BGC0002170 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002170 (Aspergillus stellatus (Emericella variecolor))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	36,500	High	4-methyl-5-dimethyltetradecahexaene-β-ketolactone/4-methyl-5-methylheptatriene-β-ketolactone	PKS

BGC0002170 - Region 1 - T1PKS

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Location: 1 - 36,500 nt. (total: 36,500 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 36,501
Label		BGC0002170

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

BBM05072.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BBM05073.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

BBM05074.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

BBM05076.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BBM05078.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

BBM05079.1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

BBM05080.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Hydrolases: hydrolase

BBM05075.1: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: synthase

Ev460pks: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002170.2	0.98	PKS	4-methyl-5-dimethyltetradecahexaene-β-ketolactone, 4-methyl-5-methylheptatriene-β-ketolactone	Aspergillus stellatus
BGC0002168.3	0.98	PKS	decumbenone a, calbistrin A, calbistrin C, decumbenone B, decumbenone c, dioic acid moiety	Aspergillus stellatus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002192.3	0.65	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002170.2	0.98	PKS	4-methyl-5-dimethyltetradecahexaene-β-ketolactone, 4-methyl-5-methylheptatriene-β-ketolactone	Aspergillus stellatus
BGC0002168.3	0.98	PKS	decumbenone a, calbistrin A, calbistrin C, decumbenone B, decumbenone c, dioic acid moiety	Aspergillus stellatus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002192.3	0.65	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1753 - 36500:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Ev460pks: pk

PKS_AT (550..866): pk

ATSignature: Methylmalonyl-CoA, Malonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 54.2%; Malonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 56.1
Methylmalonyl-CoA: 50.7
Ethylmalonyl-CoA: 30.3
Malonyl-CoA: 28.7
trans-1,2-CPDA: 19.0
Propionyl-CoA: 18.9
Isobutyryl-CoA: 18.8
fatty_acid: 14.7
inactive: 14.2
3-Methylbutyryl-CoA: 12.3
Benzoyl-CoA: 11.9
CHC-CoA: 0.0
Acetyl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor