BGC0002198 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002198 (Aspergillus terreus var. terreus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	114,922	High	nanangelenin B/terreazepine	NRPS:Type I

BGC0002198 - Region 1 - NRPS

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Location: 1 - 114,922 nt. (total: 114,922 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 114,923
Label		BGC0002198

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

FAC38_04: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

FAC38_10: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FAC38_11: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

FAC38_17: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

FAC38_21: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

FAC38_25: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

FAC38_31: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

FAC38_39: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Hydrolases: amidase

FAC38_08: amidase

smcogs: SMCOG1105: amidase

FAC38_19: amidase

smcogs: SMCOG1105: amidase

Ligases: ligase

FAC38_35: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

FAC38_22: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002198.3	0.83	NRPS	nanangelenin B, terreazepine	Aspergillus terreus var. terreus
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.66	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002198.3	0.99	NRPS	nanangelenin B, terreazepine	Aspergillus terreus var. terreus
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.66	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 72114 - 114922:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FAC38_35: X - X

AMP-binding (245..648): X

nrpys: Ant

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GIILFGVGVK
Nearest Stachelhaus code(s):: Ant GIILFGVGVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1351..1753): X

nrpys: Kyn

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAAMIMGIAK
Nearest Stachelhaus code(s):: Kyn DAAMIMGIAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor