BGC0002172 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002172 (Fusarium graminearum PH-1 (Gibberella zeae PH-1))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,NRPS	1	54,915	fusatrixin/fusapentaxin/fusaoctaxin A	NRPS:Type I	100%

BGC0002172 - Region 1 - NRPS,NRPS-like

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Location: 1 - 54,915 nt. (total: 54,915 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 54,916
Label		BGC0002172

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002172	1.49	NRP	fusatrixin, fusapentaxin, fusaoctaxin A	Fusarium graminearum PH-1
BGC0000900	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.63	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.61	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0002157	0.58	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002208	0.57	NRP	oxepinamide F	Aspergillus ustus
BGC0000348	0.57	NRP	ergovaline	Epichloe festucae var. lolii
BGC0002242	0.56	NRP	oxepinamide D	Aspergillus ustus
BGC0002260	0.54	Terpene	trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D	Annulohypoxylon truncatum
BGC0001718	0.53	NRP	okaramine D	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002172	1.00	NRP	fusatrixin, fusapentaxin, fusaoctaxin A	Fusarium graminearum PH-1
BGC0002208	0.67	NRP	oxepinamide F	Aspergillus ustus
BGC0000900	0.67	Other	ferrichrome	Aspergillus oryzae
BGC0002242	0.67	NRP	oxepinamide D	Aspergillus ustus
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.67	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0002157	0.67	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000901	0.65	Other	ferrichrome	Aspergillus niger
BGC0000348	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001261	0.64	NRP	AM-toxin	Alternaria alternata

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 54915:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala - D-Ile - D-Ser - D-Val - D-Ser - D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 36807:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala - D-Ile - D-Ser - D-Val - D-Ser - D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 684 - 54915:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala - D-Ile - D-Ser - D-Val - D-Ser - D-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGSG_10990

AMP-binding (198..591): X

nrpys: 4-Abu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVTFMGVLWK
Nearest Stachelhaus code(s):: 4-Abu DVTFMGVLWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

FGSG_13878

Search NORINE for peptide: strict or relaxed

AMP-binding (18..413): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: RASCIAAGYK
Nearest Stachelhaus code(s):: Tyr DASTIAAVCK (53% 8Å match); Tyr or Pro DASTIAAVCK (50% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (918..1310): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGFVGGIYK
Nearest Stachelhaus code(s):: Ala DVGFVGGIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2404..2805): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAGFIGAVFK
Nearest Stachelhaus code(s):: Ile DAGFIGAVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3975..4371): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLGFAAAICK
Nearest Stachelhaus code(s):: Ser DLGFAAAICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (5520..5918): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALFAGGALK
Nearest Stachelhaus code(s):: Val DALFAGGALK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (7096..7491): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGFVGGIWK
Nearest Stachelhaus code(s):: Ser DVGFVGGIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (8659..9030): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: --TLAGAVMK
Nearest Stachelhaus code(s):: Leu DAMLAGAVAK (44% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (10134..10529): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAIIIGAVMK
Nearest Stachelhaus code(s):: Leu DAIIIGAVMK (100% 8Å match)
Stachelhaus code match:: 100% (strong)