BGC0002169 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002169 (Aspergillus aculeatus ATCC 16872)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	44,935	acurin A	PKS+NRPS:Type I	100%

BGC0002169 - Region 1 - NRPS,T1PKS

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Location: 1 - 44,935 nt. (total: 44,935 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 44,936
Label		BGC0002169

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002169	1.17	Polyketide, NRP	acurin A	Aspergillus aculeatus ATCC 16872
BGC0002670	0.54	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0002538	0.44	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0000286	0.43	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002268	0.42	Polyketide, NRP	CJ-16,173, CJ-15,696, citridone B, citridone A, citridone B'	Penicillium sp.
BGC0000631	0.41	Terpene	botcinin H, botcinin I, botcinin J, cinbotolide D, botcinin K	Botrytis cinerea B05.10
BGC0002213	0.41	Polyketide	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5
BGC0000064	0.41	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001268	0.41	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0001255	0.40	NRP, Polyketide	equisetin	Fusarium heterosporum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002169	1.00	Polyketide, NRP	acurin A	Aspergillus aculeatus ATCC 16872
BGC0001254	0.69	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002538	0.68	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0002192	0.68	Polyketide	FR901512	fungal sp. No.14919
BGC0001264	0.68	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002745	0.68	Polyketide	verrucosidin	Penicillium polonicum
BGC0002258	0.67	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0002067	0.67	NRP, Polyketide	atpenin B	Penicillium oxalicum 114-2
BGC0002268	0.67	Polyketide, NRP	CJ-16,173, CJ-15,696, citridone B, citridone A, citridone B'	Penicillium sp.
BGC0002139	0.66	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 44935:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 29606:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 16605 - 44935:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ASPACDRAFT_48

PKS_AT (540..859): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 83.7
Methoxymalonyl-CoA: 69.8
Ethylmalonyl-CoA: 68.4
Malonyl-CoA: 40.5
Isobutyryl-CoA: 37.7
Propionyl-CoA: 33.5
Benzoyl-CoA: 30.4
fatty_acid: 28.6
trans-1,2-CPDA: 21.2
Acetyl-CoA: 18.0
3-Methylbutyryl-CoA: 16.6
CHC-CoA: 9.2
2-Methylbutyryl-CoA: 8.4
inactive: 0.0

ASPACDRAFT_122295

Search NORINE for peptide: strict or relaxed

AMP-binding (591..992): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DADQFGRVSK
Nearest Stachelhaus code(s):: Ser DADQFGRVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)