LOCUS       BGC0002193              3728 bp    DNA     linear   CON 23-MAR-2015
DEFINITION  Aspergillus terreus NIH2624 scaffold_13 genomic scaffold, whole
            genome shotgun sequence.
ACCESSION   BGC0002193
VERSION     BGC0002193
KEYWORDS    .
SOURCE      Aspergillus terreus NIH2624
  ORGANISM  Aspergillus terreus NIH2624
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:07:08
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..3728
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[447:3288]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      448..3288
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..3728
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..3728
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002193"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3728
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<448..>3288)
                     /locus_tag="ATEG_08899"
     mRNA            complement(<448..>3288)
                     /locus_tag="ATEG_08899"
                     /product="predicted protein"
     CDS             complement(448..3288)
                     /NRPS_PKS="Domain: AMP-binding (32-450). E-value: 1.3e-60.
                     Score: 196.9. Matches aSDomain:
                     nrpspksdomains_ATEG_08899_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (601-655). E-value: 5.5e-08.
                     Score: 25.2. Matches aSDomain:
                     nrpspksdomains_ATEG_08899_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (680-930). E-value:
                     3.4e-32. Score: 104.6. Matches aSDomain:
                     nrpspksdomains_ATEG_08899_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     213.5; E-value: 7.1e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ATEG_08899"
                     /product="predicted protein"
                     /protein_id="EAU31031.1"
                     /sec_met_domain="AMP-binding (E-value: 5.9e-70, bitscore:
                     221.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.9e-10, bitscore:
                     25.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKLKLFSMPGAQTSQIVIMLFQSLLHLLEAIASREPTRYIITY
                     SIGNTHTPEIFSYSDLLQSARKAAGALRFKYHVVPGSVVLLHFNDHWNSMLWFWATLIA
                     DCIPAMSTPFSNNPETRLRHLKHLSTTLRSPKCLTTASLAAEFAGQEYITPICVQSLDY
                     ENLVHLPIKEGGDIAVLMFTSGSSGHCKVVPLTHEQILASLSGKAWTFPLPDNTAQLNW
                     VGMNHVASLVEVHLFSIYTHSDQVHIPTVEVLSHVTLFLDLIHRHRVSRTFAPNFFLAK
                     LRAALSADDTLAKYTGSLSNLRYIVSGGEANVTQTINDLAQMLKKCGAVSNVIVPAFGM
                     TETCAGAIYNTSFPQYDVEHGLPFASVGSCMPGIQVRIVQLNGNGNSVPPGTVGNLEIC
                     GPVVLKGYFNNPAATKSTFTNDNWFKTGDLAFVDDNGMLVLAGREKDSIIVNGANYSPH
                     DIESAIDEANIPGLISGFTCCFSTFPPSADTEEVIIVYLPNYTPADTVRRSETAAAIRK
                     VAMMSVGVRATVLPLDRTMLEKSTLGKLARGKIKAAYERGDYKSYQEANEQMMALHHKV
                     SHHQPRSGLEQSLLGVFTRTIPENLTEDFDVLTSIFDLGITSIELLKLKRGIEDLIGHG
                     QIPLITLMTNPTIRTLSDALKQHAQQRDCSIYNPVVVLQSQGKKPPIWLVHPVGGEVMI
                     FMNLAKFIIDRPVYGLRARGFNDGEDPFHTFEEIVSTYHASIKEKQPSGPYAIAGYSYG
                     AKVAFDIAKALEHNGDEVRFLGLLDLPPSLNGTQMRAVAWKEMLLHICRMVGVIREEGI
                     KKIYPRLEPENISPRHAIETVMGEADVTRLAELGLTASALERWANLTHALQRCIVDHKT
                     NGSVAGADAFYCDPMASMAISNEQWACDYIGKWSDHTRSPPRFHHIAGTHYTILDAENI
                     FSFQKTFLRALNDRGI"
     aSDomain        complement(499..1248)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_08899_Thioesterase.1"
                     /evalue="3.40E-32"
                     /label="ATEG_08899_Thioesterase.1"
                     /locus_tag="ATEG_08899"
                     /protein_end="930"
                     /protein_start="680"
                     /score="104.6"
                     /tool="antismash"
                     /translation="PIWLVHPVGGEVMIFMNLAKFIIDRPVYGLRARGFNDGEDPFHTF
                     EEIVSTYHASIKEKQPSGPYAIAGYSYGAKVAFDIAKALEHNGDEVRFLGLLDLPPSLN
                     GTQMRAVAWKEMLLHICRMVGVIREEGIKKIYPRLEPENISPRHAIETVMGEADVTRLA
                     ELGLTASALERWANLTHALQRCIVDHKTNGSVAGADAFYCDPMASMAISNEQWACDYIG
                     KWSDHTRSPPRFHHIAGTHYTILDAENI"
     aSModule        complement(499..3192)
                     /complete
                     /domains="nrpspksdomains_ATEG_08899_AMP-binding.1"
                     /domains="nrpspksdomains_ATEG_08899_PP-binding.1"
                     /domains="nrpspksdomains_ATEG_08899_Thioesterase.1"
                     /final_module
                     /locus_tags="ATEG_08899"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(997..1071)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_08899_0003"
                     /evalue="9.70E-10"
                     /label="NRPS-te1"
                     /locus_tag="ATEG_08899"
                     /protein_end="764"
                     /protein_start="739"
                     /score="30.9"
                     /tool="antismash"
                     /translation="QPSGPYAIAGYSYGAKVAFDIAKAL"
     aSDomain        complement(1324..1485)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_08899_PP-binding.1"
                     /evalue="5.50E-08"
                     /label="ATEG_08899_PP-binding.1"
                     /locus_tag="ATEG_08899"
                     /protein_end="655"
                     /protein_start="601"
                     /score="25.2"
                     /tool="antismash"
                     /translation="TEDFDVLTSIFDLGITSIELLKLKRGIEDLIGHGQIPLITLMTNP
                     TIRTLSDAL"
     aSDomain        complement(1939..3192)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ATEG_08899_AMP-binding.1"
                     /evalue="1.30E-60"
                     /label="ATEG_08899_AMP-binding.1"
                     /locus_tag="ATEG_08899"
                     /protein_end="450"
                     /protein_start="32"
                     /score="196.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="IASREPTRYIITYSIGNTHTPEIFSYSDLLQSARKAAGALRFKYH
                     VVPGSVVLLHFNDHWNSMLWFWATLIADCIPAMSTPFSNNPETRLRHLKHLSTTLRSPK
                     CLTTASLAAEFAGQEYITPICVQSLDYENLVHLPIKEGGDIAVLMFTSGSSGHCKVVPL
                     THEQILASLSGKAWTFPLPDNTAQLNWVGMNHVASLVEVHLFSIYTHSDQVHIPTVEVL
                     SHVTLFLDLIHRHRVSRTFAPNFFLAKLRAALSADDTLAKYTGSLSNLRYIVSGGEANV
                     TQTINDLAQMLKKCGAVSNVIVPAFGMTETCAGAIYNTSFPQYDVEHGLPFASVGSCMP
                     GIQVRIVQLNGNGNSVPPGTVGNLEICGPVVLKGYFNNPAATKSTFTNDNWFKTGDLAF
                     VDDNGMLVLAGREKDSIIV"
     CDS_motif       complement(2035..2124)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_08899_0002"
                     /evalue="6.30E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ATEG_08899"
                     /protein_end="418"
                     /protein_start="388"
                     /score="25.0"
                     /tool="antismash"
                     /translation="PPGTVGNLEICGPVVLKGYFNNPAATKSTF"
     CDS_motif       complement(2698..2757)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ATEG_08899_0001"
                     /evalue="1.40E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="ATEG_08899"
                     /protein_end="197"
                     /protein_start="177"
                     /score="11.7"
                     /tool="antismash"
                     /translation="AVLMFTSGSSGHCKVVPLTH"
ORIGIN
        1 gtgaagagaa gatcacaata gagatggaca tgtaatgtgc tcttcatatg caacaggagg
       61 gtagtcactg gtgtgctgac tgtttctcgt ccagtcctag tgcttcctgt ggctatctca
      121 cggtgttggt ctcgatgata caactaggcc gaccgcatat ctctgttcaa aacctccatt
      181 atgcggcttg ccgcgggtcg agataccttg attaaggtca gcttgtggtg ccccacgtgc
      241 ttttctactc acgatgaaat ttcgtttagc ccctttctgg tgctaaacta gaagtgaatg
      301 ggacaggcga tagataaaca tatcccaaag aatcctaaga atgaacacga tcaagcttcc
      361 tcctgaatca caacaaatat caattttttg ctctcacttt cctctttaca ttgtatctat
      421 cttgacatcc aaccccaaca cgccgggtta gattccacgg tcattcagcg ccctgagaaa
      481 tgtcttctga aatgagaaga tattttctgc atccagtatg gtgtaatgcg tccccgcaat
      541 gtgatggaac ctcggtggtg accgtgtatg gtcactccac ttcccaatat agtcacatgc
      601 ccattgctcg ttcgatatcg ccatcgaagc cattggatca cagtaaaacg cgtcagcgcc
      661 tgcaacggag ccattcgtct tatgatcgac aatacaacgt tgcagagcat gtgttagatt
      721 agcccacctc tccaacgcgg acgctgtcaa ccctagttcc gccaatcgcg tgacatcagc
      781 ctcacccatc actgtttcta tcgcatggcg tggagagata ttttctggtt ccaacctcgg
      841 gtatattttc ttgatgccct cctcccgaat cacaccaacc atacggcata tatgaagcag
      901 catttccttc caggcgactg cacgcatctg cgtaccattc agactaggtg gaagatcaag
      961 caaacccaga aagcggacct cgtctccatt gtgctccagg gccttggcaa tatcaaatgc
     1021 aactttcgcg ccgtaggaat aaccggcaat tgcgtacggg ccacttggtt gcttttcctt
     1081 gatacttgca tgatatgtgc tgactatttc ttcgaacgtg tggaatggat cctcaccgtc
     1141 gttgaacccg cgtgctcgca gcccatacac aggtcgatcg atgataaact ttgctaggtt
     1201 catgaatatc atgacttctc cgccgactgg gtggacaagc cagatgggtg gttttttgcc
     1261 ttgactctgt aatacgacta cagggttgta tatgctgcag tctctttgct gagcgtgctg
     1321 cttcagcgcg tctgataatg tccggatagt ggggtttgtc atcagggtga tgagaggaat
     1381 ctgtccgtga cctatcagat cttcgatacc tctcttgagc ttgaggagct cgatggatgt
     1441 gattcccaga tcaaatattg acgtcaacac gtcgaagtcc tccgtcaagt tctcgggtat
     1501 agtgcgggtg aagacgccga gtagactctg ttcgagacca gaccgcggct gatgatgcga
     1561 cactttgtgg tgtagagcca tcatctgttc gttcgcttct tgataacttt tatagtctcc
     1621 cctttcataa gcagccttga tcttgccgcg ggcaagcttg cccagagtcg atttctccag
     1681 cattgtccgg tcgagcggga gaactgtggc acgcacgccg actgacatca tggcgacctt
     1741 tctgatcgcg gctgcagttt cagatcgtcg aactgtgtcc gctggtgtgt aatttgggag
     1801 ataaacaatg atgacctcct ctgtgtctgc gctgggcggg aacgtggaga aacaacaagt
     1861 gaaaccagag ataaggccgg ggatgtttgc ttcgtcgatg gcggactcga tatcgtgtgg
     1921 actgtagttg gccccattca caatgatgct atccttttca cgtccagcaa gtaccagcat
     1981 tccgttatcg tcaacgaaag ctaaatctcc ggttttgaac caattgtcgt tcgtgaatgt
     2041 cgactttgta gcagcaggat tgttgaaata acctttgaga accaccggac cgcagatctc
     2101 gagattacct actgtgcccg gaggaacact attgccgttt ccattaagct ggacaattct
     2161 cacttggatc cctggcatgc aggaccccac ggaagcaaat ggaagtccgt gctcgacatc
     2221 atactgggga aacgaggtat tgtaaatggc gcccgcacag gtctctgtca tgccgaaggc
     2281 aggcacaatt acgttcgaga cagctccaca cttcttcagc atctgggcca aatcattgat
     2341 cgtctgggta acgttcgcct cgccaccgga gacaatatac cgcaggttgc tgagactccc
     2401 ggtgtacttg gccaaggtat catccgcact caatgctgcg cgtagttttg cgaggaaaaa
     2461 gttaggtgcg aaagttcgag acacacggtg tcgatgtatc aaatcaagga acagggtaac
     2521 gtgagacaag acttcaactg ttgggatatg gacttgatca ctgtgggtat agatgctgaa
     2581 gagatgaact tcgaccaaag aggcgacatg attcattccg acccaattca gctgtgccgt
     2641 gttgtctggc agtgggaagg tccatgcttt tcccgaaaga gatgccaata tctgctcgtg
     2701 agtcaaaggc acgaccttgc agtggcctga gctcccagac gtaaacataa gcactgcaat
     2761 gtcgcccccc tccttgatcg gtaaatgtac caggttttcg taatcaagcg attgcacgca
     2821 gattggtgta atgtattctt ggccagcgaa ttccgcggcc agagaagccg tggtcaggca
     2881 tttcggactc cttaaagtgg ttgataggtg tttcaaatgg cgtaatcttg tctcgggatt
     2941 gttggagaat ggagtggaca tagctgggat acagtctgct atgagggtgg cccagaacca
     3001 caacatcgaa ttccaatgat cattaaagtg tagaagaaca accgatccgg ggacgacatg
     3061 gtatttgaaa cgaagagctc cggcggcctt tctggctgat tgtaagaggt cggagtatga
     3121 aaatatctcc ggcgtatggg tgtttccaat agaataggta ataatgtagc gtgtcggctc
     3181 ccgcgaagcg atagcttcga gaagatgcag taggctttgg aacaacatga tcacgatttg
     3241 agatgtttgt gcgcctggca tagagaaaag cttgagcttc ttattcatgt catcagacac
     3301 ccagcgtaag acactacggt ccatcaggct gggccccata catggctcct tacatctgat
     3361 cggttggata tcggtgatgc tattcgtagg cagcctgcag gataaccagg tattgatatt
     3421 cctcttgacg ccggccggac acattagcct tggtaggcgg caaggtttgg cggcaagagg
     3481 tcacattcca agataaactc ctttcttatt tacgaagtat gtgataacta tgagtcgaat
     3541 ttatggacgt gccgtccgac agaacaagtg aattgcacta tgccgccgac tctgagagcc
     3601 ccacaatact atatgctcca gaccaaatcc ttcactagat cacataagat ggttatgcag
     3661 caccgagcaa aacggaatat gtgactggct ctaagattga gccctcttgt gtatgtatga
     3721 ctatgaga
//
