LOCUS       BGC0002199             17425 bp    DNA     linear   PLN 31-MAR-2020
DEFINITION  Aspergillus nanangensis strain MST-FP2251 BGC nanangelenin
            biosynthetic gene cluster, complete sequence.
ACCESSION   BGC0002199
VERSION     BGC0002199
KEYWORDS    .
SOURCE      Aspergillus nanangensis
  ORGANISM  Aspergillus nanangensis
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:07:47
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17425
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[5657:13175]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5658..13175
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(<1..>1335)
                     /gene="nanB"
                     /locus_tag="FE257_001449"
     mRNA            complement(join(<1..502,584..>1335))
                     /gene="nanB"
                     /locus_tag="FE257_001449"
                     /product="hypothetical protein"
     CDS             complement(join(1..502,584..1335))
                     /codon_start=1
                     /db_xref="InterPro:IPR032805"
                     /db_xref="PFAM:PF13813"
                     /gene="nanB"
                     /locus_tag="FE257_001449"
                     /note="SECRETED:SignalP(1-24); TransMembrane:5
                     (n5-16c21/22o145-167i284-304o310-328i349-373o393-413i);
                     EggNog:ENOG410PP8D"
                     /product="hypothetical protein"
                     /protein_id="QIQ51362.1"
                     /transl_table=11
                     /translation="MRPSTTTLSLLVFLISSILLATTGKNSIIRYTYFPILLIICHLQL
                     TNPPVNTASNIFDGSFEGTTLLNGLQQLNILVLTGVDVNDESGSSVFRRLKSALIYPFN
                     ARGVGTKYQIKNLPVLSSFICKEKQGESGLSSFLSSARYRFAIRQLAVSAWQYLLADIG
                     FSLLKNIPTEKRLEYYGPEEEWMPQSLDQLRVRIEATLVFWVTLKAFAEIQSKIATALL
                     TAVGVTSPHDWPPFFGSLREAYTLRGFWGKWWHQQLRWPLTSYSNFITRRVLKLTRSPL
                     ERYLNNALVFAQSGIVHVYFNWIKGVQDGDVGCMAFYISFVAGYFLEDHVQGLWRKAFD
                     RTSAQESSLWLLERLVGALWVATFLTIVTPWWVYPFLRLSSSLKMPYSFVDVFGFQGAL
                     TVVFMGAAALRIGLNAEP"
     misc_feature    1..17425
                     /note="BGC nanangelenin biosynthetic gene cluster"
     cand_cluster    1..17425
                     /SMILES="NC([*])C(=O)NC(Cc1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..17425
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002199"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17425
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="indole"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..15451
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4089:5451]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      4090..5451
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    1..15451
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     gene            complement(<1919..>3275)
                     /gene="nanC"
                     /locus_tag="FE257_001450"
     mRNA            complement(join(<1919..2254,2328..2930,2982..>3275))
                     /gene="nanC"
                     /locus_tag="FE257_001450"
                     /product="hypothetical protein"
     CDS             complement(join(1919..2254,2328..2930,2982..3275))
                     /codon_start=1
                     /db_xref="InterPro:IPR000898"
                     /db_xref="InterPro:IPR037217"
                     /db_xref="PFAM:PF01231"
                     /gene="nanC"
                     /locus_tag="FE257_001450"
                     /note="EggNog:ENOG410PFRQ; COG:E; GO_function: GO:0020037 -
                     heme binding [Evidence IEA]; GO_function: GO:0046872 -
                     metal ion binding [Evidence IEA]; GO_process: GO:0019441 -
                     tryptophan catabolic process to kynurenine [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="QIQ51363.1"
                     /transl_table=11
                     /translation="MLSPVEVDLEAYDISRVSGFLPDKCPLRKLPDPYYVPWERLTAHL
                     EPLIRAKRLQHELDQMPVLGITRLTSQPMRRRAYVLLSFLAQAYLWGEDIPNTTLPQAI
                     AKPLTEVSTLLEIKPFATFAAFCLWSFSVHFDDDIGGDCHKFLDNMSMTCSFTGTTDEA
                     WFFNVSTAIEARGGRIIPSILNAISAVQNNDMLTVEGFLLDFTICLRDLCDLIDRMHEN
                     CRPSVFYHRIRPFLSGTSNNNPATENSKGVFYVQAEDGTGEWHRYSGGSNAQSSLIQLF
                     DITLGINHDIGYKTRYLREMRSYMPAQHRRFLARMEEISNLRPYALSHGPGSSNMCSLY
                     NSAVLGLKNLRDKHMALVFRYIIIPRAKEKAGNGLAIRQKDLVGTGGTDMIPFLRETRD
                     DTMNAVHLPYS"
     gene            <4090..>5451
                     /gene="nanD"
                     /locus_tag="FE257_001451"
     mRNA            join(<4090..5297,5352..>5451)
                     /gene="nanD"
                     /locus_tag="FE257_001451"
                     /product="hypothetical protein"
     CDS             join(4090..5297,5352..5451)
                     /codon_start=1
                     /db_xref="InterPro:IPR017795"
                     /db_xref="PFAM:PF11991"
                     /gene="nanD"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /locus_tag="FE257_001451"
                     /note="EggNog:ENOG410PVDJ; COG:O; MEROPS:MER0126985;
                     GO_function: GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]; GO_process: GO:0009820 - alkaloid metabolic
                     process [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="QIQ51364.1"
                     /sec_met_domain="dmat (E-value: 3.7e-118, bitscore: 383.8,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIIEPQMENQNTIPIYAREETPYDTLSKVLTFSNIDQEEYWRRI
                     APLLGKLLQQGSNYTIHQQYQHLCFYALHVIPLLGPFPVEGRSSYNCPLGGVGAIEPSQ
                     NFQKSGTSLRYTFEPTSTGAISGRSDPFNRFMIDDALSRFRQAGVRFNPHLYEALKKEV
                     LLTDEEAEAICQHHDVPKMEFRAQACIAVDLDGGNMSVKLYVYPMLKATLLNIPNWELC
                     LNAIRHVDGEGQFTSATAALETYLRTQCPTTVREQTSATTQVSYIACDLVDLQRARFKV
                     YLFDLHVSFERIITHWTMGGRLNDEVTMSGLGILRELWDELKIPEGRRKPIERPPKPGD
                     GPTMPLFFNYEMKAGDRLPKVKAYLPLVGMPEMPIARKLAAFFQRYGFPVEGRQYVDTL
                     AGYFPDEDLEIVTHHQAFLSFSYSAKTGPYMTIYYH"
     gene            complement(<5658..>13175)
                     /gene="nanA"
                     /locus_tag="FE257_001452"
     mRNA            complement(join(<5658..12695,12753..>13175))
                     /gene="nanA"
                     /locus_tag="FE257_001452"
                     /product="hypothetical protein"
     CDS             complement(join(5658..12695,12753..13175))
                     /NRPS_PKS="Domain: AMP-binding (231-637). E-value: 9.3e-76.
                     Score: 246.8. Matches aSDomain:
                     nrpspksdomains_FE257_001452_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (793-859). E-value: 2e-16. Score:
                     51.9. Matches aSDomain: nrpspksdomains_FE257_001452_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (901-1176). E-value:
                     3.7e-34. Score: 110.1. Matches aSDomain:
                     nrpspksdomains_FE257_001452_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1338-1735). E-value:
                     6.9e-85. Score: 276.9. Matches aSDomain:
                     nrpspksdomains_FE257_001452_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1877-1943). E-value: 2.9e-17.
                     Score: 54.5. Matches aSDomain:
                     nrpspksdomains_FE257_001452_PCP.2"
                     /NRPS_PKS="Domain: Condensation_DCL (1981-2261). E-value:
                     7.4e-34. Score: 109.0. Matches aSDomain:
                     nrpspksdomains_FE257_001452_Condensation_DCL.2"
                     /NRPS_PKS="Domain: PCP (2412-2479). E-value: 1.1e-17.
                     Score: 55.9. Matches aSDomain:
                     nrpspksdomains_FE257_001452_PCP.3"
                     /codon_start=1
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR020806"
                     /db_xref="InterPro:IPR036736"
                     /db_xref="PFAM:PF00501"
                     /db_xref="PFAM:PF00550"
                     /db_xref="PFAM:PF00668"
                     /gene="nanA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     266.5; E-value: 5.9e-81)"
                     /gene_kind="biosynthetic"
                     /locus_tag="FE257_001452"
                     /note="EggNog:ENOG41KOG1178; COG:I; GO_function: GO:0031177
                     - phosphopantetheine binding [Evidence IEA]; GO_function:
                     GO:0003824 - catalytic activity [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="QIQ51365.1"
                     /sec_met_domain="Condensation (E-value: 1.3e-34, bitscore:
                     108.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-94, bitscore:
                     305.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.4e-15, bitscore:
                     45.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLTTDEAGRKSICLFPAIVTNTKSANKPGMQKVALDPILCRDLN
                     DHDRFQNRGELQLLLSTAWTIVLHRFAEANPVHFAVVVDIKRKKLCESWSVEVRPRSLV
                     SSLLDLESWTISTLSRPSYHTFNTAVFIRDEYLTESEMSDVNIVAHTNKSQITVNLVYR
                     CRHLSAFHAENLMSSFSCAMQSVLREPHQPLGKISLCSLAQQQQISRWQNQPLKEDSKT
                     AMWHRLAEFSARQPLSPAVQSTSGYLTYADLDELSSRMAVCLQDKHRVKPGDMVLLCVQ
                     KTPWAIVAMLAINKTGGCFVPCDPTHPVARRQVMATRCQARLAVVSPGYEDLLARIVPE
                     ISINPEPAMTEWRESFVPGDDNRTHRPIFSPSAPAYCFFTSGSTGEPKGCIGSHSALAA
                     LAHQVPALRMSTESRVLQFAKFGFGISFIEIFCTLAAGGTVCILSDGERLDALPDAMNQ
                     MRVNWALLTPTVTQSLVPEQIPGLGMLFLGGEAPDDGLILRWKDKVSLFQVFGTTEMAG
                     VTLVSSRITSPAQRKTVGFGANARVWLCDVSEEEENNAGNLSLAPIGAVGELVIGGPSL
                     GAGYLGDPQRTHALFLELPTSVVAGFSSNLQRVYKTGDLVRYNHDGSLSYIGRRGTQVK
                     LRGQRLELEEVECHIIRLLAGTKTWTGALRVIALVIDPSGQDQTQVDRCTLAAFILMPQ
                     ASREPRTSSNGTLEFLKLREQDHRDLDMVQEKLRDTLPPFMVPQIFLALVDVPRTATGK
                     VDRNRIQRQINALPYQDLQHLAGRRVQMLRAQTDIELKVHALICDVLQIQPEDVSMLDD
                     FFQLGGNSMTAITLVSAAKKQEALKLAVADVFKHPVLADLARSAKETSKVSTVQIATQR
                     PFMMLDEESLDLNELKQTVVTQCNIGLSSLEDAYPCTPLQEGMMALTEQRRFSYRAKVQ
                     CHLQPEIDLSQFRRAWERVVVRNEILRTRLVSVSSQGVWQVVLRGSFAWDDTESQADEA
                     PMGLGAKLVRGVIISTRSKGTFFILTIHHAICDLWAIRLLLDQVWREYTNVHAGTGSAA
                     PNRFSQFVRYVRRMRNDPASEAYWKGQFAGLDSQVFPELPQPNFIPSPDDEIQHQISLP
                     VRISETSTLSNYIRLAWAMVISHYTATDDVVFGEILNGRGAIMSEHGEDAVEHIVGPTL
                     VSVPRRVELDYEMSVSEALSRIQEQRTEMIPFEQVGLQYIQRYSPETEVACMFQSHIVV
                     QSAWNPPGQIFQSVQAGASITGGFASYAIGLECRLSMNESRLGLTACFDSRVVSRPHMQ
                     RLLNHLHMVLESMIQDPYQRLKSVPRVSSQDLDRIYTWNVGIPTNICGNVHESIRAQAR
                     KTPLAPAIDAWDGKLNFNELEHHSNQAALELQRRGLVPGDFVPLLFERSMWTPVAMIAV
                     NKAGAAFVPMDTEQPLPRLQAMAKQVKCTVIVCSDSMRSMACQVTPAATVIPFSNVRSS
                     GLRHCPLELQQLPTVTAHGAMYAAFTSGSTGTPKGVVIEHGSYCVAAQEYNKQTLIDRH
                     SRVLQFASYSFDAHIGETISTLMAGACVCIPSDQDRQNALAQAASSMQITHAMLTPAVA
                     RLIRREEMPSLRTLTLMGEAMRPSDYAYWAEKVRLFNGYGPTECTVAISCREYRPGDAV
                     QDIGWPRAAGVWITDPRDYHQLMPMGAVGELLLEGPPVARGYLNNPEQTAKAFISRPRW
                     RPDIGHAHRIYRTGDLVRYTEDKSLQYVGRIGDQMKIRGQRIERGEVESQLRRFWLPTG
                     VEMAVDAVLAGDNRDRVCLVAFIEHNRKKVDGTDQGLCQSMLTSPDGDFSLQVIRVETQ
                     LQQHLPRFMVPVIFVPIYRLPHMLSGKIDRPRLKRELQAYTWEELRQFFPAAAPTRPPS
                     TDQERALQDVWAHVLQVPASRIGVDDNFFHIGGDSVTGMQAVAQARTKHLDHSLADIFR
                     YKTIAEILSHTSSASKTGADLANDIGGPVQLLGGRDALEQLDVSKEEIEDIYPCAPVQQ
                     GILLVQARKPAFYHVAFSWEVTNSTVEKTGRAIEQIIARHAIFRTCFLQPGSNSSSFFQ
                     VVLRCRKQEIPIRALSDEIHQFPGDFQPSARVSSRFSIYYNHGNTSIFVRLDISHALWD
                     GGPIMVVQRELDLGSQGQLIRYPEPSLYRNYIAYIARQDQEAAAGFWTTHLKDMAACHF
                     PSLLTSDLRGPDTPEDLNFELRDYAAIRPYCRRINVTVPNFFCLVWAMVLRCVTLKDQI
                     CFGNLVSGRDLPLDDVLNIAGPMINLLPCRIDLSNGKVAEILQQIYSDYAASLSHQTFP
                     IANLRSPCGRSPMAQFDTQLSIRRADSTNDTRNVHLCNIQSWDPHESRVNCYVILEDTR
                     TQVNIRYWKSTMSTEQAALVRTCFCSAVSQLLDGENARVADLALISAVQRARIWGFLSS
                     SETIVEPLERIWAEVLNRAQTQIGGNDDFFRLGGDSILAVRMVSLARKGGIDIRVADVF
                     KFSTIYKLARLLQTQAQTAEGE"
     aSDomain        complement(5682..5882)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_PCP.3"
                     /evalue="1.10E-17"
                     /label="FE257_001452_PCP.3"
                     /locus_tag="FE257_001452"
                     /protein_end="2479"
                     /protein_start="2412"
                     /score="55.9"
                     /tool="antismash"
                     /translation="LERIWAEVLNRAQTQIGGNDDFFRLGGDSILAVRMVSLARKGGID
                     IRVADVFKFSTIYKLARLLQTQ"
     aSModule        complement(5682..7175)
                     /domains="nrpspksdomains_FE257_001452_Condensation_DCL.2"
                     /domains="nrpspksdomains_FE257_001452_PCP.3"
                     /incomplete
                     /locus_tags="FE257_001452"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(5793..5822)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0016"
                     /evalue="2.40E-01"
                     /label="PCP_mE"
                     /locus_tag="FE257_001452"
                     /protein_end="2442"
                     /protein_start="2432"
                     /score="5.0"
                     /tool="antismash"
                     /translation="DFFRLGGDSI"
     aSDomain        complement(6336..7175)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_Condensation_DCL.2"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="7.40E-34"
                     /label="FE257_001452_Condensation_DCL.2"
                     /locus_tag="FE257_001452"
                     /protein_end="2261"
                     /protein_start="1981"
                     /score="109.0"
                     /tool="antismash"
                     /translation="EDIYPCAPVQQGILLVQARKPAFYHVAFSWEVTNSTVEKTGRAIE
                     QIIARHAIFRTCFLQPGSNSSSFFQVVLRCRKQEIPIRALSDEIHQFPGDFQPSARVSS
                     RFSIYYNHGNTSIFVRLDISHALWDGGPIMVVQRELDLGSQGQLIRYPEPSLYRNYIAY
                     IARQDQEAAAGFWTTHLKDMAACHFPSLLTSDLRGPDTPEDLNFELRDYAAIRPYCRRI
                     NVTVPNFFCLVWAMVLRCVTLKDQICFGNLVSGRDLPLDDVLNIAGPMINLLPCRIDL"
     CDS_motif       complement(6345..6437)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0015"
                     /evalue="8.60E-08"
                     /label="C5_DCL_263-294"
                     /locus_tag="FE257_001452"
                     /protein_end="2258"
                     /protein_start="2227"
                     /score="24.7"
                     /tool="antismash"
                     /translation="ICFGNLVSGRDLPLDDVLNIAGPMINLLPCR"
     CDS_motif       complement(7134..7166)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0014"
                     /evalue="5.80E-02"
                     /label="C1_dual_004-017"
                     /locus_tag="FE257_001452"
                     /protein_end="1995"
                     /protein_start="1984"
                     /score="6.8"
                     /tool="antismash"
                     /translation="YPCAPVQQGIL"
     aSDomain        complement(7290..7487)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_PCP.2"
                     /evalue="2.90E-17"
                     /label="FE257_001452_PCP.2"
                     /locus_tag="FE257_001452"
                     /protein_end="1943"
                     /protein_start="1877"
                     /score="54.5"
                     /tool="antismash"
                     /translation="ERALQDVWAHVLQVPASRIGVDDNFFHIGGDSVTGMQAVAQARTK
                     HLDHSLADIFRYKTIAEILSH"
     aSModule        complement(7290..10415)
                     /complete
                     /domains="nrpspksdomains_FE257_001452_Condensation_DCL.1"
                     /domains="nrpspksdomains_FE257_001452_AMP-binding.2"
                     /domains="nrpspksdomains_FE257_001452_PCP.2"
                     /locus_tags="FE257_001452"
                     /monomer_pairings="Tyr -> Tyr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(7389..7418)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0013"
                     /evalue="6.60E-01"
                     /label="PCP_mE"
                     /locus_tag="FE257_001452"
                     /protein_end="1910"
                     /protein_start="1900"
                     /score="3.8"
                     /tool="antismash"
                     /translation="NFFHIGGDSV"
     CDS_motif       complement(7884..7949)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0012"
                     /evalue="5.10E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="FE257_001452"
                     /protein_end="1745"
                     /protein_start="1723"
                     /score="25.3"
                     /tool="antismash"
                     /translation="YVGRIGDQMKIRGQRIERGEVE"
     aSDomain        complement(7914..9104)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_AMP-binding.2"
                     /evalue="6.90E-85"
                     /label="FE257_001452_AMP-binding.2"
                     /locus_tag="FE257_001452"
                     /protein_end="1735"
                     /protein_start="1338"
                     /score="276.9"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="RAQARKTPLAPAIDAWDGKLNFNELEHHSNQAALELQRRGLVPGD
                     FVPLLFERSMWTPVAMIAVNKAGAAFVPMDTEQPLPRLQAMAKQVKCTVIVCSDSMRSM
                     ACQVTPAATVIPFSNVRSSGLRHCPLELQQLPTVTAHGAMYAAFTSGSTGTPKGVVIEH
                     GSYCVAAQEYNKQTLIDRHSRVLQFASYSFDAHIGETISTLMAGACVCIPSDQDRQNAL
                     AQAASSMQITHAMLTPAVARLIRREEMPSLRTLTLMGEAMRPSDYAYWAEKVRLFNGYG
                     PTECTVAISCREYRPGDAVQDIGWPRAAGVWITDPRDYHQLMPMGAVGELLLEGPPVAR
                     GYLNNPEQTAKAFISRPRWRPDIGHAHRIYRTGDLVRYTEDKSLQYVGRIGDQMKIR"
     CDS_motif       complement(8046..8135)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0011"
                     /evalue="8.40E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="FE257_001452"
                     /protein_end="1691"
                     /protein_start="1661"
                     /score="46.9"
                     /tool="antismash"
                     /translation="PMGAVGELLLEGPPVARGYLNNPEQTAKAF"
     CDS_motif       complement(8616..8675)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0010"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="FE257_001452"
                     /protein_end="1501"
                     /protein_start="1481"
                     /score="26.8"
                     /tool="antismash"
                     /translation="MYAAFTSGSTGTPKGVVIEH"
     CDS_motif       complement(8880..8918)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0009"
                     /evalue="8.60E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="FE257_001452"
                     /protein_end="1413"
                     /protein_start="1400"
                     /score="12.8"
                     /tool="antismash"
                     /translation="AVNKAGAAFVPMD"
     aSDomain        complement(9591..10415)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="3.70E-34"
                     /label="FE257_001452_Condensation_DCL.1"
                     /locus_tag="FE257_001452"
                     /protein_end="1176"
                     /protein_start="901"
                     /score="110.1"
                     /tool="antismash"
                     /translation="EDAYPCTPLQEGMMALTEQRRFSYRAKVQCHLQPEIDLSQFRRAW
                     ERVVVRNEILRTRLVSVSSQGVWQVVLRGSFAWDDTESQADEAPMGLGAKLVRGVIIST
                     RSKGTFFILTIHHAICDLWAIRLLLDQVWREYTNVHAGTGSAAPNRFSQFVRYVRRMRN
                     DPASEAYWKGQFAGLDSQVFPELPQPNFIPSPDDEIQHQISLPVRISETSTLSNYIRLA
                     WAMVISHYTATDDVVFGEILNGRGAIMSEHGEDAVEHIVGPTLVSVPRRVELD"
     CDS_motif       complement(9603..9713)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0008"
                     /evalue="4.00E-03"
                     /label="C5_DCL_263-294"
                     /locus_tag="FE257_001452"
                     /protein_end="1172"
                     /protein_start="1135"
                     /score="9.7"
                     /tool="antismash"
                     /translation="DVVFGEILNGRGAIMSEHGEDAVEHIVGPTLVSVPRR"
     CDS_motif       complement(10236..10328)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0007"
                     /evalue="1.20E-07"
                     /label="C2_DCL_024-062"
                     /locus_tag="FE257_001452"
                     /protein_end="961"
                     /protein_start="930"
                     /score="24.0"
                     /tool="antismash"
                     /translation="CHLQPEIDLSQFRRAWERVVVRNEILRTRLV"
     CDS_motif       complement(10374..10406)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0006"
                     /evalue="8.00E-02"
                     /label="C1_dual_004-017"
                     /locus_tag="FE257_001452"
                     /protein_end="915"
                     /protein_start="904"
                     /score="6.4"
                     /tool="antismash"
                     /translation="YPCTPLQEGMM"
     aSDomain        complement(10542..10739)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_PCP.1"
                     /evalue="2.00E-16"
                     /label="FE257_001452_PCP.1"
                     /locus_tag="FE257_001452"
                     /protein_end="859"
                     /protein_start="793"
                     /score="51.9"
                     /tool="antismash"
                     /translation="ALICDVLQIQPEDVSMLDDFFQLGGNSMTAITLVSAAKKQEALKL
                     AVADVFKHPVLADLARSAKET"
     aSModule        complement(10542..12425)
                     /complete
                     /domains="nrpspksdomains_FE257_001452_AMP-binding.1"
                     /domains="nrpspksdomains_FE257_001452_PCP.1"
                     /locus_tags="FE257_001452"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(10656..10685)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0005"
                     /evalue="4.00E+00"
                     /label="PCP_mE"
                     /locus_tag="FE257_001452"
                     /protein_end="821"
                     /protein_start="811"
                     /score="1.7"
                     /tool="antismash"
                     /translation="DFFQLGGNSM"
     CDS_motif       complement(11178..11243)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0004"
                     /evalue="6.80E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="FE257_001452"
                     /protein_end="647"
                     /protein_start="625"
                     /score="24.9"
                     /tool="antismash"
                     /translation="YIGRRGTQVKLRGQRLELEEVE"
     aSDomain        complement(11208..12425)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FE257_001452_AMP-binding.1"
                     /evalue="9.30E-76"
                     /label="FE257_001452_AMP-binding.1"
                     /locus_tag="FE257_001452"
                     /protein_end="637"
                     /protein_start="231"
                     /score="246.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SARQPLSPAVQSTSGYLTYADLDELSSRMAVCLQDKHRVKPGDMV
                     LLCVQKTPWAIVAMLAINKTGGCFVPCDPTHPVARRQVMATRCQARLAVVSPGYEDLLA
                     RIVPEISINPEPAMTEWRESFVPGDDNRTHRPIFSPSAPAYCFFTSGSTGEPKGCIGSH
                     SALAALAHQVPALRMSTESRVLQFAKFGFGISFIEIFCTLAAGGTVCILSDGERLDALP
                     DAMNQMRVNWALLTPTVTQSLVPEQIPGLGMLFLGGEAPDDGLILRWKDKVSLFQVFGT
                     TEMAGVTLVSSRITSPAQRKTVGFGANARVWLCDVSEEEENNAGNLSLAPIGAVGELVI
                     GGPSLGAGYLGDPQRTHALFLELPTSVVAGFSSNLQRVYKTGDLVRYNHDGSLSYIGRR
                     GTQVKLR"
     CDS_motif       complement(11352..11435)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0003"
                     /evalue="5.00E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="FE257_001452"
                     /protein_end="589"
                     /protein_start="561"
                     /score="38.0"
                     /tool="antismash"
                     /translation="PIGAVGELVIGGPSLGAGYLGDPQRTHA"
     CDS_motif       complement(11937..11996)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0002"
                     /evalue="5.90E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="FE257_001452"
                     /protein_end="394"
                     /protein_start="374"
                     /score="22.0"
                     /tool="antismash"
                     /translation="AYCFFTSGSTGEPKGCIGSH"
     CDS_motif       complement(12207..12248)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FE257_001452_0001"
                     /evalue="1.10E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="FE257_001452"
                     /protein_end="304"
                     /protein_start="290"
                     /score="9.5"
                     /tool="antismash"
                     /translation="LAINKTGGCFVPCD"
     gene            complement(<13784..>15277)
                     /gene="nanE"
                     /locus_tag="FE257_001453"
     mRNA            complement(join(<13784..14063,14134..14521,14614..14723,
                     14777..14900,14962..>15277))
                     /gene="nanE"
                     /locus_tag="FE257_001453"
                     /product="hypothetical protein"
     CDS             complement(join(13784..14063,14134..14521,14614..14723,
                     14777..14900,14962..15277))
                     /codon_start=1
                     /db_xref="InterPro:IPR001077"
                     /db_xref="InterPro:IPR016461"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="PFAM:PF00891"
                     /gene="nanE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 185.8; E-value:
                     2e-56)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="FE257_001453"
                     /note="GO_function: GO:0008171 - O-methyltransferase
                     activity [Evidence IEA]; GO_function: GO:0008168 -
                     methyltransferase activity [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="QIQ51366.1"
                     /transl_table=11
                     /translation="MTIANTPAELLASSISTLASRYAEKVQAGENADTEIASIVSACKD
                     LDALVTPPESWNDRMAMSYTISTAIALLLNWDVFQILAAQAKPTSLETLATSCGCSKSL
                     LRCALREAVAHRMLDELSPETYALNSRSSCLLDENKAAWIHYLTDIGLVTAAYLPKYVK
                     SINGKIPEHSHRIALQMAFNVDETFYEFLHRKDPKRGVNFDKAMQRHIKGDAQASIESV
                     FDFSILRPGAVVVDVGGGKGHHCIRIAKKHPHLSFIIQDYEANGPSDGEDTLPEALARR
                     VRWQRHNFHHKQPMDGADVYLLSNILMDNTVSDCNRILTNIVDAMVPNHSVLLVDDAID
                     TLSEDSHSAYSSSMNLHMLSCFGTLFRTQEDWLMLFSEVAGGKLSIVSSWMIDAGRMIF
                     ALRRKF"
     gene            complement(<15897..>17425)
                     /gene="nanF"
                     /locus_tag="FE257_013097"
     mRNA            complement(join(<15897..16508,16593..17188,17254..>17425))
                     /gene="nanF"
                     /locus_tag="FE257_013097"
                     /product="hypothetical protein"
     CDS             complement(join(15897..16508,16593..17188,17254..17425))
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="PFAM:PF01494"
                     /gene="nanF"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 210.5; E-value: 7.7e-64)"
                     /gene_kind="other"
                     /locus_tag="FE257_013097"
                     /note="EggNog:ENOG410PMET; COG:C; GO_function: GO:0071949 -
                     FAD binding [Evidence IEA]"
                     /product="hypothetical protein"
                     /protein_id="QIQ51367.1"
                     /transl_table=11
                     /translation="MTVDDSLSPAGVATPHSSGIRVVVVGLGIAGLTTAIECHRKGHTV
                     IALEKSPVIRVLGDSLGLGSNATNVLEKWADGKILQQLKSLADDISIFEALDSAGKLYA
                     KDDAKGFGADNGMIINRGSLATTLHEYAKMLEIDIRFGAAVTGHWEDESAAGVIINGEQ
                     RLVADCVIGCDGIHSKTREAVLTKEPTAVPSGQAVFRASFDSTSVCNDPNARWILAEKG
                     VRDRLSQYMAEGGLALSLATGKRGQNITWQLWHEDNHNANELWSEHNSAKLENALGMIR
                     HWPIYSKVVPILRHTPKEALTDFKLVNRAALPTWISHAGRIIIIGDAAHPVLPIVGQGG
                     GQGIEDAATVAICLQLAGKTHISLALQAVERLRYARTSIIQSSGPKIYAGVRNPDWKAI
                     EKDPSLIMLPRPKWIFGYDVPRDVYEQFPLVKRAIEEGSSYTPKNIPPGGRYEFLHDFK
                     E"
ORIGIN
        1 ctatggctca gcgttaagac ctatcctgag agccgcagca cccataaaaa cgacagtcaa
       61 cgccccttga aagccgaata cgtcgacgaa gctatatggc atcttcaacg agctagaaag
      121 tcgtagaaaa ggatagaccc accagggtgt cacgatcgtc aggaacgtag ctacccataa
      181 agcgccaacc aacctctcaa gcaaccacaa gctactttct tgagcagatg tcctgtcaaa
      241 tgcctttctc cataaacctt gaacgtggtc ttccagaaaa tatcctgcca cgaaggagat
      301 gtagaaagcc atacatccaa catcaccatc ctggacccct tttatccaat tgaagtaaac
      361 gtggacaatt cccgactggg caaaaaccaa cgcgttattt aggtatcgtt ccaatgggga
      421 gcgtgtcaac ttgaggactc ggcgagtaat gaagtttgag tagctcgtca atggccatct
      481 cagctgttga tgccaccatt tactagtcat agtaaaaccc tcgtatcagt ttacctcaat
      541 cgggaacaaa accaaacaaa atagaaaagc gttggaaact cacccccaaa aaccgcgtaa
      601 tgtgtaagct tctctcaagc taccaaaaaa gggtggccag tcatgtggtg acgtgacgcc
      661 gacagcagtg agtagagcag tcgcaatctt ggactggatc tccgcaaaag cttttaacgt
      721 gacccaaaat accaaagttg cctcgatgcg caccctcaat tgatcgaggc tctggggcat
      781 ccactcctcc tctggcccat aatactccag tctcttctcg gtggggatgt tcttcaacag
      841 agagaatcca atatcggcaa gaaggtactg ccaagccgac acagccagct gtcttatagc
      901 aaatcgatag cgggcggacg ataggaagga agaaagacca gattcgccct gtttttcttt
      961 acagataaac gacgatagaa ccggcagatt ctttatctgg tatttggttc caactcctcg
     1021 ggcgttgaaa ggatatatta gagcagactt gagacgccga aacacacttg atcccgactc
     1081 atcattgaca tcgacacctg taagcactag gatgtttagc tgctgaaggc cattcaaaag
     1141 tgtggtaccc tcaaatgatc catcgaatat attactcgcc gtgttaaccg gcgggttggt
     1201 gagttgtaaa tggcatataa tcagcaatat tgggaagtac gtatatcgaa ttatggagtt
     1261 tttgccagtg gtcgctaaca ggatactgct tattagaaac acaagcagtg acagagttgt
     1321 cgtgctgggt cgcatgacgg aaagcatgct tgaaagtcag tgattagaag aatgtcagac
     1381 tggtttttct aactacagaa acaatgatgg tttatatatg acacttttgc ttgtggtaac
     1441 tttgacatgt tgggaaagga agattctttg gccctcgcac acacatactt ctctattgca
     1501 tagccccttt ttttgaatga cacgtctgac atctagctag gtaactcgat tctactgcca
     1561 ccaaaacgac atatacaacg cataatgtac tgtatgccaa tgttgctgga caggctgtat
     1621 gtaaccatgt ctcatttctg caaaagggat tctttgcatg gtgaaataat acgacatgat
     1681 tattgcattc ttgactcgcc ttcactgcac caattatttc caggaagcta catggatata
     1741 ttacactgtg tctaccatat aaataccttg aagtatgacg aaggttacac aggataacac
     1801 gacatacttg tctaattagg agatgaattc cacaaacaaa agtaaattag ctcctgcaac
     1861 aagtctgcaa ggaacgatag acgcggacta ccattctaga cattaattta ggcatgcttc
     1921 acgaataagg caagtgcacg gcattcatcg tatcatctcg agtctccctg agaaacggga
     1981 tcatatccgt ccctccagta ccgaccagat ccttttgtcg aatggccaga ccattccctg
     2041 ctttttcttt ggcacgggga ataatgatat accgaaatac taaagccata tgcttatctc
     2101 gcagattttt gagccctagg actgccgagt tatagagcga gcacatattg gatgaacccg
     2161 gaccgtggct taaggcatac ggtctaaggt tggatatttc ctccatacgg gcaaggaagc
     2221 gcctgtgctg tgcgggcatg taagagcgca tttcctagaa gatcttcctc agcatccaga
     2281 gtaatcccgt gagagagaga aggggaaggg ggggggctta ttattacccg cagatatcgt
     2341 gtcttatagc caatatcatg attgatcccg agcgttatgt caaaaagctg gataagggag
     2401 ctttgtgcat tgctgcctcc actgtaccgg tgccattctc cggtgccgtc ttctgcttgc
     2461 acgtaaaaca ctcctttgga attttccgtg gcggggttat tattgctagt accagatagg
     2521 aatgggcgaa tgcgatgata aaataccgag ggccggcagt tttcatgcat cctgtcgata
     2581 aggtcacaga gatccctcaa acagatggta aagtcgagta agaagccttc caccgtgagc
     2641 atgtcgttgt tctggacggc ggaaatcgcg ttcaatatcg atgggatgat cctcccaccc
     2701 cgggcttcta tcgcggttga cacgttgaaa aaccacgctt cgtctgttgt tccggtgaaa
     2761 gagcatgtca tcgacatatt gtccaggaac ttatggcagt ccccaccaat gtcgtcgtcg
     2821 aagtgaacgg agaaactcca gaggcagaag gcggcaaatg ttgcaaatgg cttgatctct
     2881 agcaacgtcg agacttcggt caatggcttt gcaattgcct gtggaagggt cttaaaaaga
     2941 aacggtaagc accttcttgt gaatgatgac gataaaccca cagtatttgg tatgtcctcc
     3001 ccccatagat acgcctgagc aaggaaggac agtaacacat acgctcttcg gcgcataggc
     3061 tgtgatgtta gccgtgtgat tcccaatacc ggcatttgat caagttcgtg ttgaagtcgt
     3121 ttagcccgaa tcaggggctc taggtgagct gttaggcgtt cccatgggac ataatacggg
     3181 tctggtagct ttcttagggg gcatttgtcc gggagaaatc ccgaaactcg cgatatgtca
     3241 taagcttcca gatcgacttc cacaggtgat aacattgctg cgagtgtgcg agtgtagtag
     3301 cgattgcttt agtcagggcg gatagttttg tatatgccta cataactgta gagatgcacc
     3361 aaagtgttgg tttgcctctt atatccatgg tagggccaca ttgcatgtat cccacagata
     3421 ccttaagcct taccgcacag taaatggatg gaccggggtt gaggatggga gaatgtagta
     3481 gtgcatcaag aatgattgta gaacgtagta gtatgccata ccgactctat aaagatgagt
     3541 ctggaacatg agacccgcgg attttatcgt cgataaacta acatattagg tatagatcta
     3601 cgagccaagg tatgctagga ttttatctgt taaatctcac gcaatctgtg gtatgaatgc
     3661 ccatcgtaca tagtacattc atacatagta cgtgctctta gaattcatga cttggtatgg
     3721 aactggattc cagccaatag aaacaacaag gaggcttaat taggtagaac atgtcctaag
     3781 gcattgtcca gaaattaata gtggatatgt gaaataataa atcgtgacac agattcagcc
     3841 ggcatatatg catatatgtc ttacaacccg tggaaaagcg taagccaggg acggaaacaa
     3901 attcccccag ttaaaatcaa gaggaagcca tgccacacct caagggacca aggaagggat
     3961 gataaacaaa tgtccaagag caaagttccc gtggaacttg tcatgatggt tgttctcatc
     4021 gatttattct caggtcacct ttcgattctc cactgatcat ctatcctatt cgctttgtcc
     4081 ccagccagaa tggccattat agaacctcag atggaaaacc agaataccat tcccatttac
     4141 gcccgcgaag agaccccata cgatactctc agcaaggtct tgaccttttc gaatatagac
     4201 caagaggagt actggcgacg aattgcccca ttgctgggga agcttctcca gcaaggcagc
     4261 aactacacca ttcaccaaca ataccagcac ttatgcttct acgccctgca tgtaattcct
     4321 ctcctcgggc cctttccagt cgagggaagg agttcttaca actgcccatt gggcggagta
     4381 ggagccattg agccaagcca gaacttccaa aaatccggca caagcctccg atatacattt
     4441 gaaccgacca gcacgggggc tatcagtgga agaagcgatc ccttcaaccg gttcatgatc
     4501 gacgatgcac taagccgatt tcgacaagcc ggcgtgcgct tcaacccgca tctctatgaa
     4561 gcgttgaaga aagaagtcct gctgacggat gaagaagcgg aggccatttg ccagcaccat
     4621 gacgtcccca agatggagtt tcgggctcag gcatgtattg ccgttgacct tgacggcggg
     4681 aacatgtccg tcaaattgta cgtttacccg atgttgaagg ccactctcct caacataccg
     4741 aactgggagc tatgcctgaa tgccattcga catgtcgacg gggagggcca attcaccagt
     4801 gcaaccgccg cactggagac ataccttcga actcaatgtc cgacgaccgt ccgcgagcag
     4861 acatctgcca ctacccaggt cagttacatc gcctgtgatc tagtagatct acagcgcgcg
     4921 cgattcaagg tgtacctgtt cgatctgcat gtctcgtttg agcggattat aacgcattgg
     4981 acgatgggag gtcggctcaa cgatgaagtc accatgagtg ggctggggat actgcgagag
     5041 ttgtgggacg agctgaagat ccctgagggc agacgcaagc cgattgagcg tcccccgaag
     5101 cccggcgatg gacctacaat gcctttgttc ttcaattatg aaatgaaggc tggggatcgt
     5161 cttcccaaag tgaaggccta tctcccgctc gttggaatgc cagagatgcc gattgcgagg
     5221 aagttggcgg ccttcttcca gcggtatggc ttccctgtcg agggacggca atatgtcgat
     5281 actttggcag gatacttgta agtcatggct ctgatgatgt acttcctttg acacttctga
     5341 cattcgtata gccccgacga ggatttggag atagttactc accaccaggc gtttctttcg
     5401 ttttcgtact ctgcgaagac tgggccgtat atgaccatat actaccacta agaacttagt
     5461 aaaatgaggt gttattgtta gtatttgaga ttgagttgca ggcctatcta gatttgccgg
     5521 tgcggctgaa ttaggaagtt tataagtaac agtcaaaata ctctggattt gagatttacc
     5581 tccctggagc caacatgaaa aagatgtatt gattatatct acccaaatac caggggacta
     5641 tttccaacat caccaaatca ttccccctcc gcagtctgtg cctgtgtctg taacagtcga
     5701 gccaatttat aaatcgtcga aaacttaaag acatccgcca cacgaatatc aatcccccct
     5761 ttcctcgcca gagaaaccat gcgaacagcc aatatagagt cacctcccag ccggaaaaag
     5821 tcatcatttc ccccaatctg tgtttgcgcc ctgttcaaca cctccgccca aatccgctcc
     5881 agaggctcca ctatcgtctc cgacgaggac aagaaccccc atatgcgggc tcgttgcacg
     5941 gcgctgataa gagccaggtc cgcgacacgg gcattctcac cgtctagaag ctgcgaaact
     6001 gcgctgcaaa agcacgttcg caccaaggcc gcttgctcag ttgacattgt ggacttccag
     6061 tatcggatgt tgacttgcgt tcgggtatct tcgagaatga catagcaatt cacgcgcgat
     6121 tcgtgcggat cccacgattg gatgttgcag agatgaacgt tgcgtgtgtc gttggtggaa
     6181 tcggctcgtc ggatggatag ctgggtatca aattgcgcca tgggcgagcg gccacaggga
     6241 ctccggaggt tggcaatggg aaaggtctgg tgggagaggc tcgctgcgta atcgctgtag
     6301 atttgctgga ggatttcggc gactttgccg ttgcttaggt cgattcgaca cggcaacagg
     6361 ttgatcatcg gcccggcgat gttcaggacg tcatctagag gcaggtctcg gcctgagact
     6421 aggttgccga agcagatttg gtctttcagt gtgacacagc gcagcaccat cgcccagact
     6481 aggcagaaaa aattgggcac ggtgacgttg atacgtcggc agtatggcct gatggcagca
     6541 tagtcgcgca gttcaaaatt gagatcctca ggcgtatctg gtcctcgcag gtccgatgtc
     6601 agtagcgaag ggaaatgaca tgcggccata tctttcaggt gtgtggtcca gaaccccgca
     6661 gctgcctctt ggtcctgtct cgcaatgtat gcaatatagt tgcgatacag agaaggctct
     6721 gggtatcgaa ttaattggcc ctgagatcca aggtccagct cacgttggac caccattatt
     6781 ggccccccat cccacagtgc gtggctgata tccagacgaa caaatatgga tgtatttcca
     6841 tgattatagt agattgagaa ccgtgaagaa acgcgggcag agggctgaaa atcccctgga
     6901 aattgatgta tctcatcaga caaggctcga ataggaatct cctgttttct acaacgaaga
     6961 acaacttgaa agaaagatga gctattggac ccaggctgaa gaaaacaggt gcgaaatatg
     7021 gcatgtcgcg cgattatctg ctcaatggcc ctaccagtct tctcaacggt ggaatttgtc
     7081 acctcccacg aaaacgcgac gtgataaaac gctggttttc gggcctggac cagcagaatc
     7141 ccctgctgga ctggggcaca ggggtagata tcctctatct cctctttcga cacatcgagc
     7201 tgctccagcg cgtccctgcc ccctaatagc tgaaccgggc cacctatatc attcgctaga
     7261 tctgctccgg tcttggaggc gctagatgta tggctaagga tctctgcaat ggttttgtac
     7321 cggaagatgt ccgccagcga gtggtccaaa tgctttgttc gagcctgtgc cactgcctgc
     7381 atgccggtga ctgaatcgcc cccaatgtgg aagaagttgt catccacccc gatgcgagag
     7441 gctgggactt gaaggacatg agcccaaacg tcttgcaaag cgcgttcctg atccgtcgag
     7501 ggcggccgag tgggcgcagc agccggaaag aactggcgca gctcctccca agtatatgcc
     7561 tgcagctctc ttttgaggcg tggtcgatcg atcttcccac tcagcatgtg cggcaagcgg
     7621 tagattggca caaatatcac cggcaccata aatcgaggca gatgctgttg aagctgggtc
     7681 tctaccctga tgacctgcaa cgagaagtct ccgtccggcg aagtgagcat cgattggcag
     7741 agaccttggt ccgtcccatc taccttcttc ctattgtgct ctataaacgc caccagacac
     7801 acacgatccc tattatcccc tgctaggacg gcatcaaccg ccatttcgac tccagtggga
     7861 agccagaatc gtcgcagctg agattcaact tcgccccgtt cgattctctg gccacggatt
     7921 ttcatctggt ccccgattcg acccacatac tgcagcgact tatcctcggt gtatcgaacc
     7981 aggtcgccgg tccggtatat ccgatgcgcg tggccgatat ccggcctcca tctgggccgg
     8041 gaaatgaacg cttttgccgt ctgctcaggg ttgttcaggt atcctctcgc caccgggggc
     8101 ccttccaaga gcagctcccc gacagcaccc atgggcataa gctggtggta gtcgcgaggg
     8161 tctgtgatcc aaaccccagc agcgcgcggc cagccaatat cttgcacggc atcgcccggt
     8221 cgatactccc ggcaggaaat ggccacggtg cactcggtcg gtccatatcc gttaaagaga
     8281 cggaccttct cggcccagta ggcgtagtca gatggccgca tcgcttcccc catcagagtc
     8341 aaggtcctca acgagggcat ctcttcccgc cgaatcagtc gagcaacggc cggggtgagc
     8401 attgcatgcg tgatctgcat ggaggacgca gcttgtgcaa gggcgttttg ccggtcttgg
     8461 tctgatggaa tacacacaca tgccccggcc atcaaggtgc tgattgtctc gccaatgtgg
     8521 gcatcaaagc tgtacgaggc aaactgtagt acccgcgaat gccggtcgat gagcgtctgc
     8581 ttattgtact cctgggctgc gacacagtag gatccgtgct caatgacgac ccctttgggc
     8641 gtgcctgtcg acccggaggt aaaagctgca tacattgcac catgcgcagt gaccgtgggt
     8701 aattgctgca gttctaacgg acagtgtctt aggccgctgg atctgacatt ggagaaaggt
     8761 atgactgtcg ctgcaggggt gacttggcag gccatcgatc tcatcgaatc tgagcacaca
     8821 attaccgtgc atttgacttg ctttgccatg gcctggagac gcggcaatgg ctgttctgta
     8881 tccataggga cgaatgccgc acccgcctta ttcactgcaa tcatcgccac gggcgtccac
     8941 atactccttt cgaaaagcag cggaacaaag tctcccggaa caagtccacg gcgctgcagc
     9001 tcgagggcgg cctggttaga gtgatgttca agttcattga aattcaactt tccatcccag
     9061 gcgtctatag ctggcgccag cggtgtcttc cttgcttgtg cccggatgga ttcgtgcaca
     9121 ttcccacaga tattcgttgg tatcccgaca ttccaagtgt atatccggtc caggtcttgg
     9181 gagctgaccc tgggcactga tttgagccgc tgataaggat cctggatcat actctccaga
     9241 accatatgta gatggtttaa tagccgctgc atgtgtggtc gtgacactac tcggctatca
     9301 aagcatgctg tcagaccaag gcggctctcg ttcatgctga gccgacattc aagcccgatg
     9361 gcatacgaag caaacccccc ggtaatgctg gctccagcct gcacactctg gaagatctga
     9421 cctggtgggt tccatgccga ctgcacaacg atgtgactct ggaacataca tgccacctcg
     9481 gtctcggggc tgtatcgctg aatatactgc aggccaacct gctcaaatgg gatcatctcg
     9541 gtccgttgct cttggattct ggacaatgcc tcagacacag acatctcata gtcaagttca
     9601 actcgcctag ggacgctcac aagggtagga cccacgatgt gctcgacagc gtcttctcca
     9661 tgttcagaca ttatggctcc gcgcccattc aggatctcgc caaacaccac atcatccgtc
     9721 gcggtataat gtgagatcac catggcccac gcgagccgga tgtagttcga cagcgtgctg
     9781 gtctctgaaa tccgtaccgg gagagagatc tgatgctgta tctcgtcatc tggacttggt
     9841 atgaagttcg gctgcggtag ctccggaaag acctgggagt cgaggccagc aaactgaccc
     9901 ttccagtagg cctccgaagc aggatcgttg cgcatccggc gcacgtatcg gacaaactga
     9961 gaaaatcgat ttggagcagc tgatccagtc cccgcatgaa cattggtgta ttcccgccat
    10021 acttgatcca ggagtaggcg gatcgcccac agatcacata tcgcatggtg gatggtcagg
    10081 atgaagaacg tcccctttga ccttgtgcta ataatgaccc cgcgaaccag ctttgctcct
    10141 aagcccatgg gtgcctcgtc cgcctggctt tccgtgtcat cccaagcaaa tgatcccctt
    10201 agcaccactt gccaaacgcc ctgggaagac accgacacca gtcgcgtgcg aagaatctca
    10261 ttccgcacca ccaccctctc ccatgcccgt cggaattgac tgagatcaat ctctggctgc
    10321 aagtggcatt gcacttttgc gcgataggaa aatcgacgct gttctgtcaa agccatcatg
    10381 ccttcctgca acggggtgca gggatatgcg tcctcgagag aagatagacc gatattgcat
    10441 tgggtcacaa ctgtctgctt cagctcattg agatcaagcg attcctcatc cagcatcata
    10501 aaaggcctct gtgtggcaat ctgcaccgtc gaaactttgc tagtttcttt ggcgcttcgt
    10561 gccagatccg ccagaacagg atgtttaaac acatccgcga cagccagttt cagagcttcc
    10621 tgctttttcg ctgcactcac cagcgttatt gctgtcatgg aattgccccc aagctggaag
    10681 aaatcgtcta acatgctcac atcctcgggc tggatctgaa ggacatcaca gatcaatgca
    10741 tgtaccttga gctcaatgtc cgtctgtgct cggagcattt ggactcgtcg tcccgccagg
    10801 tgttgtagat cttgatatgg cagggcgttt atttgccgtt ggatgcgatt ccgatcgacc
    10861 tttcctgtcg ccgtccgggg cacatccacc aacgccagaa agatctgcgg caccataaag
    10921 gggggcagcg tgtcgcgcag cttctcctgc accatatcga gatccctatg gtcttgttcc
    10981 cgcagcttca agaattccag tgtcccatta ctgctagtgc gaggctcacg gcttgcttgg
    11041 ggcatcagaa taaatgccgc cagggtacac cggtcgactt gcgtttgatc ctgtcccgat
    11101 ggatcgatga cgagggcgat gacgcgaagt gcccccgtcc atgtcttagt accagcgagc
    11161 aaacggataa tatggcactc cacctcttcc agctcaagcc gttgtccccg aagcttcacc
    11221 tgtgtccctc gacgtccaat atagctgagc gacccatcgt ggttgtatcg caccaagtct
    11281 cccgtcttat atactcgctg caggtttgaa gaaaaaccag caactactga agttggcagc
    11341 tctagaaaca gtgcgtgggt gcgctgtgga tctcccagat atcctgctcc caaactcggc
    11401 cccccgatga cgagctcacc aacagcacca ataggagcca gcgacaggtt tcccgcatta
    11461 ttttcttctt cctctgatac atcgcacaac catacccgag cattggctcc gaaacctact
    11521 gtcttgcgct gcgccggcga cgtaatccgc gaagacacca gcgtgacacc tgccatctcc
    11581 gtcgtgccaa acacctgaaa cagcgacacc ttgtccttcc accgcaaaat aagaccatcg
    11641 tctggtgcct cgcctccgag gaaaagcatt cccagtccgg ggatctgctc cggcaccaat
    11701 gactgcgtga cggtcggtgt gagcagagcc cagttcaccc gcatttgatt catagcatcc
    11761 ggcagtgcat ccaggcgctc gccatccgac aaaatacaca cagttcctcc tgcagcaagc
    11821 gtgcaaaaaa tctcgatgaa ggagatccca aacccgaact tggcgaactg gagcacccgg
    11881 ctttccgtgc tcatgcgcaa ggcgggcacc tggtgtgcta acgcggcgag agcactgtgc
    11941 gagccaatac atccctttgg ctcccccgtg ctgcccgagg tgaagaagca gtatgcaggg
    12001 gctgacgggc tgaagatagg cctgtgtgtg cggttgtcgt cgcctggcac gaagctttct
    12061 cgccattccg tcatcgctgg ttcgggattg atagagattt ccggcacgat tctcgcaagc
    12121 aagtcctcgt accctggaga caccactgcg aggcgggctt gacaacgagt cgccattacc
    12181 tgtcgacggg cgacgggatg tgtcgggtcg cagggaacga agcatccgcc ggtcttgtta
    12241 atggccagca tggcgacgat cgcccagggg gtcttttgga cacagagaag caccatgtcc
    12301 ccgggtttta ctctgtgctt gtcttgtagg caaacggcca tgcgagaaga tagttcgtct
    12361 aggtcggcat atgtgaggta gccactggtg ctctggactg cgggtgagag aggctgtcgt
    12421 gccgaaaatt ctgccagtcg gtgccacatc gctgtcttcg agtcctcttt tagaggttga
    12481 ttctgccacc gtgagatctg ctgttgctgg gccaggctgc agagtgatat ctttcccagt
    12541 ggttgatggg gctcacggag gacggactgc atggcgcaag agaaagaact catcagattc
    12601 tcggcgtgaa atgcagatag atgtcggcag cggtagacga ggtttacagt aatctgggac
    12661 ttgtttgtgt gtgcaacgat gttgacgtca gacatctaac caggtggtta atcatagtcg
    12721 ccgtgaacac ttggtgatgg gggttacggt acctcagact ctgttagata ctcgtctcta
    12781 atgaagactg cagtattgaa tgtgtggtat gatggtctag aaagggttga aattgtccag
    12841 ctttccaaat ccagcaacga agaaaccaaa cttcggggcc gcacttccac gctccaactt
    12901 tcgcataatt ttttgcgctt tatgtcgacc accacggcaa agtgcacagg gttggcctca
    12961 gcaaatctat gaagaacaat tgtccacgcc gtagacagca ggagttgtag ttcaccccta
    13021 ttctggaacc ggtcatggtc gttgagatca cggcataaga tcggatcgag tgccaccttc
    13081 tgcatcccgg gcttgttcgc agatttggta tttgtaacga ttgctgggaa taaacagatg
    13141 cttttgcgcc ctgcttcatc tgtagtcaaa ctcatgttca gcaataaagg agaagagtat
    13201 acggcttctg ctatcgaacg gcaaatgggg gtgtctatag actatggtgg tctttttttt
    13261 tttttttttc cacttataac agccaacact tgtaatgcct ttccatgtca gcacattctc
    13321 agctccgtct cattatgtat cagaaggccg aggaattaaa atcagcaagg gtctttccgg
    13381 gatgtctttg tcgatctgat gacgatgtta gacattctgt ttccttacat gctttgtatc
    13441 caggtgttca ttgatgtggc gcgcatagtt tacaaggctc tgcatgagga atttgttcct
    13501 cagaagacgc caatcccttt ctactgcacg gtagaaagta gagcagcccg aaaagaattt
    13561 cctgtgacga tgccagcttt atcagcccct aggtatctga ctttcgcgga catcgagtgt
    13621 caaccccggc aagaacaaga gaacgaaacg gcatgatagg tttgtctagg agcaagatat
    13681 acgaaccagg tatctattct gtcatatgtc taccactcag agggagctta aagcatttta
    13741 atcacttttt tctctattcg actttttcca accaacttat ggctcaaaac tttcgccgca
    13801 atgcaaaaat catccgtccc gcgtcaatca tccatgaaga gacaatagaa agtttccccc
    13861 ccgcaacctc ggagaaaagc atcagccaat cctcttgcgt ccgaaataga gtcccaaagc
    13921 aggataacat gtgtagattc atagaactag agtaagcgga gtgagagtcc tcggacaaag
    13981 tgtcaatagc gtcatccacc aggagaaccg aatggtttgg taccatggca tcgacgatgt
    14041 ttgtcagtat gcggttgcaa tcactaataa agaaaaggga agacctcaga attccagcac
    14101 gagtagcaag aggagaggga agattattca tacctaacag tgttgtccat cagtatattg
    14161 ctcagcaggt aaacgtcggc tccatccatg ggctgcttat ggtggaaatt gtgcctttgc
    14221 catctcacgc gtcgagctaa ggcttcgggc agagtatcct cgccatcgct ggggccattc
    14281 gcttcataat cctgaatgat gaaagacaga tgtggatgtt tcttggcgat tcggatgcaa
    14341 tgatggcctt tcccaccccc gacatccacc actactgctc ctggtctcag gatactgaaa
    14401 tcgaagactg actctattga cgcctgggcg tctcccttta tgtgtcgctg catggctttg
    14461 tcgaaattca ctccacgctt ggggtccttc cgatggagaa attcgtagaa tgtttcgtcc
    14521 actagaaaga aaaaaaaaaa aagggggggg ggggggtttg ttaatcataa aactacctaa
    14581 atatgtgact gagaataggt tcgggcgtcc taccattaaa tgccatctgt aacgctatcc
    14641 ggtgggaatg ctctggtatc ttcccattga tcgatttcac gtattttggt agatacgcag
    14701 cggtcaccaa cccaatatcg gtcctgacgc agaatcagcc tcttcttcgg gtgcgttgaa
    14761 cactatcacc acttacaggt aatggatcca tgccgccttg ttctcgtcta atagacaaga
    14821 ggatcggctg ttaagagcgt aggtctcggg ggataattca tccaacatgc gatgggccac
    14881 agcttccctc agagcacacc ctacacaaac acgccagagc tcattagtgt taaaagctga
    14941 agctcagtag ggatcaaata cttaaaagtg acttggagca tccacagctt gttgcaagtg
    15001 tctccaagga ggttggtttt gcctgggcag cgaggatctg aaaaacatcc caattcaaga
    15061 gcaaagcaat ggctgtgcta atagtgtatg acatggccat ccgatcattc cagctttcag
    15121 gaggagtgac caaagcatcg aggtccttgc aggcggacac aatagacgcg atctcagtat
    15181 cggcattctc cccggcctgg accttctcag catatctgct cgcgagggta gagatcgacg
    15241 aggctagaag ctccgctggc gtgtttgcaa tcgtcatttt ggtagaggat aaatgaatat
    15301 tcccaatagt atgaactacg atcagcaccc attattgggg tcttacggta atataacttc
    15361 catggacttg gtagttcttg ttcttgttct agatgatgtg atgttgttta cttcattggc
    15421 ggatataggc tggcggcgca ttagatacat gaggtcctag gagagacata atgattctat
    15481 caagccaaac tgcaggtggt gcatatcctg cataaataat ctcaacccgg taggcaggct
    15541 ctttcaaccg catgcaaggg gccatacttc atttccacat accttgccaa caaactgtct
    15601 cacctcgttg cgtacacaga agttgggata gggatgtcgg gtgcattttc atttgttgct
    15661 ttcatgttcc gacaggccag atatcaacgt tctaatgaat catctccttc ttacatccct
    15721 atctgtttct cggtgcgaga atgcactgaa tacatacctg agctttttga aatattctac
    15781 ctacattgca ttgttttatg tacctctaaa tttcaaccac gatctcattt ccactaatta
    15841 atagctttac ctttatatgc tctactgaat ttcagtagca ttggtagata tttcttctat
    15901 tccttaaaat catgtagaaa ctcgtacctc ccccccggcg ggatattctt gggcgtatag
    15961 gagcttcctt cctcgatagc tctcttgacc agcggaaact gctcgtagac atctcgcggg
    16021 acatcataac caaaaatcca ctttggcctt ggtagcataa tcaacgatgg atctttctca
    16081 attgccttcc aatctgggtt acgcaccccg gcatagatct tcggcccact ggattggatg
    16141 atgctagtgc gcgcatatcg cagcctttcc actgcctgaa gtgcaagcga tatatgagtt
    16201 ttccctgcaa gctgcagaca tattgccact gtcgcagcat cttcaatacc ttgtccgcca
    16261 ccttgaccca caattggtaa gacagggtgt gctgcatccc cgatgataat tattcgtccc
    16321 gcatgagaga tccatgttgg caacgcagcc cggttcacca atttgaagtc ggtaagggct
    16381 tctttcggcg tatgtcgaag aattgggacc actttcgagt aaataggcca gtggcgtatc
    16441 atccccaggg cgttctccag cttcgcactg ttgtgttcgg accacaattc attggcgtta
    16501 tggttgtcct gtttgggtgt caatcacatt tagtattaat ttttttttgg ctcctccaac
    16561 cacctcttcc ggtgtatttg caaacaacgt acctcatgcc acagctgcca tgtaatgttc
    16621 tggccacgct ttcccgtggc cagagacaga gcgaggccac cttctgccat atattgcgac
    16681 aacctatccc ggacaccctt ctctgccagg atccacctag cattgggatc attgcataca
    16741 gatgtggagt caaaggaggc ccggaagaca gcctggccgg atgggactgc ggtaggctct
    16801 ttagtcaaca ctgcttctcg cgttttgcta tgtattccgt cgcagccaat cacgcagtca
    16861 gccacgaggc gttgctcgcc attaataata acaccggcgg cgctttcatc ctcccagtgt
    16921 ccagtgacag ccgcaccaaa tcgaatgtca atctccagca tcttagcata ctcatggagt
    16981 gtggtggcaa gacttccgcg attgatgatc atgccgttgt cagctccaaa ccctttcgcg
    17041 tcatccttgg catacagttt gccagcagaa tcaagggcct caaagatcga gatatcatct
    17101 gctaggctct ttaactgctg aagaattttt ccatctgccc atttttctag gacgttggtt
    17161 gcgttgctcc caagcccaag gctgtcccct gcgcagtgtt agcaaacata catttgattc
    17221 tcttccctag ccagtagggg gggaggggtt taccgagcac tcgaatcacc gggcttttct
    17281 ccagggcaat caccgtatgt cctttgcgat ggcactcgat agctgtggtg agacccgcga
    17341 ttccgagacc aacaacgacg accctaattc cactcgaatg gggggtggcc accccagccg
    17401 gactcaggct gtcatctact gtcat
//
