BGC0002191 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002191 (Fusarium graminearum PH-1 (Gibberella zeae PH-1))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	9,064	prolipyrone B/gibepyrone D	PKS	100%

BGC0002191 - Region 1 - T1PKS

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Location: 1 - 9,064 nt. (total: 9,064 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 9,065
Label		BGC0002191

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191	1.00	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.36	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002155	0.29	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001252	0.28	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002525	0.22	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002240	0.21	Polyketide	BAB, BAA	Metarhizium anisopliae
BGC0001254	0.21	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001257	0.21	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154	0.20	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107	0.20	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191	1.00	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.69	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002155	0.62	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001252	0.61	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002525	0.55	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002240	0.54	Polyketide	BAB, BAA	Metarhizium anisopliae
BGC0001254	0.53	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001257	0.53	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154	0.53	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107	0.53	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 9064:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGSG_03340

PKS_AT (576..876): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 52.0
Methoxymalonyl-CoA: 48.1
Malonyl-CoA: 22.1
trans-1,2-CPDA: 18.6
Propionyl-CoA: 17.3
fatty_acid: 16.0
Isobutyryl-CoA: 12.7
Benzoyl-CoA: 9.3
Ethylmalonyl-CoA: 0.5
inactive: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: -0.6
Acetyl-CoA: -0.7
2-Methylbutyryl-CoA: -2.9