgca ttgaagtatg
    19441 ttctagaaaa gaagttgtcg aagcgaaaat agctatactc tatctataca agcaatgaat
    19501 ctctcaggaa agacttccta aaccctgcaa agacgaccag tggcatcgct agtccaagaa
    19561 gcactaccaa tagcagtgcg agcatagaag acgtgctgcg ggtcatactt gttcttgata
    19621 ctcagcagac gatcgtagtt ctcgccatag agctcagtga tccagtctcc cttccagccg
    19681 gcgtcaatct cattgaggta agttccagaa ccgggggtgg cctcttcaag gccggggatg
    19741 agagtgtcca cgagcaggtc cttcttctcc cacatctcgg cctcgctgat gtcccagtcc
    19801 cagtaggtga cgatgttgca ggttgcgatg gcttcgcgcc aggcgggaag gacggcgttg
    19861 tcggggtgtt cgacgtttgc gacgttcagg gcgtggcagc cgagggaggc ttcggggtcg
    19921 agctcgacga cttggcggag ggcatcgacg atgacctttg tctcggtctt gttgtacatg
    19981 gcggcacggg ggatgagacg ggaggtgagt tgaacagtcg caggaccagc accggcaatt
    20041 cctggaccga agcggctgga gaagtactcg aggtagttgt ctgagtcagt ggggataaaa
    20101 gagtactgaa taccacgcct ggagacagag ctcaaccagg gctgcaggag agactggacc
    20161 tcagtgccgt tcttgtcggg gacagtgatg gcgtaggctt ggaaaccggc agcagtcagg
    20221 gcaaagtccc agctgttggg gccggcgtcg acaaactcgg ggaggaacat ccagagatcc
    20281 tcaatggcgc cccagtagtc ctcggttgcg ttggcagtga tgttgaacat caggatacca
    20341 ctgccgatgg gaccatcagc gaagaccttg gtagtcatgc tgaggacgac agcgtaggta
    20401 ccggcaccac caccgctgag agcccaatag aggtcggaat tttcagactg cgaggcagtg
    20461 aggtgctttc catcggcggt gatgacctcc cattcgagga ctgcatcagc agccattcca
    20521 taggcaccgt tgagcagaga gtggccacca ccagaggtat agccaccagc gaggccaaca
    20581 gtagggcaag taccacccat gacacggtat ccagcggcac caacgacttc atagacttgg
    20641 cctgagatga caccagcgcc gagtttagca gcggggccag agtagccagc gccctcgtag
    20701 ttctcgatga tcttggtcgt gttcaggttg tgtgtccaga gagaaagagc gccaggtcca
    20761 gtcgacttgc cagagaagct gtcattgtta gtcaggaagt agggcaggaa tgaacgcact
    20821 tactcatgac cagtgttctt aatgaccaag cgaacgttgt tctctcgcgc aaacttgatt
    20881 ccagcaatca cgtcgtcggc gccagtaaca ttgatagagt agctggcata gttgcccatg
    20941 ttgcatgctt gcgatgaaga agtgaaaggc acgcaagagt agttctgagt aggagggttc
    21001 atgacttcgg caggatggtt gatgctggtc atgttagata gtactcaagc ttgtggtctg
    21061 gcaacttaca aggtagtgtc ctcaagccat tcggtcttca tggcagcgca ggcatcttca
    21121 ttgaaggtgc caaagggagt ctgatgacag acgctgggca gaggaactgt agcgatcaaa
    21181 cgaccaccaa cggtgcggtt gagggcattc caagccccgg ccgatggcca tgcagcatca
    21241 ccagggaaag ccttgcaaga gctcgatggc gcctggcgag gaacaagtcc aagcgcagga
    21301 gaaagaagag atagcgaaag aaggaataat ttggccagca tggcgacaac aatcaaatca
    21361 aagagaggaa gcacaaatac cgatgtaaca taaaagagcg acaagagttg gtgattagtt
    21421 tttatttact tttttttttc taagttttca tgaagctctc aagtcaagca tcggacaagc
    21481 aaacgatctg gggccaaggg gcagtgcagg ctcaggctga gttccaatgc tgacgaccgt
    21541 tcagccccaa ataattaccg atgcggcccc ctcgagtcgg caattttggt aatgatagtc
    21601 agcccatgat catggcccaa tcatacggtg ctctttggaa ttacccgatg gctttagctt
    21661 cgagatgttg ttcaagaagt ggtcagattc gctcagggtt catgggctgg acttctacac
    21721 tcaaccctac attcaacagg aggaatgagc aaactcagca atatcccgca gcctccgggc
    21781 gtgccctttt tgggtaatct atttgacatt gatatggaat tgcccttaca gtcgctctat
    21841 gatttagggg ctaaacatgg tatgaggacc aaatagcttc accaatgcac gctgacccac
    21901 caaggcgaga tctatcgcat gaagtttccg gggcacacct ttatcattgc ctgcagctat
    21961 gacatggtca acgagttttg cgatgagaag aggtttccaa agacgatctt tgctctcaag
    22021 gtgggtttat tggtacccta tgcctggcac ctttaacctt gtgtaggaaa tgagacatgc
    22081 tatgcacgat ggactgttca ctgtaagcct acctcttcaa tcaaaaataa agaaacttct
    22141 gactttcgaa ggccatcgat ggagagacag agcccgcctg ggcaattgca cacagaatcc
    22201 tggtcccagc ctttggaccc tcgtcgctcc ggatgatgta cgatggaatg tacgatattg
    22261 ccagccagct agccctgaaa tgggctcgat acggaggcga agcaattaca gtgaccgacg
    22321 actttacgcg actgactctc gacacaatcg ccctgtgctc gatggacttt cgatttaaca
    22381 gctactacaa ggagggtgtc cacccctttg ttgaagccat gggtgacttc ctcacagaga
    22441 gtggtgatcg agcacgacgg ttgccgatcc cttcattctt ctaccgtgga aaggacaaga
    22501 agttttttgg tgatatcgaa gttatgcgac gcactgcaaa cgagattctg caagagcgca
    22561 agaaggagaa gaatctggat acgcgcaagg atctgctgtc agccatgctg aacggggtcg
    22621 atcccaagac tggcaagaag atgactgaag aaagtatcct ggataacctc atcacatttc
    22681 tcattgctgg acacgagacg acatcgggca tgctgtcgtt tgctttgtac catttaatga
    22741 aggaccctga ctgctaccgc aaggcccagc aggaagtcga cagcgtctgt ggaaagacgc
    22801 cgatccggtt tgatcagttg aacaaactag gatatatttc agctgtatgc aatattcctt
    22861 ggcctctgag tttcattgtg ttaacagccc acaggtcctc agagagacac ttcgtctaac
    22921 accaccgctc cccgtcttca acgtcgctcc caagaaagac gagattgtcg gcggacagta
    22981 tgtgatcaag gaaggcgagc ttgttattgt tctcattggc gcatcgcaaa tggacccgaa
    23041 ggtttttggc gcagatgtcg gagtcttcaa gccagagcgc atgctggatg agaacttcaa
    23101 caagctgaac aaggagttcc ctaatgcctg gaagcccttc ggtaacggca caagaggatg
    23161 tattggccgg ccatttgcct ggcaggaggc tctccttgtt cttgcgatgc ttctgcaaaa
    23221 cttcgacttc gagttcgacg acccttcgta taccctcacg ctcaagcaga ccttgactgt
    23281 caagccagcc aactttaagg tcaaggctat ccctcgcgac ggactgagag cgtttgagat
    23341 gcagaacaga cttgctggta tgtcggtatc gaccaagacg acgtccggtg ctgccgcaaa
    23401 tggaacagct gcaccagtat ctggtggaac tggcaagccg atgaagatct tctacggctc
    23461 caacagtggg acatgtcagt ctatggccga gcgtctggct gctgacgcct tttcgcacgg
    23521 tttctctgcc acgactgtgg actgcgtcga caacgccact gcacaattgc ccaaggacga
    23581 accggtggtg atcatcaccg cttcctacga aggtcagccc ccagacaacg ctgccaaatt
    23641 tgtaccctgg cttgagggcc ttaaggagga tagcaaggag ctcaaggatg tcaactacgc
    23701 tgtctttggt tgtggtcacc acgactggtc tgctacattc caccgcatcc ccaagttggt
    23761 ggattacact atcgacaagc atggaggcaa cagagtcgca gcgcttggtc tgactgatgt
    23821 tgctcaaggc aacgagatga ctgactttga agcctgggag gacaatatcc tgtggccagc
    23881 cctgatggag aagtatggcg ctgaagcccc tcaaggaccg tcgctcagtg tggaagtgag
    23941 cacacctcgc aagtcaactc tgcgtcaaga tgtcaaggag gctgcggttg tctctacctc
    24001 cgttcttacc tccgaggatg ctctgatcaa gaagaagcac attgagattg aactgccctc
    24061 cgacatgact tacaaggctg gcgactacct cgctgtcctc cctgtcaacc ctccggacca
    24121 ggtccaccgc gttatgcgac acttccacct gcctcgcgat gctcacctta ccatctcgtc
    24181 caaggcagtg acctccctcc cgtccgacgg cccaatgccc gccgtggata tcttcggatc
    24241 ctacgtggag ctggcccaag ccgctaccaa gcgtgacatc cagactttga ttgatgctgc
    24301 gaaagacgag aagaccaaga ccaagctcgc agctctcgcg acagacgagg aatacgcatc
    24361 tacgatcatc gccagtcgtc tctccgtgct cgatctactg gagagtaacc ctgacatcaa
    24421 gctcccaatc tcggcgttcc tccgtatgct tcctcccatg cgagtcagac agtacagcat
    24481 tggctcatcg cctgtctgga gtaagaaccg tgttattctg acttacactg tcctcgacga
    24541 gccgcgcatt ggaactgatg ggaagcgtca cgtcggagtc gcgaccaact acatgtctac
    24601 tcttcaagct ggtgatgtgg tgcacgttgc tgtgcgccca tcccatgcag cattccacct
    24661 tcctgccgac gctgggagga cgtccatggt tatgatcgcc gctggcaccg gtgttgcacc
    24721 tttccgaggt ttcattcaag agcgagcggg aatgaagggt gccggtcgca agattgcgcc
    24781 tgctactctc tacttcggat gccgtcaacc aggacaggat gacttgtaca gaagtgactt
    24841 ggacaactgg gagtctagtg gagtcgtcga tgttcgaagg acttttagtc gccaggttga
    24901 agccagcgag ggacacaagt acgtccagga ccggctgtgg caggagagaa aggagatcat
    24961 gtcgctctgg gatcagggtg ctatgatcta catctgtggt ggacgagcta tgggcgagtc
    25021 tgctaaagag atgatgattg agattctcta cgatgcgaag aaggagaaag gcgaagagac
    25081 gagcaaggag gaggtagcaa agtggttcga aggactgaag aacacgcgat atgccgtgga
    25141 tatttttgac tagattatga attatttttt tttctacgtt atttggcgtt agctggcctt
    25201 gtgatgcgtt caattagcag actgtcaata gttcatagta atctatacag caatacttct
    25261 cactactact ccttgacgta catagcccct agcctgtaca ctcaaattct atagtcaacc
    25321 tcgagggcct ggcagtgaca aggcgtacaa tcctgcccct agcggaggat agacgaaact
    25381 cccgaggatt actccgaata attgcattct cagctagcaa actaccgatc caggtagact
    25441 atcggtgctg tgaatcggga tttacaagga tcgatctgac agacattgcc ctaaaagatg
    25501 gcctgagtcg tgtaccaaag ttgatgtaga cgcttgtgaa tccacttcaa tatctactgt
    25561 ctttgaccga agttgagtac atcgattcac gacatccaca ccatggcctc catcgatctc
    25621 tccaactggc aaacagtcga cctacaatgg acgccagact caactcccac ccccgtctcg
    25681 caactcctcc acccaacgcg cgagtcgcaa tccgagcaag aaatgatcgc gcggatgtgg
    25741 gtgctctgcg caatccagat gcaagagaag ctgaagagcg caacctgcac gaagccccac
    25801 ttcgaaaagt accgcaactg gcttgcaagt gagtatgagc gcttcaagca gcctggttac
    25861 ccacaggttc cggattcggg cgatctcgtg gcgctgagtg atggggagcg cttgaaggca
    25921 atgaatgaga tgagagaaag ggtcaaggat acttatctgt ggcctgttat tgaggggccg
    25981 tggagggtct atgacaatgt tgttgatatt gtggagggac gggtcaagct tgtcaaggtc
    26041 ttgctgaagg atggattgct ggagaagttc tatgactggg caaacagtct gtctgaagtg
    26101 cgtcctctga tcaatcttat gggccggaca aaccctggac tgcgcattct ggagattgga
    26161 gctggtactg gagggacaac tgctcgtgtc tttgaagggt tgaatccaga cgcaggaaag
    26221 cagctctaca gcagctacgt cttcactgac atctcgccct tattctttga ctcggcaaag
    26281 cgtcggttcg aggcctacga caatgtggaa taccgtgcgc tggacatttc caaggacccc
    26341 gttgagcagg gctttgaagc aggcgcctac gatgttgtca ttgcatccaa tgtgagtgat
    26401 gaagacaata agttggatta aatggtatgc taacgggaaa taggtcctcc acgccacgcc
    26461 gtgccttgtg gaaacactga agaatgttcg cacccttctc cagcccaagg gattcctctt
    26521 caaccaggag ctgtcgcccc cgggcaagta cgtggacttc atggtggtga gtatcgtccc
    26581 cagtgtacaa aggggtcagt actgaccttc gcagggcctt ctccccggat ggtggctagg
    26641 cgaggcagac ggacgcgcag gaggaccatg cattcctcct gcagaatggg atcgtcgtct
    26701 gaagcaagct ggattcgaag gattgcacgc tgtgggcttg gatagtgagc ctccattcta
    26761 ctacaacgcg aacatgctgg ctagagtagc tgctagcgat taagcataac atagatacgt
    26821 caatgcatgt tttgattcaa ttcattcaat aagaaaagta tcttcgtgtg ctatcaatct
    26881 aagcaagtcc aaccatctcg agactatcct tccatagtct agcagccatt tcctcatccc
    26941 agatccaggg cttccaaccc ggaagacaca tctgaccctc aaacttggcc tccttagcta
    27001 cttggacatc gtcaaggtac agtcctccct tgccctcaag ttccttagca atagacgccc
    27061 aaacctgggt agcagcaccc tgttcaacgt ccttctccca gcttgccaga agcggctcca
    27121 tcttgtagta cattgggcgg cgcgactcct tggttccagg catatcgcga gagatttcag
    27181 tgtccataat gataccaggg ttgagactca gagcgtggac accgcggctg ccatacttgc
    27241 gctcgaattc gttggccatg agaatcgcag cggatttgct gcgcgcgtag gctttggatg
    27301 ggtcgtaacc ctcgcccata aagttgtact tttcgggatc gacattacct gcgcggtgac
    27361 cggcgctgga aacgacgacg agtctggatt tgaattcggg agttgtcgag gcttcgagag
    27421 caggcgcaag cagctgagtg aggaggaagg tcgagagata gttgatcgca aagacagcct
    27481 cgaagccatc cttggtctcc ttgactggtg aagcaacaat accggcgttg gccataaaca
    27541 cgttcaactt cctaccactc ttcttgagga attccgctgc accatcgtga acactctgca
    27601 gactgctctg gtccattgta atgacttcga ttggtgggaa ctgcgggttg acggcggaga
    27661 tgttgtcggc caatttctgg cccttgacgg cgtcgcggcc catgatgaag atctttgcgc
    27721 cggtcttgtg cagtacgcgt gtcgattcag cacctagacc agctgttcca ccagtgatga
    27781 gaataacctt gtcgctccag tcgcccagtg gttcctggtc gcggaggatc tgctcggcgg
    27841 ttggacggcc atcgcctcgg ccttggggag tttcagcgtg aaaagcagcg tagcggtcga
    27901 gagacatatt tgcgtattgg tcgtataagg ggtgatgtgt atagaaccat tatgcaggtc
    27961 atggtggttt taatgtgctg tatagatccc ggcaatccga atggccccca acatgaggat
    28021 agtatagctc tgatattccc gaaacgcccg aaacccaccg aatgcgcatt gattggacac
    28081 tttcgggcga acaaatgggt tcaggcagaa actggcgcta cacaaaggga ttcattcctg
    28141 ttacagggca agtggccttc ttacaggatt agacgggctt agtacagagc catgtccacc
    28201 taaagaggaa gtgtaccctg tggaaagagc cacagagcct gtgccactag cgagtctcca
    28261 aacaaagaag cattccaatc cttcgaatct accccgctga ggcttggtgt ctctgcaatc
    28321 cttctccaag ctcctgggca agctctggac aagcgcatca tggccgactt tgacgctctc
    28381 ctcgccgact acaccaagaa ggagaacccc aaggtgcacg gggctatctt caaatgtgtg
    28441 gatggacagg gtatgtatgt ccctttgaca caatacgtaa gctgacagtc caggaaatga
    28501 aatttacagc aaagtcgctg gttgggattc tgtcgagccc aatgctgccc ctcttaccga
    28561 agacgtcgtg ctcaaggtcg ccagcgccac gaagctcatt actagtatcg ccttgcttca
    28621 atgcgtcgac aagggactta tcgggctaga tgagcccctt gggaagcatg ttcctgagct
    28681 cgcggacaag cagatcctca tcgacgtcaa ggatttggag tttgtccatg aacctagcaa
    28741 ggttcctatc actgcgcgac atcttcttac gcacacttct ggttttggat atcgcttcac
    28801 ccaccgattg ctcaggatga gagccgaggc gaagactgcc gctggagaga aaccgtcgct
    28861 gcgcatcact gaacgatacg agatgccgct tgtctttgag cctggaactg gatggttgta
    28921 tggatgcagt ttggactggg ctggtgtcac cgtcagtcgt ctaaatggtg gaatcactct
    28981 ggagcagtac tttgtggaga acatctggaa gaaactgggt ctctctgcgc cattcccctg
    29041 cttcaacatc gctacgcatc ctgaatacaa tgctcgcacc atgggaggcg caatgaggac
    29101 tcccgacggt cgccttcagc caaacaacac ctgggcgttt gataaccctg aagatcagga
    29161 cggaggtagt ggtctctctt gcacggcaaa ggactatgtt gcggtgctgg ccgatttgat
    29221 ctcagactcg cccaagcttc ttagtcctgg aatcattgca gagatgtttg ttccccagct
    29281 acagcccaag tcagtgcccg tcgagcagat gttgggtttg cgtcctgcct gggataccgt
    29341 ctctggtccc atcgcagaag acgcgatcaa ccacggactt ggaggtatcg tgacaacagg
    29401 cgatgtagct gagattggac aacccaaggg catgctaggc tggggaggtg catcgaacat
    29461 tgtctggtgg gtaaacagag acctgcgcgt tgctggattc tttgcgacgc agcaggcccc
    29521 ctttggcaat cctacagtta cggcgctggt gaatgcgtgg aagaaggact tttggactca
    29581 gttcaagaac aaggaaaatg catagataga tctagagaat aactaattct ggggaatctt
    29641 cacaaccaac ttctgtccgc gcacttcgcc cttgcgtagc atgttcagtc cttcgatgat
    29701 tgcatcgaag cctcctggta gttcgcgcaa tgggtgtgcc ttgagctggc ccgttgccat
    29761 caacgtctca aactcacgcg cccactgtgt tccaattgtg aacaacttct ggtcaccaag
    29821 ccttgtgtat gttgagtcgc cgaggttgat atccactccg agcacctgga atcccataac
    29881 ctccttgacc ttgacaatgc gacggcttct ccaagcctca gggcactctt cgagacaggc
    29941 gtaattgcca cccgtacgag ccatggcgct gtagcacatg gcagcggact cggcatctgt
    30001 gatgcagtcg aggactttgc gaatgggctt gccggcgatg gacttgacag tgtcgacgca
    30061 gtctttcgaa gtgtacgagg ctgttcctgc ggcgccgtat tctgtcgcga gttcggctga
    30121 gcggttcgag gcgattgcga ttggagtgta gttcatcctg tatttgtcaa catacgtcaa
    30181 gggtgaacca ggagtaaacg tacaatttca gcagttggca tgccagtgta ccagaagcag
    30241 taccaccacc atagaccagc acaggctcct tgttctgatg cgtaggctgg gtaggaagac
    30301 cctccagtcc cagtgcattg ggatcagaga atgcaagaga aatggtcgac cagccgacac
    30361 cgagagaagc agcctcaagg tcactccagg tatcagggac cttgaccagc aagcgcgcat
    30421 caacaacaca gtattgcgca aaggatccgt tgtcggggtc ggcaggactg taggggaaca
    30481 gagcaccaca gactcttgtt ccctctgtca atccaagggg tgcattgctg cttgcgacaa
    30541 caccacagaa gtcacatcct gcgatactgc ctgcggtgtt gaaatgggtg accatcttgt
    30601 ggtcgttggg gttcagcgcc accgccagca ccttgaccag cacatggttc tctgattgta
    30661 cttggggaat gggagccgac ttgctgacga caagaggaat ctctgatgag tcgcctttag
    30721 cgatttgcac gatggctgtc tgtgttggtg gcgccattgt tggtgtatgt caagggcgta
    30781 tgcaagacaa tgctgtatag cgaatgggag tctccatgat cagcccatac tcgaccacag
    30841 taataaacaa ttctgcaaag cactgacatt ccgtttccgc cccgaattga atccaatcgt
    30901 acggttgaat cgggaataac gagaccggcc attatgagga ttactccgaa cgatcggcgc
    30961 agctgctgtc agcctctggg cagctcttgg ggccagaact atccgtactt aaaaatgaat
    31021 aaagtcgaaa caggaggggt cgcgttacta accgcggcat ttacactgga taaaccaaaa
    31081 tgatcgctga acttggacct ctcgtctggg gtgtcgcagc gtgcattgcg ctggccatct
    31141 tcattcccaa atggattggc aagggcgcaa aagaaccacc ttcgctggga ggatggatga
    31201 ttgccaacac ttatcagtac atgactgata tgcatggttt cttgcagaga gtcgcgtaag
    31261 ttcagagcta ctacataggc ccaagatggc actaatggtt aatcgtatag atccgcccaa
    31321 cgcaagagca aaatcgtcaa attccgactg ggaccaaaga aaatctacat ggtctctggc
    31381 gaacagaata tccaagccat caacaagccc tcacacagca tcagccccga tgtcttcttc
    31441 ctcgaggtca tggccaacgt ctggggcgcg cgcaaggacg aagtgtccaa attcgccaac
    31501 gacaagtctg gacgcagcaa gaacccagtg cctggacacg acgtcaagcc aggacagccg
    31561 cgactctggc atggacagca ccatgtctac tcggaatacc tccagcgagc ggaccatgcg
    31621 aatgccctga gcgacaagta ctacgaactg ttctccgacc gtctgaagaa acaacccctc
    31681 ggcgaatggc aggagatccg gctcagcgag ttcttcgaga gtgaaatggc tgaagctgcc
    31741 ctggttgcac ttatgggacc tcgcattgtg aagctgaacc caggattctg gcctgcgatg
    31801 tgggagtttg ctcgtctggc accgcgtctt atgtgggggt tgcctcgctg ggtgaacccc
    31861 aagccctggg agattcgtga acagttccac ggaatgtgtc gtcgctacct tgattctgct
    31921 gaaaaggagt ttgactggaa tggacctgat actgactctg aatgggagcc tcactatggc
    31981 tccagaatgg cacgcgagct catcggatgg gcaaagaaca acctgtcgcc tgagaccacc
    32041 gctggtatgg ttgcgacttt catctttggc acgaatgcca actctgtacc gctgtcgaca
    32101 tgggccatga tggagttgat tgcagatcct gagctgtaca aggctgtgca tgaggaatgt
    32161 attgctgcca gcactgtcga ccctgcgacc ggcgagcgcg tcttcaaccc tcagaagctg
    32221 cttggaatgc ctcttctgca atctgtctat atcgagacac tgcgcctgca tgtatcaatc
    32281 aatgtcactc gtgaagttac tcagcctatc acgctggatg ggcatctttt gactcctggt
    32341 tctctcatcc aagcccccag ccagatcggc cagtacaacg aagcagtctg ggcctctgaa
    32401 ggtcatcctg cctctcaatt ctgggcaggc aggaacctga agcatgagaa tggcaaggct
    32461 gagtttacaa tggctggaag aactacttca ttcttcccat ttggtatgtt tctgctcttc
    32521 ttcaacccta attgatccga ctaacatatt ataggtggtg gcccttccat ctgccctggt
    32581 cgtgttttcg ctaagcaaga gattttgatg accatcgctg ctctggttac gagatttgaa
    32641 attgaactga ttgactgggt gcatcctgat ggcaccaagt ctgatcgtcc agcgcagaat
    32701 gatcagtcgt atattggcgc tgtgggcatt ccgcccgacc gagacatgaa ggtccgatgg
    32761 aagcgtttgt ggtagactcg aagatctaat aactggaata cgaatagtaa tgcacttcaa
    32821 tttacttgtt aagctgtttt taatgtcaaa tatctggtgc gtcgaatttg cgaccgtagc
    32881 gaatactgtg aggtagggct cgggtatcag cacttcaacg gccacgatcg ggcatgtcga
    32941 acgaagacga cgcagacaaa tatacaaaat cattccgaaa gtactttgaa agtacgttga
    33001 acttgttcta actgcaagcc aagggcatag taaatgttca gagaatttat ttcatagtga
    33061 agagaggtcg tcataaaatc attcattgca cctagaacta ccagcgaact aagaaaagaa
    33121 aacagcttaa accttgaact gagcctggcc aacatcaata gcactcagct cagcagtggt
    33181 ctccagatcc tgcagctggc cctgcagctt agcagtgatg agcttgacag cagtggcgct
    33241 cagaggcaga cgcaggggga ccttctcgtt gcggctggcg acctggtaca gcaccttggc
    33301 cacagcactg ggctcgaaac caacaccggc agcaagaccc ttcttgacga acatctcgag
    33361 ctggcgggcg ggcatgtcgg cgccggcgta ggcctcgtgg ggggcagtgc gcttcttgct
    33421 ggtggtctcg aagttggtct tgacggccga aggctcgacg atgcagaagt tgactataga
    33481 ataacttagc agttggccat acaaagagat ataaaagaca tactgttcca gtcagggtgg
    33541 acctcgcgag caacagattc gctccatccc tcgacggcga acttgctggc gtggtagaag
    33601 gcgtggccgg ggaaggcgca gataccagcc agagaagaaa tgttgaagat cagaccaccg
    33661 cgcttctcct tggactggcg cataacctcg atggccttga gagagacacg gacgagacca
    33721 aagaagttgg tctcaaaggc ctcgtgcatc tcgccctcag tcacagactc ggtgtctccg
    33781 gagagagagt atccagcgtt gttcacgaca acgtcgaggt agtagctgtc gccaaagtga
    33841 gcagcagcag ccttgaaggc agcgtcaaca gactccggct tggtgacatc gagaccgagc
    33901 ttcaggatag aggcgctgtc ttggaggtag gagaggctgg cagggtctct ggcagtggca
    33961 atcagacggt ggccaggctg agcagcgaca tgttcggcga tggcacggcc gataccgcta
    34021 gagcaaccgg tgactgtata attagctatg aaatgggttg aaagtgagaa gagacatacc
    34081 aaaccaggtg gcgtcggcgg ggagttgata gggcttggtg ttgacggggt tcatggcgac
    34141 tgtgtaattc tgtagatgct tgaggatgaa tagctgattc agtccgtctt tccaaagcta
    34201 tatacctttc tgactcttgt taatctgtct gatc
//
