BGC0002188 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002188 (Fusarium pseudograminearum CS3096)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	52,599	W493 B/W493 A	NRPS:Type I+PKS	100%

BGC0002188 - Region 1 - NRPS,T1PKS

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Location: 1 - 52,599 nt. (total: 52,599 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 52,600
Label		BGC0002188

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002188	1.52	NRP, Polyketide	W493 B, W493 A	Fusarium pseudograminearum CS3096
BGC0002191	0.61	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001252	0.59	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0001606	0.57	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002155	0.57	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002222	0.55	Polyketide	zopfiellin	Diffractella curvata
BGC0002194	0.52	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002224	0.51	Polyketide	zopfiellin	Diffractella curvata
BGC0002525	0.50	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002515	0.48	Polyketide	solanapyrone A	Ascochyta rabiei

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002188	1.00	NRP, Polyketide	W493 B, W493 A	Fusarium pseudograminearum CS3096
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001252	0.64	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0001606	0.63	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002155	0.63	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001399	0.63	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001261	0.62	NRP	AM-toxin	Alternaria alternata
BGC0002222	0.62	Polyketide	zopfiellin	Diffractella curvata
BGC0001825	0.61	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833	0.61	NRP	icosalide A, icosalide B	Burkholderia gladioli

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 52599:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - D-Ala - Ala - Gln - D-Tyr - X) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 47332:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - D-Ala - Ala - Gln - D-Tyr - X) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 17971 - 52599:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - D-Ala - Ala - Gln - D-Tyr - X) + (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FPSE_09183

Search NORINE for peptide: strict or relaxed

AMP-binding (988..1386): X

nrpys: Thr, Ser

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQTIMAIHK
Nearest Stachelhaus code(s):: Thr or Ser DAQTIMAIHK (100% 8Å match); Thr DAQTIMAIHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2542..2934): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVATVTAIWK
Nearest Stachelhaus code(s):: Ala DVATVTAIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4097..4488): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVATVTAIWK
Nearest Stachelhaus code(s):: Ala DVATVTAIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (5203..5605): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVQIIGGIHK
Nearest Stachelhaus code(s):: Gln DVQIIGGIHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6305..6700): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQTIVGIAK
Nearest Stachelhaus code(s):: Tyr DAQTIVGIAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (7854..8254): X

nrpys: Ile, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFIGAIFK
Nearest Stachelhaus code(s):: Ile or Val DAYFIGAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

FPSE_09184

AMP-binding (44..471): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLTYVGGGIK
Nearest Stachelhaus code(s):: Ala DLGIVGGMIK (29% 8Å match); nohBza GLGLVGAIIK (26% 8Å match)
Stachelhaus code match:: 60% (weak)

FPSE_09187

PKS_AT (580..903): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.7
Methylmalonyl-CoA: 67.2
Methoxymalonyl-CoA: 66.9
Isobutyryl-CoA: 38.1
Ethylmalonyl-CoA: 38.0
fatty_acid: 26.8
Propionyl-CoA: 22.3
inactive: 21.7
trans-1,2-CPDA: 18.6
Benzoyl-CoA: 17.0
3-Methylbutyryl-CoA: 13.9
CHC-CoA: 13.3
2-Methylbutyryl-CoA: 7.4
Acetyl-CoA: 0.0