BGC0002186 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002186 (Fusarium graminearum PH-1 (Gibberella zeae PH-1))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	29,475	fusaristatin A	NRPS:Type I+PKS	100%

BGC0002186 - Region 1 - NRPS,T1PKS

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Location: 1 - 29,475 nt. (total: 29,475 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 29,476
Label		BGC0002186

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002186	2.00	NRP, Polyketide	fusaristatin A	Fusarium graminearum PH-1
BGC0002525	0.65	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002191	0.64	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002518	0.62	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.61	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001252	0.61	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002155	0.59	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002194	0.57	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001261	0.57	NRP	AM-toxin	Alternaria alternata
BGC0001166	0.57	NRP	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002186	1.00	NRP, Polyketide	fusaristatin A	Fusarium graminearum PH-1
BGC0002525	0.66	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002518	0.64	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.64	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001252	0.64	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002155	0.63	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002194	0.62	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001261	0.62	NRP	AM-toxin	Alternaria alternata
BGC0001166	0.62	NRP	HC-toxin	Alternaria jesenskae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 29475:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - X - Gln) + (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGSG_08209

Search NORINE for peptide: strict or relaxed

AMP-binding (1006..1404): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVSSVFAIFK
Nearest Stachelhaus code(s):: Ser DVSSVFAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2101..2500): X

nrpys: Ibu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQVQAIVYK
Nearest Stachelhaus code(s):: Ibu DVQVQAIVYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3204..3609): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVALLGSITK
Nearest Stachelhaus code(s):: Gln DVALLGSITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

FGSG_08208

PKS_AT (594..912): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 54.2%; Ethylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 59.8
Methylmalonyl-CoA: 58.8
Malonyl-CoA: 41.9
trans-1,2-CPDA: 29.7
Propionyl-CoA: 27.6
Ethylmalonyl-CoA: 20.1
fatty_acid: 19.3
Isobutyryl-CoA: 16.0
CHC-CoA: 16.0
inactive: 15.2
2-Methylbutyryl-CoA: 15.1
Benzoyl-CoA: 12.2
Acetyl-CoA: 10.9
3-Methylbutyryl-CoA: 8.3