BGC0002168 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002168 (Aspergillus stellatus (Emericella variecolor))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	34,234	High	decumbenone a/calbistrin A/calbistrin C/decumbenone B/decumbenone c/dioic acid moiety	PKS

BGC0002168 - Region 1 - T1PKS

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Location: 1 - 34,234 nt. (total: 34,234 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,235
Label		BGC0002168

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

calE_: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

calF_: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

calG_: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

calI_: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

calK_: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

calL_: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

calM_: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

calJ_: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: synthase

calA_: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002168.3	0.98	PKS	decumbenone a, calbistrin A, calbistrin C, decumbenone B, decumbenone c, dioic acid moiety	Aspergillus stellatus
BGC0002170.2	0.98	PKS	4-methyl-5-dimethyltetradecahexaene-β-ketolactone, 4-methyl-5-methylheptatriene-β-ketolactone	Aspergillus stellatus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002192.3	0.65	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002168.3	0.98	PKS	decumbenone a, calbistrin A, calbistrin C, decumbenone B, decumbenone c, dioic acid moiety	Aspergillus stellatus
BGC0002170.2	0.98	PKS	4-methyl-5-dimethyltetradecahexaene-β-ketolactone, 4-methyl-5-methylheptatriene-β-ketolactone	Aspergillus stellatus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002192.3	0.65	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 34234:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

calA_: pk

PKS_AT (550..866): pk

ATSignature: Methylmalonyl-CoA, Malonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 54.2%; Malonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 56.1
Methylmalonyl-CoA: 50.7
Ethylmalonyl-CoA: 30.3
Malonyl-CoA: 28.7
trans-1,2-CPDA: 19.0
Propionyl-CoA: 18.9
Isobutyryl-CoA: 18.8
fatty_acid: 14.7
inactive: 14.2
3-Methylbutyryl-CoA: 12.3
Benzoyl-CoA: 11.9
CHC-CoA: 0.0
Acetyl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor