BGC0002185 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002185 (Penicillium sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	28,322	High	gregatin A	PKS

BGC0002185 - Region 1 - T1PKS

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Location: 1 - 28,322 nt. (total: 28,322 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,323
Label		BGC0002185

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

grgB: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

grgG: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

grgA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002185.2	1.00	PKS	gregatin A	Penicillium sp.
BGC0001254.3	0.74	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.73	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.69	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001305.4	0.57	PKS	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002185.2	1.00	PKS	gregatin A	Penicillium sp.
BGC0001254.3	0.74	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.73	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.69	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001305.4	0.57	PKS	fujikurin A, fujikurin B, fujikurin C, fujikurin D	Fusarium fujikuroi IMI 58289

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28322:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

grgA: pk

PKS_AT (558..878): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 94.9
Methoxymalonyl-CoA: 69.7
Ethylmalonyl-CoA: 66.3
Isobutyryl-CoA: 52.1
Benzoyl-CoA: 38.7
Propionyl-CoA: 36.3
trans-1,2-CPDA: 26.3
2-Methylbutyryl-CoA: 23.2
fatty_acid: 22.3
Malonyl-CoA: 22.1
CHC-CoA: 19.8
Acetyl-CoA: 18.7
3-Methylbutyryl-CoA: 18.1
inactive: 15.9

Link to PARAS substrate predictor