BGC0002187 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002187 (Pochonia chlamydosporia 170)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	68,725	High	monorden D/monocillin IV/monocillin VI/monocillin VII/pochonin M/monocillin V/monocillin II	PKS

BGC0002187 - Region 1 - T1PKS

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Location: 1 - 68,725 nt. (total: 68,725 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 68,726
Label		BGC0002187

Tailoring functions

Oxidoreductases: oxygenase

VFPPC_08960: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: halogenase

VFPPC_08963: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Ligases: synthase

VFPPC_08959: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

VFPPC_08964: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002187.3	1.00	PKS	monorden D, monocillin IV, monocillin VI, monocillin VII, pochonin M, monocillin V, monocillin II	Pochonia chlamydosporia 170
BGC0000134.3	0.90	PKS	radicicol	Pochonia chlamydosporia
BGC0002608.2	0.80	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002187.3	1.00	PKS	monorden D, monocillin IV, monocillin VI, monocillin VII, pochonin M, monocillin V, monocillin II	Pochonia chlamydosporia 170
BGC0000134.3	0.90	PKS	radicicol	Pochonia chlamydosporia
BGC0002608.2	0.80	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 68725:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: VFPPC_08959 + VFPPC_08964

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

VFPPC_08964: mal

PKS_AT (913..1207): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 89.4
inactive: 58.5
Methoxymalonyl-CoA: 57.4
Methylmalonyl-CoA: 44.3
Isobutyryl-CoA: 43.5
Benzoyl-CoA: 28.9
Propionyl-CoA: 24.3
2-Methylbutyryl-CoA: 24.2
Acetyl-CoA: 23.7
3-Methylbutyryl-CoA: 21.2
fatty_acid: 20.1
trans-1,2-CPDA: 19.2
Ethylmalonyl-CoA: 19.0
CHC-CoA: 18.7

VFPPC_08959: pk

PKS_AT (550..862): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 93.9
Methoxymalonyl-CoA: 82.0
Malonyl-CoA: 63.9
Ethylmalonyl-CoA: 63.9
Isobutyryl-CoA: 51.7
Benzoyl-CoA: 49.0
2-Methylbutyryl-CoA: 33.7
Propionyl-CoA: 32.6
trans-1,2-CPDA: 30.3
CHC-CoA: 26.0
3-Methylbutyryl-CoA: 22.3
fatty_acid: 17.8
inactive: 14.2
Acetyl-CoA: 0.0

Link to PARAS substrate predictor